DK165620C - Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet - Google Patents
Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatetInfo
- Publication number
- DK165620C DK165620C DK481585A DK481585A DK165620C DK 165620 C DK165620 C DK 165620C DK 481585 A DK481585 A DK 481585A DK 481585 A DK481585 A DK 481585A DK 165620 C DK165620 C DK 165620C
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- anthracycliclycoside
- annostation
- cosolubilizing
- freeze
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848426672A GB8426672D0 (en) | 1984-10-22 | 1984-10-22 | Pharmaceutical compositions |
GB8426672 | 1984-10-22 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK481585D0 DK481585D0 (da) | 1985-10-21 |
DK481585A DK481585A (da) | 1986-04-23 |
DK165620B DK165620B (da) | 1992-12-28 |
DK165620C true DK165620C (da) | 1993-06-01 |
Family
ID=10568553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK481585A DK165620C (da) | 1984-10-22 | 1985-10-21 | Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet |
Country Status (35)
Country | Link |
---|---|
US (4) | US4675311A (cs) |
JP (1) | JPH0611700B2 (cs) |
KR (1) | KR920005813B1 (cs) |
CN (1) | CN85107562B (cs) |
AT (1) | AT401345B (cs) |
AU (1) | AU572003B2 (cs) |
BE (1) | BE903484A (cs) |
BG (1) | BG60934B2 (cs) |
CA (1) | CA1248453A (cs) |
CH (1) | CH667594A5 (cs) |
CS (1) | CS270421B2 (cs) |
DE (1) | DE3536896C2 (cs) |
DK (1) | DK165620C (cs) |
ES (1) | ES8605374A1 (cs) |
FI (2) | FI853913A7 (cs) |
FR (1) | FR2571966B1 (cs) |
GB (2) | GB8426672D0 (cs) |
GR (1) | GR852549B (cs) |
HK (1) | HK94390A (cs) |
HU (1) | HU197988B (cs) |
IE (1) | IE56992B1 (cs) |
IL (1) | IL76732A (cs) |
IT (1) | IT1186779B (cs) |
MY (1) | MY103956A (cs) |
NL (1) | NL191308C (cs) |
NO (1) | NO170616C (cs) |
NZ (1) | NZ213885A (cs) |
PH (1) | PH23982A (cs) |
PT (1) | PT81347B (cs) |
RU (2) | RU1836088C (cs) |
SE (1) | SE467520B (cs) |
SG (1) | SG80290G (cs) |
UA (2) | UA34419C2 (cs) |
YU (1) | YU46160B (cs) |
ZA (1) | ZA858033B (cs) |
Families Citing this family (34)
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US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5124317A (en) | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5124318A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.R.L. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
PT86285B (pt) * | 1986-12-05 | 1990-11-07 | Erba Farmitalia | Processo para a preparacao de solucoes injectaveis contendo um glicosido antraciclinico anti-tumor |
JP2603480B2 (ja) * | 1987-08-05 | 1997-04-23 | 住友製薬株式会社 | 安定化されたアンスラサイクリン系製剤 |
DE3801178A1 (de) * | 1988-01-18 | 1989-07-27 | Hoechst Ag | Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung |
US6300362B1 (en) | 1990-07-25 | 2001-10-09 | Novartis Ag (Formerly Sandoz Ltd.) | Stabilized pharmaceutical compositions comprising acid donors |
ES2285743T3 (es) | 1996-12-30 | 2007-11-16 | Battelle Memorial Institute | Uso de un farmaco anticancerigeno no encapsulado para la preparacion de una formulacion para tratar neoplasias mediante inhlacion. |
US5942508A (en) * | 1997-02-04 | 1999-08-24 | Senju Pharmaceutical Co., Ltd. | Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid |
RU2292216C2 (ru) * | 2000-10-31 | 2007-01-27 | Фарма Мар, С.А. | Кахалалид f |
CN101172104B (zh) | 2002-02-22 | 2013-04-03 | 默沙东公司 | 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途 |
EP1474995B1 (en) * | 2003-05-06 | 2012-11-14 | Gumlink A/S | A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product |
ATE520702T1 (de) * | 2003-07-02 | 2011-09-15 | Solux Corp | Thermisch stabiles kristallines epirubicin- hydrochlorid und herstellungsverfahren dafür |
