IT8468241A0 - Derivati del triptofano farmaceuti camente attivi e composizioni farmaceutiche che li contengono - Google Patents
Derivati del triptofano farmaceuti camente attivi e composizioni farmaceutiche che li contengonoInfo
- Publication number
- IT8468241A0 IT8468241A0 IT8468241A IT6824184A IT8468241A0 IT 8468241 A0 IT8468241 A0 IT 8468241A0 IT 8468241 A IT8468241 A IT 8468241A IT 6824184 A IT6824184 A IT 6824184A IT 8468241 A0 IT8468241 A0 IT 8468241A0
- Authority
- IT
- Italy
- Prior art keywords
- compositions containing
- pharmaceutical
- tryptophan derivatives
- pharmaceutical compositions
- active
- Prior art date
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT68241/84A IT1179866B (it) | 1984-12-12 | 1984-12-12 | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
IE302985A IE58502B1 (en) | 1984-12-12 | 1985-12-02 | Pharmaceutically active derivatives of tryptophan and pharmaceutical compostitions containing them |
PCT/EP1985/000672 WO1986003489A1 (en) | 1984-12-12 | 1985-12-05 | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
AT86900106T ATE85976T1 (de) | 1984-12-12 | 1985-12-05 | Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. |
EP86900106A EP0237522B1 (en) | 1984-12-12 | 1985-12-05 | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
AU52099/86A AU589938B2 (en) | 1984-12-12 | 1985-12-05 | Tryptophan derivatives |
JP61500191A JPS62501292A (ja) | 1984-12-12 | 1985-12-05 | トリプトファンの医薬的活性誘導体および該誘導体を含有する医薬組成物 |
DE8686900106T DE3587122T2 (de) | 1984-12-12 | 1985-12-05 | Pharmakologisch aktive derivate von tryptophan und diese enthaltende pharmazeutische zusammensetzungen. |
CA000497174A CA1256441A (en) | 1984-12-12 | 1985-12-09 | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
ES549822A ES8706630A1 (es) | 1984-12-12 | 1985-12-11 | Procedimiento para la preparacion de derivados n-acilados del-triptofano |
ZA859526A ZA859526B (en) | 1984-12-12 | 1985-12-12 | Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them |
PT81674A PT81674B (pt) | 1984-12-12 | 1985-12-12 | Processo para a preparacao de derivados n-acilados de l-triptofano farmaceuticamente activos, das composicoes farmaceuticas e de um produto farmaceutico que os contem, aplicaveis para aliviar a dor em seres humanos |
DK381486A DK168564B1 (da) | 1984-12-12 | 1986-08-11 | Anvendelse af N-acylerede derivater af L-tryptophan til fremstilling af et lægemiddel til lindring af human smerte, farmaceutiske præparater indeholdende dem, samt sådanne nye farmaceutisk aktive derivater |
US07/217,116 US4870097A (en) | 1984-12-12 | 1988-07-11 | Pharmaceutical use of derivatives of tryptophan |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT68241/84A IT1179866B (it) | 1984-12-12 | 1984-12-12 | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8468241A0 true IT8468241A0 (it) | 1984-12-12 |
IT8468241A1 IT8468241A1 (it) | 1986-06-12 |
IT1179866B IT1179866B (it) | 1987-09-16 |
Family
ID=11308641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT68241/84A IT1179866B (it) | 1984-12-12 | 1984-12-12 | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
Country Status (14)
Country | Link |
---|---|
US (1) | US4870097A (it) |
EP (1) | EP0237522B1 (it) |
JP (1) | JPS62501292A (it) |
AT (1) | ATE85976T1 (it) |
AU (1) | AU589938B2 (it) |
CA (1) | CA1256441A (it) |
DE (1) | DE3587122T2 (it) |
DK (1) | DK168564B1 (it) |
ES (1) | ES8706630A1 (it) |
IE (1) | IE58502B1 (it) |
IT (1) | IT1179866B (it) |
PT (1) | PT81674B (it) |
WO (1) | WO1986003489A1 (it) |
ZA (1) | ZA859526B (it) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
US5089638A (en) * | 1986-06-16 | 1992-02-18 | Merck & Co., Inc. | Amino acid analogs as CCK-antagonists |
SE8901149D0 (sv) * | 1989-04-03 | 1989-04-03 | Pharmacia Ab | Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat |
US5360814A (en) * | 1991-02-28 | 1994-11-01 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
US5484814A (en) * | 1991-02-28 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
DE69201141T2 (de) * | 1991-02-28 | 1995-05-11 | Merrell Dow Pharma | NMDA-Antagonisten. |
US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
AU2003275075A1 (en) | 2002-09-20 | 2004-04-08 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved activity |
