RS50546B - Postupak sinteze derivata 1,3-dihidro-2h-3-benzazepin-2-on-a i primena u sintezi ivabradina i adicionih soli farmaceutski prihvatljive kiseliine - Google Patents
Postupak sinteze derivata 1,3-dihidro-2h-3-benzazepin-2-on-a i primena u sintezi ivabradina i adicionih soli farmaceutski prihvatljive kiseliineInfo
- Publication number
- RS50546B RS50546B RSP-2007/0493A RSP20070493A RS50546B RS 50546 B RS50546 B RS 50546B RS P20070493 A RSP20070493 A RS P20070493A RS 50546 B RS50546 B RS 50546B
- Authority
- RS
- Serbia
- Prior art keywords
- preparation
- formula
- compound
- ivabradine
- benzazepin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Postupak sinteze jedinjenja formule (I): u kojoj R1 i R2, isti ili različiti, svaki predstavlja linearnu ili razgranatu (C1-C8) alkoksi grupu, ili, zajedno sa atomom ugljenika koji ih nosi, obrazuju prsten 1,3-dioksana, 1,3-dioksolana ili 1,3-dioksepana, naznačen time što se jedinjenje formule (IV): podvrgava reakciji alkilacije sa jedinjenjem formule (V): u kojoj su R1 i R2 kao što su prethodno definisani i, X predstavlja odlazeću grupu, u N-metilpirolidonu, u prisustvu baze odabrane između natrijum hidroksida u vodenom rastvoru i natrijum ili kalijum karbonata da bi se dobilo posle izolovanja jedinjenje formule (I). Prijava sadrži još 10 zavisnih patentnih zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0403829A FR2868776B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
Publication Number | Publication Date |
---|---|
RS50546B true RS50546B (sr) | 2010-05-07 |
Family
ID=34941960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RSP-2007/0493A RS50546B (sr) | 2004-04-13 | 2005-02-21 | Postupak sinteze derivata 1,3-dihidro-2h-3-benzazepin-2-on-a i primena u sintezi ivabradina i adicionih soli farmaceutski prihvatljive kiseliine |
Country Status (33)
Country | Link |
---|---|
US (1) | US7074920B2 (sr) |
EP (1) | EP1589014B1 (sr) |
JP (2) | JP4511970B2 (sr) |
KR (1) | KR100636500B1 (sr) |
CN (1) | CN1332951C (sr) |
AR (1) | AR047686A1 (sr) |
AT (1) | ATE375339T1 (sr) |
AU (1) | AU2005200860B2 (sr) |
BR (1) | BRPI0500478B8 (sr) |
CA (1) | CA2496721C (sr) |
CY (1) | CY1107101T1 (sr) |
DE (1) | DE602005002776T2 (sr) |
DK (1) | DK1589014T3 (sr) |
EA (1) | EA007744B1 (sr) |
ES (1) | ES2294652T3 (sr) |
FR (1) | FR2868776B1 (sr) |
GE (1) | GEP20074137B (sr) |
HK (1) | HK1079776A1 (sr) |
HR (1) | HRP20070503T3 (sr) |
MA (1) | MA27599A1 (sr) |
ME (1) | ME01402B (sr) |
MX (1) | MXPA05003695A (sr) |
MY (1) | MY141223A (sr) |
NO (1) | NO329438B1 (sr) |
NZ (1) | NZ538327A (sr) |
PL (1) | PL1589014T3 (sr) |
PT (1) | PT1589014E (sr) |
RS (1) | RS50546B (sr) |
SG (1) | SG116573A1 (sr) |
SI (1) | SI1589014T1 (sr) |
UA (1) | UA81772C2 (sr) |
WO (1) | WO2005111026A1 (sr) |
ZA (1) | ZA200501467B (sr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
ES2528026T3 (es) | 2007-05-30 | 2015-02-03 | Ind-Swift Laboratories Limited | Sales de oxalato de ivabridina cristalino y polimorfos de los mismos |
