DK151624C - Analogifremgangsmaade til fremstilling af et 1-ethyl-6,8-difluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinolinderivat eller farmaceutisk acceptable salte deraf. - Google Patents

Analogifremgangsmaade til fremstilling af et 1-ethyl-6,8-difluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinolinderivat eller farmaceutisk acceptable salte deraf.

Info

Publication number
DK151624C
DK151624C DK098582A DK98582A DK151624C DK 151624 C DK151624 C DK 151624C DK 098582 A DK098582 A DK 098582A DK 98582 A DK98582 A DK 98582A DK 151624 C DK151624 C DK 151624C
Authority
DK
Denmark
Prior art keywords
difluor
piperazinyl
dihydro
oxo
ethyl
Prior art date
Application number
DK098582A
Other languages
Danish (da)
English (en)
Other versions
DK98582A (da
DK151624B (da
Inventor
Tsutomu Irikura
Hiroshi Koga
Akira Ito
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of DK98582A publication Critical patent/DK98582A/da
Publication of DK151624B publication Critical patent/DK151624B/da
Application granted granted Critical
Publication of DK151624C publication Critical patent/DK151624C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK098582A 1981-03-06 1982-03-05 Analogifremgangsmaade til fremstilling af et 1-ethyl-6,8-difluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinolinderivat eller farmaceutisk acceptable salte deraf. DK151624C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56032274A JPS57145862A (en) 1981-03-06 1981-03-06 Quinolinecarboxylic acid derivative
JP3227481 1981-03-06

Publications (3)

Publication Number Publication Date
DK98582A DK98582A (da) 1982-09-07
DK151624B DK151624B (da) 1987-12-21
DK151624C true DK151624C (da) 1988-06-27

Family

ID=12354397

Family Applications (1)

Application Number Title Priority Date Filing Date
DK098582A DK151624C (da) 1981-03-06 1982-03-05 Analogifremgangsmaade til fremstilling af et 1-ethyl-6,8-difluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinolinderivat eller farmaceutisk acceptable salte deraf.

Country Status (22)

Country Link
US (1) US4429127A (fr)
JP (1) JPS57145862A (fr)
KR (1) KR880000689B1 (fr)
AR (1) AR228085A1 (fr)
AT (1) AT382146B (fr)
AU (1) AU544761B2 (fr)
BE (1) BE892388A (fr)
CA (1) CA1215986A (fr)
CH (1) CH649290A5 (fr)
DE (1) DE3205655A1 (fr)
DK (1) DK151624C (fr)
ES (1) ES8306484A1 (fr)
FR (1) FR2501204B1 (fr)
GB (1) GB2094305B (fr)
HU (1) HU187449B (fr)
IN (1) IN155968B (fr)
IT (1) IT1150198B (fr)
MX (1) MX167628B (fr)
NL (1) NL192618C (fr)
PH (1) PH17166A (fr)
SE (1) SE446984B (fr)
ZA (1) ZA821027B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
EP0154780B1 (fr) * 1984-01-26 1990-04-11 Abbott Laboratories Composés antibactériens quinoléiques
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
DE3409922A1 (de) * 1984-03-17 1985-09-26 Bayer Ag, 5090 Leverkusen 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen
DE3571974D1 (en) * 1984-12-06 1989-09-07 Pfizer Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
US4755513A (en) * 1985-01-30 1988-07-05 Otsuka Pharmaceutical Company, Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
DE3504643A1 (de) * 1985-02-12 1986-08-14 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4940710A (en) * 1986-01-17 1990-07-10 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
CA2114981A1 (fr) 1993-02-09 1994-08-10 Kazumi Ogata Derives de l'acide quinolonecarboxylique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5312889A (en) 1976-07-22 1978-02-04 Dainippon Pharmaceut Co Ltd P-aminobenzylpiperazine dervatives
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
US4292317A (en) 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
GB2030562B (en) * 1978-10-04 1982-10-27 Kyorin Seiyaku Kk Substituted quinolinecarboxylic acid
JPS5653656A (en) 1979-10-05 1981-05-13 Tanabe Seiyaku Co Ltd Quinoline derivative and its preparation

Also Published As

Publication number Publication date
ATA89982A (de) 1986-06-15
HU187449B (en) 1986-01-28
AT382146B (de) 1987-01-12
GB2094305A (en) 1982-09-15
SE8201386L (sv) 1982-09-07
PH17166A (en) 1984-06-13
FR2501204B1 (fr) 1986-03-28
KR880000689B1 (ko) 1988-04-23
DE3205655C2 (fr) 1988-12-08
NL8200582A (nl) 1982-10-01
DK98582A (da) 1982-09-07
MX167628B (es) 1993-03-31
IN155968B (fr) 1985-04-13
ZA821027B (en) 1983-01-26
CA1215986A (fr) 1986-12-30
ES510163A0 (es) 1983-06-01
BE892388A (fr) 1982-09-06
SE446984B (sv) 1986-10-20
IT8219831A0 (it) 1982-02-24
JPH0145468B2 (fr) 1989-10-03
FR2501204A1 (fr) 1982-09-10
JPS57145862A (en) 1982-09-09
GB2094305B (en) 1984-08-01
AU544761B2 (en) 1985-06-13
US4429127A (en) 1984-01-31
DE3205655A1 (de) 1982-09-23
NL192618B (nl) 1997-07-01
IT1150198B (it) 1986-12-10
DK151624B (da) 1987-12-21
KR830009084A (ko) 1983-12-17
CH649290A5 (de) 1985-05-15
ES8306484A1 (es) 1983-06-01
AU8045182A (en) 1982-09-09
AR228085A1 (es) 1983-01-14
NL192618C (nl) 1997-11-04

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