DK158994C - Analogifremgangsmaade til fremstilling af enzymderivater indeholdende et streptokinase/plasminogen-kompleks - Google Patents

Analogifremgangsmaade til fremstilling af enzymderivater indeholdende et streptokinase/plasminogen-kompleks

Info

Publication number
DK158994C
DK158994C DK468880A DK468880A DK158994C DK 158994 C DK158994 C DK 158994C DK 468880 A DK468880 A DK 468880A DK 468880 A DK468880 A DK 468880A DK 158994 C DK158994 C DK 158994C
Authority
DK
Denmark
Prior art keywords
striptkinase
derivatives containing
analogy procedure
preparing enzyme
enzyme derivatives
Prior art date
Application number
DK468880A
Other languages
Danish (da)
English (en)
Other versions
DK158994B (da
DK468880A (da
Inventor
Richard Anthony Godwin Smith
John Gordon Winchester
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of DK468880A publication Critical patent/DK468880A/da
Publication of DK158994B publication Critical patent/DK158994B/da
Application granted granted Critical
Publication of DK158994C publication Critical patent/DK158994C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK468880A 1979-11-05 1980-11-04 Analogifremgangsmaade til fremstilling af enzymderivater indeholdende et streptokinase/plasminogen-kompleks DK158994C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7938279 1979-11-05
GB7938279 1979-11-05

Publications (3)

Publication Number Publication Date
DK468880A DK468880A (da) 1981-05-06
DK158994B DK158994B (da) 1990-08-13
DK158994C true DK158994C (da) 1991-01-07

Family

ID=10508982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK468880A DK158994C (da) 1979-11-05 1980-11-04 Analogifremgangsmaade til fremstilling af enzymderivater indeholdende et streptokinase/plasminogen-kompleks

Country Status (18)

