DK1546327T3 - Udvælgelse og isolation af levende celler ved brug af RNA-bindingssonder - Google Patents
Udvælgelse og isolation af levende celler ved brug af RNA-bindingssonderInfo
- Publication number
- DK1546327T3 DK1546327T3 DK02807718.8T DK02807718T DK1546327T3 DK 1546327 T3 DK1546327 T3 DK 1546327T3 DK 02807718 T DK02807718 T DK 02807718T DK 1546327 T3 DK1546327 T3 DK 1546327T3
- Authority
- DK
- Denmark
- Prior art keywords
- living cells
- isolation
- selection
- rna binding
- binding probes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16698799P | 1999-11-23 | 1999-11-23 | |
US09/718,448 US6692965B1 (en) | 1999-11-23 | 2000-11-22 | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
PCT/US2002/027749 WO2004020625A1 (en) | 1999-11-23 | 2002-08-28 | SELECTION AND ISOLATION OF LIVING CELLS USING mRNA-BINDING PROBES |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1546327T3 true DK1546327T3 (da) | 2012-03-26 |
Family
ID=36640908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02807718.8T DK1546327T3 (da) | 1999-11-23 | 2002-08-28 | Udvælgelse og isolation af levende celler ved brug af RNA-bindingssonder |
DK10179993.0T DK2264165T3 (da) | 1999-11-23 | 2002-08-28 | Udvælgelse og selektion af levende celler ved hjælp af mRNA-bindende prober |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10179993.0T DK2264165T3 (da) | 1999-11-23 | 2002-08-28 | Udvælgelse og selektion af levende celler ved hjælp af mRNA-bindende prober |
Country Status (16)
Country | Link |
---|---|
US (4) | US6692965B1 (da) |
EP (2) | EP2264165B1 (da) |
JP (1) | JP4502808B2 (da) |
KR (1) | KR101257500B1 (da) |
CN (1) | CN1688693B (da) |
AT (1) | ATE541924T1 (da) |
AU (1) | AU2002332768A1 (da) |
CA (1) | CA2496821C (da) |
DK (2) | DK1546327T3 (da) |
ES (2) | ES2423598T3 (da) |
HK (1) | HK1079238A1 (da) |
IL (1) | IL166757A0 (da) |
MX (1) | MXPA05002192A (da) |
NZ (1) | NZ538852A (da) |
PT (1) | PT1546327E (da) |
WO (1) | WO2004020625A1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
KR20150005720A (ko) * | 2004-02-18 | 2015-01-14 | 크로모셀 코포레이션 | 신호 프로브를 이용하는 방법 및 물질 |
PT2097541E (pt) | 2006-10-10 | 2013-03-18 | Miacom Diagnostics Gmbh | Sondas fluorescentes de ácidos nucleicos para hibridação in-situ fluorescente e tecnologia de chip |
JP2010511385A (ja) * | 2006-11-30 | 2010-04-15 | クロモセル コーポレイション | タンパク質産生のための至適化された宿主細胞 |
US20080216185A1 (en) * | 2007-01-19 | 2008-09-04 | Invitrogen Corporation | Compositions and Methods for Genetic Manipulation and Monitoring of Cell Lines |
EP2036989B1 (en) * | 2007-09-12 | 2012-07-25 | Institut Pasteur | Polynucleotide suitable for single cell based reporter assay to monitor gene expression patterns with high spatio-temporal resolution |
WO2009094218A2 (en) * | 2008-01-22 | 2009-07-30 | Chromocell Corporation | Novel cell lines expressing nav and methods using them |
EP2245057B1 (en) * | 2008-01-25 | 2019-09-04 | Chromocell Corporation | Novel cell lines expressing enac and methods using them |
EP3009513A1 (en) * | 2008-02-01 | 2016-04-20 | Chromocell Corporation | Novel cell lines and methods |
EP2186827A1 (en) | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Surrogate marker directed cDNA cloning of selectively induced mRNAs |
EP2391711B1 (en) | 2009-02-02 | 2015-04-08 | Chromocell Corporation | Novel cell lines and methods |
JP6083559B2 (ja) * | 2009-07-31 | 2017-02-22 | クロモセル コーポレーション | 細胞運命の修飾因子を同定および検証するための方法および組成物 |
