DK1589014T3 - Fremgangsmåde til syntese af derivater af 1,3-dihydro-2H-3-benzazepin-2-on og anvendelse heraf ved syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre - Google Patents
Fremgangsmåde til syntese af derivater af 1,3-dihydro-2H-3-benzazepin-2-on og anvendelse heraf ved syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syreInfo
- Publication number
- DK1589014T3 DK1589014T3 DK05290382T DK05290382T DK1589014T3 DK 1589014 T3 DK1589014 T3 DK 1589014T3 DK 05290382 T DK05290382 T DK 05290382T DK 05290382 T DK05290382 T DK 05290382T DK 1589014 T3 DK1589014 T3 DK 1589014T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- ivabradine
- benzazepin
- dihydro
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0403829A FR2868776B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1589014T3 true DK1589014T3 (da) | 2008-02-25 |
Family
ID=34941960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05290382T DK1589014T3 (da) | 2004-04-13 | 2005-02-21 | Fremgangsmåde til syntese af derivater af 1,3-dihydro-2H-3-benzazepin-2-on og anvendelse heraf ved syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre |
Country Status (33)
Country | Link |
---|---|
US (1) | US7074920B2 (uk) |
EP (1) | EP1589014B1 (uk) |
JP (2) | JP4511970B2 (uk) |
KR (1) | KR100636500B1 (uk) |
CN (1) | CN1332951C (uk) |
AR (1) | AR047686A1 (uk) |
AT (1) | ATE375339T1 (uk) |
AU (1) | AU2005200860B2 (uk) |
BR (1) | BRPI0500478B8 (uk) |
CA (1) | CA2496721C (uk) |
CY (1) | CY1107101T1 (uk) |
DE (1) | DE602005002776T2 (uk) |
DK (1) | DK1589014T3 (uk) |
EA (1) | EA007744B1 (uk) |
ES (1) | ES2294652T3 (uk) |
FR (1) | FR2868776B1 (uk) |
GE (1) | GEP20074137B (uk) |
HK (1) | HK1079776A1 (uk) |
HR (1) | HRP20070503T3 (uk) |
MA (1) | MA27599A1 (uk) |
ME (1) | ME01402B (uk) |
MX (1) | MXPA05003695A (uk) |
MY (1) | MY141223A (uk) |
NO (1) | NO329438B1 (uk) |
NZ (1) | NZ538327A (uk) |
PL (1) | PL1589014T3 (uk) |
PT (1) | PT1589014E (uk) |
RS (1) | RS50546B (uk) |
SG (1) | SG116573A1 (uk) |
SI (1) | SI1589014T1 (uk) |
UA (1) | UA81772C2 (uk) |
WO (1) | WO2005111026A1 (uk) |
ZA (1) | ZA200501467B (uk) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
EP2162438A4 (en) | 2007-05-30 | 2011-07-06 | Ind Swift Lab Ltd | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE |
ES2402765T3 (es) | 2008-12-22 | 2013-05-08 | Krka, D.D., Novo Mesto | Procedimiento de preparación de ivabradina |
EA201290772A1 (ru) | 2010-02-12 | 2013-02-28 | КРКА, д.д., НОВО МЕСТО | Новые формы ивабрадина гидрохлорида |
FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
EP0204349A3 (de) * | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE3519735A1 (de) * | 1985-06-01 | 1986-12-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JP2568416B2 (ja) * | 1986-11-04 | 1997-01-08 | 大塚製薬株式会社 | ヒドロフルオレン誘導体 |
JPH0495078A (ja) * | 1990-08-08 | 1992-03-27 | Nippon Shoji Kk | ピリミドン誘導体の製造法、そのための中間体 |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
TW279860B (uk) * | 1993-11-12 | 1996-07-01 | Ciba Geigy Ag | |
FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2004
- 2004-04-13 FR FR0403829A patent/FR2868776B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-07 CA CA2496721A patent/CA2496721C/fr active Active
- 2005-02-14 US US11/057,491 patent/US7074920B2/en active Active
- 2005-02-15 SG SG200500769A patent/SG116573A1/en unknown
- 2005-02-17 BR BRPI0500478A patent/BRPI0500478B8/pt active IP Right Grant
- 2005-02-18 GE GEAP8648A patent/GEP20074137B/en unknown
- 2005-02-18 MY MYPI20050622A patent/MY141223A/en unknown