EP2367782B1 (en) | 2008-12-22 | 2013-02-13 | KRKA, D.D., Novo Mesto | Process for preparation of ivabradine |
HUE035588T2 (en) | 2010-02-12 | 2018-05-28 | Krka D D Novo Mesto | Form of ivabradine hydrochloride |
FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
EP0204349A3 (de) * | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE3519735A1 (de) * | 1985-06-01 | 1986-12-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JP2568416B2 (ja) * | 1986-11-04 | 1997-01-08 | 大塚製薬株式会社 | ヒドロフルオレン誘導体 |
JPH0495078A (ja) * | 1990-08-08 | 1992-03-27 | Nippon Shoji Kk | ピリミドン誘導体の製造法、そのための中間体 |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
TW279860B (sr) * | 1993-11-12 | 1996-07-01 | Ciba Geigy Ag | |
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2004
- 2004-04-13 FR FR0403829A patent/FR2868776B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-07 CA CA2496721A patent/CA2496721C/fr active Active
- 2005-02-14 US US11/057,491 patent/US7074920B2/en active Active
- 2005-02-15 SG SG200500769A patent/SG116573A1/en unknown
- 2005-02-17 BR BRPI0500478A patent/BRPI0500478B8/pt active IP Right Grant
- 2005-02-18 NZ NZ538327A patent/NZ538327A/en unknown
- 2005-02-18 MY MYPI20050622A patent/MY141223A/en unknown
- 2005-02-18 UA UAA200501523A patent/UA81772C2/uk unknown
- 2005-02-18 JP JP2005041811A patent/JP4511970B2/ja active Active
- 2005-02-18 MA MA28113A patent/MA27599A1/fr unknown
- 2005-02-18 NO NO20050885A patent/NO329438B1/no unknown
- 2005-02-18 AR ARP050100587A patent/AR047686A1/es active IP Right Grant
- 2005-02-18 CN CNB2005100542097A patent/CN1332951C/zh active Active
- 2005-02-18 AU AU2005200860A patent/AU2005200860B2/en active Active
- 2005-02-18 GE GEAP8648A patent/GEP20074137B/en unknown
- 2005-02-18 ZA ZA2005/01467A patent/ZA200501467B/en unknown
- 2005-02-19 KR KR1020050013871A patent/KR100636500B1/ko active IP Right Grant
- 2005-02-21 DK DK05290382T patent/DK1589014T3/da active
- 2005-02-21 AT AT05290382T patent/ATE375339T1/de active
- 2005-02-21 PL PL05290382T patent/PL1589014T3/pl unknown
- 2005-02-21 ME MEP-2007-493A patent/ME01402B/me unknown
- 2005-02-21 EP EP05290382A patent/EP1589014B1/fr active Active
- 2005-02-21 RS RSP-2007/0493A patent/RS50546B/sr unknown
- 2005-02-21 PT PT05290382T patent/PT1589014E/pt unknown
- 2005-02-21 DE DE602005002776T patent/DE602005002776T2/de active Active
- 2005-02-21 ES ES05290382T patent/ES2294652T3/es active Active
- 2005-02-21 EA EA200500237A patent/EA007744B1/ru unknown
- 2005-02-21 WO PCT/FR2005/000395 patent/WO2005111026A1/fr active Application Filing
- 2005-02-21 SI SI200530088T patent/SI1589014T1/sl unknown
- 2005-04-07 MX MXPA05003695A patent/MXPA05003695A/es active IP Right Grant
- 2005-12-22 HK HK05111842A patent/HK1079776A1/xx unknown
-
2007
- 2007-10-29 HR HR20070503T patent/HRP20070503T3/xx unknown
- 2007-12-19 CY CY20071101612T patent/CY1107101T1/el unknown
-
2009
- 2009-09-25 JP JP2009220282A patent/JP2010043096A/ja active Pending
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