DK1514936T3 - Nukleinsyresekvens xlnR af regulatoren af den xylanolytiske stofskiftereaktion xyIR fra Aspergillus niger - Google Patents

Nukleinsyresekvens xlnR af regulatoren af den xylanolytiske stofskiftereaktion xyIR fra Aspergillus niger

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Publication number
DK1514936T3
DK1514936T3 DK04028288T DK04028288T DK1514936T3 DK 1514936 T3 DK1514936 T3 DK 1514936T3 DK 04028288 T DK04028288 T DK 04028288T DK 04028288 T DK04028288 T DK 04028288T DK 1514936 T3 DK1514936 T3 DK 1514936T3
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Prior art keywords
nucleic acid
mutants
gene
acid sequence
regulator
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Application number
DK04028288T
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Danish (da)
English (en)
Inventor
Graaff Leendert Fungal Geno De
Jacob Visser
Den Broeck Henriette Catha Van
Original Assignee
Danisco
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Publication date
Application filed by Danisco filed Critical Danisco
Priority claimed from PCT/NL1996/000258 external-priority patent/WO1997000964A1/en
Application granted granted Critical
Publication of DK1514936T3 publication Critical patent/DK1514936T3/da

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/248—Xylanases
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    • C12N9/88—Lyases (4.)
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01003—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01015—Polygalacturonase (3.2.1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01037—Xylan 1,4-beta-xylosidase (3.2.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01055—Alpha-N-arabinofuranosidase (3.2.1.55)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01099—Arabinan endo-1,5-alpha-L-arabinosidase (3.2.1.99)

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
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  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
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  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK04028288T 1995-06-23 1996-06-24 Nukleinsyresekvens xlnR af regulatoren af den xylanolytiske stofskiftereaktion xyIR fra Aspergillus niger DK1514936T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95201707 1995-06-23
EP95202346 1995-08-30
PCT/NL1996/000258 WO1997000964A1 (en) 1995-06-23 1996-06-24 Novel beta-xylosidase, nucleotide sequence encoding it, and use thereof

Publications (1)

Publication Number Publication Date
DK1514936T3 true DK1514936T3 (da) 2008-04-14

Family

ID=26139424

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04028288T DK1514936T3 (da) 1995-06-23 1996-06-24 Nukleinsyresekvens xlnR af regulatoren af den xylanolytiske stofskiftereaktion xyIR fra Aspergillus niger
DK96921151T DK0833922T3 (da) 1995-06-23 1996-06-24 Hidtil ukendt fremgangsmåde il isolering af mutanter og til kloning af det komplementære gen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK96921151T DK0833922T3 (da) 1995-06-23 1996-06-24 Hidtil ukendt fremgangsmåde il isolering af mutanter og til kloning af det komplementære gen

Country Status (14)