US20120131701A1 (en) | 2009-08-05 | 2012-05-24 | Chromocell Corporation | Improved plants, microbes, and organisms |
US9347934B2 (en) | 2011-10-20 | 2016-05-24 | Chromocell Corporation | Assays for identifying compounds that modulate bitter taste |
KR102216949B1 (ko) * | 2012-12-14 | 2021-02-22 | 민데라 코포레이션 | 바이오마커의 검출 및 취득을 위한 방법 및 디바이스 |
US10669547B2 (en) | 2013-03-15 | 2020-06-02 | Kambiz Shekdar | Genome editing using effector oligonucleotides for therapeutic treatment |
US20160123959A1 (en) * | 2013-03-15 | 2016-05-05 | Chromocell Corporation | Methods and materials using signaling probes |
US9493742B2 (en) | 2013-03-15 | 2016-11-15 | Emory University | Purification of cell mixtures using molecular beacons targeting cell specific RNA |
WO2014176336A1 (en) | 2013-04-24 | 2014-10-30 | Chromocell Corporation | Assays for identifying compounds that modulate bitter taste |
US20160177396A1 (en) * | 2014-12-22 | 2016-06-23 | Enzo Biochem, Inc. | Comprehensive and comparative flow cytometry-based methods for identifying the state of a biological system |
EP3612629A1 (en) | 2017-04-18 | 2020-02-26 | The Broad Institute, Inc. | Compositions for detecting secretion and methods of use |
US20210147831A1 (en) | 2018-04-27 | 2021-05-20 | The Broad Institute, Inc. | Sequencing-based proteomics |
CN110819656B (zh) * | 2019-11-11 | 2021-06-04 | 中国科学院上海高等研究院 | 一种基于同步光源的x-射线多色遗传标记探针及其制备方法以及应用 |
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AU658132B2 (en) * | 1989-11-13 | 1995-04-06 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal DNA |
US5629147A (en) * | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
WO1994002646A1 (en) * | 1992-07-17 | 1994-02-03 | Aprogenex Inc. | Enriching and identyfying fetal cells in maternal blood for in situ hybridization |
US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
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US5641675A (en) | 1994-10-07 | 1997-06-24 | University Of Massachusetts Medical Center | Cis-acting sequences for intracellular localization of RNA |
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US5741657A (en) * | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
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US20030215798A1 (en) * | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
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US7098320B1 (en) * | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6361944B1 (en) * | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6416959B1 (en) * | 1997-02-27 | 2002-07-09 | Kenneth Giuliano | System for cell-based screening |
US6750052B1 (en) * | 1997-07-23 | 2004-06-15 | The Brigham And Women's Hospital, Inc. | Lens epithelial cell derived growth factor |
JP2001514859A (ja) * | 1997-09-04 | 2001-09-18 | バイエル コーポレイション | クエンチ可能な蛍光標識を有するオリゴヌクレオチドプローブおよびその使用方法 |
US6485901B1 (en) * | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
CA2319662C (en) * | 1998-01-27 | 2009-11-24 | Cytocell Limited | Modified nucleic acid probes and uses thereof |
ATE419013T1 (de) * | 1998-04-15 | 2009-01-15 | Hutchinson Fred Cancer Res | Methoden und vektorenkonstrukte zur erzeugung von transgene nagetieren, welche ein heterologes gen ubiquitär exprimieren |
ATE440963T1 (de) * | 1998-07-02 | 2009-09-15 | Gen Probe Inc | Molekulare fackeln |
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US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
JP3460673B2 (ja) * | 2000-02-04 | 2003-10-27 | 浜松ホトニクス株式会社 | 特定の遺伝子を発現した生細胞の選択的分離方法 |
