WO2003047336A3 - TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES - Google Patents

TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES Download PDF

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Publication number
WO2003047336A3
WO2003047336A3 PCT/US2002/038245 US0238245W WO03047336A3 WO 2003047336 A3 WO2003047336 A3 WO 2003047336A3 US 0238245 W US0238245 W US 0238245W WO 03047336 A3 WO03047336 A3 WO 03047336A3
Authority
WO
WIPO (PCT)
Prior art keywords
light chain
transgenic animals
chain genes
animals bearing
bearing human
Prior art date
Application number
PCT/US2002/038245
Other languages
French (fr)
Other versions
WO2003047336A2 (en
Inventor
Larry L Green
Vladimir Ivanov
Original Assignee
Abgenix Inc
Larry L Green
Vladimir Ivanov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23307544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003047336(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abgenix Inc, Larry L Green, Vladimir Ivanov filed Critical Abgenix Inc
Priority to EP17185948.1A priority Critical patent/EP3269235B1/en
Priority to EP02782395.4A priority patent/EP1461442B1/en
Priority to DK02782395.4T priority patent/DK1461442T3/en
Priority to CA2468565A priority patent/CA2468565C/en
Priority to JP2003548609A priority patent/JP2005510253A/en
Priority to ES02782395.4T priority patent/ES2645563T3/en
Priority to EP20159959.4A priority patent/EP3698626A1/en
Priority to AU2002348263A priority patent/AU2002348263B2/en
Publication of WO2003047336A2 publication Critical patent/WO2003047336A2/en
Publication of WO2003047336A3 publication Critical patent/WO2003047336A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u

Abstract

The invention relates to transgenic animals bearing one or more human μ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human μ light chain loci. The invention further relates to methods of using and compositions derived from the transgenic animals that have incorporated human μ light chain loci.
PCT/US2002/038245 2001-11-30 2002-11-27 TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES WO2003047336A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP17185948.1A EP3269235B1 (en) 2001-11-30 2002-11-27 Transgenic mice bearing human ig lambda light chain genes
EP02782395.4A EP1461442B1 (en) 2001-11-30 2002-11-27 Transgenic animals bearing human ig lambda light chain genes
DK02782395.4T DK1461442T3 (en) 2001-11-30 2002-11-27 Transgenic animals with human Ig lambda light chain genes
CA2468565A CA2468565C (en) 2001-11-30 2002-11-27 Transgenic animals bearing human iglambda light chain genes
JP2003548609A JP2005510253A (en) 2001-11-30 2002-11-27 Transgenic animal carrying human Igλ light chain gene
ES02782395.4T ES2645563T3 (en) 2001-11-30 2002-11-27 Transgenic animals that carry human Ig light chain genes
EP20159959.4A EP3698626A1 (en) 2001-11-30 2002-11-27 Transgenic animals bearing human ig lambda light chain genes
AU2002348263A AU2002348263B2 (en) 2001-11-30 2002-11-27 Transgenic animals bearing human IgLamda light chain genes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33450801P 2001-11-30 2001-11-30
US60/334,508 2001-11-30

Publications (2)

Publication Number Publication Date
WO2003047336A2 WO2003047336A2 (en) 2003-06-12
WO2003047336A3 true WO2003047336A3 (en) 2004-06-24

Family

ID=23307544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038245 WO2003047336A2 (en) 2001-11-30 2002-11-27 TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES

Country Status (9)

Country Link
US (1) US7435871B2 (en)
EP (4) EP1461442B1 (en)
JP (4) JP2005510253A (en)
AU (1) AU2002348263B2 (en)
CA (2) CA2468565C (en)
DK (2) DK1461442T3 (en)
ES (2) ES2645563T3 (en)
HK (1) HK1248985A1 (en)
WO (1) WO2003047336A2 (en)

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