DK160711B - Analogifremgangsmaade til fremstilling af chirale 2-(2-benzyl-3-mercaptopropionyl)amino-1-alkanolderivater eller chirale 2-(2-benzyl-3-mercaptopropionyl)amino-4-methylthiosmoersyrer eller farmaceutisk acceptable kationsalte af syrerne - Google Patents

Analogifremgangsmaade til fremstilling af chirale 2-(2-benzyl-3-mercaptopropionyl)amino-1-alkanolderivater eller chirale 2-(2-benzyl-3-mercaptopropionyl)amino-4-methylthiosmoersyrer eller farmaceutisk acceptable kationsalte af syrerne Download PDF

Info

Publication number
DK160711B
DK160711B DK221182A DK221182A DK160711B DK 160711 B DK160711 B DK 160711B DK 221182 A DK221182 A DK 221182A DK 221182 A DK221182 A DK 221182A DK 160711 B DK160711 B DK 160711B
Authority
DK
Denmark
Prior art keywords
acid
benzyl
amino
chiral
mercaptopropionyl
Prior art date
Application number
DK221182A
Other languages
Danish (da)
English (en)
Other versions
DK221182A (da
Inventor
Jasjit Singh Bindra
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK221182A publication Critical patent/DK221182A/da
Publication of DK160711B publication Critical patent/DK160711B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK221182A 1981-05-18 1982-05-17 Analogifremgangsmaade til fremstilling af chirale 2-(2-benzyl-3-mercaptopropionyl)amino-1-alkanolderivater eller chirale 2-(2-benzyl-3-mercaptopropionyl)amino-4-methylthiosmoersyrer eller farmaceutisk acceptable kationsalte af syrerne DK160711B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/264,752 US4329495A (en) 1981-05-18 1981-05-18 Enkephalinase enzyme inhibiting compounds
US26475281 1981-05-18

Publications (2)

Publication Number Publication Date
DK221182A DK221182A (da) 1982-11-19
DK160711B true DK160711B (da) 1991-04-08

Family

ID=23007448

Family Applications (1)

Application Number Title Priority Date Filing Date
DK221182A DK160711B (da) 1981-05-18 1982-05-17 Analogifremgangsmaade til fremstilling af chirale 2-(2-benzyl-3-mercaptopropionyl)amino-1-alkanolderivater eller chirale 2-(2-benzyl-3-mercaptopropionyl)amino-4-methylthiosmoersyrer eller farmaceutisk acceptable kationsalte af syrerne

Country Status (24)

Country Link
US (1) US4329495A (no)
EP (1) EP0066956B1 (no)
JP (1) JPS57193450A (no)
KR (1) KR860001549B1 (no)
AR (1) AR231279A1 (no)
AT (1) ATE8881T1 (no)
AU (1) AU529511B2 (no)
CA (1) CA1179368A (no)
DE (1) DE3260531D1 (no)
DK (1) DK160711B (no)
ES (2) ES512278A0 (no)
FI (1) FI76555C (no)
GR (1) GR75496B (no)
HU (1) HU188058B (no)
IE (1) IE53226B1 (no)
IL (1) IL65799A (no)
IN (1) IN158365B (no)
NO (1) NO153768C (no)
NZ (1) NZ200639A (no)
PH (1) PH18206A (no)
PL (1) PL138043B1 (no)
PT (1) PT74913B (no)
YU (1) YU42468B (no)
ZA (1) ZA823386B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4474795A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
JPS58140065A (ja) * 1982-02-10 1983-08-19 Meito Sangyo Kk メルカプトベンジル脂肪酸誘導体類及びその製法
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
FR2540498B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2559770B1 (fr) * 1984-02-20 1986-10-24 Roussel Uclaf Nouveaux derives de n-alkyl-o-mercaptopropanamide, leurs procedes de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0254032A3 (en) 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
EP0355784A1 (en) * 1988-08-24 1990-02-28 Schering Corporation Mercapto-acylamino acid antihypertensives
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
US5407960A (en) * 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
AU7957291A (en) * 1990-05-17 1991-12-10 Schering Corporation Disulfide derivatives of mercaptoacylamino acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
GB2074571B (en) * 1980-04-11 1984-02-15 Wellcome Found Alpha-benzyl-substituted amides
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique

