DK166545B1 - 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling - Google Patents

17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling Download PDF

Info

Publication number
DK166545B1
DK166545B1 DK212184A DK212184A DK166545B1 DK 166545 B1 DK166545 B1 DK 166545B1 DK 212184 A DK212184 A DK 212184A DK 212184 A DK212184 A DK 212184A DK 166545 B1 DK166545 B1 DK 166545B1
Authority
DK
Denmark
Prior art keywords
group
groups
steroids
alkyl
mmol
Prior art date
Application number
DK212184A
Other languages
Danish (da)
English (en)
Other versions
DK212184A (da
DK212184D0 (da
Inventor
Albert Mattheus Van Leusen
Adriaan Marinus Van Leusen
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DK212184D0 publication Critical patent/DK212184D0/da
Publication of DK212184A publication Critical patent/DK212184A/da
Application granted granted Critical
Publication of DK166545B1 publication Critical patent/DK166545B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK212184A 1983-04-29 1984-04-27 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling DK166545B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP83200616A EP0123734A1 (en) 1983-04-29 1983-04-29 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation
EP83200616 1983-04-29

Publications (3)

Publication Number Publication Date
DK212184D0 DK212184D0 (da) 1984-04-27
DK212184A DK212184A (da) 1984-10-30
DK166545B1 true DK166545B1 (da) 1993-06-07

Family

ID=8190949

Family Applications (2)

Application Number Title Priority Date Filing Date
DK212184A DK166545B1 (da) 1983-04-29 1984-04-27 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling
DK022192A DK166831B1 (da) 1983-04-29 1992-02-21 17-(formamido-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK022192A DK166831B1 (da) 1983-04-29 1992-02-21 17-(formamido-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling

Country Status (17)

Country Link
US (1) US4647410A (ja)
EP (2) EP0123734A1 (ja)
JP (2) JPS59206399A (ja)
KR (1) KR860001469B1 (ja)
AU (1) AU568643B2 (ja)
CA (1) CA1257249A (ja)
DE (1) DE3461381D1 (ja)
DK (2) DK166545B1 (ja)
ES (2) ES8608537A1 (ja)
FI (1) FI82061C (ja)
GR (1) GR81997B (ja)
HU (2) HU193207B (ja)
IE (1) IE57328B1 (ja)
IL (1) IL71658A (ja)
NO (1) NO167093C (ja)
NZ (1) NZ207985A (ja)
PT (1) PT78503B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
AU618350B2 (en) * 1988-04-08 1991-12-19 Aventis Pharma S.A. 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
HU226413B1 (en) * 1991-06-25 2008-11-28 Aventis Pharma Sa Novel 16-(nitro-substituted methyl)pregna-1,4-dien-3,20-dion derivatives and process for producing them
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
ATE375992T1 (de) 1996-12-11 2007-11-15 Searle Llc Epoxidierungsverfahren
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
EP2287721A3 (en) 1999-11-02 2011-04-06 Canon Kabushiki Kaisha Print control method and apparatus
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
CN105481924B (zh) * 2015-11-24 2017-08-15 浙江省诸暨合力化学对外贸易有限公司 一种黄体酮的制备方法
WO2023028205A1 (en) * 2021-08-26 2023-03-02 Brandeis University Selective isonitrile inhibitors of cytochrome p450 subtypes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807631A (nl) * 1978-07-17 1980-01-21 Gist Brocades Nv Isocyanoderivaten en hun bereiding.
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto

Also Published As

Publication number Publication date
NO841700L (no) 1984-10-30
FI841679A0 (fi) 1984-04-27
DK212184A (da) 1984-10-30
IE57328B1 (en) 1992-07-29
FI82061B (fi) 1990-09-28
ES553609A0 (es) 1987-11-01
KR840008461A (ko) 1984-12-15
US4647410A (en) 1987-03-03
ES8608537A1 (es) 1986-07-16
HU193207B (en) 1987-08-28
KR860001469B1 (ko) 1986-09-26
IL71658A (en) 1988-03-31
JPS59206399A (ja) 1984-11-22
EP0123734A1 (en) 1984-11-07
DE3461381D1 (en) 1987-01-08
DK22192D0 (da) 1992-02-21
PT78503B (en) 1986-05-20
EP0124934B1 (en) 1986-11-20
NZ207985A (en) 1986-11-12
IE841038L (en) 1984-10-29
AU2713384A (en) 1984-11-01
JPH0559097A (ja) 1993-03-09
GR81997B (ja) 1984-12-12
JPH0717673B2 (ja) 1995-03-01
ES532029A0 (es) 1986-07-16
EP0124934A1 (en) 1984-11-14
DK212184D0 (da) 1984-04-27
HUT34220A (en) 1985-02-28
HU194277B (en) 1988-01-28
ES8800263A1 (es) 1987-11-01
DK22192A (da) 1992-02-21
FI82061C (fi) 1991-01-10
PT78503A (en) 1984-05-01
CA1257249A (en) 1989-07-11
DK166831B1 (da) 1993-07-19
AU568643B2 (en) 1988-01-07
NO167093B (no) 1991-06-24
JPH053478B2 (ja) 1993-01-14
IL71658A0 (en) 1984-07-31
NO167093C (no) 1991-10-02
FI841679A (fi) 1984-10-30

Similar Documents

Publication Publication Date Title
DK166545B1 (da) 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling
CA1334844C (en) 9-alpha-hydroxysteroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro-derivatives and pharmaceutical preparations containing said steroids
DK141967B (da) Analogifremgangsmaade til fremstilling af spirolactoner
DK165838B (da) Analogifremgangsmaade til fremstilling af 17,17-bis(substitueret thio)-3-ketoandrostenforbindelser
US4650610A (en) Androstane carbothioic acids
US4548749A (en) Process for the preparation of 21-hydroxy-20-keto-Δ16 -steroids and new intermediate compounds formed in this process
AU646342B2 (en) New substituted 16-methyl steroid derivatives of pregna-1,4-diene-3,20-dione, their preparation, their use in the preparation of 16-methylene steroids and new intermediates
US4427592A (en) Androstene-17-dithioketals
US4551278A (en) Preparation of 20-keto-Δ16 -steroids
NO780867L (no) Fremgangsmaate ved fremstilling av steroid-spiro-oxazolidion-derivater
CS252474B2 (en) Method of 17-halogenethinylsteroides production
Van Leusen et al. Preparation of 20-keto-Δ 16-steroids
NO125050B (ja)
IT9047917A1 (it) 2 bromo 6beta metilpregna 1, 4, 9 (11) triene 3, 20 dioni e loro uso nella preparazione di steroidi ad attivita' antinfiammatoria

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed