EP0091240B1
(en)
*
|
1982-04-07 |
1985-12-27 |
Beecham Group Plc |
Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
|
WO1984001960A1
(en)
*
|
1982-11-11 |
1984-05-24 |
Beecham Group Plc |
Pharmaceutically active compounds
|
GB8400653D0
(en)
*
|
1984-01-11 |
1984-02-15 |
Beecham Group Plc |
Conjugates
|
GB8430253D0
(en)
*
|
1984-11-30 |
1985-01-09 |
Beecham Group Plc |
Compounds
|
US5231006A
(en)
*
|
1986-10-16 |
1993-07-27 |
Behringwerke Aktiengesellschaft |
Method for the determination of plasminogen
|
US5256642A
(en)
*
|
1988-04-01 |
1993-10-26 |
The Johns Hopkins University |
Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
|
JPH0296536A
(ja)
*
|
1988-09-29 |
1990-04-09 |
Green Cross Corp:The |
プラスミノゲン乾燥製剤
|
AU647391B2
(en)
*
|
1989-05-01 |
1994-03-24 |
University Of Notre Dame Du Lac, The |
Methods and materials for expression of human plasminogen in a eukaryotic cell system
|
EP0397366A1
(en)
*
|
1989-05-09 |
1990-11-14 |
The Board Of Regents Of The University Of Oklahoma |
Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same
|
EP0472657B1
(en)
*
|
1989-05-17 |
1996-03-13 |
Research Corporation Technologies, Inc. |
Method and composition for the treatment of thrombosis in a mammal
|
AU6470590A
(en)
|
1989-10-23 |
1991-04-26 |
Smithkline Beecham Corporation |
Cyclic anti-aggregatory peptides
|
US5190756A
(en)
*
|
1989-12-01 |
1993-03-02 |
Genentech, Inc. |
Methods and materials for expression of human plasminogen variant
|
US5087572A
(en)
*
|
1989-12-01 |
1992-02-11 |
Genentech, Inc. |
Dna encoding human plasminogen modified at the cleavage site
|
GB8928163D0
(en)
*
|
1989-12-13 |
1990-02-14 |
Beecham Group Plc |
Novel treatment
|
US6458360B1
(en)
|
1990-04-25 |
2002-10-01 |
The Johns Hopkins University |
Soluble complement regulatory molecules
|
US5187069A
(en)
*
|
1990-08-06 |
1993-02-16 |
Henry Ford Health System |
Active site labelling of plasminogen
|
AU1873092A
(en)
*
|
1991-04-09 |
1992-11-17 |
Brigham And Women's Hospital |
Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
|
US5520912A
(en)
*
|
1993-07-02 |
1996-05-28 |
Immuno Aktiengesellschaft |
Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
|
DE4411143C2
(de)
*
|
1994-03-30 |
1996-08-01 |
Immuno Ag |
Thrombosemittel
|
US5760028A
(en)
*
|
1995-12-22 |
1998-06-02 |
The Dupont Merck Pharmaceutical Company |
Integrin receptor antagonists
|
US6004955A
(en)
*
|
1996-08-15 |
1999-12-21 |
Dupont Pharmaceuticals Company |
Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
|
ES2239806T3
(es)
|
1997-06-19 |
2005-10-01 |
Bristol-Myers Squibb Pharma Company |
Inhibidores del factor xa con un grupo de especificidad neutro p1.
