ES8403107A1 - Un procedimiento para la preparacion de derivados 2-(2-bencil-3-mercaptopropionilamino)-1-alcanoles quirales. - Google Patents

Un procedimiento para la preparacion de derivados 2-(2-bencil-3-mercaptopropionilamino)-1-alcanoles quirales.

Info

Publication number
ES8403107A1
ES8403107A1 ES519668A ES519668A ES8403107A1 ES 8403107 A1 ES8403107 A1 ES 8403107A1 ES 519668 A ES519668 A ES 519668A ES 519668 A ES519668 A ES 519668A ES 8403107 A1 ES8403107 A1 ES 8403107A1
Authority
ES
Spain
Prior art keywords
inhibiting compounds
enzyme inhibiting
enkephalinase
enkephalinase enzyme
mercaptopropionylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519668A
Other languages
English (en)
Other versions
ES519668A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8403107A1 publication Critical patent/ES8403107A1/es
Publication of ES519668A0 publication Critical patent/ES519668A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS 2-(2-BENCIL-3-MERCAPTOPROPIONILAMINO)-1-ALCANOL ES QUIRALES, DE FORMULA GENERAL (I).CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), CON UN COMPUESTO DE FORMULA GENERAL (III), EN LAS QUE R, R1, M Y N TIENEN LOS SIGNIFICADOS YA MENCIONADOS.DE APLICACION COMO ANALGESICOS, ANTICONVULSIVOS O COMO AGENTES TERAPEUTICOS PARA LOS TRASTORNOS EN LOS QUE LOS NIVELES DE ENCEFALINA ENDOGENA ESTAN POR DEBAJO DE LO NORMAL.
ES519668A 1981-05-18 1983-02-09 Un procedimiento para la preparacion de derivados 2-(2-bencil-3-mercaptopropionilamino)-1-alcanoles quirales. Granted ES519668A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/264,752 US4329495A (en) 1981-05-18 1981-05-18 Enkephalinase enzyme inhibiting compounds

Publications (2)

Publication Number Publication Date
ES8403107A1 true ES8403107A1 (es) 1984-03-01
ES519668A0 ES519668A0 (es) 1984-03-01

Family

ID=23007448

Family Applications (2)

Application Number Title Priority Date Filing Date
ES512278A Expired ES8306719A1 (es) 1981-05-18 1982-05-17 Un procedimiento para la preparacion de derivados de 2-c2 bencil-3-mercaptopropionilamino-1-alcanoles.
ES519668A Granted ES519668A0 (es) 1981-05-18 1983-02-09 Un procedimiento para la preparacion de derivados 2-(2-bencil-3-mercaptopropionilamino)-1-alcanoles quirales.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES512278A Expired ES8306719A1 (es) 1981-05-18 1982-05-17 Un procedimiento para la preparacion de derivados de 2-c2 bencil-3-mercaptopropionilamino-1-alcanoles.

Country Status (24)

Country Link
US (1) US4329495A (es)
EP (1) EP0066956B1 (es)
JP (1) JPS57193450A (es)
KR (1) KR860001549B1 (es)
AR (1) AR231279A1 (es)
AT (1) ATE8881T1 (es)
AU (1) AU529511B2 (es)
CA (1) CA1179368A (es)
DE (1) DE3260531D1 (es)
DK (1) DK160711B (es)
ES (2) ES8306719A1 (es)
FI (1) FI76555C (es)
GR (1) GR75496B (es)
HU (1) HU188058B (es)
IE (1) IE53226B1 (es)
IL (1) IL65799A (es)
IN (1) IN158365B (es)
NO (1) NO153768C (es)
NZ (1) NZ200639A (es)
PH (1) PH18206A (es)
PL (1) PL138043B1 (es)
PT (1) PT74913B (es)
YU (1) YU42468B (es)
ZA (1) ZA823386B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474795A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
JPS58140065A (ja) * 1982-02-10 1983-08-19 Meito Sangyo Kk メルカプトベンジル脂肪酸誘導体類及びその製法
FR2540498B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR2559770B1 (fr) * 1984-02-20 1986-10-24 Roussel Uclaf Nouveaux derives de n-alkyl-o-mercaptopropanamide, leurs procedes de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
EP0355784A1 (en) * 1988-08-24 1990-02-28 Schering Corporation Mercapto-acylamino acid antihypertensives
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
WO1991009840A1 (en) * 1989-12-22 1991-07-11 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
NZ238154A (en) * 1990-05-17 1993-07-27 Schering Corp Disulphides of 3-mercapto-acylamino acids and pharmaceutical compositions thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
IT1148006B (it) * 1980-04-11 1986-11-26 Wellcome Found Ammidi dotate di proprieta' farmaceutiche e loro preparazione
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique

Also Published As

Publication number Publication date
AR231279A1 (es) 1984-10-31
NO821595L (no) 1982-11-19
YU42468B (en) 1988-08-31
JPS637542B2 (es) 1988-02-17
FI821736A0 (fi) 1982-05-17
ZA823386B (en) 1983-03-30
NO153768C (no) 1986-05-21
IN158365B (es) 1986-11-01
DK160711B (da) 1991-04-08
AU529511B2 (en) 1983-06-09
IL65799A0 (en) 1982-08-31
ES519668A0 (es) 1984-03-01
ES512278A0 (es) 1983-06-01
GR75496B (es) 1984-07-24
NO153768B (no) 1986-02-10
PT74913B (en) 1985-05-16
ATE8881T1 (de) 1984-08-15
DE3260531D1 (en) 1984-09-13
NZ200639A (en) 1985-08-30
KR860001549B1 (ko) 1986-10-04
HU188058B (en) 1986-03-28
YU104282A (en) 1985-06-30
JPS57193450A (en) 1982-11-27
AU8375982A (en) 1982-11-25
DK221182A (da) 1982-11-19
FI76555C (fi) 1988-11-10
IL65799A (en) 1985-12-31
EP0066956B1 (en) 1984-08-08
IE53226B1 (en) 1988-09-14
EP0066956A1 (en) 1982-12-15
FI76555B (fi) 1988-07-29
CA1179368A (en) 1984-12-11
IE821168L (en) 1982-11-18
PL236425A1 (en) 1983-08-01
PT74913A (en) 1982-06-01
KR830010063A (ko) 1983-12-24
PH18206A (en) 1985-04-25
PL138043B1 (en) 1986-08-30
ES8306719A1 (es) 1983-06-01
US4329495A (en) 1982-05-11

Similar Documents

Publication Publication Date Title
ES8403107A1 (es) Un procedimiento para la preparacion de derivados 2-(2-bencil-3-mercaptopropionilamino)-1-alcanoles quirales.
DE3580057D1 (de) Heterocylische mercaptocarbonsaeureamide, -imide und -nitrile als korrosionsinhibitoren.
IT8320064A0 (it) Inibitori dell'enzima che trasforma l'angiotensina, costituiti da acidi amminoalchilfosfinici e da acidi amminofosfinici sostituiti simili.
IL129147A0 (en) The preparation and use of ortho-sulfonamide aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
EG18081A (en) Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as the use indurugs
IL66256A0 (en) Water containing compositions comprising salts of n-substituted-2-pyrrolidone-4-carboxylic acids as humectants
MY106202A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
GB8426042D0 (en) Salts as corrosion inhibitors
BR8605984A (pt) Composicao detergente liquida enzimatica
IT8567714A1 (it) Procedimento enzimatico di depilazione di pelli.
ZA978400B (en) Use of inhibitors of the activity of retinoic acid to promote healing.
PT83076A (en) Dopamine-beta-hydroxylase inhibitors
IT1237792B (it) Composti attivi come inibitori dell'enzima hmg-coa reduttasi
DK515786D0 (da) Inhibitorer for dopamin-beta-hydroxylase samt fremgangsmaade til fremstilling heraf
EP0228625A3 (en) Peptide derivatives inhibitors of hydroxyling enzymes, their process of preparation, the agents thereof and their use
EP0152274A3 (en) Method for the determination of enzyme activity
EP0237796A3 (en) New use of prostaglandin biosynthesis inhibitors
IL72487A0 (en) Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors
DE3884277D1 (de) Verwendung von Salzen von Sulfonamidocarbonsäuren als Korrosionsinhibitoren in wässrigen Systemen.
ES557180A1 (es) Un procedimiento para producir aminocarnitina
NO863956L (no) Korrosjonsinhiberende preparat for saltloesninger med hoey densitet.
GB8712215D0 (en) Inhibitors against corrosion
IL87327A0 (en) Aqueous enzyme compositions comprising proteolytic inhibitors as stabilizers
IT1211781B (it) Procedimento per la idrolisi enzimatica di sego di bue
IT1213059B (it) Sali imidazolici di acidi arilalcanoici antiflogistica,antipiretica, analgesica, loro preparazione e composizioni farmaceutiche che licontengono.

Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401