Country Link
US (1) US4808405A (no)
EP (1) EP0028489B1 (no)
JP (1) JPS5678590A (no)
AR (1) AR224786A1 (no)
CA (1) CA1174621A (no)
CS (2) CS391991A3 (no)
DE (1) DE3065190D1 (no)
DK (1) DK158994C (no)
ES (1) ES496586A0 (no)
GR (1) GR72121B (no)
HK (1) HK65886A (no)
HU (1) HU185223B (no)
IE (1) IE50174B1 (no)
IL (1) IL61408A (no)
NL (1) NL930029I2 (no)
NO (1) NO163867C (no)
NZ (1) NZ195469A (no)
ZA (1) ZA806641B (no)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091240B1 (en) * 1982-04-07 1985-12-27 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US5231006A (en) * 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
JPH0296536A (ja) * 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
AU647391B2 (en) * 1989-05-01 1994-03-24 University Of Notre Dame Du Lac, The Methods and materials for expression of human plasminogen in a eukaryotic cell system
EP0397366A1 (en) * 1989-05-09 1990-11-14 The Board Of Regents Of The University Of Oklahoma Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same
EP0472657B1 (en) * 1989-05-17 1996-03-13 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
GB8928163D0 (en) * 1989-12-13 1990-02-14 Beecham Group Plc Novel treatment
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
US5187069A (en) * 1990-08-06 1993-02-16 Henry Ford Health System Active site labelling of plasminogen
AU1873092A (en) * 1991-04-09 1992-11-17 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
US5520912A (en) * 1993-07-02 1996-05-28 Immuno Aktiengesellschaft Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
DE4411143C2 (de) * 1994-03-30 1996-08-01 Immuno Ag Thrombosemittel
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
US6004955A (en) * 1996-08-15 1999-12-21 Dupont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
ES2239806T3 (es) 1997-06-19 2005-10-01 Bristol-Myers Squibb Pharma Company Inhibidores del factor xa con un grupo de especificidad neutro p1.
AU768859B2 (en) * 1999-07-29 2004-01-08 Dyax Corp. Binding moieties for fibrin
US6388073B1 (en) 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
KR20010000669A (ko) * 2000-10-12 2001-01-05 김기환 스트렙토키나제와 사람 혈청알부민의 포합체를유효성분으로 함유하는 전신투여용 지속성 혈전 용해제
US6984373B2 (en) * 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
CH1427415H1 (de) 2001-09-21 2023-12-21 Bristol Myers Squibb Holdings Ireland Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
WO2006076575A2 (en) 2005-01-13 2006-07-20 Bristol-Myers Squibb Company Substituted biaryl compounds as factor xia inhibitors
MX2007008434A (es) 2005-01-19 2007-07-25 Squibb Bristol Myers Co Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos.
AU2006261828A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
DE602006017694D1 (de) 2005-06-27 2010-12-02 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
EP1896417B1 (en) 2005-06-27 2011-03-23 Bristol-Myers Squibb Company Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US8222453B2 (en) 2006-06-08 2012-07-17 Bristol-Myers Squibb Company Benzamide factor VIIa inhibitors useful as anticoagulants
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
EP2102189B1 (en) 2006-12-15 2015-07-29 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
PE20081775A1 (es) 2006-12-20 2008-12-18 Bristol Myers Squibb Co Compuestos macrociclicos como inhibidores del factor viia
AR067329A1 (es) 2007-06-13 2009-10-07 Bristol Myers Squibb Co Analogos dipeptidos como inhibidores del factor de coagulacion
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
WO2009143039A2 (en) 2008-05-19 2009-11-26 Schering Corporation Heterocyclic compounds as factor ixa inhibitors
WO2010147978A1 (en) 2009-06-16 2010-12-23 Pfizer Inc. Dosage forms of apixaban
EP2462123B1 (en) 2009-08-04 2013-10-02 Merck Sharp & Dohme Corp. 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
TWI577665B (zh) 2010-02-11 2017-04-11 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之巨環類
TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
PL2766346T3 (pl) 2011-10-14 2017-09-29 Bristol-Myers Squibb Company Podstawione związki tetrahydroizochinoliny jako inhibitory czynnika XIA
ES2699226T3 (es) 2011-10-14 2019-02-08 Bristol Myers Squibb Co Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa
CN103987696B (zh) 2011-10-14 2016-12-21 百时美施贵宝公司 作为因子xia抑制剂的取代的四氢异喹啉化合物
WO2013068875A1 (en) 2011-11-11 2013-05-16 Pfizer Inc. 2-thiopyrimidinones
US9296745B2 (en) 2012-04-06 2016-03-29 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors
CN108250199B (zh) 2012-08-03 2021-07-16 百时美施贵宝公司 二氢吡啶酮p1作为凝血因子xia抑制剂
UY34959A (es) 2012-08-03 2014-01-31 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Dihidropiridona p1 como inhibidores del factor xia
EP2978751B1 (en) 2013-03-25 2018-12-05 Bristol-Myers Squibb Company Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
HUE040226T2 (hu) 2014-01-31 2019-02-28 Bristol Myers Squibb Co Makrociklusok heterociklusos P2' csoportokkal XIA faktor inhibitorokként
NO2760821T3 (no) 2014-01-31 2018-03-10
CN106103425A (zh) 2014-03-17 2016-11-09 辉瑞公司 用于治疗代谢及相关病症的二酰甘油酰基转移酶2抑制剂
ES2718552T3 (es) 2014-04-04 2019-07-02 Pfizer Compuestos de heteroarilo o arilo bicíclicos fusionados y su uso como inhibidores de IRAK4
US9969724B2 (en) 2014-04-16 2018-05-15 Merck Sharp & Dohme Corp. Factor IXa inhibitors
NO2721243T3 (no) 2014-10-01 2018-10-20
WO2016178113A1 (en) 2015-05-05 2016-11-10 Pfizer Inc. 2-thiopyrimidinones
WO2016203347A1 (en) 2015-06-17 2016-12-22 Pfizer Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
ES2937156T3 (es) 2015-07-29 2023-03-24 Bristol Myers Squibb Co Inhibidores macrocíclicos del factor XIa que llevan un grupo P2' no aromático
JP6785838B2 (ja) 2015-08-05 2020-11-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 新規な置換グリシン誘導のｆｘｉａ阻害剤
MX2018002402A (es) 2015-08-27 2018-04-11 Pfizer Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4).
EP3423458A1 (en) 2016-03-02 2019-01-09 Bristol-Myers Squibb Company Diamide macrocycles having factor xia inhibiting activity
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
KR102614808B1 (ko) 2018-08-31 2023-12-19 화이자 인코포레이티드 Nash/nafld 및 관련 질환의 치료를 위한 조합물
EP3972596A1 (en) 2019-05-20 2022-03-30 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
CN116133660A (zh) 2020-07-22 2023-05-16 詹森药业有限公司 可用作因子XIa抑制剂的化合物
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178368A (en) * 1971-09-30 1979-12-11 Behringwerke Aktiengesellschaft Method for the treatment of thromboembolism
JPS5325775A (en) * 1976-08-24 1978-03-09 Miller Fluid Power Corp Module type fluid flow control element
US4082612A (en) * 1976-09-24 1978-04-04 Michael Reese Research Foundation Plasminogen activator complex
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