|
AU768859B2
(en)
*
|
1999-07-29 |
2004-01-08 |
Dyax Corp. |
Binding moieties for fibrin
|
US6388073B1
(en)
|
2000-07-26 |
2002-05-14 |
Shire Us Inc. |
Method for the manufacture of anagrelide
|
KR20010000669A
(ko)
*
|
2000-10-12 |
2001-01-05 |
김기환 |
스트렙토키나제와 사람 혈청알부민의 포합체를유효성분으로 함유하는 전신투여용 지속성 혈전 용해제
|
US6984373B2
(en)
*
|
2000-12-23 |
2006-01-10 |
Dyax Corp. |
Fibrin binding moieties useful as imaging agents
|
CH1427415H1
(de)
|
2001-09-21 |
2023-12-21 |
Bristol Myers Squibb Holdings Ireland |
Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
|
US7550499B2
(en)
|
2004-05-12 |
2009-06-23 |
Bristol-Myers Squibb Company |
Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
US7700608B2
(en)
*
|
2004-08-04 |
2010-04-20 |
Shire Holdings Ag |
Quinazoline derivatives and their use in the treatment of thrombocythemia
|
US20060030574A1
(en)
*
|
2004-08-04 |
2006-02-09 |
Shire Holdings Ag |
Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
|
WO2006076575A2
(en)
|
2005-01-13 |
2006-07-20 |
Bristol-Myers Squibb Company |
Substituted biaryl compounds as factor xia inhibitors
|
MX2007008434A
(es)
|
2005-01-19 |
2007-07-25 |
Squibb Bristol Myers Co |
Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos.
|
AU2006261828A1
(en)
|
2005-06-27 |
2007-01-04 |
Bristol-Myers Squibb Company |
N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
DE602006017694D1
(de)
|
2005-06-27 |
2010-12-02 |
Bristol Myers Squibb Co |
C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
|
EP1896417B1
(en)
|
2005-06-27 |
2011-03-23 |
Bristol-Myers Squibb Company |
Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
|
WO2007002634A1
(en)
|
2005-06-27 |
2007-01-04 |
Bristol-Myers Squibb Company |
Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
|
US8222453B2
(en)
|
2006-06-08 |
2012-07-17 |
Bristol-Myers Squibb Company |
Benzamide factor VIIa inhibitors useful as anticoagulants
|
US7960569B2
(en)
|
2006-10-17 |
2011-06-14 |
Bristol-Myers Squibb Company |
Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
US7910597B2
(en)
*
|
2006-11-28 |
2011-03-22 |
Shire Llc |
Substituted quinazolines
|
US8304420B2
(en)
|
2006-11-28 |
2012-11-06 |
Shire Llc |
Substituted quinazolines for reducing platelet count
|
EP2102189B1
(en)
|
2006-12-15 |
2015-07-29 |
Bristol-Myers Squibb Company |
Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
|
PE20081775A1
(es)
|
2006-12-20 |
2008-12-18 |
Bristol Myers Squibb Co |
Compuestos macrociclicos como inhibidores del factor viia
|
AR067329A1
(es)
|
2007-06-13 |
2009-10-07 |
Bristol Myers Squibb Co |
Analogos dipeptidos como inhibidores del factor de coagulacion
|
US20090130017A1
(en)
*
|
2007-11-19 |
2009-05-21 |
Searete Llc |
Targeted short-lived drug delivery
|
WO2009143039A2
(en)
|
2008-05-19 |
2009-11-26 |
Schering Corporation |
Heterocyclic compounds as factor ixa inhibitors
|
WO2010147978A1
(en)
|
2009-06-16 |
2010-12-23 |
Pfizer Inc. |
Dosage forms of apixaban
|
EP2462123B1
(en)
|
2009-08-04 |
2013-10-02 |
Merck Sharp & Dohme Corp. |
4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
|
TWI577665B
(zh)
|
2010-02-11 |
2017-04-11 |
必治妥美雅史谷比公司 |
作為因子xia抑制劑之巨環類
|
TW201319068A
(zh)
|
2011-08-05 |
2013-05-16 |
