DK166507B1 - Fremgangsmaade til kontinuerlig fremstilling af l-carnitin ad mikrobiologisk vej samt mikroorganisme til anvendelse derved - Google Patents

Fremgangsmaade til kontinuerlig fremstilling af l-carnitin ad mikrobiologisk vej samt mikroorganisme til anvendelse derved Download PDF

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Publication number
DK166507B1
DK166507B1 DK088586A DK88586A DK166507B1 DK 166507 B1 DK166507 B1 DK 166507B1 DK 088586 A DK088586 A DK 088586A DK 88586 A DK88586 A DK 88586A DK 166507 B1 DK166507 B1 DK 166507B1
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DK
Denmark
Prior art keywords
carnitine
butyrobetaine
process according
crotonobetaine
bioreactor
Prior art date
Application number
DK088586A
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Danish (da)
English (en)
Other versions
DK88586A (da
DK88586D0 (da
Inventor
Hans Kulla
Pavel Lehky
Armand Squaratti
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of DK88586D0 publication Critical patent/DK88586D0/da
Publication of DK88586A publication Critical patent/DK88586A/da
Application granted granted Critical
Publication of DK166507B1 publication Critical patent/DK166507B1/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/007Carnitine; Butyrobetaine; Crotonobetaine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/824Achromobacter
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/825Actinomadura

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK088586A 1985-02-27 1986-02-26 Fremgangsmaade til kontinuerlig fremstilling af l-carnitin ad mikrobiologisk vej samt mikroorganisme til anvendelse derved DK166507B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH890/85A CH664374A5 (de) 1985-02-27 1985-02-27 Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
CH89085 1985-02-27

Publications (3)

Publication Number Publication Date
DK88586D0 DK88586D0 (da) 1986-02-26
DK88586A DK88586A (da) 1986-08-28
DK166507B1 true DK166507B1 (da) 1993-06-01

Family

ID=4197565

Family Applications (1)

Application Number Title Priority Date Filing Date
DK088586A DK166507B1 (da) 1985-02-27 1986-02-26 Fremgangsmaade til kontinuerlig fremstilling af l-carnitin ad mikrobiologisk vej samt mikroorganisme til anvendelse derved

Country Status (9)

Country Link
US (1) US4708936A (fr)
EP (1) EP0195944B1 (fr)
JP (1) JP2545788B2 (fr)
AT (1) ATE68211T1 (fr)
CA (1) CA1247549A (fr)
CH (1) CH664374A5 (fr)
DE (1) DE3681811D1 (fr)
DK (1) DK166507B1 (fr)
IE (1) IE58779B1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
FR2623520B1 (fr) * 1987-11-23 1990-04-20 Sanofi Sa Procede enzymatique continu de preparation de la l-carnitine
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag r―ブチロベタインの製造方法
CA2021869C (fr) * 1989-07-28 2000-09-05 Frans Hoeks Procede de production microbiologique de l-carnitine
IN170700B (fr) * 1989-12-20 1992-05-02 Lonza Ag
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
US5750028A (en) * 1996-09-18 1998-05-12 Envirogen, Inc. Biomass separation apparatus and method with media return
US5788842A (en) * 1996-09-18 1998-08-04 Envirogen, Inc. Biomass separation apparatus and method
DE19749480A1 (de) * 1997-11-08 1999-05-20 Univ Leipzig Verfahren zur Herstellung von L-Carnitin aus Crotonobetain
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
ES2270620T3 (es) * 1999-10-11 2007-04-01 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Uso de l-carnitina y sus derivados alcanoilo como agentes osmoticos en soluciones para uso medico.
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7815894B2 (en) * 2003-05-29 2010-10-19 Jay W. Pettegrew Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
US7611890B2 (en) * 2004-06-25 2009-11-03 Samuel Frisch System and method for separating biomass from media in a fluidized bed reactor
KR100713103B1 (ko) * 2005-07-07 2007-05-02 씨제이 주식회사 뉴로스포라 크라사 유래 l-카르니틴 생합성 관련 유전자를포함하는 엔테로박테리아세 속 미생물 및 이를 이용한l-카르니틴의 제조방법
ATE472600T1 (de) * 2005-07-19 2010-07-15 Cj Cheiljedang Corp Mikroorganismus der gattung enterobacteriacae mit genen in zusammenhang mit der biosynthese von l- carnitin sowie verfahren zur produktion von l- carnitin mit dem mikroorganismus
JP2009102258A (ja) * 2007-10-23 2009-05-14 Mitsubishi Rayon Co Ltd L−カルニチンの精製方法
JP5561506B2 (ja) * 2007-10-24 2014-07-30 三菱レイヨン株式会社 L−カルニチンの単離精製方法
TWI400223B (zh) * 2007-11-16 2013-07-01 Lonza Ag 製備甜菜鹼的方法
JP2010143857A (ja) * 2008-12-18 2010-07-01 Mitsubishi Rayon Co Ltd カルニチンの精製方法
EP2216088A1 (fr) * 2009-02-04 2010-08-11 Lonza Ltd. Récupération des pertes de produit provenant de flux de déchets ED
US8604237B2 (en) 2009-11-18 2013-12-10 Lonza Ltd Methods for the production of L-carnitine
EP2325164A1 (fr) 2009-11-18 2011-05-25 Lonza Ltd. Procédés pour la production de L-carnitine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835077B2 (ja) * 1979-05-02 1983-07-30 日東化学工業株式会社 微生物によるアクリルアミドまたはメタアクリルアミドの連続製造法
IT1142201B (it) * 1980-06-24 1986-10-08 Sigma Tau Ind Farmaceuti Procedimento per la produzione enzimatica di l-carnitina
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc L−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten

Also Published As

Publication number Publication date
IE58779B1 (en) 1993-11-17
EP0195944A3 (en) 1987-07-29
US4708936A (en) 1987-11-24
ATE68211T1 (de) 1991-10-15
EP0195944B1 (fr) 1991-10-09
EP0195944A2 (fr) 1986-10-01
DE3681811D1 (de) 1991-11-14
DK88586A (da) 1986-08-28
IE860387L (en) 1987-08-27
JPS61199793A (ja) 1986-09-04
CA1247549A (fr) 1988-12-28
DK88586D0 (da) 1986-02-26
JP2545788B2 (ja) 1996-10-23
CH664374A5 (de) 1988-02-29

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ATS Application withdrawn
B1 Patent granted (law 1993)
PUP Patent expired