DK141624B - Analogifremgangsmåde til fremstilling af morphinanderivater. - Google Patents

Analogifremgangsmåde til fremstilling af morphinanderivater. Download PDF

Info

Publication number
DK141624B
DK141624B DK440172AA DK440172A DK141624B DK 141624 B DK141624 B DK 141624B DK 440172A A DK440172A A DK 440172AA DK 440172 A DK440172 A DK 440172A DK 141624 B DK141624 B DK 141624B
Authority
DK
Denmark
Prior art keywords
compound
formula
give
methanol
ether
Prior art date
Application number
DK440172AA
Other languages
Danish (da)
English (en)
Other versions
DK141624C (sv
Inventor
Irwin J Pachter
Bernard R Belleau
Ivo Monkovic
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to DK329977A priority Critical patent/DK142620B/da
Publication of DK141624B publication Critical patent/DK141624B/da
Application granted granted Critical
Publication of DK141624C publication Critical patent/DK141624C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK440172AA 1971-09-08 1972-09-06 Analogifremgangsmåde til fremstilling af morphinanderivater. DK141624B (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK329977A DK142620B (da) 1971-09-08 1977-07-20 Fremgangsmåde til fremstilling af morphinanderivater.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17883771A 1971-09-08 1971-09-08
US17883771 1971-09-08
US00217633A US3819635A (en) 1971-09-08 1972-01-13 14-hydroxymorphinan derivatives
US21763372 1972-01-13

Publications (2)

Publication Number Publication Date
DK141624B true DK141624B (da) 1980-05-12
DK141624C DK141624C (sv) 1980-10-13

Family

ID=26874723

Family Applications (1)

Application Number Title Priority Date Filing Date
DK440172AA DK141624B (da) 1971-09-08 1972-09-06 Analogifremgangsmåde til fremstilling af morphinanderivater.

Country Status (19)

Country Link
US (1) US3819635A (sv)
JP (1) JPS5310596B2 (sv)
AU (1) AU470102B2 (sv)
BE (1) BE788478A (sv)
CA (1) CA999578A (sv)
CH (1) CH590845A5 (sv)
CY (1) CY980A (sv)
DD (1) DD100255A5 (sv)
DE (3) DE2243961A1 (sv)
DK (1) DK141624B (sv)
FR (1) FR2154481B1 (sv)
GB (2) GB1412130A (sv)
HK (1) HK2679A (sv)
IE (2) IE36687B1 (sv)
KE (1) KE2911A (sv)
MY (1) MY7900027A (sv)
NL (1) NL162072C (sv)
SE (2) SE398877B (sv)
YU (1) YU45099B (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
JPS52136176A (en) * 1976-03-23 1977-11-14 Bristol Myers Co Method of improving 144hydroxymorphinan derivatives
US4058531A (en) * 1976-03-23 1977-11-15 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4338320A (en) * 1978-11-15 1982-07-06 The Board Of Regents Of The University Of Nebraska Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them
US4228285A (en) * 1979-02-28 1980-10-14 Bristol-Myers Company 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
JP3948026B2 (ja) * 1993-07-19 2007-07-25 東レ株式会社 脳細胞保護剤
AU686203B2 (en) * 1993-07-23 1998-02-05 Toray Industries, Inc. Morphinan derivative and medicinal use
CZ281174B6 (cs) * 1993-08-13 1996-07-17 Galena, A.S. Způsob přípravy 3,14ß-dihydroxy-17-normorfinanu
ATE265846T1 (de) 1998-02-25 2004-05-15 Abbott Lab Butorphanol enthaltende formulierungen mit verzögerter freisetzung
US20040167164A1 (en) * 1998-05-05 2004-08-26 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
CN1653050B (zh) 2002-05-17 2013-04-24 詹肯生物科学公司 阿片和阿片样化合物及其用途
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103073496B (zh) * 2013-02-18 2015-08-26 苏州立新制药有限公司 右美沙芬的制备方法
EP3207923B1 (en) 2014-10-14 2019-09-04 Hisamitsu Pharmaceutical Co., Inc. Adhesive patch