Also Published As

Publication number Publication date
GR75496B (no) 1984-07-24
FI76555C (fi) 1988-11-10
NO153768C (no) 1986-05-21
IL65799A0 (en) 1982-08-31
IE821168L (en) 1982-11-18
DK221182A (da) 1982-11-19
ATE8881T1 (de) 1984-08-15
ES8306719A1 (es) 1983-06-01
NZ200639A (en) 1985-08-30
IE53226B1 (en) 1988-09-14
KR860001549B1 (ko) 1986-10-04
KR830010063A (ko) 1983-12-24
JPS57193450A (en) 1982-11-27
EP0066956B1 (en) 1984-08-08
JPS637542B2 (no) 1988-02-17
YU42468B (en) 1988-08-31
PH18206A (en) 1985-04-25
AU8375982A (en) 1982-11-25
US4329495A (en) 1982-05-11
PT74913B (en) 1985-05-16
FI76555B (fi) 1988-07-29
ES512278A0 (es) 1983-06-01
EP0066956A1 (en) 1982-12-15
CA1179368A (en) 1984-12-11
PL236425A1 (en) 1983-08-01
ES519668A0 (es) 1984-03-01
IL65799A (en) 1985-12-31
YU104282A (en) 1985-06-30
DE3260531D1 (en) 1984-09-13
IN158365B (no) 1986-11-01
PT74913A (en) 1982-06-01
NO821595L (no) 1982-11-19
AU529511B2 (en) 1983-06-09
AR231279A1 (es) 1984-10-31
NO153768B (no) 1986-02-10
PL138043B1 (en) 1986-08-30
HU188058B (en) 1986-03-28
ZA823386B (en) 1983-03-30
ES8403107A1 (es) 1984-03-01
FI821736A0 (fi) 1982-05-17

Similar Documents

Publication Publication Date Title
DK160711B (da) Analogifremgangsmaade til fremstilling af chirale 2-(2-benzyl-3-mercaptopropionyl)amino-1-alkanolderivater eller chirale 2-(2-benzyl-3-mercaptopropionyl)amino-4-methylthiosmoersyrer eller farmaceutisk acceptable kationsalte af syrerne
US5801274A (en) N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives
US4153725A (en) Relieving angiotension related hypertension with carboxyalkylacylamino acids
US4461896A (en) 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
DK169029B1 (da) Collagenaseinhibitorderivater baseret på hydroxamsyre, og farmaceutisk præparat deraf
US4192878A (en) Derivatives of thiazolidinecarboxylic acids and related acids
JPS6121226B2 (no)
JPH05310664A (ja) ビアリール置換４−アミノ酪酸アミド
KR19990087756A (ko) 제약 제제로서 신규한 치환 시클릭 아미노산
US4937243A (en) Thiol carboxylic acid derivatives and their use as colagenase inhibitors
US4206232A (en) Relieving hypertension with carboxyalkylacylamino acids
US4500467A (en) Benzoylthio compounds, their preparation and their use as drugs
US5010097A (en) Novel compounds
US4134991A (en) Derivatives of 2-(3-phenyl-2-aminopropionyloxy)-acetic acid
EP0634396B1 (fr) Dérivés d'amino-acides et leur utilisation comme inhibiteurs de l'enképhalinase
US4282235A (en) Derivatives of thiazolidinecarboxylic acids and related acids
US5451606A (en) Anthraquinone compounds useful to treat osteoarticular conditions, pharmaceutical compositions and method of treatment
US5750524A (en) Remedy for hyperlipidemia
CS199693B2 (cs) Způsob výroby derivátů thiazolidin-, thiazana morfolinkarboxylových kyselin
WO2006073042A1 (ja) Ｎｒｆ２依存遺伝子の活性化剤
US3778511A (en) Alpha-(1,2,3,4-tetrahydro-6-quinoyl)-carboxylic acids and derivatives thereof for treating inflammation
NO751401L (no)
JP3250806B2 (ja) Ｎ−（メルカプトアシル）アミノ酸と、その製造方法と、その治療での使用と、それを含む医薬組成物
US4237129A (en) Derivatives of thiazolidinecarboxylic acids and related acids
US4237134A (en) Derivatives of thiazolidinecarboxylic acids and related acids

Legal Events

Date Code Title Description
PHB Application deemed withdrawn due to non-payment or other reasons