DK1684763T3 - 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel - Google Patents

6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel

Info

Publication number
DK1684763T3
DK1684763T3 DK04784454T DK04784454T DK1684763T3 DK 1684763 T3 DK1684763 T3 DK 1684763T3 DK 04784454 T DK04784454 T DK 04784454T DK 04784454 T DK04784454 T DK 04784454T DK 1684763 T3 DK1684763 T3 DK 1684763T3
Authority
DK
Denmark
Prior art keywords
imidazo
halo
aryl
pyrimidines
anticancer agent
Prior art date
Application number
DK04784454T
Other languages
Danish (da)
English (en)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1684763T3 publication Critical patent/DK1684763T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04784454T 2003-09-24 2004-09-17 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel DK1684763T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
DK1684763T3 true DK1684763T3 (da) 2008-09-01

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04784454T DK1684763T3 (da) 2003-09-24 2004-09-17 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel

Country Status (14)

Country Link
US (2) US7285555B2 (zh)
EP (1) EP1684763B1 (zh)
JP (1) JP4695595B2 (zh)
CN (1) CN100486580C (zh)
AT (1) ATE398452T1 (zh)
AU (1) AU2004275728A1 (zh)
BR (1) BRPI0414778A (zh)
CA (1) CA2537520A1 (zh)
DE (1) DE602004014525D1 (zh)
DK (1) DK1684763T3 (zh)
ES (1) ES2308256T3 (zh)
MX (1) MXPA06002939A (zh)
PL (1) PL1684763T3 (zh)
WO (1) WO2005030218A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2353593A1 (en) * 1998-12-18 2000-06-22 Hadasit Medical Research Services & Development Ltd. Method of administering a compound to multi-drug resistant cells
DK1973545T3 (da) 2005-12-23 2013-02-25 Ariad Pharma Inc Bicykliske heteroarylforbindelser
BRPI0807458A2 (pt) * 2007-01-08 2014-06-03 Basf Se Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
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TW224044B (zh) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) * 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
TW258648B (zh) * 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
EP0984919B1 (en) 1997-03-18 2003-01-22 Basf Aktiengesellschaft Process for the preparation of arylmalonates
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
PT1054888E (pt) 1998-02-11 2004-02-27 Basf Ag 7-alquil-triazolopirimidinas fungicidas
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) * 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
EP1066291B8 (en) 1998-03-23 2005-09-14 Basf Aktiengesellschaft Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6284762B1 (en) * 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US6268371B1 (en) * 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) * 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
EP0988790B1 (en) 1998-09-25 2003-05-21 Basf Aktiengesellschaft Fungicidal mixtures
US5986135A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
ATE258009T1 (de) 1998-09-25 2004-02-15 Basf Ag Nicht-wässriges suspensionskonzentrat
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
AU3154601A (en) * 1999-11-18 2001-05-30 Basf Aktiengesellschaft Non-aqueous concentrated spreading oil composition
US6559151B2 (en) * 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
AU7306201A (en) * 2000-06-30 2002-01-14 American Home Prod Substituted-triazolopyrimidines as anticancer agents
WO2002015697A2 (en) * 2000-08-25 2002-02-28 Basf Aktiengesellschaft Fungicidal formulation
ES2226968T3 (es) 2000-12-06 2005-04-01 Wyeth 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas.
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
PT1381609E (pt) 2001-04-11 2005-05-31 Wyeth Corp 5-halogeno-6-fenil-7-fluoroalquilamino-triazolopirimidinas como fungicidas
DE60220296T2 (de) * 2001-09-04 2008-01-17 Sumitomo Chemical Co., Ltd. IMIDAZO(1,2-a)PYRIMIDINE UND DIESE ENTHALTENDE FUNGIZIDZUSAMMENSETZUNGEN
WO2003089433A1 (fr) * 2002-04-19 2003-10-30 Sumitomo Chemical Company, Limited 5,6-diphenylimidazo [1,2-a] pyrimidine et composition bactericide la renfermant

Also Published As

Publication number Publication date
EP1684763A1 (en) 2006-08-02
CN100486580C (zh) 2009-05-13
JP4695595B2 (ja) 2011-06-08
EP1684763B1 (en) 2008-06-18
DE602004014525D1 (de) 2008-07-31
BRPI0414778A (pt) 2006-11-21
MXPA06002939A (es) 2006-05-31
PL1684763T3 (pl) 2008-11-28
CN1856311A (zh) 2006-11-01
WO2005030218A1 (en) 2005-04-07
ES2308256T3 (es) 2008-12-01
CA2537520A1 (en) 2005-04-07
AU2004275728A1 (en) 2005-04-07
JP2007506745A (ja) 2007-03-22
US7285555B2 (en) 2007-10-23
US20080255157A1 (en) 2008-10-16
US20050065167A1 (en) 2005-03-24
US7915266B2 (en) 2011-03-29
ATE398452T1 (de) 2008-07-15

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