DK154977C - Analogifremgangsmaade til fremstilling af et inklusionskompleks af cyclodextrin og aeindomethacinae - Google Patents

Analogifremgangsmaade til fremstilling af et inklusionskompleks af cyclodextrin og aeindomethacinae

Info

Publication number
DK154977C
DK154977C DK035079A DK35079A DK154977C DK 154977 C DK154977 C DK 154977C DK 035079 A DK035079 A DK 035079A DK 35079 A DK35079 A DK 35079A DK 154977 C DK154977 C DK 154977C
Authority
DK
Denmark
Prior art keywords
aeindomethacinae
cyclodextrin
preparing
inclusion complex
analogy procedure
Prior art date
Application number
DK035079A
Other languages
Danish (da)
English (en)
Other versions
DK35079A (da
DK154977B (da
Inventor
Jozsef Szejtli
Lajos Szente
Agoston David
Sandor Virag
Gyula Sebestyen
Attila Mandi
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of DK35079A publication Critical patent/DK35079A/da
Publication of DK154977B publication Critical patent/DK154977B/da
Application granted granted Critical
Publication of DK154977C publication Critical patent/DK154977C/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/281-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK035079A 1978-01-27 1979-01-26 Analogifremgangsmaade til fremstilling af et inklusionskompleks af cyclodextrin og aeindomethacinae DK154977C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU78CI1803A HU176215B (en) 1978-01-27 1978-01-27 Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
HUCI001803 1978-01-27

Publications (3)

Publication Number Publication Date
DK35079A DK35079A (da) 1979-07-28
DK154977B DK154977B (da) 1989-01-16
DK154977C true DK154977C (da) 1989-06-12

Family

ID=10994689

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035079A DK154977C (da) 1978-01-27 1979-01-26 Analogifremgangsmaade til fremstilling af et inklusionskompleks af cyclodextrin og aeindomethacinae

Country Status (23)

Country Link
US (1) US4228160A (US06515009-20030204-C00004.png)
JP (1) JPS54117018A (US06515009-20030204-C00004.png)
AT (1) AT360554B (US06515009-20030204-C00004.png)
AU (1) AU518750B2 (US06515009-20030204-C00004.png)
BE (1) BE873725A (US06515009-20030204-C00004.png)
CA (1) CA1119115A (US06515009-20030204-C00004.png)
CH (1) CH638819A5 (US06515009-20030204-C00004.png)
CS (1) CS207742B2 (US06515009-20030204-C00004.png)
DD (1) DD141312A1 (US06515009-20030204-C00004.png)
DE (1) DE2902297A1 (US06515009-20030204-C00004.png)
DK (1) DK154977C (US06515009-20030204-C00004.png)
ES (1) ES477181A1 (US06515009-20030204-C00004.png)
FI (1) FI65441C (US06515009-20030204-C00004.png)
FR (1) FR2415631A1 (US06515009-20030204-C00004.png)
GB (1) GB2016499B (US06515009-20030204-C00004.png)
HU (1) HU176215B (US06515009-20030204-C00004.png)
IL (1) IL56309A (US06515009-20030204-C00004.png)
IT (1) IT1118282B (US06515009-20030204-C00004.png)
NL (1) NL7808792A (US06515009-20030204-C00004.png)
NO (1) NO146637C (US06515009-20030204-C00004.png)
PL (1) PL117208B1 (US06515009-20030204-C00004.png)
SE (1) SE445353B (US06515009-20030204-C00004.png)
SU (1) SU915807A3 (US06515009-20030204-C00004.png)

