DK1461442T3 - Transgenic animals with human Ig lambda light chain genes - Google Patents
Transgenic animals with human Ig lambda light chain genes Download PDFInfo
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- DK1461442T3 DK1461442T3 DK02782395.4T DK02782395T DK1461442T3 DK 1461442 T3 DK1461442 T3 DK 1461442T3 DK 02782395 T DK02782395 T DK 02782395T DK 1461442 T3 DK1461442 T3 DK 1461442T3
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2267/035—Animal model for multifactorial diseases
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- C—CHEMISTRY; METALLURGY
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (2)
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| US33450801P | 2001-11-30 | 2001-11-30 | |
| PCT/US2002/038245 WO2003047336A2 (en) | 2001-11-30 | 2002-11-27 | TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES |
Publications (1)
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| DK1461442T3 true DK1461442T3 (en) | 2017-12-04 |
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| DK10178127.6T DK2319301T3 (en) | 2001-11-30 | 2002-11-27 | Transgenic animals with human Ig lambda light chain genes |
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| DK10178127.6T DK2319301T3 (en) | 2001-11-30 | 2002-11-27 | Transgenic animals with human Ig lambda light chain genes |
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| DK (2) | DK1461442T3 (enExample) |
| ES (2) | ES2645698T3 (enExample) |
| WO (1) | WO2003047336A2 (enExample) |
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| US20070077256A1 (en) | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US8541008B2 (en) * | 1999-11-19 | 2013-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| MXPA03004793A (es) | 2000-11-30 | 2004-12-03 | Medarex Inc | Roedores transgenicos transcromosomales para elaborar anticuerpos humnanos. |
| CA2446968C (en) * | 2001-05-11 | 2012-07-03 | Kirin Beer Kabushiki Kaisha | Human artificial chromosome containing human antibody .lambda. light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| JP4808614B2 (ja) | 2003-06-27 | 2011-11-02 | アムジエン・フレモント・インコーポレイテツド | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| AU2005227313A1 (en) | 2004-03-19 | 2005-10-06 | Amgen Inc. | Reducing the risk of human and anti-human antibodies through V gene manipulation |
| US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
| US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
| KR20070072608A (ko) * | 2004-10-22 | 2007-07-04 | 레비비코르 인코포레이션 | 유전자 변형된 면역계를 가지는 유제류 |
| AU2006208286A1 (en) | 2005-01-26 | 2006-08-03 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
| MX2007013058A (es) | 2005-04-20 | 2008-02-22 | Amgen Fremont Inc | Anticuerpos monoclonales de alta afinidad completamente humanos para interleucina-8 y epitopes para dichos anticuerpos. |
| WO2006117699A2 (en) * | 2005-04-29 | 2006-11-09 | Innate Pharma | Transgenic animals and methods of making recombinant antibodies |
| NL1029605C2 (nl) * | 2005-07-25 | 2007-01-26 | Li-Te Chin | Nieuwe uit menselijke kiemlijnsequenties gewonnen antilichaamstructuren. |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| EP2167669A2 (en) | 2007-05-31 | 2010-03-31 | Genmab A/S | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
| SI2602323T1 (en) | 2007-06-01 | 2018-05-31 | Open Monoclonal Technology, Inc. | Compositions and procedures for inhibiting endogenous immunoglobin gene and the formation of transgenic human idiopathic antibodies |
| DK2346994T3 (da) | 2008-09-30 | 2022-02-28 | Ablexis Llc | Knock-in-mus til fremstilling af kimære antistoffer |
| ES2548377T3 (es) * | 2008-10-27 | 2015-10-16 | Revivicor, Inc. | Ungulados inmunodeprimidos |