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166559A (en) * 1965-01-19 J-lower alkoxy-x-phenyloxy-ix-hydroxy-
GB1028407A (en) * 1962-04-06 1966-05-04 Shionogi & Co Improvements in or relating to morphinan derivatives and their preparation
FR1362540A (fr) * 1963-04-05 1964-06-05 Shionogi & Co Dérivés n substitués du morphinane et leur production

Also Published As

Publication number Publication date
CH590845A5 (sv) 1977-08-31
SE398877B (sv) 1978-01-23
NL162072B (nl) 1979-11-15
SE7506292L (sv) 1975-06-02
IE36688B1 (en) 1977-02-02
DE2265256A1 (de) 1977-01-27
DE2265256C2 (de) 1985-10-24
JPS5310596B2 (sv) 1978-04-14
DE2265255A1 (de) 1977-01-27
GB1412129A (en) 1975-10-29
CY980A (en) 1979-03-23
IE36687L (en) 1973-03-08
HK2679A (en) 1979-01-19
DK141624C (sv) 1980-10-13
IE36687B1 (en) 1977-02-02
FR2154481B1 (sv) 1976-04-23
KE2911A (en) 1979-01-26
FR2154481A1 (sv) 1973-05-11
BE788478A (fr) 1973-03-06
NL162072C (nl) 1980-04-15
DD100255A5 (sv) 1973-09-12
DE2265255C2 (de) 1986-06-05
AU470102B2 (en) 1976-03-04
DE2243961C2 (sv) 1988-07-21
DE2243961A1 (de) 1973-04-05
AU4622872A (en) 1974-03-07
US3819635A (en) 1974-06-25
YU227772A (en) 1982-02-28
NL7212176A (sv) 1973-03-12
JPS4834864A (sv) 1973-05-22
SE403286B (sv) 1978-08-07
YU45099B (sh) 1992-07-20
CA999578A (en) 1976-11-09
GB1412130A (en) 1975-10-29
MY7900027A (en) 1979-12-31

Similar Documents

Publication Publication Date Title
DK141624B (da) Analogifremgangsmåde til fremstilling af morphinanderivater.
US7476679B2 (en) Octahydroisoquinoline compounds as opioid receptor modulators
JPS5936675A (ja) 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
US3272707A (en) Pharmaceutical compositions and methods for their use
US3639407A (en) Novel 1 2 3 4 5 6-hexahydro-6-phenyl-2 6-methano-3-benzazocines
US4797488A (en) Psychotropic polycyclic imides
US3775414A (en) Process for the preparation of 14-hydroxymorphinan derivatives
DE2311570A1 (de) 4-aminochinoline, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
US3247208A (en) Piperidyl-naphthalene-1:8-dicarboxylic acid imides
JPS62240665A (ja) 新規化合物、その製造方法及びそれを含む医薬組成物
DK144094B (da) Analogifremgangsmaade til fremstilling af n-substituerede 3-hydroxy-8-oxamorphianer eller syreadditionssalte deraf
DE1620198A1 (de) Heterozyklische Verbindungen
US2999091A (en) 3,9-diazabicyclo[4.2.1]nonane derivatives
US3267107A (en) 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines
US3823150A (en) 2-(furfuryl-methyl)-6,7-benzomorphans and acid addition salts thereof
IE42978B1 (en) Triaryl alkyl azabicyclo compounds
AU622911B2 (en) Novel benzazepine derivatives
US3225031A (en) Phenyl-benzazepines and methods for their manufacture
US4243808A (en) 4-Pyridinamine derivatives
WO1990001025A1 (en) Enamine quaternary compounds, methods of making and their use as muscle relaxants
FI76075B (fi) Foerfarande foer framstaellning av farmaceutiskt vaerdefulla bensazepinderivat.
US4232160A (en) Isoquinoline propionamides exhibiting analgesic properties
Huckle et al. 4-Amino-2, 3, 4, 5-tetrahydro-1-benzoxepin-5-ols, 4-amino-2, 3, 4, 5-tetrahydro-1-benzothiepin-5-ols, and related compounds
IL41562A (en) History of morphine, their manufacture and the pharmaceutical preparations containing them
JPS5919096B2 (ja) ベンゾモルフィナン誘導体の製造法

Legal Events

Date Code Title Description
PUP Patent expired