US20090099346A1 (en) * | 2003-07-02 | 2009-04-16 | Victor Matvienko | Thermally stable crystalline epirubicin hydrochloride |
ES2344899T3 (es) * | 2003-09-25 | 2010-09-09 | Astellas Pharma Inc. | Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii. |
RU2262923C2 (ru) * | 2003-12-25 | 2005-10-27 | Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации | Иммобилизованная форма доксорубицина |
US7388083B2 (en) * | 2005-03-07 | 2008-06-17 | Solux Corporation | Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics |
CA2606390A1 (en) * | 2005-05-11 | 2006-11-16 | Sicor, Inc. | Stable lyophilized anthracycline glycosides |
PL1921919T3 (pl) | 2005-07-14 | 2012-09-28 | Lithera Inc | Ulepszona lipolityczna formulacja o podtrzymywanym uwalnianiu do traktowania lokalnej tkanki tłuszczowej |
DE06848583T1 (de) * | 2005-12-13 | 2011-03-17 | Solux Corporation, San Diego | Verfahren zur herstellung von 4-demethyldaunorubicin |
US8802830B2 (en) * | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
US8148338B2 (en) * | 2006-02-22 | 2012-04-03 | Supratek Pharma Inc. | Doxorubicin formulations for anti-cancer use |
US7470672B2 (en) * | 2006-07-31 | 2008-12-30 | Savvipharm Inc. | Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives |
EP2152312B1 (en) * | 2007-05-16 | 2014-12-31 | KTB Tumorforschungsgesellschaft mbH | Low-viscous anthracycline formulation |
EP2184066B1 (en) * | 2007-09-04 | 2013-11-06 | Meiji Seika Pharma Co., Ltd. | Injection, injection solution and injection kit preparation |
KR20100058662A (ko) * | 2007-10-26 | 2010-06-03 | 화이자 프로덕츠 인코포레이티드 | 개에게서 림프종을 치료하기 위한 이다루비신 |
US8357785B2 (en) * | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
MX2012008171A (es) * | 2010-01-15 | 2012-12-17 | Lithera Inc | Formulaciones aglomeradas liofilizadas. |
JP2013543897A (ja) | 2010-11-24 | 2013-12-09 | リセラ,インク. | 脂肪症及び輪郭の膨れの美容処置のための、選択的な、親油性の、及び長時間作用性のベータアゴニストの単剤療法製剤、及び方法 |
DE102011103751A1 (de) | 2011-05-31 | 2012-12-06 | Heraeus Precious Metals Gmbh & Co. Kg | Kristallisierung von Epirubicinhydrochlorid |
DE102011111991A1 (de) * | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | Neue Cyclosporin-Derivate |
WO2014093815A1 (en) | 2012-12-13 | 2014-06-19 | Cytrx Corporation | Anthracycline formulations |
US10278981B2 (en) | 2013-06-05 | 2019-05-07 | Cytrx Corporation | Cytotoxic agents for the treatment of cancer |
Family Cites Families (18)
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YU33730B (en) * | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
US4039663A (en) * | 1975-03-19 | 1977-08-02 | Societa' Farmaceutici Italia S.P.A. | Daunomycins, process for their uses and intermediates |
GB1506200A (en) * | 1975-04-30 | 1978-04-05 | Farmaceutici Italia | Glycosides |
GB1567456A (en) * | 1976-11-16 | 1980-05-14 | Farmaceutici Italia | Daunomycin derivatives |
GB2007645B (en) * | 1977-10-17 | 1982-05-12 | Stanford Res Inst Int | Benzyl anthracyclines and pharmaceutical compositions containing them |
US4177264A (en) * | 1977-10-17 | 1979-12-04 | Sri International | N-benzyl anthracyclines |
JPS563851A (en) * | 1979-06-22 | 1981-01-16 | Matsushita Electric Works Ltd | Fireplace in floor |
JPS5756494A (en) * | 1980-09-22 | 1982-04-05 | Microbial Chem Res Found | New anthracyclin derivative |
US4325947A (en) * | 1981-05-12 | 1982-04-20 | Farmitalia Carlo Erba S.P.A. | 4-Demethoxy-4'-deoxydoxorubicin |
IT1210476B (it) * | 1981-05-28 | 1989-09-14 | Erba Farmitalia | Antracicline. |
US4438105A (en) * | 1982-04-19 | 1984-03-20 | Farmaitalia Carlo Erba S.P.A | 4'-Iododerivatives of anthracycline glycosides |
