DK142802B - Fremgangsmåde til fremstilling af terapeutiske præparater til indføring i mavesækken. - Google Patents
Fremgangsmåde til fremstilling af terapeutiske præparater til indføring i mavesækken. Download PDFInfo
- Publication number
- DK142802B DK142802B DK97875AA DK97875A DK142802B DK 142802 B DK142802 B DK 142802B DK 97875A A DK97875A A DK 97875AA DK 97875 A DK97875 A DK 97875A DK 142802 B DK142802 B DK 142802B
- Authority
- DK
- Denmark
- Prior art keywords
- stomach
- parts
- coated
- preparation
- gastric juice
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title description 23
- 210000002784 stomach Anatomy 0.000 title description 22
- 238000002360 preparation method Methods 0.000 title description 15
- 230000001225 therapeutic effect Effects 0.000 title description 11
- 238000000034 method Methods 0.000 title description 10
- 239000004480 active ingredient Substances 0.000 description 17
- 210000004051 gastric juice Anatomy 0.000 description 17
- 239000011248 coating agent Substances 0.000 description 14
- 238000000576 coating method Methods 0.000 description 14
- 239000001856 Ethyl cellulose Substances 0.000 description 10
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 10
- 235000019325 ethyl cellulose Nutrition 0.000 description 10
- 229920001249 ethyl cellulose Polymers 0.000 description 10
- ZEEXVYNJSAWEML-UHFFFAOYSA-N 3-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]prop-2-enoic acid Chemical compound C1=CC(C)=CC=C1SC1=CC=C(C=CC(O)=O)C=C1[N+]([O-])=O ZEEXVYNJSAWEML-UHFFFAOYSA-N 0.000 description 9
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 9
- VVWYOYDLCMFIEM-UHFFFAOYSA-N Propantheline Chemical compound C1=CC=C2C(C(=O)OCC[N+](C)(C(C)C)C(C)C)C3=CC=CC=C3OC2=C1 VVWYOYDLCMFIEM-UHFFFAOYSA-N 0.000 description 9
- 229960001377 benactyzine hydrochloride Drugs 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 235000000346 sugar Nutrition 0.000 description 8
- 241000209094 Oryza Species 0.000 description 7
- 235000007164 Oryza sativa Nutrition 0.000 description 7
- 239000002775 capsule Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 235000009566 rice Nutrition 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 235000013339 cereals Nutrition 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 4
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 3
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 description 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 3
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 3
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 3
- 230000004962 physiological condition Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920006327 polystyrene foam Polymers 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 235000020374 simple syrup Nutrition 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 241001342895 Chorus Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 241000482268 Zea mays subsp. mays Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002467 anti-pepsin effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2767374A JPS5512411B2 (Direct) | 1974-03-12 | 1974-03-12 | |
| JP2767374 | 1974-03-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK97875A DK97875A (Direct) | 1975-09-13 |
| DK142802B true DK142802B (da) | 1981-02-02 |
| DK142802C DK142802C (Direct) | 1981-09-21 |
Family
ID=12227459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97875AA DK142802B (da) | 1974-03-12 | 1975-03-11 | Fremgangsmåde til fremstilling af terapeutiske præparater til indføring i mavesækken. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3976764A (Direct) |
| JP (1) | JPS5512411B2 (Direct) |
| BE (1) | BE826498A (Direct) |
| CA (1) | CA1054056A (Direct) |
| CH (1) | CH604719A5 (Direct) |
| DE (1) | DE2510620C2 (Direct) |
| DK (1) | DK142802B (Direct) |
| ES (1) | ES435500A1 (Direct) |
| FR (1) | FR2263744B1 (Direct) |
| GB (1) | GB1507521A (Direct) |
| NL (1) | NL7502952A (Direct) |
| SE (1) | SE409286B (Direct) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985003437A1 (en) * | 1984-02-10 | 1985-08-15 | A/S Alfred Benzon | Diffusion coated multiple-units dosage form |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630257A5 (en) * | 1975-03-17 | 1982-06-15 | Hoffmann La Roche | Sustained release formulation |
| US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