| EP2517556B2 (en) * | 2009-07-08 | 2023-03-22 | Kymab Limited | Site-Specific Recombination Method, Rodents & Rodent Cells capable of Expressing Chimaeric Antibodies or Chains |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| PL2719708T3 (pl) | 2009-11-13 | 2018-04-30 | Daiichi Sankyo Europe Gmbh | Materiał i sposoby leczenia lub zapobiegania chorobom związanym z HER-3 |
| WO2011097603A1 (en) | 2010-02-08 | 2011-08-11 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| KR102004106B1 (ko) | 2010-03-31 | 2019-07-25 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| SMT201900241T1 (it) * | 2010-06-22 | 2019-05-10 | Regeneron Pharma | Topi esprimenti una catena leggera ibrida di immunoglobulina con una regione variabile umana |
| RS55495B1 (sr) * | 2010-08-02 | 2017-04-28 | Regeneron Pharma | Miševi koji stvaraju vezujuće proteine koji sadrže vl domene |
| CA2815154A1 (en) | 2010-08-06 | 2012-02-09 | U3 Pharma Gmbh | Use of her3 binding agents in prostate treatment |
| CA2815181C (en) | 2010-10-27 | 2020-09-15 | William Gleason Richards | Dkk1 antibodies and methods of use |
| WO2012151481A1 (en) * | 2011-05-04 | 2012-11-08 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement acitivation |
| EP2734229B1 (en) | 2011-07-22 | 2019-01-02 | Novadigm Therapeutics, Inc. | Methods and copositions for vaccinating against staphylococcus aureus |
| SI3865581T1 (sl) | 2011-08-05 | 2024-12-31 | Regeneron Pharmaceuticals, Inc. | Miši s humanizirano univerzalno lahko verigo |
| CA2846319A1 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| JP2014531452A (ja) * | 2011-09-19 | 2014-11-27 | カイマブ・リミテッド | 動物、レパートリーおよび方法 |
| KR101720394B1 (ko) | 2011-09-21 | 2017-03-27 | 후지레비오 가부시키가이샤 | 친화성 복합체에 대한 항체 |
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| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
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| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PL2793567T3 (pl) | 2011-12-20 | 2019-09-30 | Regeneron Pharmaceuticals, Inc. | Myszy z humanizowanym łańcuchem lekkim |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| AU2013204581B2 (en) | 2012-03-16 | 2015-06-25 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing pH-sensitive immunoglobulin sequences |
| RU2644684C2 (ru) | 2012-03-16 | 2018-02-13 | Регенерон Фармасьютикалз, Инк. | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
| HUE045537T2 (hu) | 2012-03-16 | 2019-12-30 | Regeneron Pharma | PH-érzékeny immunglobulin-szekvenciákat expresszáló rágcsálók |
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- 2002-11-27 EP EP20159959.4A patent/EP3698626A1/en not_active Withdrawn
- 2002-11-27 AU AU2002348263A patent/AU2002348263B2/en not_active Expired
- 2002-11-27 WO PCT/US2002/038245 patent/WO2003047336A2/en not_active Ceased
- 2002-11-27 ES ES10178127.6T patent/ES2645698T3/es not_active Expired - Lifetime
- 2002-11-27 CA CA2468565A patent/CA2468565C/en not_active Expired - Lifetime
- 2002-11-27 EP EP02782395.4A patent/EP1461442B1/en not_active Revoked
- 2002-11-27 EP EP10178127.6A patent/EP2319301B1/en not_active Revoked
- 2002-11-27 DK DK02782395.4T patent/DK1461442T3/en active
- 2002-11-27 JP JP2003548609A patent/JP2005510253A/ja active Pending
- 2002-11-27 DK DK10178127.6T patent/DK2319301T3/en active
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- 2002-11-27 EP EP17185948.1A patent/EP3269235B1/en not_active Expired - Lifetime
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2009
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2010
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| US7435871B2 (en) | 2008-10-14 |
| CA2847885A1 (en) | 2003-06-12 |
| JP2009100765A (ja) | 2009-05-14 |
| HK1248985A1 (en) | 2018-10-26 |
| EP1461442A4 (en) | 2006-11-29 |
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| EP3269235A1 (en) | 2018-01-17 |
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