DK142870B - Analogifremgangsmåde til fremstilling af pyridazinonforbindelser. - Google Patents
Analogifremgangsmåde til fremstilling af pyridazinonforbindelser. Download PDFInfo
- Publication number
- DK142870B DK142870B DK634074AA DK634074A DK142870B DK 142870 B DK142870 B DK 142870B DK 634074A A DK634074A A DK 634074AA DK 634074 A DK634074 A DK 634074A DK 142870 B DK142870 B DK 142870B
- Authority
- DK
- Denmark
- Prior art keywords
- pyridazinone
- dihydro
- hydroxy
- formula
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5872673 | 1973-12-19 | ||
| GB58726/73A GB1488330A (en) | 1973-12-19 | 1973-12-19 | Dihydropyridazinones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK634074A DK634074A (sv) | 1975-08-25 |
| DK142870B true DK142870B (da) | 1981-02-16 |
| DK142870C DK142870C (sv) | 1981-09-21 |
Family
ID=10482281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK634074AA DK142870B (da) | 1973-12-19 | 1974-12-05 | Analogifremgangsmåde til fremstilling af pyridazinonforbindelser. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3931177A (sv) |
| JP (1) | JPS5093984A (sv) |
| BE (1) | BE823103A (sv) |
| CA (1) | CA1033733A (sv) |
| CH (1) | CH608794A5 (sv) |
| DE (1) | DE2459468A1 (sv) |
| DK (1) | DK142870B (sv) |
| ES (1) | ES433135A1 (sv) |
| FI (1) | FI356974A (sv) |
| FR (1) | FR2255070B1 (sv) |
| GB (1) | GB1488330A (sv) |
| HU (1) | HU170633B (sv) |
| IE (1) | IE40428B1 (sv) |
| IL (1) | IL46158A (sv) |
| NL (1) | NL7416578A (sv) |
| SE (1) | SE413405B (sv) |
| SU (1) | SU578872A3 (sv) |
| ZA (1) | ZA747462B (sv) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4111936A (en) * | 1974-06-18 | 1978-09-05 | Smith Kline & French Laboratories Limited | Pyridazinethiones |
| US4082843A (en) * | 1975-11-26 | 1978-04-04 | Smith Kline & French Laboratories Limited | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents |
| CH624395A5 (sv) * | 1976-01-08 | 1981-07-31 | Ciba Geigy Ag | |
| US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
| DE2845456A1 (de) * | 1978-10-19 | 1980-08-14 | Merck Patent Gmbh | 6-arylpyridazin-3-one und verfahren zu ihrer herstellung |
| US4281125A (en) * | 1980-05-15 | 1981-07-28 | Diamond Shamrock Corporation | Quinoline catalyzed synthesis of pyridazinone pharmaceutical intermediates |
| DE3048487A1 (de) * | 1980-12-22 | 1982-07-29 | Cassella Ag, 6000 Frankfurt | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
| ATE13294T1 (de) * | 1981-03-04 | 1985-06-15 | Ciba Geigy Ag | Pyridazinone, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen und deren verwendung. |
| GB8323553D0 (en) * | 1983-09-02 | 1983-10-05 | Smith Kline French Lab | Pharmaceutical compositions |
| JPS6193169A (ja) * | 1984-10-12 | 1986-05-12 | Sankyo Co Ltd | ピリダジノン誘導体及びその製法 |
| GB8426804D0 (en) * | 1984-10-23 | 1984-11-28 | Ciba Geigy Ag | Pyridazinones preparations |
| JPH0629254B2 (ja) * | 1986-09-08 | 1994-04-20 | 帝国臓器製薬株式会社 | ピリダジノン誘導体 |