- 2005-02-18 NZ NZ538327A patent/NZ538327A/en unknown
- 2005-02-18 NO NO20050885A patent/NO329438B1/no unknown
- 2005-02-18 AU AU2005200860A patent/AU2005200860B2/en active Active
- 2005-02-18 CN CNB2005100542097A patent/CN1332951C/zh active Active
- 2005-02-18 UA UAA200501523A patent/UA81772C2/uk unknown
- 2005-02-18 AR ARP050100587A patent/AR047686A1/es active IP Right Grant
- 2005-02-18 ZA ZA2005/01467A patent/ZA200501467B/en unknown
- 2005-02-18 JP JP2005041811A patent/JP4511970B2/ja active Active
- 2005-02-18 MA MA28113A patent/MA27599A1/fr unknown
- 2005-02-19 KR KR1020050013871A patent/KR100636500B1/ko active IP Right Grant
- 2005-02-21 EP EP05290382A patent/EP1589014B1/fr active Active
- 2005-02-21 AT AT05290382T patent/ATE375339T1/de active
- 2005-02-21 WO PCT/FR2005/000395 patent/WO2005111026A1/fr active Application Filing
- 2005-02-21 RS RSP-2007/0493A patent/RS50546B/sr unknown
- 2005-02-21 SI SI200530088T patent/SI1589014T1/sl unknown
- 2005-02-21 ME MEP-2007-493A patent/ME01402B/me unknown
- 2005-02-21 DE DE602005002776T patent/DE602005002776T2/de active Active
- 2005-02-21 ES ES05290382T patent/ES2294652T3/es active Active
- 2005-02-21 PL PL05290382T patent/PL1589014T3/pl unknown
- 2005-02-21 PT PT05290382T patent/PT1589014E/pt unknown
- 2005-02-21 DK DK05290382T patent/DK1589014T3/da active
- 2005-02-21 EA EA200500237A patent/EA007744B1/ru unknown
- 2005-04-07 MX MXPA05003695A patent/MXPA05003695A/es active IP Right Grant
- 2005-12-22 HK HK05111842A patent/HK1079776A1/xx unknown
-
2007
- 2007-10-29 HR HR20070503T patent/HRP20070503T3/xx unknown
- 2007-12-19 CY CY20071101612T patent/CY1107101T1/el unknown
-
2009
- 2009-09-25 JP JP2009220282A patent/JP2010043096A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1589005T3 (da) | Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre | |
NO20050883L (no) | Ny fremgangsmate for syntesen (IS)-4,5-dimetoksy-1-(metylaminometyl)-benzocyklobutan og addisjonssalter derav, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre | |
DK1614687T3 (da) | Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onderivater og deres anvendelse ved syntese af ivabradin og farmaceutisk acceptable salte deraf | |
DK2135861T3 (da) | Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre | |
IL179424A0 (en) | Substituted oxazole -benzoisothiazole dioxide derivatives, process for their preparation and their use | |
PL1876169T3 (pl) | Pochodne amin n-acylowych i aminokwasów zawierające fenyl, sposoby ich wytwarzania, kompozycje farmaceutyczne i ich zastosowanie | |
DK1589014T3 (da) | Fremgangsmåde til syntese af derivater af 1,3-dihydro-2H-3-benzazepin-2-on og anvendelse heraf ved syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre | |
SI1994005T1 (sl) | Tetrahidronaftalenski derivati postopek za njihovo pripravo in njihova uporaba kot protivnetna sredstva | |
PL1753720T3 (pl) | Proces wytwarzania peryndoprylu i jego soli | |
IL188260A0 (en) | 6-oxazol-4-ylmethoxy-alkoxymethyl substituted benzoic acid derivatives forming ppar ligands, methods for production and the use thereof in the form of drugs | |
DE602004012275D1 (de) | zu dessen Herstellung und Impstoffderivate davon | |
GB0807094D0 (en) | 4,4-dimethylpiperidine-2, 6-dione derivatives for use in the treatment of hypertension | |
SG117528A1 (en) | New process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and application in the synthesis of ivabradine and addition salts thereof, with | |
WO2008005955A8 (en) | Synthesis of heterocyclic compounds |