必治妥美雅史谷比公司 |
作為xia因子抑制劑之環狀p1接合劑
|
TW201311689A
(zh)
|
2011-08-05 |
2013-03-16 |
必治妥美雅史谷比公司 |
作為因子xia抑制劑之新穎巨環化合物
|
PL2766346T3
(pl)
|
2011-10-14 |
2017-09-29 |
Bristol-Myers Squibb Company |
Podstawione związki tetrahydroizochinoliny jako inhibitory czynnika XIA
|
ES2699226T3
(es)
|
2011-10-14 |
2019-02-08 |
Bristol Myers Squibb Co |
Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa
|
CN103987696B
(zh)
|
2011-10-14 |
2016-12-21 |
百时美施贵宝公司 |
作为因子xia抑制剂的取代的四氢异喹啉化合物
|
WO2013068875A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
2-thiopyrimidinones
|
US9296745B2
(en)
|
2012-04-06 |
2016-03-29 |
Pfizer Inc. |
Diacylglycerol acyltransferase 2 inhibitors
|
CN108250199B
(zh)
|
2012-08-03 |
2021-07-16 |
百时美施贵宝公司 |
二氢吡啶酮p1作为凝血因子xia抑制剂
|
UY34959A
(es)
|
2012-08-03 |
2014-01-31 |
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware |
Dihidropiridona p1 como inhibidores del factor xia
|
EP2978751B1
(en)
|
2013-03-25 |
2018-12-05 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors
|
ES2665153T3
(es)
|
2013-10-09 |
2018-04-24 |
Pfizer Inc. |
Antagonistas del receptor EP3 de prostaglandina
|
HUE040226T2
(hu)
|
2014-01-31 |
2019-02-28 |
Bristol Myers Squibb Co |
Makrociklusok heterociklusos P2' csoportokkal XIA faktor inhibitorokként
|
NO2760821T3
(no)
|
2014-01-31 |
2018-03-10 |
|
|
CN106103425A
(zh)
|
2014-03-17 |
2016-11-09 |
辉瑞公司 |
用于治疗代谢及相关病症的二酰甘油酰基转移酶2抑制剂
|
ES2718552T3
(es)
|
2014-04-04 |
2019-07-02 |
Pfizer |
Compuestos de heteroarilo o arilo bicíclicos fusionados y su uso como inhibidores de IRAK4
|
US9969724B2
(en)
|
2014-04-16 |
2018-05-15 |
Merck Sharp & Dohme Corp. |
Factor IXa inhibitors
|
NO2721243T3
(no)
|
2014-10-01 |
2018-10-20 |
|
|
WO2016178113A1
(en)
|
2015-05-05 |
2016-11-10 |
Pfizer Inc. |
2-thiopyrimidinones
|
WO2016203347A1
(en)
|
2015-06-17 |
2016-12-22 |
Pfizer Inc. |
Tricyclic compounds and their use as phosphodiesterase inhibitors
|
WO2016203335A1
(en)
|
2015-06-18 |
2016-12-22 |
Pfizer Inc. |
Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
|
ES2937156T3
(es)
|
2015-07-29 |
2023-03-24 |
Bristol Myers Squibb Co |
Inhibidores macrocíclicos del factor XIa que llevan un grupo P2' no aromático
|
JP6785838B2
(ja)
|
2015-08-05 |
2020-11-18 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
新規な置換グリシン誘導のfxia阻害剤
|
MX2018002402A
(es)
|
2015-08-27 |
2018-04-11 |
Pfizer |
Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4).
|
EP3423458A1
(en)
|
2016-03-02 |
2019-01-09 |
Bristol-Myers Squibb Company |
Diamide macrocycles having factor xia inhibiting activity
|
AR109179A1
(es)
|
2016-08-19 |
2018-11-07 |
Pfizer |
Inhibidores de diacilglicerol aciltransferasa 2
|
KR102614808B1
(ko)
|
2018-08-31 |
2023-12-19 |
화이자 인코포레이티드 |
Nash/nafld 및 관련 질환의 치료를 위한 조합물
|
EP3972596A1
(en)
|
2019-05-20 |
2022-03-30 |
Pfizer Inc. |
Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
|
CN116133660A
(zh)
|
2020-07-22 |
2023-05-16 |
詹森药业有限公司 |
可用作因子XIa抑制剂的化合物
|
WO2023026180A1
(en)
|
2021-08-26 |
2023-03-02 |
Pfizer Inc. |
Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
|
WO2024118524A1
(en)
|
2022-11-28 |
2024-06-06 |
Cerevel Therapeutics, Llc |
Azaindole compounds and their use as phosphodiesterase inhibitors
|