ATE375339T1 - Verfahren zur herstellung von 1,3-dihydro-2h-3- benzazepin-2-on und anwendung zur herstellung von ivabradine und ihren pharmazeutischen annehmbaren salzen - Google Patents
Verfahren zur herstellung von 1,3-dihydro-2h-3- benzazepin-2-on und anwendung zur herstellung von ivabradine und ihren pharmazeutischen annehmbaren salzenInfo
- Publication number
- ATE375339T1 ATE375339T1 AT05290382T AT05290382T ATE375339T1 AT E375339 T1 ATE375339 T1 AT E375339T1 AT 05290382 T AT05290382 T AT 05290382T AT 05290382 T AT05290382 T AT 05290382T AT E375339 T1 ATE375339 T1 AT E375339T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- ivabradine
- benzazepin
- dihydro
- pharmaceutically acceptable
- Prior art date
Links
- WUYVQJOTPXVUIS-UHFFFAOYSA-N 1,3-dihydro-3-benzazepin-2-one Chemical compound C1=CNC(=O)CC2=CC=CC=C21 WUYVQJOTPXVUIS-UHFFFAOYSA-N 0.000 title 1
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title 1
- 229960003825 ivabradine Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0403829A FR2868776B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE375339T1 true ATE375339T1 (de) | 2007-10-15 |
Family
ID=34941960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05290382T ATE375339T1 (de) | 2004-04-13 | 2005-02-21 | Verfahren zur herstellung von 1,3-dihydro-2h-3- benzazepin-2-on und anwendung zur herstellung von ivabradine und ihren pharmazeutischen annehmbaren salzen |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7074920B2 (de) |
| EP (1) | EP1589014B1 (de) |
| JP (2) | JP4511970B2 (de) |
| KR (1) | KR100636500B1 (de) |
| CN (1) | CN1332951C (de) |
| AR (1) | AR047686A1 (de) |
| AT (1) | ATE375339T1 (de) |
| AU (1) | AU2005200860B2 (de) |
| BR (1) | BRPI0500478B8 (de) |
| CA (1) | CA2496721C (de) |
| CY (1) | CY1107101T1 (de) |
| DE (1) | DE602005002776T2 (de) |
| DK (1) | DK1589014T3 (de) |
| EA (1) | EA007744B1 (de) |
| ES (1) | ES2294652T3 (de) |
| FR (1) | FR2868776B1 (de) |
| GE (1) | GEP20074137B (de) |
| HR (1) | HRP20070503T3 (de) |
| MA (1) | MA27599A1 (de) |
| ME (1) | ME01402B (de) |
| MX (1) | MXPA05003695A (de) |
| MY (1) | MY141223A (de) |
| NO (1) | NO329438B1 (de) |
| NZ (1) | NZ538327A (de) |
| PL (1) | PL1589014T3 (de) |
| PT (1) | PT1589014E (de) |
| RS (1) | RS50546B (de) |
| SG (1) | SG116573A1 (de) |
| SI (1) | SI1589014T1 (de) |
| UA (1) | UA81772C2 (de) |
| WO (1) | WO2005111026A1 (de) |
| ZA (1) | ZA200501467B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| KR101478855B1 (ko) | 2007-05-30 | 2015-01-02 | 인드-스위프트 래버러토리즈 리미티드 | 이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법 |
| EP2367782B1 (de) | 2008-12-22 | 2013-02-13 | KRKA, D.D., Novo Mesto | Verfahren zur herstellung von ivabradin |
| SI23290A (sl) | 2010-02-12 | 2011-08-31 | Krka D.D., Novo Mesto | Nove oblike ivabradin hidroklorida |
| FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3519735A1 (de) * | 1985-06-01 | 1986-12-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0204349A3 (de) * | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JP2568416B2 (ja) * | 1986-11-04 | 1997-01-08 | 大塚製薬株式会社 | ヒドロフルオレン誘導体 |
| JPH0495078A (ja) * | 1990-08-08 | 1992-03-27 | Nippon Shoji Kk | ピリミドン誘導体の製造法、そのための中間体 |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| TW279860B (de) * | 1993-11-12 | 1996-07-01 | Ciba Geigy Ag | |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2004
- 2004-04-13 FR FR0403829A patent/FR2868776B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-07 CA CA2496721A patent/CA2496721C/fr not_active Expired - Lifetime
- 2005-02-14 US US11/057,491 patent/US7074920B2/en not_active Expired - Lifetime
- 2005-02-15 SG SG200500769A patent/SG116573A1/en unknown
- 2005-02-17 BR BRPI0500478A patent/BRPI0500478B8/pt not_active IP Right Cessation
- 2005-02-18 AU AU2005200860A patent/AU2005200860B2/en not_active Expired
- 2005-02-18 NZ NZ538327A patent/NZ538327A/en not_active IP Right Cessation
- 2005-02-18 CN CNB2005100542097A patent/CN1332951C/zh not_active Expired - Lifetime
- 2005-02-18 GE GEAP8648A patent/GEP20074137B/en unknown
- 2005-02-18 AR ARP050100587A patent/AR047686A1/es active IP Right Grant
- 2005-02-18 NO NO20050885A patent/NO329438B1/no unknown
- 2005-02-18 ZA ZA2005/01467A patent/ZA200501467B/en unknown
- 2005-02-18 JP JP2005041811A patent/JP4511970B2/ja not_active Expired - Lifetime
- 2005-02-18 UA UAA200501523A patent/UA81772C2/uk unknown
- 2005-02-18 MA MA28113A patent/MA27599A1/fr unknown
- 2005-02-18 MY MYPI20050622A patent/MY141223A/en unknown
- 2005-02-19 KR KR1020050013871A patent/KR100636500B1/ko not_active Expired - Lifetime
- 2005-02-21 AT AT05290382T patent/ATE375339T1/de active
- 2005-02-21 WO PCT/FR2005/000395 patent/WO2005111026A1/fr not_active Ceased
- 2005-02-21 DE DE602005002776T patent/DE602005002776T2/de not_active Expired - Lifetime
- 2005-02-21 SI SI200530088T patent/SI1589014T1/sl unknown
- 2005-02-21 EP EP05290382A patent/EP1589014B1/de not_active Expired - Lifetime
- 2005-02-21 ES ES05290382T patent/ES2294652T3/es not_active Expired - Lifetime
- 2005-02-21 RS RSP-2007/0493A patent/RS50546B/sr unknown
- 2005-02-21 PL PL05290382T patent/PL1589014T3/pl unknown
- 2005-02-21 DK DK05290382T patent/DK1589014T3/da active
- 2005-02-21 ME MEP-2007-493A patent/ME01402B/de unknown
- 2005-02-21 EA EA200500237A patent/EA007744B1/ru unknown
- 2005-02-21 PT PT05290382T patent/PT1589014E/pt unknown
- 2005-04-07 MX MXPA05003695A patent/MXPA05003695A/es active IP Right Grant
-
2007
- 2007-10-29 HR HR20070503T patent/HRP20070503T3/xx unknown
- 2007-12-19 CY CY20071101612T patent/CY1107101T1/el unknown
-
2009
- 2009-09-25 JP JP2009220282A patent/JP2010043096A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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