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US20020129397A1 (en) * | 2000-12-13 | 2002-09-12 | Allen Keith D. | Transgenic mice containing brain-specific membrane-anchored protein gene disruptions |
JP2004516834A (ja) * | 2000-12-22 | 2004-06-10 | ユニヴァーシティー オブ エディンバラ | 胸腺上皮前駆細胞およびその使用 |
US20020090614A1 (en) | 2001-01-09 | 2002-07-11 | Jia Zhang | Direct measurement method for gene expression using single chain antisense array |
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CA2438297A1 (en) * | 2001-12-04 | 2003-06-12 | Genome Biosciences, Llc | Gene targeting methods and vectors |
MX2009008470A (es) * | 2007-02-09 | 2009-11-26 | Univ Northwestern | Particulas para detectar objetivos intracelulares. |
-
2000
- 2000-11-22 US US09/718,448 patent/US6692965B1/en not_active Expired - Lifetime
-
2002
- 2002-08-28 KR KR1020057003536A patent/KR101257500B1/ko active IP Right Grant
- 2002-08-28 WO PCT/US2002/027749 patent/WO2004020625A1/en active Application Filing
- 2002-08-28 NZ NZ538852A patent/NZ538852A/xx not_active IP Right Cessation
- 2002-08-28 JP JP2004532540A patent/JP4502808B2/ja not_active Expired - Fee Related
- 2002-08-28 ES ES10179993T patent/ES2423598T3/es not_active Expired - Lifetime
- 2002-08-28 EP EP10179993.0A patent/EP2264165B1/en not_active Expired - Lifetime
- 2002-08-28 AU AU2002332768A patent/AU2002332768A1/en not_active Abandoned
- 2002-08-28 MX MXPA05002192A patent/MXPA05002192A/es active IP Right Grant
- 2002-08-28 EP EP02807718A patent/EP1546327B1/en not_active Expired - Lifetime
- 2002-08-28 ES ES02807718T patent/ES2379731T3/es not_active Expired - Lifetime
- 2002-08-28 DK DK02807718.8T patent/DK1546327T3/da active
- 2002-08-28 CA CA2496821A patent/CA2496821C/en not_active Expired - Fee Related
- 2002-08-28 AT AT02807718T patent/ATE541924T1/de active
- 2002-08-28 PT PT02807718T patent/PT1546327E/pt unknown
- 2002-08-28 DK DK10179993.0T patent/DK2264165T3/da active
- 2002-08-28 CN CN028296869A patent/CN1688693B/zh not_active Expired - Fee Related
- 2002-08-28 IL IL16675702A patent/IL166757A0/xx active IP Right Grant
-
2003
- 2003-09-02 US US10/654,241 patent/US20060147937A1/en not_active Abandoned
-
2005
- 2005-12-05 HK HK05111073.2A patent/HK1079238A1/xx not_active IP Right Cessation
-
2010
- 2010-04-30 US US12/771,223 patent/US20100212040A1/en not_active Abandoned
-
2015
- 2015-01-16 US US14/599,319 patent/US20150143563A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2005537005A (ja) | 2005-12-08 |
NZ538852A (en) | 2006-03-31 |
US20060147937A1 (en) | 2006-07-06 |
WO2004020625A1 (en) | 2004-03-11 |
CN1688693A (zh) | 2005-10-26 |
CA2496821C (en) | 2012-06-19 |
US20150143563A1 (en) | 2015-05-21 |
ES2423598T3 (es) | 2013-09-23 |
PT1546327E (pt) | 2012-03-12 |
EP2264165A3 (en) | 2011-02-16 |
CA2496821A1 (en) | 2004-03-11 |
US20100212040A1 (en) | 2010-08-19 |
EP2264165A2 (en) | 2010-12-22 |
EP2264165B1 (en) | 2013-05-01 |
EP1546327A4 (en) | 2005-11-09 |
ATE541924T1 (de) | 2012-02-15 |
IL166757A0 (en) | 2006-01-15 |
HK1079238A1 (en) | 2006-03-31 |
KR20050084810A (ko) | 2005-08-29 |
AU2002332768A1 (en) | 2004-03-19 |
JP4502808B2 (ja) | 2010-07-14 |
DK2264165T3 (da) | 2013-08-05 |
EP1546327A1 (en) | 2005-06-29 |
CN1688693B (zh) | 2010-12-22 |
ES2379731T3 (es) | 2012-05-03 |
MXPA05002192A (es) | 2005-08-18 |
KR101257500B1 (ko) | 2013-04-23 |
US6692965B1 (en) | 2004-02-17 |
EP1546327B1 (en) | 2012-01-18 |
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