IL46158A - 6-((3-alkylamino-2-hydroxypropoxyl)phenyl)-4, 5- dihydro -3-(2h) -pyridazinone derivatives,process for their preparation and paharmaceutical compositions containing them - Google Patents

6-((3-alkylamino-2-hydroxypropoxyl)phenyl)-4, 5- dihydro -3-(2h) -pyridazinone derivatives,process for their preparation and paharmaceutical compositions containing them

Info

Publication number
IL46158A
IL46158A IL46158A IL4615874A IL46158A IL 46158 A IL46158 A IL 46158A IL 46158 A IL46158 A IL 46158A IL 4615874 A IL4615874 A IL 4615874A IL 46158 A IL46158 A IL 46158A
Authority
IL
Israel
Prior art keywords
paharmaceutical
hydroxypropoxyl
alkylamino
dihydro
phenyl
Prior art date
Application number
IL46158A
Other languages
English (en)
Other versions
IL46158A0 (en
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of IL46158A0 publication Critical patent/IL46158A0/xx
Publication of IL46158A publication Critical patent/IL46158A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL46158A 1973-12-19 1974-11-29 6-((3-alkylamino-2-hydroxypropoxyl)phenyl)-4, 5- dihydro -3-(2h) -pyridazinone derivatives,process for their preparation and paharmaceutical compositions containing them IL46158A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB58726/73A GB1488330A (en) 1973-12-19 1973-12-19 Dihydropyridazinones

Publications (2)

Publication Number Publication Date
IL46158A0 IL46158A0 (en) 1975-02-10
IL46158A true IL46158A (en) 1978-08-31

Family

ID=10482281

Family Applications (1)

Application Number Title Priority Date Filing Date
IL46158A IL46158A (en) 1973-12-19 1974-11-29 6-((3-alkylamino-2-hydroxypropoxyl)phenyl)-4, 5- dihydro -3-(2h) -pyridazinone derivatives,process for their preparation and paharmaceutical compositions containing them

Country Status (18)

Country Link
US (1) US3931177A (sv)
JP (1) JPS5093984A (sv)
BE (1) BE823103A (sv)
CA (1) CA1033733A (sv)
CH (1) CH608794A5 (sv)
DE (1) DE2459468A1 (sv)
DK (1) DK142870B (sv)
ES (1) ES433135A1 (sv)
FI (1) FI356974A (sv)
FR (1) FR2255070B1 (sv)
GB (1) GB1488330A (sv)
HU (1) HU170633B (sv)
IE (1) IE40428B1 (sv)
IL (1) IL46158A (sv)
NL (1) NL7416578A (sv)
SE (1) SE413405B (sv)
SU (1) SU578872A3 (sv)
ZA (1) ZA747462B (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4111936A (en) * 1974-06-18 1978-09-05 Smith Kline & French Laboratories Limited Pyridazinethiones
US4082843A (en) * 1975-11-26 1978-04-04 Smith Kline & French Laboratories Limited 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents
CH624395A5 (sv) * 1976-01-08 1981-07-31 Ciba Geigy Ag
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
US4281125A (en) * 1980-05-15 1981-07-28 Diamond Shamrock Corporation Quinoline catalyzed synthesis of pyridazinone pharmaceutical intermediates
DE3048487A1 (de) * 1980-12-22 1982-07-29 Cassella Ag, 6000 Frankfurt Basisch substituierte pyridazine, ihre herstellung und ihre verwendung
ATE13294T1 (de) * 1981-03-04 1985-06-15 Ciba Geigy Ag Pyridazinone, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen und deren verwendung.
GB8323553D0 (en) * 1983-09-02 1983-10-05 Smith Kline French Lab Pharmaceutical compositions
JPS6193169A (ja) * 1984-10-12 1986-05-12 Sankyo Co Ltd ピリダジノン誘導体及びその製法
GB8426804D0 (en) * 1984-10-23 1984-11-28 Ciba Geigy Ag Pyridazinones preparations
JPH0629254B2 (ja) * 1986-09-08 1994-04-20 帝国臓器製薬株式会社 ピリダジノン誘導体
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
NZ530051A (en) 2001-06-12 2006-12-22 Wellstat Therapeutics Corp Polycyclic oxy-aromatic acid derivatives for the treatment of metabolic disorders
JP2006509790A (ja) * 2002-11-27 2006-03-23 アルテシアン セラピューティック，インコーポレイティド 心不全の治療のための混合されたＰＤＥ阻害およびβアドレナリン拮抗薬活性または部分的作用薬活性を有する化合物
CA2588949A1 (en) * 2004-11-30 2006-06-08 Artesian Therapeutics, Inc. Compounds with mixed pde-inhibitory and .beta.-adrenergic antagonist or partial agonist activity for treatment of heart failure
EP1833480A2 (en) * 2004-11-30 2007-09-19 Artesian Therapeutics, Inc. Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
WO2006127133A2 (en) 2005-04-01 2006-11-30 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP2492263A1 (en) 2006-07-25 2012-08-29 Cephalon, Inc. Pyridizinone Derivatives
BRPI0809498A2 (pt) * 2007-04-02 2014-09-23 Inst Oneworld Health Compostos inibidores de cftr e seus usos
WO2009154754A2 (en) * 2008-06-17 2009-12-23 Concert Pharmaceuticals, Inc. Synthesis of deuterated morpholine derivatives
US9346802B2 (en) 2013-03-15 2016-05-24 Epizyme, Inc. CARM1 inhibitors and uses thereof
EA201591532A1 (ru) 2013-03-15 2016-03-31 Эпизим, Инк. Ингибиторы carm1 и их применение
WO2014144455A1 (en) 2013-03-15 2014-09-18 Epizyme, Inc. 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3689652A (en) * 1970-10-09 1972-09-05 William Vincent Curran Method of lowering blood pressure in mammals
GB1383906A (en) * 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones

Also Published As

Publication number Publication date
US3931177A (en) 1976-01-06
SE413405B (sv) 1980-05-27
CH608794A5 (sv) 1979-01-31
JPS5093984A (sv) 1975-07-26
DK634074A (sv) 1975-08-25
FR2255070A1 (sv) 1975-07-18
CA1033733A (en) 1978-06-27
IL46158A0 (en) 1975-02-10
ZA747462B (en) 1975-12-31
IE40428B1 (en) 1979-05-23
DK142870B (da) 1981-02-16
HU170633B (sv) 1977-07-28
GB1488330A (en) 1977-10-12
NL7416578A (nl) 1975-06-23
SE7415691L (sv) 1975-06-23
IE40428L (en) 1975-06-19
SU578872A3 (ru) 1977-10-30
AU7572474A (en) 1976-05-27
FI356974A (sv) 1975-06-20
ES433135A1 (es) 1976-11-16
DE2459468A1 (de) 1975-07-03
FR2255070B1 (sv) 1979-09-21
BE823103A (fr) 1975-06-09
DK142870C (sv) 1981-09-21

Similar Documents

Publication Publication Date Title
IL46158A (en) 6-((3-alkylamino-2-hydroxypropoxyl)phenyl)-4, 5- dihydro -3-(2h) -pyridazinone derivatives,process for their preparation and paharmaceutical compositions containing them
IL46231A0 (en) 2-cyclohexen-1-one derivatives,their preparation and herbicidal compositions containing them
KE3000A (en) Herbicidally active heterocyclic phenyl ethers, process for their preparation and compositions containing them
IL48481A0 (en) New triazole derivatives,their production and compositions containing them
IL33410A0 (en) Novel 3-(3',5'-dihalogenophenyl)imidazolidine-2,4-dione derivatives,process for their preparation and microbiocidal compositions containing the same
EP0084250A3 (en) Novel 6-(substituted phenyl)-4,5-dihydro-3-(2h)-pyridazinone compounds and processes for their preparation
IL54816A (en) 3-(1-pyrazolyl)-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
YU1877A (en) Process for preparing 1,3,4-substituted pyrazoline derivatives
HU172568B (hu) Sposob poluchenija azinov i ikh tautomerov
IL48525A (en) Fungicidal compositions containing 1-phenoxy-1-triazolyl-3,3-dimethyl-butan-2-one(ol)derivatives and certain such novel compounds
IL66321A (en) 4-cyano-5-amino-n-phenyl pyrazole derivatives,process for their preparation and herbicidal compositions containing them
IL48524A (en) Fungicidal compositions containing certain 1-imidazol-1-yl-1-phenoxy-3,3-dimethylbutan-2-one(ol)derivatives
CA925509A (en) 5-methyldipyrazolo (3,4-b:3',4'-d) pyridin-3-(2h) -ones
DE3063196D1 (en) Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
PT75251B (en) Process for the preparation of 6-<3,6-dihydro-1(2h)-pyridyl>-pyrimidine-3-oxides
IL47345A0 (en) Novel s-triazine derivatives,their preparation and herbicidal compositions containing them
AU479912B2 (en) Substituted 4,5-dihydro-3(2h)-pyridazinones
PT65242B (en) Process for preparing 3,5-diphenyl-4(1h)-pyridazinones(thiones)
IL45167A0 (en) New substituted imidazo(1,2b)pyridazines,process for preparing them and insecticidal compositions
IL55466A (en) 6-methyl-8-(substituted phenyl)amino-ergoline derivatives,their production and pharamceutical compositions containing them
IL46667A0 (en) Novel herbicidal compositions containing certain pyridazone derivatives
PH15051A (en) Pyrimidine derivative,process for the preparation and compositions containing same
YU161270A (en) Process for preparing 1,2-diphenyl-3,5-dioxo-substituted pyrazolidines
AU460296B2 (en) l, 3-DIMETHYL-4, 5-DI(P-SUBSTITUTED PHENYL)-6H-PYRROLO (2, 3-c) PYRAZOLES
IL44840A0 (en) Novel halogenated triazines,process for the preparation thereof,insecticidal and herbicidal compositions containing the same