| US4167558A (en) * | 1976-02-13 | 1979-09-11 | Hoffmann-La Roche Inc. | Novel sustained release tablet formulations |
| US4207890A (en) * | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| JPS6024767B2 (ja) * | 1979-08-24 | 1985-06-14 | 塩野義製薬株式会社 | 腸溶性硬カプセル剤 |
| JPS58501128A (ja) * | 1981-07-15 | 1983-07-14 | キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド | 徐放性テオフイリン |
| US4451260A (en) * | 1982-03-26 | 1984-05-29 | Minnesota Mining And Manufacturing Company | Sustained release oral medicinal delivery device |
| JPS5953410A (ja) * | 1982-09-20 | 1984-03-28 | Fujisawa Pharmaceut Co Ltd | 新型ソフトカプセル剤 |
| JPS59193831A (ja) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
| US4505890A (en) * | 1983-06-30 | 1985-03-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation and method |
| SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
| US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| JPS61107782U (Direct) * | 1984-12-19 | 1986-07-08 | ||
| US4735804A (en) * | 1985-05-10 | 1988-04-05 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4767627A (en) * | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4758436A (en) * | 1985-05-29 | 1988-07-19 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4666705A (en) * | 1985-06-03 | 1987-05-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4756911A (en) * | 1986-04-16 | 1988-07-12 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4814178A (en) * | 1987-07-01 | 1989-03-21 | Sanford Bolton | Floating sustained release therapeutic compositions |
| DE3803482A1 (de) * | 1988-02-05 | 1989-08-17 | Lohmann Therapie Syst Lts | Schwimmfaehiges orales therapeutisches system |
| JPH082781B2 (ja) * | 1988-10-18 | 1996-01-17 | 嘉明 川島 | 中空顆粒状医薬及びその製法 |
| CA2085585A1 (en) * | 1990-06-25 | 1991-12-26 | George Torosian | Amantadine hydrochloride suspension with enhanced dissolution characteristics for use in soft gelatin capsules |
| US5232704A (en) * | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
| US5198229A (en) * | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
| US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
| DE4406424A1 (de) * | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| JP2671257B2 (ja) * | 1995-07-13 | 1997-10-29 | エーザイ株式会社 | 溶解遅延性ゼラチン製剤組成物 |
| SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
| IN186245B (Direct) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| ID26082A (id) | 1998-03-19 | 2000-11-23 | Briston Myers Squib Company | Sistem pengiriman lepas terkendali dwifasa untuk zat-zat farmasi kelarutan tinggi dan metodenya |
| EP1245227A1 (en) * | 2001-03-31 | 2002-10-02 | Jagotec Ag | A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same |
| US20030203027A1 (en) * | 2002-04-26 | 2003-10-30 | Ethicon, Inc. | Coating technique for deposition of drug substance on a substrate |
| US20040086566A1 (en) * | 2002-11-04 | 2004-05-06 | Alpharma, Inc. | Waxy matrix dosage forms |
| US7485322B2 (en) * | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
| PL213804B1 (pl) * | 2003-02-21 | 2013-05-31 | Lek Pharmaceuticals | Uklad terapeutyczny do podawania amoksycyliny i kwasu klawulanowego, oraz kapsulka unoszaca sie na powierzchni cieczy |
| WO2005046655A1 (en) * | 2003-11-04 | 2005-05-26 | Shire Laboratories, Inc. | Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms |
| KR20090065524A (ko) * | 2006-09-04 | 2009-06-22 | 파나세아 바이오테크 리미티드 | 프로그래머블 부력전달기술 |
| WO2009087665A2 (en) * | 2007-12-11 | 2009-07-16 | Vishwanath Sudhir Nande | Novel gastroretentive drug delivery system |
| GB2460915B (en) * | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
| EP2329810A4 (en) * | 2008-08-18 | 2012-09-19 | Team Academy Of Pharmaceutical Science | DRUG DISPENSING SYSTEM WITH MAGNETIC RETENTION, MANUFACTURING PROCESS AND APPLICATION |
| FR2945947B1 (fr) | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Compositions pharmaceutiques flottantes a liberation controlee |
| FR2945945B1 (fr) * | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Procede de preparation de particules creuses et leurs applications |
| CA2767143A1 (en) * | 2009-07-06 | 2011-01-13 | Kyorin Pharmaceutical Co., Ltd. | Tablet having hollow structure |
| US9314430B2 (en) * | 2010-07-05 | 2016-04-19 | Jagotec Ag | Floating gastric retentive dosage form |
| WO2013009186A1 (en) * | 2011-07-14 | 2013-01-17 | APET Holding B.V. | Nicotinamide compositions and the therapeutic use thereof |
| AU2012322323B2 (en) | 2011-10-11 | 2016-04-21 | Sun Pharmaceutical Industries Limited | A gastroretentive dosage system and process of preparation thereof |
| MX2015000760A (es) * | 2012-07-16 | 2015-09-10 | Apet Holding B V | Sistema de suministro de farmaco gastro - retentivo. |
| RS54024B1 (sr) | 2012-10-12 | 2015-10-30 | Omya International Ag | Gastroretenciona formulacija leka i sistemi za dostavu i metodi njihovog pripremanja korišćenjem funkcionalizovanog kalcijum-karbonata |
| US10413507B2 (en) | 2014-06-11 | 2019-09-17 | Massachusetts Institute Of Technology | Enteric elastomers |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| EP3034070A1 (en) | 2014-12-18 | 2016-06-22 | Omya International AG | Method for the production of a pharmaceutical delivery system |
| CN104706613B (zh) * | 2015-03-20 | 2018-01-16 | 华侨大学 | 一种胃漂浮空心缓释片的制备方法 |
| EP3069713A1 (en) | 2015-03-20 | 2016-09-21 | Omya International AG | Dispersible dosage form |
| US10953208B2 (en) | 2015-05-01 | 2021-03-23 | Massachusetts Institute Of Technology | Triggerable shape memory induction devices |
| CA3002916C (en) | 2015-10-23 | 2024-06-11 | Lyndra, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
| KR102796240B1 (ko) | 2015-12-08 | 2025-04-16 | 린드라 테라퓨틱스 인코퍼레이티드 | 위 체류 시스템을 위한 기하 구성형태 |
| EP3429556A1 (en) * | 2016-03-18 | 2019-01-23 | Grünenthal GmbH | Floating pharmaceutical dosage form |
| AU2017268840B2 (en) | 2016-05-27 | 2022-02-10 | Nortiva Bio, Inc. | Materials architecture for gastric residence systems |
| EP3269361A1 (en) | 2016-07-14 | 2018-01-17 | Omya International AG | Dosage form |
| US11576866B2 (en) | 2016-09-30 | 2023-02-14 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| WO2018227147A1 (en) | 2017-06-09 | 2018-12-13 | Lyndra, Inc. | Gastric residence systems with release rate-modulating films |
| JP7624750B2 (ja) * | 2020-03-02 | 2025-01-31 | クラフト ヘルス プライベート リミテッド | 持続的薬物放出のための経口剤形 |
| ES2955784T3 (es) * | 2020-10-14 | 2023-12-07 | Hannes Bichsel | Granos biogranulados espumados |
| WO2023166225A1 (en) * | 2022-03-04 | 2023-09-07 | APET Holding B.V. | Digestive enzyme formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3418999A (en) * | 1964-02-12 | 1968-12-31 | Donald W. Davis | Method of swallowing a pill |
| FR1454013A (fr) * | 1965-08-18 | 1966-07-22 | Pluripharm | Mode de présentation de deux médicaments associés |
| US3870790A (en) * | 1970-01-22 | 1975-03-11 | Forest Laboratories | Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose |
-
1974
- 1974-03-12 JP JP2767374A patent/JPS5512411B2/ja not_active Expired
-
1975
- 1975-03-10 FR FR7507336A patent/FR2263744B1/fr not_active Expired
- 1975-03-10 BE BE154189A patent/BE826498A/xx not_active IP Right Cessation
- 1975-03-11 ES ES435500A patent/ES435500A1/es not_active Expired
- 1975-03-11 DE DE2510620A patent/DE2510620C2/de not_active Expired
- 1975-03-11 US US05/557,408 patent/US3976764A/en not_active Expired - Lifetime
- 1975-03-11 DK DK97875AA patent/DK142802B/da not_active IP Right Cessation
- 1975-03-11 SE SE7502725A patent/SE409286B/xx not_active IP Right Cessation
- 1975-03-12 GB GB10214/75A patent/GB1507521A/en not_active Expired
- 1975-03-12 CH CH315475A patent/CH604719A5/xx not_active IP Right Cessation
- 1975-03-12 NL NL7502952A patent/NL7502952A/xx not_active Application Discontinuation
- 1975-03-12 CA CA221,903A patent/CA1054056A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985003437A1 (en) * | 1984-02-10 | 1985-08-15 | A/S Alfred Benzon | Diffusion coated multiple-units dosage form |
Also Published As
| Publication number | Publication date |
|---|---|
| DK142802C (Direct) | 1981-09-21 |
| ES435500A1 (es) | 1977-02-01 |
| JPS5512411B2 (Direct) | 1980-04-02 |
| DE2510620C2 (de) | 1984-01-05 |
| NL7502952A (nl) | 1975-09-16 |
| SE409286B (sv) | 1979-08-13 |
| US3976764A (en) | 1976-08-24 |
| GB1507521A (en) | 1978-04-19 |
| FR2263744A1 (Direct) | 1975-10-10 |
| CA1054056A (en) | 1979-05-08 |
| JPS50121418A (Direct) | 1975-09-23 |
| FR2263744B1 (Direct) | 1978-11-24 |
| BE826498A (fr) | 1975-06-30 |
| SE7502725L (Direct) | 1975-09-15 |
| DE2510620A1 (de) | 1975-09-18 |
| CH604719A5 (Direct) | 1978-09-15 |
| DK97875A (Direct) | 1975-09-13 |
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