FI75834C (fi) * | 1982-05-24 | 1988-08-08 | Erba Farmitalia | Foerfarande foer framstaellning av antracyklinglykosidfoereningar. |
US4464529A (en) * | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
CA1248944A (en) * | 1982-09-28 | 1989-01-17 | Gareth J. Thomas | Anthracycline glycosides |
JPS5982395A (ja) * | 1982-11-02 | 1984-05-12 | Microbial Chem Res Found | アントラサイクリン化合物、その製造法およびその用途 |
GR79729B (cs) * | 1982-12-20 | 1984-10-31 | Univ Ohio State Res Found | |
JPS6092212A (ja) * | 1983-10-26 | 1985-05-23 | Kyowa Hakko Kogyo Co Ltd | ドキソルビシン塩の製剤 |
US4537882A (en) * | 1984-05-10 | 1985-08-27 | Ohio State University | 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same |
-
1984
- 1984-10-22 GB GB848426672A patent/GB8426672D0/en active Pending
-
1985
- 1985-10-03 ES ES547578A patent/ES8605374A1/es not_active Expired
- 1985-10-08 FI FI853913A patent/FI853913A7/fi not_active Application Discontinuation
- 1985-10-15 HU HU853988A patent/HU197988B/hu unknown
- 1985-10-15 CN CN85107562A patent/CN85107562B/zh not_active Expired
- 1985-10-16 IT IT22507/85A patent/IT1186779B/it active Protection Beyond IP Right Term
- 1985-10-16 FI FI854035A patent/FI86252C/fi not_active IP Right Cessation
- 1985-10-16 YU YU164485A patent/YU46160B/sh unknown
- 1985-10-16 US US06/788,158 patent/US4675311A/en not_active Expired - Lifetime
- 1985-10-16 DE DE3536896A patent/DE3536896C2/de not_active Expired - Lifetime
- 1985-10-17 IL IL76732A patent/IL76732A/xx not_active IP Right Cessation
- 1985-10-17 AU AU48805/85A patent/AU572003B2/en not_active Expired
- 1985-10-17 CH CH4476/85A patent/CH667594A5/de not_active IP Right Cessation
- 1985-10-17 JP JP60230055A patent/JPH0611700B2/ja not_active Expired - Lifetime
- 1985-10-18 UA UA5010680A patent/UA34419C2/uk unknown
- 1985-10-18 ZA ZA858033A patent/ZA858033B/xx unknown
- 1985-10-18 PH PH32947A patent/PH23982A/en unknown
- 1985-10-18 UA UA3964940A patent/UA19169A/uk unknown
- 1985-10-18 NZ NZ213885A patent/NZ213885A/en unknown
- 1985-10-18 AT AT0303285A patent/AT401345B/de not_active IP Right Cessation
- 1985-10-18 RU SU853964940A patent/RU1836088C/ru active
- 1985-10-18 GB GB08525709A patent/GB2165751B/en not_active Expired
- 1985-10-21 FR FR8515596A patent/FR2571966B1/fr not_active Expired
- 1985-10-21 IE IE2593/85A patent/IE56992B1/en not_active IP Right Cessation
- 1985-10-21 SE SE8504945A patent/SE467520B/sv not_active IP Right Cessation
- 1985-10-21 NL NL8502869A patent/NL191308C/xx not_active IP Right Cessation
- 1985-10-21 NO NO854194A patent/NO170616C/no not_active IP Right Cessation
- 1985-10-21 BE BE0/215752A patent/BE903484A/fr not_active IP Right Cessation
- 1985-10-21 DK DK481585A patent/DK165620C/da not_active IP Right Cessation
- 1985-10-21 PT PT81347A patent/PT81347B/pt unknown
- 1985-10-21 KR KR1019850007740A patent/KR920005813B1/ko not_active Expired
- 1985-10-21 CA CA000493459A patent/CA1248453A/en not_active Expired
- 1985-10-22 GR GR852549A patent/GR852549B/el unknown
- 1985-10-22 CS CS857565A patent/CS270421B2/cs not_active IP Right Cessation
-
1986
- 1986-08-06 US US06/893,613 patent/US4840938A/en not_active Expired - Lifetime
-
1988
- 1988-12-30 MY MYPI88001588A patent/MY103956A/en unknown
-
1990
- 1990-09-26 US US07/588,526 patent/US5091372A/en not_active Expired - Lifetime
- 1990-09-28 US US07/590,536 patent/US5091373A/en not_active Expired - Lifetime
- 1990-10-03 SG SG802/90A patent/SG80290G/en unknown
- 1990-11-15 HK HK943/90A patent/HK94390A/xx not_active IP Right Cessation
-
1992
- 1992-01-30 RU SU5010680A patent/RU2101018C1/ru active
-
1994
- 1994-02-23 BG BG098530A patent/BG60934B2/bg unknown
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