DK1560584T3 - Fab I inhibitorer - Google Patents
Fab I inhibitorerInfo
- Publication number
- DK1560584T3 DK1560584T3 DK02807262T DK02807262T DK1560584T3 DK 1560584 T3 DK1560584 T3 DK 1560584T3 DK 02807262 T DK02807262 T DK 02807262T DK 02807262 T DK02807262 T DK 02807262T DK 1560584 T3 DK1560584 T3 DK 1560584T3
- Authority
- DK
- Denmark
- Prior art keywords
- fab
- inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28222501P | 2001-04-06 | 2001-04-06 | |
PCT/US2002/010332 WO2003088897A2 (en) | 2001-04-06 | 2002-04-03 | Fab i inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1560584T3 true DK1560584T3 (da) | 2009-05-18 |
Family
ID=29250372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02807262T DK1560584T3 (da) | 2001-04-06 | 2002-04-03 | Fab I inhibitorer |
Country Status (12)
Country | Link |
---|---|
US (4) | US7049310B2 (ja) |
EP (1) | EP1560584B1 (ja) |
JP (1) | JP4387804B2 (ja) |
AR (1) | AR035812A1 (ja) |
AT (1) | ATE420640T1 (ja) |
AU (1) | AU2002367773A1 (ja) |
CA (1) | CA2444597A1 (ja) |
DE (1) | DE60230934D1 (ja) |
DK (1) | DK1560584T3 (ja) |
ES (1) | ES2320984T3 (ja) |
MY (1) | MY138285A (ja) |
WO (1) | WO2003088897A2 (ja) |
Families Citing this family (35)
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CA2387016C (en) * | 1999-10-08 | 2010-09-28 | William H. Miller | Acrylamide derivatives as fab i inhibitors |
US7048926B2 (en) | 2000-10-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Methods of agonizing and antagonizing FabK |
US7496368B2 (en) * | 2001-04-03 | 2009-02-24 | Sharp Kabushiki Kaisha | Method and device for controlling frequency selection within a wireless communication system |
DK1560584T3 (da) * | 2001-04-06 | 2009-05-18 | Affinium Pharm Inc | Fab I inhibitorer |
JP4859460B2 (ja) * | 2002-12-06 | 2012-01-25 | アフィニウム ファーマシューティカルズ, インク. | ヘテロ環化合物、その製造方法および治療におけるその使用 |
CA2519429C (en) | 2003-03-17 | 2013-08-06 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
DK1828167T3 (da) * | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
US20090156578A1 (en) * | 2005-12-05 | 2009-06-18 | PAULS Henry | 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents |
EP2054422B1 (en) | 2006-07-20 | 2017-06-14 | Debiopharm International SA | Acrylamide derivatives as fab i inhibitors |
GB0709513D0 (en) * | 2007-05-17 | 2007-06-27 | Helperby Therapeutics Ltd | Topical formulations |
FR2912133B1 (fr) * | 2007-02-01 | 2009-04-24 | Univ Grenoble 1 | Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens |
EP2125802A4 (en) * | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
NZ599444A (en) | 2009-11-18 | 2014-02-28 | Fab Pharma Sas | Novel heterocyclic acrylamides and their use as pharmaceuticals |
CA2802107A1 (en) * | 2010-06-11 | 2011-12-15 | Affinium Pharmaceuticals, Inc. | Compounds for treatment of bovine mastitis |
JO3611B1 (ar) * | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
EA038317B1 (ru) | 2011-08-10 | 2021-08-09 | Янссен Сайенсиз Айрлэнд Юси | Антибактериальные 3,4-дигидро-1н-[1,8]нафтиридиноны, замещенные гомопиперидинилом |
JP6294822B2 (ja) | 2011-08-10 | 2018-03-14 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 抗菌性ピペリジニル置換3,4−ジヒドロ−1h−[1,8]−ナフチリジノン類 |
CA2849057C (en) * | 2011-09-19 | 2021-05-11 | Vitas Pharma Research Pvt Ltd | Heterocyclic compounds as inhibitors of fatty acid biosynthesis for bacterial infections |
US9062075B2 (en) | 2011-12-02 | 2015-06-23 | Aurigene Discovery Technologies Limited | Tetrahydropyridine derivatives as FabI inhibitors |
US9062002B2 (en) | 2011-12-02 | 2015-06-23 | Aurigene Discovery Technologies Limited | Substituted pyridine derivatives as FabI inhibitors |
IN2014KN02915A (ja) | 2012-06-19 | 2015-05-08 | Debiopharm Int Sa | |