| DE3934436A1 (de) * | 1989-06-01 | 1991-04-18 | Thomae Gmbh Dr K | 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| NZ530051A (en) | 2001-06-12 | 2006-12-22 | Wellstat Therapeutics Corp | Polycyclic oxy-aromatic acid derivatives for the treatment of metabolic disorders |
| JP2006509790A (ja) * | 2002-11-27 | 2006-03-23 | アルテシアン セラピューティック，インコーポレイティド | 心不全の治療のための混合されたＰＤＥ阻害およびβアドレナリン拮抗薬活性または部分的作用薬活性を有する化合物 |
| US20080255134A1 (en) * | 2004-11-30 | 2008-10-16 | Artesian Therapeutics, Inc. | Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase |
| CA2588949A1 (en) * | 2004-11-30 | 2006-06-08 | Artesian Therapeutics, Inc. | Compounds with mixed pde-inhibitory and .beta.-adrenergic antagonist or partial agonist activity for treatment of heart failure |
| ATE540675T1 (de) | 2005-04-01 | 2012-01-15 | Wellstat Therapeutics Corp | Verbindungen zur behandlung von stoffwechselstörungen |
| SI2069312T1 (sl) | 2006-07-25 | 2013-03-29 | Cephalon, Inc. | Derivati piridizinona |
| JP2010523579A (ja) * | 2007-04-02 | 2010-07-15 | インスティテュート フォア ワンワールド ヘルス | Ｃｆｔｒ阻害剤化合物およびそれらの使用 |
| US8354557B2 (en) * | 2008-06-17 | 2013-01-15 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated morpholine derivatives |
| KR20160003647A (ko) | 2013-03-15 | 2016-01-11 | 에피자임, 인코포레이티드 | Carm1 억제제 및 이의 용도 |
| US9718816B2 (en) | 2013-03-15 | 2017-08-01 | Epizyme, Inc. | 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof |
| US9346802B2 (en) | 2013-03-15 | 2016-05-24 | Epizyme, Inc. | CARM1 inhibitors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3689652A (en) * | 1970-10-09 | 1972-09-05 | William Vincent Curran | Method of lowering blood pressure in mammals |
| GB1383906A (en) * | 1971-02-22 | 1974-02-12 | Bdh Pharmaceuticals Ltd | Pyridazinones |
-
1973
- 1973-12-19 GB GB58726/73A patent/GB1488330A/en not_active Expired
-
1974
- 1974-11-21 ZA ZA00747462A patent/ZA747462B/xx unknown
- 1974-11-27 CA CA214,774A patent/CA1033733A/en not_active Expired
- 1974-11-29 IL IL46158A patent/IL46158A/xx unknown
- 1974-11-29 IE IE2477/74A patent/IE40428B1/xx unknown
- 1974-12-05 DK DK634074AA patent/DK142870B/da unknown
- 1974-12-09 BE BE151287A patent/BE823103A/xx not_active IP Right Cessation
- 1974-12-11 FI FI3569/74A patent/FI356974A/fi unknown
- 1974-12-12 US US05/531,957 patent/US3931177A/en not_active Expired - Lifetime
- 1974-12-13 SE SE7415691A patent/SE413405B/sv unknown
- 1974-12-16 DE DE19742459468 patent/DE2459468A1/de not_active Ceased
- 1974-12-17 FR FR7441471A patent/FR2255070B1/fr not_active Expired
- 1974-12-17 CH CH7416775A patent/CH608794A5/xx not_active IP Right Cessation
- 1974-12-18 SU SU7402088301A patent/SU578872A3/ru active
- 1974-12-18 HU HUSI1445A patent/HU170633B/hu unknown
- 1974-12-18 JP JP49146279A patent/JPS5093984A/ja active Pending
- 1974-12-19 NL NL7416578A patent/NL7416578A/xx not_active Application Discontinuation
- 1974-12-19 ES ES433135A patent/ES433135A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE40428L (en) | 1975-06-19 |