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US2606074A (en) * 1946-08-21 1952-08-05 Edward H Ackermann Air distributing nozzle
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DE2947742C2 (de) * 1979-11-27 1986-04-03 Koch, Jürgen, Dr., 2000 Hamburg Arzneimittel, enthaltend β-Cyclodextrin
HU184066B (en) * 1979-12-28 1984-06-28 Chinoin Gyogyszer Es Vegyeszet Plant growth regulating substance and process for preparing such compound
HU181733B (en) * 1980-08-07 1983-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing sorbents containing cyclodextrin on cellulose base
HU182217B (en) * 1980-10-17 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing inclusive complexes of cyclodextrines and strong inorganic oxyacids
JPS5830032B2 (ja) * 1981-02-18 1983-06-27 呉羽化学工業株式会社 ビフイダス菌の増殖剤
HU183430B (en) * 1981-05-12 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing cyclodextrine inclusion complexes of n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine or n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine-hydrochloride
JPS58177949A (ja) * 1982-04-12 1983-10-18 Takeda Chem Ind Ltd ランカシジン群抗生物質包接化合物
US4425336A (en) 1982-05-24 1984-01-10 Key Pharmaceuticals, Inc. 3,4-Dihydroxy-N-[3-(4-dihydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamine cyclodextrin complexes
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
HU190818B (en) * 1982-11-09 1986-11-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing complexes of piperonyl-butoxide-cyclodextrin
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
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JPS6025967A (ja) * 1983-07-21 1985-02-08 Eisai Co Ltd トリパミド包接化合物
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JPS60202115A (ja) * 1984-03-27 1985-10-12 Ichiro Shibauchi エポキシ樹脂用硬化剤
DE3427787A1 (de) * 1984-07-27 1986-01-30 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Wirkstoffkomplexe von 5-methoxy-2((4-methoxy-3,5-dimethyl-2-pyridyl) methylsulfinyl)-1h-benzimidazol mit cyclodextrinen, deren herstellung und arzneimittel
YU43290B (en) * 1986-11-13 1989-06-30 Lek Tovarna Farmacevtskih Process for preparing inclusioned complex of ibuproxane with beta-cyclodextrine
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
US4885275A (en) * 1987-10-15 1989-12-05 Eli Lilly And Company Vancomycin-HCL solutions and the lyophilization thereof
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
YU45837B (sh) * 1988-01-18 1992-07-20 LEK TOVARNA FARMACEVTSKIH IN KEMIČKIH IZDELKOV d.d. Postopek za pripravo novega inkluzijskega kompleksa nikardipina oz. njegovega hidroklorida z beta-ciklodekstrinom
DE3809808A1 (de) * 1988-03-23 1989-10-05 Hexal Pharma Gmbh & Co Kg Feste, insbesondere festorale und rektale, etofenamat enthaltende arzneimittel
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
CA2013485C (en) * 1990-03-06 1997-04-22 John Michael Gardlik Solid consumer product compositions containing small particle cyclodextrin complexes
US5246611A (en) * 1990-05-09 1993-09-21 The Procter & Gamble Company Non-destructive carriers for cyclodextrin complexes
US5139687A (en) * 1990-05-09 1992-08-18 The Proctor & Gamble Company Non-destructive carriers for cyclodextrin complexes
US5384186A (en) * 1990-05-09 1995-01-24 The Proctor & Gamble Company Non-destructive carriers for cyclodextrin complexes
JPH07583B2 (ja) * 1990-11-21 1995-01-11 北海道糖業株式会社 水溶性五環性トリテルペン包接化合物及びその製造方法並びにそれを利用した食品、飲料、口腔用組成物
US5321014A (en) * 1991-06-28 1994-06-14 The United States Of America As Represented By The Department Of Health And Human Services Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells
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US5602112A (en) * 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
US5403828A (en) * 1992-08-13 1995-04-04 American Maize-Products Company Purification of cyclodextrin complexes
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ZA959469B (en) * 1994-11-15 1996-05-15 South African Druggists Ltd Pharmaceutical composition
US5744154A (en) * 1995-09-06 1998-04-28 Laboratoire Chauvin S.A. Ready-to-use indomethacin-based eye lotion
US5824668A (en) * 1996-11-07 1998-10-20 Supergen, Inc. Formulation for administration of steroid compounds
US5942501A (en) * 1996-08-16 1999-08-24 Collaborative Laboratories, Inc. Cyclodextrin derivative complex
US6287603B1 (en) * 1999-09-16 2001-09-11 Nestec S.A. Cyclodextrin flavor delivery systems
US20020176842A1 (en) * 2001-04-09 2002-11-28 Lyn Hughes Extended release of active ingredients
KR100473716B1 (ko) * 2002-03-27 2005-03-08 주식회사 참 존 7-디하이드로콜레스테롤 및 사이클로덱스트린의 포접복합체, 이를 포함하는 화장료 조성물 및7-디하이드로콜레스테롤의 안정화방법
AU2006259878A1 (en) * 2005-06-13 2006-12-28 Cargill, Incorporated Cyclodextrin inclusion complexes and methods of preparing same
JP2008546386A (ja) * 2005-06-13 2008-12-25 カーギル インコーポレイテッド シクロデキストリン包接複合体及びその製造方法
US20070010487A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070009531A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar
US20070010486A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
US20070010478A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
US20070010485A1 (en) * 2005-07-06 2007-01-11 Jeff Schwegman Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins
JP2009539978A (ja) * 2006-06-13 2009-11-19 カーギル インコーポレイテッド 大粒子シクロデキストリン包接複合体及びその製造方法
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FR2989001B1 (fr) * 2012-04-06 2017-07-21 Centre Nat Rech Scient Microparticules et nanoparticules constituees de polysaccharides hydrophobises et d'une alpha-cyclodextrine
CN115154619A (zh) * 2016-02-04 2022-10-11 西泽普研究与发展有限责任公司 受控释放和层状的环糊精包合物媒介物
CN107184989B (zh) * 2017-05-18 2020-09-08 宁夏蓝博思化学技术有限公司 甘草素-环糊精或环糊精衍生物包合物及组合物及制备方法及用途
CN107158403B (zh) * 2017-05-18 2020-09-08 宁夏蓝博思化学技术有限公司 异甘草素-环糊精或环糊精衍生物包合物及组合物及制备方法及用途