WO2014023814A1 (en) | 2012-08-10 | 2014-02-13 | Janssen R&D Ireland | New antibacterial compounds |
EP2882739B1 (en) | 2012-08-10 | 2017-05-03 | Janssen Sciences Ireland UC | New antibacterial compounds |
WO2014072930A2 (en) * | 2012-11-09 | 2014-05-15 | Aurigene Discovery Technologies Limited | Fused pyridine derivatives as antibacterial agents |
KR101432078B1 (ko) | 2013-04-22 | 2014-08-21 | 영남대학교 산학협력단 | 항병원성 활성을 갖는 7-벤질옥시인돌 화합물의 신규한 용도 |
WO2014195844A1 (en) | 2013-06-04 | 2014-12-11 | Aurigene Discovery Technologies Limited | TETRAHYDROPYRIDINE DERIVATIVES AS FabI INHIBITORS |
TN2018000293A1 (en) * | 2016-02-26 | 2020-01-16 | Debiopharm Int Sa | Medicament for treatment of diabetic foot infections |
WO2018083635A2 (en) | 2016-11-04 | 2018-05-11 | Auckland Uniservices Limited | Tricyclic heterocyclic derivatives and uses thereof |
MX2020006587A (es) | 2017-12-22 | 2020-12-10 | Ravenna Pharmaceuticals Inc | Derivados de aminopiridina como inhibidores de fosfatidilinositol fosfato cinasa. |
US11691967B2 (en) | 2018-03-12 | 2023-07-04 | The Board Of Trustees Of The University Of Illinois | Antibiotics effective for gram-negative pathogens |
EP3880675A1 (en) | 2018-11-12 | 2021-09-22 | Debiopharm International SA | Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof |
CA3129508A1 (en) * | 2019-02-14 | 2020-08-20 | Debiopharm International S.A. | Solid formulations of afabicin with histidine |
TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
BR112023027268A2 (pt) * | 2021-06-23 | 2024-04-30 | Debiopharm Int Sa | Compostos inovadores e seu uso |
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-
2002
- 2002-04-03 DK DK02807262T patent/DK1560584T3/da active
- 2002-04-03 AT AT02807262T patent/ATE420640T1/de not_active IP Right Cessation
- 2002-04-03 DE DE60230934T patent/DE60230934D1/de not_active Expired - Lifetime
- 2002-04-03 JP JP2003585650A patent/JP4387804B2/ja not_active Expired - Lifetime
- 2002-04-03 US US10/474,315 patent/US7049310B2/en not_active Expired - Lifetime
- 2002-04-03 ES ES02807262T patent/ES2320984T3/es not_active Expired - Lifetime
- 2002-04-03 WO PCT/US2002/010332 patent/WO2003088897A2/en active Search and Examination
- 2002-04-03 AU AU2002367773A patent/AU2002367773A1/en not_active Abandoned
- 2002-04-03 EP EP02807262A patent/EP1560584B1/en not_active Expired - Lifetime
- 2002-04-03 CA CA002444597A patent/CA2444597A1/en not_active Abandoned
- 2002-04-04 AR ARP020101249A patent/AR035812A1/es active IP Right Grant
- 2002-04-04 MY MYPI20021219A patent/MY138285A/en unknown
-
2005
- 2005-11-22 US US11/284,660 patent/US7250424B2/en not_active Expired - Lifetime
-
2007
- 2007-06-25 US US11/767,967 patent/US7741339B2/en not_active Expired - Lifetime
-
2010
- 2010-04-12 US US12/758,227 patent/US8153652B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20060116394A1 (en) | 2006-06-01 |
JP2005519984A (ja) | 2005-07-07 |
ES2320984T3 (es) | 2009-06-01 |
US20110098277A1 (en) | 2011-04-28 |
EP1560584B1 (en) | 2009-01-14 |
ATE420640T1 (de) | 2009-01-15 |
US7049310B2 (en) | 2006-05-23 |
JP4387804B2 (ja) | 2009-12-24 |
US8153652B2 (en) | 2012-04-10 |
US7250424B2 (en) | 2007-07-31 |
AU2002367773A1 (en) | 2003-11-03 |
EP1560584A2 (en) | 2005-08-10 |
AU2002367773A8 (en) | 2003-11-03 |
US20040147580A1 (en) | 2004-07-29 |
US20090221699A1 (en) | 2009-09-03 |
WO2003088897A2 (en) | 2003-10-30 |
WO2003088897A3 (en) | 2005-06-09 |
EP1560584A4 (en) | 2005-10-12 |
DE60230934D1 (de) | 2009-03-05 |
US7741339B2 (en) | 2010-06-22 |
CA2444597A1 (en) | 2002-10-06 |
MY138285A (en) | 2009-05-29 |
AR035812A1 (es) | 2004-07-14 |
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