DK1485378T3 - Piperazinyl-, piperidinyl- og morpholinylderivater som nye inhibitorer af histondeacetylase - Google Patents
Piperazinyl-, piperidinyl- og morpholinylderivater som nye inhibitorer af histondeacetylaseInfo
- Publication number
- DK1485378T3 DK1485378T3 DK03711979T DK03711979T DK1485378T3 DK 1485378 T3 DK1485378 T3 DK 1485378T3 DK 03711979 T DK03711979 T DK 03711979T DK 03711979 T DK03711979 T DK 03711979T DK 1485378 T3 DK1485378 T3 DK 1485378T3
- Authority
- DK
- Denmark
- Prior art keywords
- piperazinyl
- piperidinyl
- histone deacetylase
- novel inhibitors
- morpholinyl derivatives
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002757 morpholinyl group Chemical group 0.000 title 1
- 125000004193 piperazinyl group Chemical group 0.000 title 1
- 125000003386 piperidinyl group Chemical group 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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BR0212510A (pt) | 2001-09-14 | 2004-08-24 | Methylgene Inc | Inibidor de histona desacetilase, composto e composição |
US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
DK1485348T3 (da) | 2002-03-13 | 2008-09-29 | Janssen Pharmaceutica Nv | Carbonylamino-derivater som nye inhibitorer af histandeacetylase |
US7501417B2 (en) | 2002-03-13 | 2009-03-10 | Janssen Pharmaceutica, N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
AU2003218735B2 (en) * | 2002-03-13 | 2009-03-12 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
PL214279B1 (pl) | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
WO2005030704A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
EP1758881A1 (en) | 2004-06-14 | 2007-03-07 | F.Hoffmann-La Roche Ag | Thiophene hydroxamic acid derivatives and their use as hdac inhibitors |
EP1778683A1 (en) | 2004-06-14 | 2007-05-02 | F.Hoffmann-La Roche Ag | Thiophene derivatives, their manufacture and use as pharmaceutical agents |
ME01058B (me) | 2004-07-28 | 2012-10-20 | Janssen Pharmaceutica Nv | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
CA2572971C (en) * | 2004-07-28 | 2013-01-15 | Janssen Pharmaceutica N.V. | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase |
KR101261305B1 (ko) * | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
JPWO2006016637A1 (ja) * | 2004-08-11 | 2008-05-01 | 杏林製薬株式会社 | 新規環状アミノ安息香酸誘導体 |
ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
EP1719508A1 (en) * | 2005-05-06 | 2006-11-08 | Yih-Lin Chung | Use of histone deacetylase inhibitors for the prevention or treatment of joint destruction |
DK1885710T3 (en) | 2005-05-18 | 2015-11-23 | Janssen Pharmaceutica Nv | SUBSTITUTED AMINOPROPENYLPIPERIDINE OR MORPHOLINE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE |
BRPI0613429A2 (pt) | 2005-07-14 | 2009-02-10 | Takeda San Diego Inc | inibidores de histona desacetilase |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
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AR039565A1 (es) | 2005-02-23 |
NZ534833A (en) | 2006-07-28 |
IL164004A (en) | 2011-04-28 |
CA2475766A1 (en) | 2003-09-18 |
BR0307606A (pt) | 2004-12-21 |
TW200400961A (en) | 2004-01-16 |
US20050165016A1 (en) | 2005-07-28 |
US7592450B2 (en) | 2009-09-22 |
US8501737B2 (en) | 2013-08-06 |
ES2307909T3 (es) | 2008-12-01 |
AU2003218735A1 (en) | 2003-09-22 |
OA12788A (en) | 2006-07-10 |
CA2475766C (en) | 2012-06-05 |
HRP20040804A2 (en) | 2005-02-28 |
MXPA04008795A (es) | 2004-11-26 |
CN101007803A (zh) | 2007-08-01 |
TWI283676B (en) | 2007-07-11 |
EA200401197A1 (ru) | 2005-02-24 |
US20100009988A1 (en) | 2010-01-14 |
PL371036A1 (pl) | 2005-06-13 |
CN1642948A (zh) | 2005-07-20 |
JP4674045B2 (ja) | 2011-04-20 |
CN101007803B (zh) | 2012-03-21 |
DE60321667D1 (en) | 2008-07-31 |
EA007270B1 (ru) | 2006-08-25 |
NO20044135L (no) | 2004-09-29 |
PL208401B1 (pl) | 2011-04-29 |
AU2003218735B2 (en) | 2009-03-12 |
KR20040093692A (ko) | 2004-11-08 |
ATE398615T1 (de) | 2008-07-15 |
WO2003076438A1 (en) | 2003-09-18 |
CN100396679C (zh) | 2008-06-25 |
JP2005526766A (ja) | 2005-09-08 |
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