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Also Published As

Publication number Publication date
DD141312A1 (de) 1980-04-23
CS207742B2 (en) 1981-08-31
FR2415631A1 (fr) 1979-08-24
BE873725A (fr) 1979-05-16
HU176215B (en) 1981-01-28
DK35079A (da) 1979-07-28
FR2415631B1 (US06515009-20030204-C00004.png) 1981-12-24
DE2902297C2 (US06515009-20030204-C00004.png) 1989-02-09
PL117208B1 (en) 1981-07-31
US4228160A (en) 1980-10-14
ES477181A1 (es) 1979-10-16
CA1119115A (en) 1982-03-02
FI65441C (fi) 1984-05-10
GB2016499A (en) 1979-09-26
IT1118282B (it) 1986-02-24
CH638819A5 (de) 1983-10-14
ATA59179A (de) 1980-06-15
AU518750B2 (en) 1981-10-15
NO146637B (no) 1982-08-02
SE7900479L (sv) 1979-07-28
AT360554B (de) 1981-01-26
NO146637C (no) 1982-11-10
SE445353B (sv) 1986-06-16
FI65441B (fi) 1984-01-31
NL7808792A (nl) 1979-07-31
DE2902297A1 (de) 1979-08-02
IT7967050A0 (it) 1979-01-11
FI790198A (fi) 1979-07-28
AU4367179A (en) 1979-08-02
IL56309A (en) 1981-09-13
DK154977B (da) 1989-01-16
SU915807A3 (en) 1982-03-23
JPS54117018A (en) 1979-09-11
NO790261L (no) 1979-07-30
PL213015A1 (pl) 1979-12-17
GB2016499B (en) 1982-07-28

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