Also Published As

Publication number Publication date
HK65886A (en) 1986-09-12
JPS5678590A (en) 1981-06-27
ES8204467A1 (es) 1982-05-01
IE50174B1 (en) 1986-02-19
NO803304L (no) 1981-05-06
ES496586A0 (es) 1982-05-01
NO163867B (no) 1990-04-23
JPH0316114B2 (no) 1991-03-04
DE3065190D1 (en) 1983-11-10
GR72121B (no) 1983-09-16
IE802277L (en) 1981-05-05
NZ195469A (en) 1984-05-31
CS391191A3 (en) 1992-08-12
NO163867C (no) 1990-08-01
NL930029I2 (nl) 1993-12-01
IL61408A0 (en) 1980-12-31
AR224786A1 (es) 1982-01-15
ZA806641B (en) 1981-10-28
CA1174621A (en) 1984-09-18
HU185223B (en) 1984-12-28
AU534017B2 (en) 1983-12-22
DK158994B (da) 1990-08-13
AU6401180A (en) 1981-05-14
IL61408A (en) 1983-10-31
US4808405A (en) 1989-02-28
EP0028489B1 (en) 1983-10-05
EP0028489A1 (en) 1981-05-13
CS391991A3 (en) 1992-06-17
NL930029I1 (nl) 1993-06-01
DK468880A (da) 1981-05-06

Similar Documents

Publication Publication Date Title
DK158994C (da) Analogifremgangsmaade til fremstilling af enzymderivater indeholdende et streptokinase/plasminogen-kompleks
DK300177A (da) Fremgangsmade til fremstilling af et enzymgranulat
DK157019C (da) Analogifremgangsmaade til fremstilling af 2-amino-4-hydroxyquinazolinderivater
DK458679A (da) Fremgangsmaade til fremstilling af nitrogenholdige heterocycliske forbindelser
DK152138C (da) Fremgangsmaade til fremstilling af urokinase
DK157169C (da) Fremgangsmaade til fremstilling af et koncentrat af prothrombinkompleks
DK145698C (da) Analogifremgangsmaade til fremstilling af 2-alkoxyadeninderivater
DK453080A (da) Fremgangsmaade til fremstilling af et depllymeriserende enzym
DK147145C (da) Analogifremgangsmaade til fremstilling af chlorambucilderivater
DK289580A (da) Fremgangsmaade til fremstilling af heterocycliske phenoxyaminer
DK387480A (da) Fremgangsmaade til fremstilling af 2-alkyl-eller 2-aryithiomethylphenoler
DK154136C (da) Analogifremgangsmaade til fremstilling af 2-amino-3-benzoylphenylacetamider
DK355180A (da) Fremgangsmaade til fremstilling af heterocycliske forbindelser
DK255279A (da) Piperidinderivater af 1,3,5-triazoxycloheptan-2,4-dion samt fremgangsmaade til fremstilling og anvendelse af disse
DK493780A (da) Fremgangsmaade til fremstilling af et nicotinamidderivat
DK134880A (da) Fremgangsmaade til fremstilling af benzothiazolderivater fremgangsmaade til fe
DK464777A (da) Fremgangsmaade til fremstilling af et glucoseisomeriserende enzym
DK197477A (da) Fremgangsmade til fremstilling af et lipaserigt enzympreparat
DK159878A (da) Fremgangsmaade til fremstilling af urokinase
DK56480A (da) Fremgangsmaade til fremstilling af et kombinationsemne
DK569078A (da) Fremgangsmaade til fremstilling af nye arylaminoimidazolinderivater
DK183780A (da) Femgangsmaade til fremstilling af hydroxyderivater af isopropylaminopyrimidin
DK152379C (da) Fremgangsmaade til fremstilling af et granulaert tripolyphosphatmateriale
DK12879A (da) R fremgangsmaade til fremstilling af ergopeptidalkaloidderivate
DK146130C (da) Fremgangsmaade til stabilisering af triarylphosphit-halogen-komplekser

Legal Events

Date Code Title Description
PBP Patent lapsed