DK1367062T3 - Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf - Google Patents
Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte herafInfo
- Publication number
- DK1367062T3 DK1367062T3 DK03291930T DK03291930T DK1367062T3 DK 1367062 T3 DK1367062 T3 DK 1367062T3 DK 03291930 T DK03291930 T DK 03291930T DK 03291930 T DK03291930 T DK 03291930T DK 1367062 T3 DK1367062 T3 DK 1367062T3
- Authority
- DK
- Denmark
- Prior art keywords
- perindopril
- synthesis
- pharmaceutically acceptable
- acceptable salts
- new method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291930A EP1367062B1 (fr) | 2003-07-31 | 2003-07-31 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1367062T3 true DK1367062T3 (da) | 2007-01-02 |
Family
ID=29414889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03291930T DK1367062T3 (da) | 2003-07-31 | 2003-07-31 | Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7368580B2 (xx) |
| EP (1) | EP1367062B1 (xx) |
| JP (1) | JP4263744B2 (xx) |
| CN (1) | CN100439392C (xx) |
| AR (1) | AR045150A1 (xx) |
| AT (1) | ATE338058T1 (xx) |
| AU (1) | AU2004261440B2 (xx) |
| CY (1) | CY1105789T1 (xx) |
| DE (1) | DE60307925T2 (xx) |
| DK (1) | DK1367062T3 (xx) |
| EA (1) | EA008644B1 (xx) |
| ES (1) | ES2271497T3 (xx) |
| HK (1) | HK1096407A1 (xx) |
| MY (1) | MY139098A (xx) |
| NZ (1) | NZ544880A (xx) |
| PL (1) | PL211802B1 (xx) |
| PT (1) | PT1367062E (xx) |
| SI (1) | SI1367062T1 (xx) |
| WO (1) | WO2005012328A2 (xx) |
| ZA (1) | ZA200600480B (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8604144A1 (es) * | 1984-11-21 | 1986-01-16 | Farmhispania | Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| DK1321471T3 (da) * | 2003-03-12 | 2005-08-29 | Servier Lab | Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf |
| SI1319668T1 (en) * | 2003-03-12 | 2005-02-28 | Les Laboratoires Servier | Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril |
-
2003
- 2003-07-31 AT AT03291930T patent/ATE338058T1/de active
- 2003-07-31 ES ES03291930T patent/ES2271497T3/es not_active Expired - Lifetime
- 2003-07-31 PT PT03291930T patent/PT1367062E/pt unknown
- 2003-07-31 DE DE60307925T patent/DE60307925T2/de not_active Expired - Lifetime
- 2003-07-31 EP EP03291930A patent/EP1367062B1/fr not_active Expired - Lifetime
- 2003-07-31 SI SI200330449T patent/SI1367062T1/sl unknown
- 2003-07-31 DK DK03291930T patent/DK1367062T3/da active
-
2004
- 2004-07-29 ZA ZA200600480A patent/ZA200600480B/en unknown
- 2004-07-29 WO PCT/FR2004/002036 patent/WO2005012328A2/fr active Application Filing
- 2004-07-29 PL PL379625A patent/PL211802B1/pl unknown
- 2004-07-29 AU AU2004261440A patent/AU2004261440B2/en not_active Ceased
- 2004-07-29 MY MYPI20043052A patent/MY139098A/en unknown
- 2004-07-29 JP JP2006521622A patent/JP4263744B2/ja not_active Expired - Fee Related
- 2004-07-29 CN CNB2004800212086A patent/CN100439392C/zh not_active Expired - Fee Related
- 2004-07-29 NZ NZ544880A patent/NZ544880A/en not_active IP Right Cessation
- 2004-07-29 EA EA200600249A patent/EA008644B1/ru not_active IP Right Cessation
- 2004-07-29 AR ARP040102692A patent/AR045150A1/es not_active Application Discontinuation
- 2004-07-29 US US10/566,558 patent/US7368580B2/en not_active Expired - Fee Related
-
2006
- 2006-11-16 CY CY20061101671T patent/CY1105789T1/el unknown
-
2007
- 2007-02-01 HK HK07101183.8A patent/HK1096407A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CY1105789T1 (el) | 2011-02-02 |
| CN1826351A (zh) | 2006-08-30 |
| PL379625A1 (pl) | 2006-10-30 |
| DE60307925T2 (de) | 2007-05-24 |
| EP1367062A1 (fr) | 2003-12-03 |
| MY139098A (en) | 2009-08-28 |
| NZ544880A (en) | 2009-03-31 |
| EP1367062B1 (fr) | 2006-08-30 |
| JP4263744B2 (ja) | 2009-05-13 |
| ZA200600480B (en) | 2007-05-30 |
| SI1367062T1 (sl) | 2006-12-31 |
| HK1096407A1 (en) | 2007-06-01 |
| EA200600249A1 (ru) | 2006-06-30 |
| AR045150A1 (es) | 2005-10-19 |
| WO2005012328A3 (fr) | 2005-03-24 |
| AU2004261440B2 (en) | 2008-07-31 |
| US7368580B2 (en) | 2008-05-06 |
| DE60307925D1 (de) | 2006-10-12 |
| JP2006528653A (ja) | 2006-12-21 |
| PT1367062E (pt) | 2006-12-29 |
| EA008644B1 (ru) | 2007-06-29 |
| PL211802B1 (pl) | 2012-06-29 |
| WO2005012328A2 (fr) | 2005-02-10 |
| ATE338058T1 (de) | 2006-09-15 |
| ES2271497T3 (es) | 2007-04-16 |
| AU2004261440A1 (en) | 2005-02-10 |
| CN100439392C (zh) | 2008-12-03 |
| US20060189813A1 (en) | 2006-08-24 |
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