Country Link
US (3) US6177261B1 (de)
EP (2) EP1514936B1 (de)
JP (2) JP4339400B2 (de)
CN (2) CN1661014B (de)
AT (2) ATE429499T1 (de)
AU (1) AU714511B2 (de)
BR (1) BR9608910A (de)
CA (2) CA2224626C (de)
DE (2) DE69637908D1 (de)
DK (2) DK1514936T3 (de)
NZ (1) NZ311181A (de)
PL (2) PL185052B1 (de)
PT (1) PT833922E (de)
WO (1) WO1997000962A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1514936B1 (de) 1995-06-23 2007-12-05 Danisco A/S Nucleinsäuresequenz xlnR des Regulators XylR des xylanolytischen Biosyntheseweges aus Aspergillus niger
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
WO2002008286A2 (en) * 2000-07-21 2002-01-31 Syngenta Participations Ag Zinc finger domain recognition code and uses thereof
KR100428998B1 (ko) * 2001-09-10 2004-04-28 한국과학기술원 모체 단백질과는 크기와 서열이 다른 단백질의 변이집단을생산하는 방법
EP2009093A3 (de) * 2004-09-22 2009-04-08 Bioworks, Inc. Transgene Trichoderm-Stämme und ihre Verwendung bei der Biokontrolle
GB0424940D0 (en) 2004-11-11 2004-12-15 Danisco Transcription factors
KR100801960B1 (ko) 2006-11-14 2008-02-12 건국대학교 산학협력단 ｍＲＮＡ 결합 단백질 ＸａｉＦ, 이를 부착하는 유전자구조물 그리고 이들을 이용한 외래 유전자의 과발현 방법
EP2350272A4 (de) * 2008-11-03 2013-01-16 Iogen Energy Corp Wirte und fermentierungsverfahren zur zellulaseherstellung
WO2010129287A2 (en) 2009-04-27 2010-11-11 The Board Of Trustees Of The University Of Illinois Hemicellulose-degrading enzymes
EP2508600B1 (de) * 2009-12-05 2015-08-12 Amano Enzyme Inc. Mutantes enzym und seine anwendung
US9267126B2 (en) 2010-08-30 2016-02-23 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
DK2735611T3 (en) 2010-08-30 2019-01-28 Novozymes As POLYPEPTIDES WITH CELLULOLYSE INCREASING ACTIVITY AND POLYNUCLEOTIDES CODING THEM
EP2611901B1 (de) 2010-08-30 2016-05-11 Novozymes A/S Polypeptide mit beta-glucosidase-aktivität, beta-xylosidase-aktivität oder beta-glucosidase- und beta-xylosidase-aktivität sowie dafür kodierende polynukleotide
WO2012030849A1 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
WO2012030811A1 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
WO2013159710A1 (zh) * 2012-04-25 2013-10-31 中国科学院上海生命科学研究院 一种提高拜氏梭菌木糖消耗率的方法
US10590497B2 (en) 2016-03-31 2020-03-17 Toray Industries, Inc. Trichoderma fungus having mutant-type BXL1 gene and method of producing xylooligosaccharide and glucose by using same
CN108315313A (zh) * 2018-03-21 2018-07-24 中国农业科学院饲料研究所 多聚半乳糖醛酸酶及其突变体TePG28b_N85E/S86W和应用
CA3109062A1 (en) * 2018-08-31 2020-03-05 Genomatica, Inc. Xylr mutant for improved xylose utilization or improved co-utilization of glucose and xylose
CN116355881B (zh) * 2023-03-10 2024-02-23 云南师范大学 酸耐受性提高的β-木糖苷酶突变体D395G及其应用
CN116515841B (zh) * 2023-06-21 2023-09-05 中国科学院天津工业生物技术研究所 一种真菌来源的启动子元件及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028530A (en) * 1985-01-28 1991-07-02 Xoma Corporation AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
DK160947C (da) * 1986-04-17 1991-10-21 Novo Industri As Gen-udtrykkelsessystem
US5264350A (en) 1986-08-18 1993-11-23 Institut Pasteur DNA sequence performing a function which is expressed in an over-production of extracellular proteins by various strains of bacillus, and vectors containing this sequence
GB8807939D0 (en) * 1988-04-05 1988-05-05 Univ Brunel Regulatory cassette for expression vectors
ES2140359T1 (es) 1993-06-14 2000-03-01 Basf Ag Control preciso de expresion genetica en celulas eucarioticas mediante promotores que responden a la tetaciclina.
US5464758A (en) * 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
DE69432543T2 (de) * 1993-07-23 2003-12-24 Dsm N.V., Te Heerlen Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
EP1514936B1 (de) 1995-06-23 2007-12-05 Danisco A/S Nucleinsäuresequenz xlnR des Regulators XylR des xylanolytischen Biosyntheseweges aus Aspergillus niger

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PL185052B1 (pl) 2003-02-28
CN1661014A (zh) 2005-08-31
CA2672126C (en) 2013-01-08
DK0833922T3 (da) 2009-08-03
AU6244396A (en) 1997-01-22
DE69637359D1 (de) 2008-01-17
CA2224626C (en) 2011-11-01
JPH11507838A (ja) 1999-07-13
PL324186A1 (en) 1998-05-11
JP2007244387A (ja) 2007-09-27
US8461320B2 (en) 2013-06-11
EP1514936B1 (de) 2007-12-05
BR9608910A (pt) 1999-05-04
EP0833922B1 (de) 2009-04-22
US6599745B1 (en) 2003-07-29
CN1661014B (zh) 2013-05-29
US6177261B1 (en) 2001-01-23
JP4339400B2 (ja) 2009-10-07
DE69637359T2 (de) 2008-10-30
CN1207128A (zh) 1999-02-03
DE69637908D1 (de) 2009-06-04
WO1997000962A1 (en) 1997-01-09
JP4339901B2 (ja) 2009-10-07
ATE380242T1 (de) 2007-12-15
CN1192106C (zh) 2005-03-09
ATE429499T1 (de) 2009-05-15
US20030175893A1 (en) 2003-09-18
AU714511B2 (en) 2000-01-06
EP1514936A2 (de) 2005-03-16
CA2224626A1 (en) 1997-01-09
EP1514936A3 (de) 2005-04-13
CA2672126A1 (en) 1997-01-09
EP0833922A1 (de) 1998-04-08
PL184463B1 (pl) 2002-11-29
PT833922E (pt) 2009-07-27
NZ311181A (en) 2000-02-28

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