DK163174C - Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf - Google Patents

Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf

Info

Publication number
DK163174C
DK163174C DK246886A DK246886A DK163174C DK 163174 C DK163174 C DK 163174C DK 246886 A DK246886 A DK 246886A DK 246886 A DK246886 A DK 246886A DK 163174 C DK163174 C DK 163174C
Authority
DK
Denmark
Prior art keywords
procedures
preparing
tissue plasminogen
parenteral solution
activates
Prior art date
Application number
DK246886A
Other languages
Danish (da)
English (en)
Other versions
DK246886D0 (da
DK163174B (da
DK246886A (da
Inventor
Michael Denis Johnston
Henry Berger
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521704A external-priority patent/GB8521704D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK246886D0 publication Critical patent/DK246886D0/da
Publication of DK246886A publication Critical patent/DK246886A/da
Publication of DK163174B publication Critical patent/DK163174B/da
Application granted granted Critical
Publication of DK163174C publication Critical patent/DK163174C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
DK246886A 1985-05-28 1986-05-27 Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf DK163174C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8513358 1985-05-28
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB8521704 1985-08-31
GB858521704A GB8521704D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (4)

Publication Number Publication Date
DK246886D0 DK246886D0 (da) 1986-05-27
DK246886A DK246886A (da) 1986-11-29
DK163174B DK163174B (da) 1992-02-03
DK163174C true DK163174C (da) 1992-06-22

Family

ID=26289289

Family Applications (1)

Application Number Title Priority Date Filing Date
DK246886A DK163174C (da) 1985-05-28 1986-05-27 Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf

Country Status (22)

Country Link
US (1) US5112609A (el)
AT (1) AT391812B (el)
AU (1) AU569429B2 (el)
BE (1) BE904831A (el)
CA (1) CA1297008C (el)
CH (1) CH664495A5 (el)
DE (1) DE3617753A1 (el)
DK (1) DK163174C (el)
ES (1) ES8706443A1 (el)
FI (1) FI85334C (el)
FR (1) FR2593393B1 (el)
GB (1) GB2176703B (el)
GR (1) GR861365B (el)
HU (1) HU200695B (el)
IL (1) IL78937A (el)
IT (1) IT1191925B (el)
LU (1) LU86445A1 (el)
NL (1) NL8601354A (el)
NO (1) NO171344C (el)
NZ (1) NZ216306A (el)
PT (1) PT82647B (el)
SE (1) SE462893B (el)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
KR840004781A (ko) * 1982-05-05 1984-10-24 월터 에이치·드레거 인체의 조직 플라스미노겐 활성화제
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
HUT41632A (en) * 1985-03-06 1987-05-28 Survival Technology Process for preparing agents for the enhancement of protein absorption
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
IE59895B1 (en) * 1986-05-12 1994-04-20 Wellcome Found Medicaments containing tissue plasminogen activator
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
GB8814604D0 (en) * 1988-06-20 1988-07-27 Wellcome Found Medicaments
WO1990001334A1 (en) * 1988-08-05 1990-02-22 Codon Formulations for plasminogen activator using aspartate
GB8819607D0 (en) * 1988-08-17 1988-09-21 Wellcome Found Novel combination
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
GB9000629D0 (en) * 1990-01-11 1990-03-14 Porton Prod Ltd Tissue plasminogen activator
DK0643772T3 (da) * 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
KR20040062535A (ko) * 2001-09-07 2004-07-07 글로벌 바이오텍 인코포레이티드 인간 조직 유로키나아제형 플라스미노겐 활성화제 배합물
KR20110017903A (ko) * 2008-06-04 2011-02-22 테일크리스 바이오쎄러퓨틱스 아이엔씨. 플라스민의 제조를 위한 조성물, 방법 및 키트
WO2010101903A2 (en) 2009-03-03 2010-09-10 Talecris Biotherapeutics, Inc. Compositions, methods and kits for preparing plasminogen; and plasmin prepared therefrom

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (el) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4314994A (en) * 1979-07-27 1982-02-09 Pierre Fabre S.A. Process for obtaining a plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
GR79202B (el) * 1982-05-05 1984-10-22 Genentech Inc
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
EP0124613B1 (en) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
DE3382389D1 (de) * 1982-12-14 1991-10-02 South African Inventions Plasminogenaktivator.
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
DE59009964D1 (de) * 1989-09-13 1996-01-25 Rieter Ag Maschf Verfahren zum Starten eines Arbeitsablaufs eines Bedienungsautomaten an einer Textilmaschine

Also Published As

Publication number Publication date
FI862226A (fi) 1986-11-29
SE8602404D0 (sv) 1986-05-27
US5112609A (en) 1992-05-12
NZ216306A (en) 1989-10-27
CH664495A5 (de) 1988-03-15
SE462893B (sv) 1990-09-17
DE3617753A1 (de) 1986-12-04
NO171344C (no) 1993-03-03
AU569429B2 (en) 1988-01-28
DK246886D0 (da) 1986-05-27
LU86445A1 (fr) 1986-12-05
BE904831A (fr) 1986-11-27
AT391812B (de) 1990-12-10
FR2593393A1 (fr) 1987-07-31
ES555352A0 (es) 1987-07-01
IL78937A (en) 1990-11-29
FI85334B (fi) 1991-12-31
IT1191925B (it) 1988-03-31
ES8706443A1 (es) 1987-07-01
AU5796586A (en) 1986-12-04
SE8602404L (sv) 1986-11-29
HUT42330A (en) 1987-07-28
NO862095L (no) 1986-12-01
DK163174B (da) 1992-02-03
DK246886A (da) 1986-11-29
IT8648064A0 (it) 1986-05-27
HU200695B (en) 1990-08-28
CA1297008C (en) 1992-03-10
GB2176703A (en) 1987-01-07
NL8601354A (nl) 1986-12-16
IL78937A0 (en) 1986-09-30
PT82647B (pt) 1989-01-30
PT82647A (en) 1986-06-01
DE3617753C2 (el) 1988-06-30
ATA141186A (de) 1990-06-15
FR2593393B1 (fr) 1989-06-02
GB8612781D0 (en) 1986-07-02
FI862226A0 (fi) 1986-05-27
GB2176703B (en) 1988-12-07
NO171344B (no) 1992-11-23
FI85334C (fi) 1992-04-10
GR861365B (en) 1986-09-29

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