DK149751C - Analogifremgangsmaade til fremstilling af et salt af et bistetrahydroisoquinolinium-derivat og mellemproduktforbindelsen til udaevelse af fremgangsmaaden - Google Patents
Analogifremgangsmaade til fremstilling af et salt af et bistetrahydroisoquinolinium-derivat og mellemproduktforbindelsen til udaevelse af fremgangsmaadenInfo
- Publication number
- DK149751C DK149751C DK553676A DK553676A DK149751C DK 149751 C DK149751 C DK 149751C DK 553676 A DK553676 A DK 553676A DK 553676 A DK553676 A DK 553676A DK 149751 C DK149751 C DK 149751C
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- bistetrahydroisoquinolinium
- presentation
- derivative
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5058975 | 1975-12-10 | ||
GB5058975 | 1975-12-10 | ||
GB4502876 | 1976-10-29 | ||
GB4502876A GB1579822A (en) | 1976-10-29 | 1976-10-29 | Tetrahydroisoquinolinium muscle relaxants |
Publications (3)
Publication Number | Publication Date |
---|---|
DK553676A DK553676A (da) | 1977-06-11 |
DK149751B DK149751B (da) | 1986-09-22 |
DK149751C true DK149751C (da) | 1987-03-23 |
Family
ID=26265501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK553676A DK149751C (da) | 1975-12-10 | 1976-12-09 | Analogifremgangsmaade til fremstilling af et salt af et bistetrahydroisoquinolinium-derivat og mellemproduktforbindelsen til udaevelse af fremgangsmaaden |
Country Status (24)
Country | Link |
---|---|
US (1) | US4179507A (ru) |
JP (1) | JPS6043342B2 (ru) |
AT (1) | AT365579B (ru) |
AU (1) | AU506657B2 (ru) |
CA (1) | CA1075241A (ru) |
CH (1) | CH625223A5 (ru) |
CY (1) | CY1217A (ru) |
DD (1) | DD128320A5 (ru) |
DE (1) | DE2655883A1 (ru) |
DK (1) | DK149751C (ru) |
FI (1) | FI61485C (ru) |
FR (1) | FR2334359A1 (ru) |
HK (1) | HK35084A (ru) |
IE (1) | IE44569B1 (ru) |
IL (1) | IL51074A (ru) |
IT (1) | IT1188908B (ru) |
KE (1) | KE3361A (ru) |
LU (1) | LU76355A1 (ru) |
MC (1) | MC1119A1 (ru) |
MY (1) | MY8500287A (ru) |
NL (1) | NL178688C (ru) |
NZ (1) | NZ182847A (ru) |
SE (1) | SE434154B (ru) |
SU (1) | SU718008A3 (ru) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1125287A (en) * | 1978-07-21 | 1982-06-08 | John J. Savarese | Bis isoquinolinium compositions and methods of use |
US4235906A (en) | 1978-07-21 | 1980-11-25 | Massachusetts General Hospital | Bis-isoquinolinium compounds, compositions and methods of use |
US4491665A (en) * | 1979-10-19 | 1985-01-01 | Burroughs Wellcome Co. | Method of preparing isomers of bis isoquinolinium compounds |
US4315935A (en) * | 1980-04-14 | 1982-02-16 | Smithkline Corporation | N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use |
US4317826A (en) * | 1980-05-27 | 1982-03-02 | Smithkline Corporation | N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use |
US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
GB9015473D0 (en) * | 1990-07-13 | 1990-08-29 | Wellcome Found | Neuromuscular blocking agents |
US5453510A (en) * | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
US5240939A (en) * | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
US5510355A (en) * | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
IT1277700B1 (it) * | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura |
US5684154A (en) * | 1996-02-16 | 1997-11-04 | Abbott Laboratories | Process for the preparation and isolation of atracurium besylate |
ATE254107T1 (de) * | 1997-03-25 | 2003-11-15 | Avera Pharmaceuticals Inc | Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker |
GB0204087D0 (en) * | 2002-02-21 | 2002-04-10 | Legislator 1563 Ltd | Di-ester derivatives as short acting neuromuscular blockers |
US8148398B2 (en) * | 2006-12-06 | 2012-04-03 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
