DK515786D0 - Inhibitorer for dopamin-beta-hydroxylase samt fremgangsmaade til fremstilling heraf - Google Patents

Inhibitorer for dopamin-beta-hydroxylase samt fremgangsmaade til fremstilling heraf

Info

Publication number
DK515786D0
DK515786D0 DK515786A DK515786A DK515786D0 DK 515786 D0 DK515786 D0 DK 515786D0 DK 515786 A DK515786 A DK 515786A DK 515786 A DK515786 A DK 515786A DK 515786 D0 DK515786 D0 DK 515786D0
Authority
DK
Denmark
Prior art keywords
dopamine
beta
procedures
preparing
hydroxylase inhibitors
Prior art date
Application number
DK515786A
Other languages
English (en)
Other versions
DK515786A (da
Inventor
Carl Kaiser
Lawrence Ivan Kruse
Stephen Torey Ross
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK515786D0 publication Critical patent/DK515786D0/da
Publication of DK515786A publication Critical patent/DK515786A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/42Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK515786A 1985-10-31 1986-10-28 Inhibitorer for dopamin-beta-hydroxylase samt fremgangsmaade til fremstilling heraf DK515786A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/793,512 US4719223A (en) 1985-10-31 1985-10-31 Imidazolethiol dopamine-beta-hydroxylase inhibitors

Publications (2)

Publication Number Publication Date
DK515786D0 true DK515786D0 (da) 1986-10-28
DK515786A DK515786A (da) 1987-05-01

Family

ID=25160082

Family Applications (1)

Application Number Title Priority Date Filing Date
DK515786A DK515786A (da) 1985-10-31 1986-10-28 Inhibitorer for dopamin-beta-hydroxylase samt fremgangsmaade til fremstilling heraf

Country Status (15)

Country Link
US (1) US4719223A (da)
EP (1) EP0221778A3 (da)
JP (1) JPS62108815A (da)
KR (1) KR870003994A (da)
CN (1) CN86107151A (da)
AU (1) AU598485B2 (da)
DK (1) DK515786A (da)
FI (1) FI864431A (da)
HU (1) HU197563B (da)
NO (1) NO864337L (da)
NZ (1) NZ218098A (da)
PH (1) PH21776A (da)
PT (1) PT83628B (da)
ZA (1) ZA868269B (da)
ZW (1) ZW21586A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
US5057613A (en) * 1986-05-06 1991-10-15 Merrell Dow Pharmaceuticals Novel thione dopamine beta hydroxylase inhibitors
US4859779A (en) * 1987-03-24 1989-08-22 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
DE19620408A1 (de) * 1996-05-21 1997-11-27 Bayer Ag Mercapto-imidazolyl-Derivate
US20080002735A1 (en) * 1997-04-01 2008-01-03 Paradox Security Systems Ltd. Device network
US7965734B2 (en) * 2005-12-15 2011-06-21 Paradox Security Systems Ltd. Device network interface
IN2012DE00661A (da) 2012-03-07 2015-08-21 Univ Delhi
CN103214421B (zh) * 2012-12-11 2016-03-02 上海博康精细化工有限公司 2-巯基-1-甲基咪唑的工业化生产方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2180772A (en) * 1935-10-25 1939-11-21 Gen Aniline Works Inc Trifluoromethyl benzaldehydes
NO120426B (da) * 1965-10-21 1970-10-19 Geigy Ag J R
DE2259627A1 (de) * 1972-12-06 1974-06-12 Hoechst Ag Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung
DK565277A (da) * 1976-12-20 1978-06-21 Wellcome Found Imidazoliner deres fremstilling og anvendelse
US4284641A (en) * 1977-08-26 1981-08-18 Burroughs Wellcome Co. Pharmaceutically active imidazole derivatives
US4340738A (en) * 1979-06-21 1982-07-20 Janssen Pharmaceutica, N.V. 2,3-Dihydro-imidazo[2,1-b]benzothiazoles
GB2096987B (en) * 1981-04-22 1984-04-04 Farmos Oy Substituted imidazole and imidazole derivatives and their preparation and use
US4487761A (en) * 1982-04-05 1984-12-11 Merck & Co., Inc. Dopamine β-hydroxylase inhibitors
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors

Also Published As

Publication number Publication date
PH21776A (en) 1988-02-24
PT83628B (en) 1988-11-15
HUT43830A (en) 1987-12-28
NZ218098A (en) 1989-07-27
NO864337D0 (no) 1986-10-30
KR870003994A (ko) 1987-05-06
HU197563B (en) 1989-04-28
AU598485B2 (en) 1990-06-28
ZW21586A1 (en) 1987-06-24
EP0221778A3 (en) 1988-03-23
CN86107151A (zh) 1987-05-13
AU6463986A (en) 1987-05-07
JPS62108815A (ja) 1987-05-20
FI864431A0 (fi) 1986-10-30
EP0221778A2 (en) 1987-05-13
ZA868269B (en) 1987-07-29
PT83628A (en) 1986-11-01
US4719223A (en) 1988-01-12
DK515786A (da) 1987-05-01
NO864337L (no) 1987-05-04
FI864431A (fi) 1987-05-01

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Legal Events

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AHB Application shelved due to non-payment