DK141726B - Fremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)-benzodiazepinderivater. - Google Patents

Fremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)-benzodiazepinderivater. Download PDF

Info

Publication number
DK141726B
DK141726B DK520370A DK520370A DK141726B DK 141726 B DK141726 B DK 141726B DK 520370 A DK520370 A DK 520370A DK 520370 A DK520370 A DK 520370A DK 141726 B DK141726 B DK 141726B
Authority
DK
Denmark
Prior art keywords
parts
benzodiazepine
phenyl
chloro
weight
Prior art date
Application number
DK520370A
Other languages
Danish (da)
English (en)
Other versions
DK141726C (xx
Inventor
Kanji Meguro
Yutaka Kuwada
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK141726B publication Critical patent/DK141726B/da
Application granted granted Critical
Publication of DK141726C publication Critical patent/DK141726C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK520370A 1969-10-23 1970-10-14 Fremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)-benzodiazepinderivater. DK141726B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8487069A JPS4927880B1 (xx) 1969-10-23 1969-10-23
JP8487069 1969-10-23

Publications (2)

Publication Number Publication Date
DK141726B true DK141726B (da) 1980-06-02
DK141726C DK141726C (xx) 1980-10-27

Family

ID=13842822

Family Applications (1)

Application Number Title Priority Date Filing Date
DK520370A DK141726B (da) 1969-10-23 1970-10-14 Fremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)-benzodiazepinderivater.

Country Status (9)

Country Link
JP (1) JPS4927880B1 (xx)
AT (1) AT299958B (xx)
CH (1) CH550810A (xx)
DK (1) DK141726B (xx)
ES (2) ES384814A1 (xx)
FI (1) FI51699C (xx)
NL (1) NL7015430A (xx)
SE (1) SE383348B (xx)
YU (1) YU34881B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879406A (en) * 1972-07-13 1975-04-22 Hoffmann La Roche Preparation of triazolobenzodiazepines
US4155913A (en) * 1973-02-08 1979-05-22 Hoffmann-La Roche Inc. Thienotriazolodiazepine derivatives

Also Published As

Publication number Publication date
ES413244A1 (es) 1976-01-01
AT299958B (de) 1972-07-10
YU34881B (en) 1980-04-30
CH550810A (de) 1974-06-28
ES384814A1 (es) 1973-09-01
SE383348B (sv) 1976-03-08
JPS4927880B1 (xx) 1974-07-22
FI51699C (fi) 1977-03-10
DK141726C (xx) 1980-10-27
FI51699B (xx) 1976-11-30
NL7015430A (xx) 1971-04-27
YU257470A (en) 1979-10-31

Similar Documents

Publication Publication Date Title
US3407211A (en) Acylaminophenyl heterocyclic ketones
SE449098B (sv) Fenyl-/2-(5-hydroxi-1-imidazolyl)fenyl/-metanonderivat till anvendning som mellanprodukter for framstellning av imidazo/1,5-a//1,4/bensodiazepinderivat
Garratt et al. One-carbon compounds as synthetic intermediates. The synthesis of hydropyrimidines and hydroquinazolines by sequential nucleophilic addition to diphenyl cyanocarbonimidate with concomitant cyclization
JP2002037787A (ja) ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法
DK152732B (da) Fremgangsmaade til fremstilling af imidazodiazepinderivater
NO126325B (xx)
DK141726B (da) Fremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)-benzodiazepinderivater.
US3249610A (en) Synthesis of 3-amino, 5-chloro, 6-substituted-pyrazinoates
Chaouni et al. Synthesis of Methyl 3-Azidothieno [2, 3-b] pyridine-2-carboxylates and Application of the Huisgen Reaction
US3297698A (en) Process for the preparation of quinazoline 3-oxides
SU468423A3 (ru) Способ получени 6-аза-3н-1,4-бензодиазепинов
DK156391B (da) Analogifremgangsmaade til fremstilling af 3-aminopyrrolderivater
AU2013280925A1 (en) Production of N-substituted sulfoximine pyridine N-oxides
SU419034A3 (ru) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ХИНАЗОЛИНА1Изобретение относитс к способу получени новых производных хиназолина, которые обладают улучшенными лекарственными свойствами и могут найти нрименение в фармацевтической промышленности.Предлагаетс основанный на известной реакции алкилировани хиназолннов способ получени производных хиназолина общей формулы ICnH,n--R.Примером галоида в формуле I могут служить атомы хлора, брома, фтора и йода; Ci—С4-алкилов — метил, этил, н-пропил, изо- пропил, н-бутил, изобутил и т/?ет-бутил; 5 Ci—С4-алкоксильных групп — метокси-, эток- СИ-, н-пропокси-, изопронокси-, н-бутокси-, изо- бутокси- и грег-бутоксигруппы; Сз—Се-цикло- алкилов — циклопропил, циклобутил, цикло- пентил, циклогексил, метилциклопропил, ди- 10 метилциклопронил и т. п. группы. Когда СпН2п группа — алкилен с 1—3 атомами углерода, она может быть представлена такими группами, как метиленова , этиленова , 1-метилэти- ленова , 2-метилэтиленова и триметиленова .где D — группаСпособ получени соединений формулы 1 заключаетс в том, что 1-незамеш,енное производное хиназолина общей формулы П15Нг; , :- ;-О "^ О ."^ -'.RI, R2 и Rs каждый — водород, галоид, нит- рогруппа, Ci—С4-алкил, Ci—Сгалкоксил, С\—С4-алкилтиогруП'Па, Ci—С^алкилсульфо- группа, Ci—С4-алкилсульфинильна группа, грифторметил;R4 — Сз—Сб-циклоалг-'ил;W — кислород или сера;п — О или целое число от 1 до 3.2025где RI, Ra, D и W имеют вышеуказанные зна- 30 чени .
NO165419B (no) Innretning for laasing og frigjoering av gjenstander beregnet for offentlig bruk, saasom bagasjetraller.
DK145892B (da) Fremgangsmaade til fremstilling af pyrazinamidderivater
SE455502B (sv) Forfarande for deacylering av 1-acyl-2-imidazolin
JPS5953479A (ja) ピリダジノン誘導体
US3632816A (en) 6-chloroimidazo(2 1-b)thiazole and its 5-substituted derivatives
Decicco et al. The synthesis of pyrimidineisothiazolones. The effect of temperature on the addition of aryl amines to functionalized pyrimidines.
SU439986A1 (ru) Сособ получени производных тиепина
NO133895B (xx)
SU417946A3 (xx)
SU312419A1 (ru) Способ получения производных хиназолинона-2
JPS6023116B2 (ja) ジアゼピン化合物の製造方法

Legal Events

Date Code Title Description
PUP Patent expired