AU2008222298A1 (en) * | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1R,1'R)-atracurium salts separation process |
US20100087650A1 (en) * | 2007-03-26 | 2010-04-08 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CA2685488A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
CA2685491A1 (en) * | 2007-05-01 | 2008-11-06 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
CA2687157A1 (en) * | 2007-06-18 | 2008-12-24 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
CN101337935B (zh) * | 2007-07-06 | 2011-01-12 | 江苏恒瑞医药股份有限公司 | 一种用两相萃取法纯化苯磺酸阿曲库铵的方法 |
CN101337936B (zh) * | 2007-07-06 | 2011-03-23 | 江苏恒瑞医药股份有限公司 | 一种用柱色谱法纯化苯磺酸阿曲库铵的方法 |
US20100256381A1 (en) * | 2007-07-09 | 2010-10-07 | Chemagis Ltd. | Process for producing cisatracurium and associated intermediates |
WO2009057086A1 (en) * | 2007-10-29 | 2009-05-07 | Chemagis Ltd. | Novel r,r'-atracurium salts |
AU2009241211A1 (en) * | 2008-05-01 | 2009-11-05 | Chemagis Ltd. | Cisatracurium derivatives, preparation and uses thereof |
US8592451B2 (en) | 2009-03-17 | 2013-11-26 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
BRPI1013562B1 (pt) * | 2009-04-14 | 2021-08-03 | Glaxo Group Limited | Processo para a preparação do composto, e, composto |
US9220700B2 (en) | 2009-08-19 | 2015-12-29 | Cornell University | Cysteine for physiological injection |
EP2514754B1 (en) | 2011-04-08 | 2013-08-21 | King Saud University | 6,7-dihydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation |
CN102249998B (zh) * | 2011-06-20 | 2013-09-25 | 浙江仙琚制药股份有限公司 | 一种制备顺苯磺酸阿曲库铵的方法 |
CN102898370A (zh) * | 2012-11-11 | 2013-01-30 | 苏州二叶制药有限公司 | 注射用顺苯磺阿曲库铵 |
WO2018193463A1 (en) * | 2017-04-21 | 2018-10-25 | Neon Laboratories Limited | An improved process for the preparation of tetrahydroisoquinoline compounds |
CN114181147A (zh) * | 2021-12-27 | 2022-03-15 | 上海药坦药物研究开发有限公司 | 一种苯磺阿曲库铵的处理方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3004031A (en) * | 1958-07-03 | 1961-10-10 | Allen & Hauburys Ltd | Diquaternary salts of papaverino esters |
GB1125619A (en) * | 1965-11-15 | 1968-08-28 | Wellcome Found | Derivatives of bis-isoquinolines |
-
1976
- 1976-12-08 AU AU20375/76A patent/AU506657B2/en not_active Expired
- 1976-12-09 CH CH1551176A patent/CH625223A5/de not_active IP Right Cessation
- 1976-12-09 FR FR7637072A patent/FR2334359A1/fr active Granted
- 1976-12-09 NL NLAANVRAGE7613695,A patent/NL178688C/xx not_active IP Right Cessation
- 1976-12-09 AT AT0908476A patent/AT365579B/de active
- 1976-12-09 SE SE7613824A patent/SE434154B/xx not_active IP Right Cessation
- 1976-12-09 NZ NZ182847A patent/NZ182847A/xx unknown
- 1976-12-09 SU SU762428001A patent/SU718008A3/ru active
- 1976-12-09 DK DK553676A patent/DK149751C/da not_active IP Right Cessation
- 1976-12-09 JP JP51148250A patent/JPS6043342B2/ja not_active Expired
- 1976-12-09 DD DD7600196214A patent/DD128320A5/xx unknown
- 1976-12-09 US US05/749,174 patent/US4179507A/en not_active Expired - Lifetime
- 1976-12-09 FI FI763543A patent/FI61485C/fi not_active IP Right Cessation
- 1976-12-09 IE IE2688/76A patent/IE44569B1/en not_active IP Right Cessation
- 1976-12-09 MC MC761222A patent/MC1119A1/xx unknown
- 1976-12-09 DE DE19762655883 patent/DE2655883A1/de active Granted
- 1976-12-09 CA CA267,529A patent/CA1075241A/en not_active Expired
- 1976-12-09 IL IL51074A patent/IL51074A/xx unknown
- 1976-12-09 LU LU76355A patent/LU76355A1/xx unknown
-
1977
- 1977-03-07 CY CY1217A patent/CY1217A/xx unknown
-
1980
- 1980-02-25 IT IT48000/80A patent/IT1188908B/it active Protection Beyond IP Right Term
-
1983
- 1983-12-08 KE KE3361A patent/KE3361A/xx unknown
-
1984
- 1984-04-18 HK HK350/84A patent/HK35084A/xx unknown
-
1985
- 1985-12-30 MY MY287/85A patent/MY8500287A/xx unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |