DK1684763T3 - 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel - Google Patents
6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddelInfo
- Publication number
- DK1684763T3 DK1684763T3 DK04784454T DK04784454T DK1684763T3 DK 1684763 T3 DK1684763 T3 DK 1684763T3 DK 04784454 T DK04784454 T DK 04784454T DK 04784454 T DK04784454 T DK 04784454T DK 1684763 T3 DK1684763 T3 DK 1684763T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazo
- halo
- aryl
- pyrimidines
- anticancer agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50548603P | 2003-09-24 | 2003-09-24 | |
PCT/US2004/030595 WO2005030218A1 (en) | 2003-09-24 | 2004-09-17 | 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1684763T3 true DK1684763T3 (da) | 2008-09-01 |
Family
ID=34393021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04784454T DK1684763T3 (da) | 2003-09-24 | 2004-09-17 | 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel |
Country Status (14)
Country | Link |
---|---|
US (2) | US7285555B2 (zh) |
EP (1) | EP1684763B1 (zh) |
JP (1) | JP4695595B2 (zh) |
CN (1) | CN100486580C (zh) |
AT (1) | ATE398452T1 (zh) |
AU (1) | AU2004275728A1 (zh) |
BR (1) | BRPI0414778A (zh) |
CA (1) | CA2537520A1 (zh) |
DE (1) | DE602004014525D1 (zh) |
DK (1) | DK1684763T3 (zh) |
ES (1) | ES2308256T3 (zh) |
MX (1) | MXPA06002939A (zh) |
PL (1) | PL1684763T3 (zh) |
WO (1) | WO2005030218A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2353593A1 (en) * | 1998-12-18 | 2000-06-22 | Hadasit Medical Research Services & Development Ltd. | Method of administering a compound to multi-drug resistant cells |
DK1973545T3 (da) | 2005-12-23 | 2013-02-25 | Ariad Pharma Inc | Bicykliske heteroarylforbindelser |
BRPI0807458A2 (pt) * | 2007-01-08 | 2014-06-03 | Basf Se | Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto |
CN107935870A (zh) * | 2017-11-09 | 2018-04-20 | 华中药业股份有限公司 | 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593996A (en) * | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
TW224044B (zh) | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
JP2794510B2 (ja) * | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
IL108747A (en) * | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
TW258648B (zh) * | 1993-03-04 | 1995-10-01 | Shell Internat Res Schappej Bv | |
RU2147584C1 (ru) * | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
US5817663A (en) * | 1996-10-07 | 1998-10-06 | American Cyanamid Company | Pentafluorophenylazolopyrimidines |
US5750766A (en) * | 1997-03-18 | 1998-05-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
EP0984919B1 (en) | 1997-03-18 | 2003-01-22 | Basf Aktiengesellschaft | Process for the preparation of arylmalonates |
TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US6117876A (en) * | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
TWI252231B (en) | 1997-04-14 | 2006-04-01 | American Cyanamid Co | Fungicidal trifluorophenyl-triazolopyrimidines |
US5948783A (en) * | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
US5994360A (en) * | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
PT1054888E (pt) | 1998-02-11 | 2004-02-27 | Basf Ag | 7-alquil-triazolopirimidinas fungicidas |
US6020338A (en) * | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
JPH11322517A (ja) | 1998-03-17 | 1999-11-24 | American Cyanamid Co | トリアゾロピリミジン類の効力の増進 |
US6124301A (en) * | 1998-03-17 | 2000-09-26 | American Cyanamid Company | Enhancement of the efficacy of triazolopyrimidines |
EP1066291B8 (en) | 1998-03-23 | 2005-09-14 | Basf Aktiengesellschaft | Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines |
US5981534A (en) * | 1998-09-25 | 1999-11-09 | American Cyanamid Company | Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines |
US6284762B1 (en) * | 1998-03-23 | 2001-09-04 | American Cyanamid Company | Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines |
US6268371B1 (en) * | 1998-09-10 | 2001-07-31 | American Cyanamid Co. | Fungicidal mixtures |
US6117865A (en) * | 1998-09-10 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
US6156925A (en) * | 1998-09-25 | 2000-12-05 | American Cyanamid Company | Process for the preparation of halogenated phenylmaloates |
JP2000103790A (ja) | 1998-09-25 | 2000-04-11 | American Cyanamid Co | 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類 |
US6242451B1 (en) * | 1998-09-25 | 2001-06-05 | Klaus-Juergen Pees | Fungicidal trihalophenyl-triazolopyrimidines |
US6277856B1 (en) * | 1998-09-25 | 2001-08-21 | American Cynamid Co. | Fungicidal mixtures |
US5985883A (en) * | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trichlorophenyl-triazolopyrimidines |
EP0988790B1 (en) | 1998-09-25 | 2003-05-21 | Basf Aktiengesellschaft | Fungicidal mixtures |
US5986135A (en) * | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
ATE258009T1 (de) | 1998-09-25 | 2004-02-15 | Basf Ag | Nicht-wässriges suspensionskonzentrat |
JP4025468B2 (ja) | 1999-07-29 | 2007-12-19 | 三井化学株式会社 | 有機電界発光素子 |