| JPS5093984A (sv) | 1975-07-26 |
| HU170633B (sv) | 1977-07-28 |
| ES433135A1 (es) | 1976-11-16 |
| AU7572474A (en) | 1976-05-27 |
| SE7415691L (sv) | 1975-06-23 |
| DK142870C (sv) | 1981-09-21 |
| US3931177A (en) | 1976-01-06 |
| ZA747462B (en) | 1975-12-31 |
| CA1033733A (en) | 1978-06-27 |
| IL46158A (en) | 1978-08-31 |
| SU578872A3 (ru) | 1977-10-30 |
| FR2255070B1 (sv) | 1979-09-21 |
| FR2255070A1 (sv) | 1975-07-18 |
| SE413405B (sv) | 1980-05-27 |
| NL7416578A (nl) | 1975-06-23 |
| IE40428B1 (en) | 1979-05-23 |
| CH608794A5 (sv) | 1979-01-31 |
| GB1488330A (en) | 1977-10-12 |
| BE823103A (fr) | 1975-06-09 |
| FI356974A (sv) | 1975-06-20 |
| IL46158A0 (en) | 1975-02-10 |
| DK634074A (sv) | 1975-08-25 |
| DE2459468A1 (de) | 1975-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK142870B (da) | Analogifremgangsmåde til fremstilling af pyridazinonforbindelser. | |
| AU683224B2 (en) | Insecticidal N'-substituted-N,N'-diacylhydrazines | |
| El-Sakka et al. | Synthesis, antimicrobial activity and Electron Impactof Mass Spectra of Phthalazine-1, 4-dione Derivatives | |
| DK145099B (da) | Analogifremgangsmaade til fremstilling af pyridazinderivater | |
| Buckle et al. | Aryloxyalkyloxy-and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis | |
| DK149230B (da) | Analogifremgangsmaade til fremstilling af 5-benzoyl-6-hydroxy-indan-1-carboxylsyrederivater eller farmaceutisk acceptable salte deraf | |
| SU474134A3 (ru) | Способ получени замещенных оксикротоновых кислот | |
| Baranac-Stojanović et al. | Transformations of 2-alkylidene-4-oxothiazolidine vinyl bromides initiated by bromophilic attack of neutral and anionic nucleophiles | |
| DE69314649T2 (de) | Chinuclidine derivate als squalen synthase inhibitoren | |
| ES2400943T3 (es) | Proceso para la preparación de N-alquil-2(hidroxi-4-benzoil)-3-benzofuranos y compuestos intermedios de los mismos | |
| JP6256484B2 (ja) | ピリダジン化合物の製造方法 | |
| DK143133B (da) | Analogifremgangsmaade til fremstilling af dibenzofuranalkansyreforbindelser | |
| US3073826A (en) | 3-pyrrolidylmethyl-4-quinazolones | |
| DK156953B (da) | Fremgangsmaade til fremstilling af phenylglyoxylsyreestere | |
| US4154743A (en) | 3-Oxobenzofuranyl-2-idenyl, haloacetic acids | |
| US4894457A (en) | 7-bromo-beta-carboline compound and method for producing same | |
| HU180916B (hu) | Eljárás benzo[c]kinolin-származékok előállítására | |
| US4857645A (en) | Process for introducing a thiocarboxylic ester group at the orthoposition of phenols or phenylamines | |
| CA1247116A (en) | 7,8,9,10-tetrahydro-6-oxo-6h-dibenzo/b,d/pyranyloxy- propanes | |
| KR20040043176A (ko) | 5-치환 이소벤조퓨란의 제조 방법 | |
| US3296259A (en) | 3, 4-dihydro-4-hydroxy-2h-1, 3-benzoxazin-2-ones and a process for their preparation | |
| US2970152A (en) | Anilinobenzoquinone derivatives | |
| KR101620158B1 (ko) | 1-알킬-2-페닐-4-퀴놀론의 제조방법 | |
| US5142091A (en) | α, β-unsaturated ketones and ketoxime derivatives | |
| US3641045A (en) | Hydroxy-phenyl oxadiazoles |