BRPI0617186A2 (pt) | 2005-10-08 | 2011-07-19 | Potentia Pharmaceuticals Inc | uso de análogo de compstatina, implante ocular, micropartìcula ou nanopartìcula, composição, composto multivalente, ácido nucléico, vetor de expressão, célula hospedeira recombinante, proteìna de fusão e método de produção e teste |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
EP2377878B1 (en) * | 2005-11-28 | 2018-03-28 | The Trustees Of The University Of Pennsylvania | Potent compstatin analogs |
WO2008097525A2 (en) | 2007-02-05 | 2008-08-14 | Potentia Pharmaceuticals, Inc. | Local complement inhibition for treatment of complement-mediated disorders |
PT2424557T (pt) | 2009-05-01 | 2018-02-05 | Univ Pennsylvania | Compstatina modificada com estrutura peptídica e modificações no terminal c |
CA2813049A1 (en) | 2010-09-23 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Modified compstatin with improved stability and binding properties |
CA2826019C (en) | 2011-01-26 | 2017-08-01 | Nico Worldwide Inc. | Remedy for migraine headache |
BR112013028816B1 (pt) | 2011-05-11 | 2020-12-15 | Apellis Pharmaceuticals, Inc | Análogos de compstatina, composição que os compreende e uso dos mesmos |
JP6618682B2 (ja) | 2011-06-22 | 2019-12-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 補体阻害剤による慢性障害の治療方法 |
WO2013036778A2 (en) | 2011-09-07 | 2013-03-14 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved pharmacokinetic properties |
DK2920201T3 (da) | 2012-11-15 | 2020-04-14 | Apellis Pharmaceuticals Inc | Langtidsvirkende compstatin-analoger og relaterede sammensætninger og fremgangsmåder |
WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
US10213476B2 (en) | 2014-03-17 | 2019-02-26 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with improved potency and pharmacokinetic properties |
EP3359555B1 (en) | 2015-10-07 | 2023-12-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
US10925857B2 (en) | 2015-11-12 | 2021-02-23 | The Trustees Of Columbia University In The City Of New York | Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics |
BR112019020955A2 (pt) | 2017-04-07 | 2020-05-05 | Apellis Pharmaceuticals Inc | regimes de dosagem e composições e métodos relacionados |
WO2018200381A1 (en) | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
CA3096078A1 (en) | 2018-04-06 | 2019-10-10 | The Trustees Of The University Of Pennsylvania | Compstatin analogs with increased solubility and improved pharmacokinetic properties |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1055518B (it) * | 1971-05-18 | 1982-01-11 | Rotta Research Lab | Derivatives del triptofano |
US4482567A (en) * | 1982-10-07 | 1984-11-13 | Research Foundation For Mental Hygiene, Inc. | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
-
1984
- 1984-12-12 IT IT68241/84A patent/IT1179866B/it active
-
1985
- 1985-12-02 IE IE302985A patent/IE58502B1/en not_active IP Right Cessation
- 1985-12-05 AT AT86900106T patent/ATE85976T1/de active
- 1985-12-05 EP EP86900106A patent/EP0237522B1/en not_active Expired - Lifetime
- 1985-12-05 JP JP61500191A patent/JPS62501292A/ja active Pending
- 1985-12-05 WO PCT/EP1985/000672 patent/WO1986003489A1/en active IP Right Grant
- 1985-12-05 AU AU52099/86A patent/AU589938B2/en not_active Ceased
- 1985-12-05 DE DE8686900106T patent/DE3587122T2/de not_active Expired - Fee Related
- 1985-12-09 CA CA000497174A patent/CA1256441A/en not_active Expired
- 1985-12-11 ES ES549822A patent/ES8706630A1/es not_active Expired
- 1985-12-12 ZA ZA859526A patent/ZA859526B/xx unknown
- 1985-12-12 PT PT81674A patent/PT81674B/pt not_active IP Right Cessation
-
1986
- 1986-08-11 DK DK381486A patent/DK168564B1/da not_active IP Right Cessation
-
1988
- 1988-07-11 US US07/217,116 patent/US4870097A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IE58502B1 (en) | 1993-10-06 |
ES8706630A1 (es) | 1987-06-01 |
DE3587122T2 (de) | 1993-07-15 |
ES549822A0 (es) | 1987-06-01 |
ATE85976T1 (de) | 1993-03-15 |
PT81674B (pt) | 1987-10-20 |
JPS62501292A (ja) | 1987-05-21 |
EP0237522B1 (en) | 1993-02-24 |
PT81674A (en) | 1986-01-01 |
EP0237522A1 (en) | 1987-09-23 |
DK168564B1 (da) | 1994-04-25 |
AU589938B2 (en) | 1989-10-26 |
DK381486A (da) | 1986-08-11 |
IT8468241A1 (it) | 1986-06-12 |
AU5209986A (en) | 1986-07-01 |
US4870097A (en) | 1989-09-26 |
WO1986003489A1 (en) | 1986-06-19 |
IE853029L (en) | 1986-06-12 |
ZA859526B (en) | 1986-08-27 |
DK381486D0 (da) | 1986-08-11 |
CA1256441A (en) | 1989-06-27 |
DE3587122D1 (de) | 1993-04-01 |
IT1179866B (it) | 1987-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19941230 |