DK155049C - Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK155049C
DK155049C DK316080A DK316080A DK155049C DK 155049 C DK155049 C DK 155049C DK 316080 A DK316080 A DK 316080A DK 316080 A DK316080 A DK 316080A DK 155049 C DK155049 C DK 155049C
Authority
DK
Denmark
Prior art keywords
imidazobenzodiazepines
procedure
preparation
acid addition
addition salts
Prior art date
Application number
DK316080A
Other languages
Danish (da)
English (en)
Other versions
DK155049B (da
DK316080A (da
Inventor
Armin Walser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK316080A publication Critical patent/DK316080A/da
Publication of DK155049B publication Critical patent/DK155049B/da
Application granted granted Critical
Publication of DK155049C publication Critical patent/DK155049C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK316080A 1979-07-25 1980-07-22 Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf DK155049C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/060,258 US4226771A (en) 1979-07-25 1979-07-25 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives
US6025879 1979-07-25

Publications (3)

Publication Number Publication Date
DK316080A DK316080A (da) 1981-01-26
DK155049B DK155049B (da) 1989-01-30
DK155049C true DK155049C (da) 1989-06-26

Family

ID=22028366

Family Applications (1)

Application Number Title Priority Date Filing Date
DK316080A DK155049C (da) 1979-07-25 1980-07-22 Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (17)

Country Link
US (1) US4226771A (fi)
JP (1) JPS5620590A (fi)
KR (1) KR840002269B1 (fi)
AT (1) AT375942B (fi)
CA (1) CA1126270A (fi)
CH (1) CH645897A5 (fi)
DK (1) DK155049C (fi)
ES (1) ES493657A0 (fi)
FI (1) FI68834C (fi)
GR (1) GR69339B (fi)
HU (1) HU182156B (fi)
LU (1) LU82651A1 (fi)
NL (2) NL193145C (fi)
NO (1) NO154168C (fi)
PT (1) PT71606B (fi)
SE (1) SE439166B (fi)
YU (1) YU43221B (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN184976B (fi) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
CA2206219A1 (en) * 1996-06-13 1997-12-13 Ranbaxy Laboratories Limited A novel process for the manufacture of 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo [1,5a] [1,4] benzodiazepine (midazolam)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852461A (en) * 1971-08-04 1974-12-03 Upjohn Co Benzodiapines used as minor tranquilizers
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
US4125726A (en) * 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates

Also Published As

Publication number Publication date
SE439166B (sv) 1985-06-03
US4226771A (en) 1980-10-07
NL980040I1 (nl) 1999-02-01
GR69339B (fi) 1982-05-17
JPS5620590A (en) 1981-02-26
YU188880A (en) 1983-09-30
NL8004271A (nl) 1981-01-27
KR840002269B1 (ko) 1984-12-14
KR830003487A (ko) 1983-06-20
NO154168C (no) 1986-07-30
JPH0250907B2 (fi) 1990-11-05
DK155049B (da) 1989-01-30
PT71606B (en) 1981-12-17
NO802243L (no) 1981-01-26
AT375942B (de) 1984-09-25
CA1126270A (en) 1982-06-22
YU43221B (en) 1989-06-30
FI68834B (fi) 1985-07-31
NO154168B (no) 1986-04-21
PT71606A (en) 1980-08-01
FI68834C (fi) 1985-11-11
DK316080A (da) 1981-01-26
CH645897A5 (de) 1984-10-31
LU82651A1 (de) 1982-02-17
NL193145C (nl) 1998-12-04
ATA383480A (de) 1984-02-15
FI802349A (fi) 1981-01-26
ES8106307A1 (es) 1981-06-16
SE8005317L (sv) 1981-01-26
ES493657A0 (es) 1981-06-16
HU182156B (en) 1983-12-28

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