AU3154601A (en) * | 1999-11-18 | 2001-05-30 | Basf Aktiengesellschaft | Non-aqueous concentrated spreading oil composition |
US6559151B2 (en) * | 2000-05-08 | 2003-05-06 | Basf Aktiengesellschaft | 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines |
AU7306201A (en) * | 2000-06-30 | 2002-01-14 | American Home Prod | Substituted-triazolopyrimidines as anticancer agents |
WO2002015697A2 (en) * | 2000-08-25 | 2002-02-28 | Basf Aktiengesellschaft | Fungicidal formulation |
ES2226968T3 (es) | 2000-12-06 | 2005-04-01 | Wyeth | 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas. |
WO2002067679A1 (en) | 2001-02-19 | 2002-09-06 | Basf Aktiengesellschaft | Fungicidal mixtures |
PT1381609E (pt) | 2001-04-11 | 2005-05-31 | Wyeth Corp | 5-halogeno-6-fenil-7-fluoroalquilamino-triazolopirimidinas como fungicidas |
DE60220296T2 (de) * | 2001-09-04 | 2008-01-17 | Sumitomo Chemical Co., Ltd. | IMIDAZO(1,2-a)PYRIMIDINE UND DIESE ENTHALTENDE FUNGIZIDZUSAMMENSETZUNGEN |
WO2003089433A1 (fr) * | 2002-04-19 | 2003-10-30 | Sumitomo Chemical Company, Limited | 5,6-diphenylimidazo [1,2-a] pyrimidine et composition bactericide la renfermant |
-
2004
- 2004-09-17 CA CA002537520A patent/CA2537520A1/en not_active Abandoned
- 2004-09-17 JP JP2006528080A patent/JP4695595B2/ja not_active Expired - Fee Related
- 2004-09-17 DE DE602004014525T patent/DE602004014525D1/de active Active
- 2004-09-17 CN CNB2004800273126A patent/CN100486580C/zh not_active Expired - Fee Related
- 2004-09-17 EP EP04784454A patent/EP1684763B1/en active Active
- 2004-09-17 BR BRPI0414778-2A patent/BRPI0414778A/pt not_active IP Right Cessation
- 2004-09-17 PL PL04784454T patent/PL1684763T3/pl unknown
- 2004-09-17 AU AU2004275728A patent/AU2004275728A1/en not_active Withdrawn
- 2004-09-17 DK DK04784454T patent/DK1684763T3/da active
- 2004-09-17 WO PCT/US2004/030595 patent/WO2005030218A1/en active Application Filing
- 2004-09-17 MX MXPA06002939A patent/MXPA06002939A/es active IP Right Grant
- 2004-09-17 ES ES04784454T patent/ES2308256T3/es active Active
- 2004-09-17 AT AT04784454T patent/ATE398452T1/de not_active IP Right Cessation
- 2004-09-24 US US10/950,542 patent/US7285555B2/en not_active Expired - Fee Related
-
2007
- 2007-09-19 US US11/903,100 patent/US7915266B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1684763A1 (en) | 2006-08-02 |
CN100486580C (zh) | 2009-05-13 |
JP4695595B2 (ja) | 2011-06-08 |
EP1684763B1 (en) | 2008-06-18 |
DE602004014525D1 (de) | 2008-07-31 |
BRPI0414778A (pt) | 2006-11-21 |
MXPA06002939A (es) | 2006-05-31 |
PL1684763T3 (pl) | 2008-11-28 |
CN1856311A (zh) | 2006-11-01 |
WO2005030218A1 (en) | 2005-04-07 |
ES2308256T3 (es) | 2008-12-01 |
CA2537520A1 (en) | 2005-04-07 |
AU2004275728A1 (en) | 2005-04-07 |
JP2007506745A (ja) | 2007-03-22 |
US7285555B2 (en) | 2007-10-23 |
US20080255157A1 (en) | 2008-10-16 |
US20050065167A1 (en) | 2005-03-24 |
US7915266B2 (en) | 2011-03-29 |
ATE398452T1 (de) | 2008-07-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2007013624A (es) | Inhibidores de proteina cinasa. | |
NO2016021I1 (no) | 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2Hpyrido[2,3-D]pyrimidinderivater og relaterte forbindelser for behandling av kreft | |
TW200728307A (en) | Novel spirochromanone derivatives | |
ATE440603T1 (de) | 8-hydroxychinolinderivate | |
GEP20115174B (en) | Triazolopyrazine derivatives useful as anti-cancer agents | |
UA83091C2 (en) | Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors | |
MXPA05011643A (es) | 5,7-diaminopirazolo[4,3-d]pirimidinas en el tratamiento de hipertension. | |
WO2006067614A3 (en) | Heteroaromatic derivatives useful as anticancer agents | |
ATE430747T1 (de) | 2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren | |
WO2005110410A3 (en) | Kinase inhibitors as therapeutic agents | |
RS20090249A (en) | Spiroketone acetyl-coa carboxylase inhibotors | |
DK1646389T3 (da) | Pyrimidin-2,4-dionderivater som gonadotropinfrigörende hormonreceptorantagonister | |
IS2517B (is) | Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki | |
MY145074A (en) | Thiazolidin-4-one derivatives | |
GB0112348D0 (en) | Compounds | |
TW200517106A (en) | Sustained release pharmaceutical compositions | |
RS50720B (sr) | 3,11 b-cis-dihidrotetrabenazin za lečenje proliferativne bolesti ili inflamacije | |
HK1118534A1 (en) | Thieno-pyrimidine compounds having fungicidal activity | |
WO2007120333A3 (en) | Tetracyclic kinase inhibitors | |
ATE489399T1 (de) | Antitumor wirksame 2-substituierte estra-1,3, 5(10)-trien-3-yl sulfamate | |
BR0207102A (pt) | Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método para a prevenção ou o tratamento de doença | |
WO2008063548A3 (en) | 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents | |
DK1684763T3 (da) | 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel | |
AU7122501A (en) | Aryl sulfonamides as serotonin antagonist for the treatment of obesity | |
WO2008098077A3 (en) | Substituted alkine derivatives as anti-cancer agents |