DK144128C - Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner - Google Patents

Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner

Info

Publication number
DK144128C
DK144128C DK328978A DK328978A DK144128C DK 144128 C DK144128 C DK 144128C DK 328978 A DK328978 A DK 328978A DK 328978 A DK328978 A DK 328978A DK 144128 C DK144128 C DK 144128C
Authority
DK
Denmark
Prior art keywords
oner
quinazolin
analogy procedure
preparing imidazo
imidazo
Prior art date
Application number
DK328978A
Other languages
Danish (da)
English (en)
Other versions
DK144128B (da
DK328978A (da
Inventor
M S Chodnekar
A Kaiser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK328978A publication Critical patent/DK328978A/da
Publication of DK144128B publication Critical patent/DK144128B/da
Application granted granted Critical
Publication of DK144128C publication Critical patent/DK144128C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
DK328978A 1977-07-25 1978-07-24 Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner DK144128C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
LU77829 1977-07-25
CH577678 1978-05-26
CH577678 1978-05-26

Publications (3)

Publication Number Publication Date
DK328978A DK328978A (da) 1979-01-26
DK144128B DK144128B (da) 1981-12-14
DK144128C true DK144128C (da) 1982-05-17

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328978A DK144128C (da) 1977-07-25 1978-07-24 Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner

Country Status (29)

Country Link
US (1) US4256748A (fr)
EP (1) EP0000718B1 (fr)
JP (1) JPS5441894A (fr)
AR (1) AR218500A1 (fr)
AT (1) AT363479B (fr)
AU (1) AU519688B2 (fr)
BR (1) BR7804763A (fr)
CA (1) CA1094555A (fr)
CS (1) CS203014B2 (fr)
DE (2) DE2832138A1 (fr)
DK (1) DK144128C (fr)
ES (2) ES471981A1 (fr)
FI (1) FI63409C (fr)
FR (1) FR2398748A1 (fr)
GB (1) GB2001638B (fr)
GR (1) GR72968B (fr)
HU (1) HU177643B (fr)
IE (1) IE47280B1 (fr)
IL (1) IL55183A (fr)
IT (1) IT1097337B (fr)
MC (1) MC1199A1 (fr)
MY (1) MY8500249A (fr)
NL (1) NL7807507A (fr)
NO (1) NO150800C (fr)
NZ (1) NZ187921A (fr)
PH (1) PH14642A (fr)
PT (1) PT68342A (fr)
SE (1) SE7808111L (fr)
YU (1) YU177578A (fr)

Families Citing this family (68)

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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
CA1131631A (fr) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Derives de la quinazoline et preparations pharmaceutiques
EP0029559A3 (fr) * 1979-11-24 1981-09-30 Sandoz Ag 5,10 Dihydroimidazo (2,1-b) quinazoléines, leur préparation et compositions pharmaceutiques les contenant
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (fr) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Procédé pour la préparation de dérivés de l'imidazoquinazoline
JPS57178234U (fr) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
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US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
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US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
WO1993003034A1 (fr) * 1991-07-29 1993-02-18 Warner-Lambert Company Derives de quinazoline utilises en tant qu'inhibiteurs d'acetylcholinesterase
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
EP1216037A2 (fr) * 1999-09-21 2002-06-26 Emory University Procedes et compositions pour le traitement de troubles lies aux plaquettes au moyen d'agents inhibiteurs de trajet de mpl
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
ATE463246T1 (de) * 2003-01-23 2010-04-15 Shire Holdings Ag Formulierung und verfahren zur behandlung von thrombocythämie
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
CA2688161C (fr) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
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GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
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WO2014131024A2 (fr) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et applications associées
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
MX2016001714A (es) 2013-08-09 2016-10-03 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
WO2020237096A1 (fr) 2019-05-21 2020-11-26 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient
EP4201403A1 (fr) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2

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DE1645917A1 (de) 1962-10-26 1970-09-24 American Home Prod Verfahren zur Herstellung von 5-Aryl-3-acyloxy-1,2-dihydro-3H-1,4-benzodiazepin-2-onen
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BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
EP0000718A3 (en) 1979-06-13
GB2001638A (en) 1979-02-07
AT363479B (de) 1981-08-10
AU519688B2 (en) 1981-12-17
CS203014B2 (en) 1981-02-27
SE7808111L (sv) 1979-01-26
IE47280B1 (en) 1984-02-08
PT68342A (en) 1978-08-01
US4256748A (en) 1981-03-17
GB2001638B (en) 1982-02-10
ES476955A1 (es) 1979-10-16
DK144128B (da) 1981-12-14
MC1199A1 (fr) 1979-03-19
GR72968B (fr) 1984-01-20
NO150800B (no) 1984-09-10
IL55183A (en) 1981-11-30
DE2861688D1 (en) 1982-04-29
NL7807507A (nl) 1979-01-29
PH14642A (en) 1981-10-12
DK328978A (da) 1979-01-26
AR218500A1 (es) 1980-06-13
DE2832138A1 (de) 1979-02-08
FI782248A (fi) 1979-01-26
IT7826019A0 (it) 1978-07-24
NO150800C (no) 1984-12-27
FI63409B (fi) 1983-02-28
FI63409C (fi) 1983-06-10
CA1094555A (fr) 1981-01-27
FR2398748B1 (fr) 1981-09-04
NO782541L (no) 1979-01-26
ES471981A1 (es) 1979-10-16
FR2398748A1 (fr) 1979-02-23
MY8500249A (en) 1985-12-31
EP0000718B1 (fr) 1982-03-24
IL55183A0 (en) 1978-09-29
JPS5441894A (en) 1979-04-03
IE781478L (en) 1979-01-25
YU177578A (en) 1983-01-21
EP0000718A2 (fr) 1979-02-21
AU3812778A (en) 1980-01-24
IT1097337B (it) 1985-08-31
NZ187921A (en) 1981-03-16
ATA535178A (de) 1981-01-15
BR7804763A (pt) 1979-04-10
HU177643B (en) 1981-11-28

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