DK1344829T3 - Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf - Google Patents

Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf

Info

Publication number
DK1344829T3
DK1344829T3 DK01997561T DK01997561T DK1344829T3 DK 1344829 T3 DK1344829 T3 DK 1344829T3 DK 01997561 T DK01997561 T DK 01997561T DK 01997561 T DK01997561 T DK 01997561T DK 1344829 T3 DK1344829 T3 DK 1344829T3
Authority
DK
Denmark
Prior art keywords
fgf2
growth factor
fibroblast growth
vector encoding
paramyxovirus vector
Prior art date
Application number
DK01997561T
Other languages
Danish (da)
English (en)
Inventor
Yoshikazu Yonemitsu
Katsuo Sueishi
Masayuki Fukumura
Xiaogang Hou
Mamoru Hasegawa
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Application granted granted Critical
Publication of DK1344829T3 publication Critical patent/DK1344829T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01997561T 2000-11-27 2001-11-27 Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf DK1344829T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000359374 2000-11-27
PCT/JP2001/010323 WO2002042481A1 (fr) 2000-11-27 2001-11-27 Vecteur paramyxovirus codant pour un gene d'angiogenese et son utilisation

Publications (1)

Publication Number Publication Date
DK1344829T3 true DK1344829T3 (da) 2008-09-01

Family

ID=18831146

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01997561T DK1344829T3 (da) 2000-11-27 2001-11-27 Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf

Country Status (12)

Country Link
US (3) US20040005296A1 (zh)
EP (1) EP1344829B1 (zh)
JP (1) JP4212357B2 (zh)
KR (1) KR100812884B1 (zh)
CN (1) CN100357443C (zh)
AT (1) ATE393235T1 (zh)
AU (1) AU2002224113A1 (zh)
CA (1) CA2430112C (zh)
DE (1) DE60133767T2 (zh)
DK (1) DK1344829T3 (zh)
ES (1) ES2305138T3 (zh)
WO (1) WO2002042481A1 (zh)

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WO1997016539A1 (fr) * 1995-11-01 1997-05-09 Dnavec Research Inc. Virus sendai recombinant
CA2336472C (en) * 1998-07-03 2010-08-31 Dnavec Research Inc. Negative-sense rna virus vector for nerve cell
US6490775B1 (en) * 1999-04-23 2002-12-10 Veri-Tek Inc. Press operation verification system
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
CA2376106A1 (en) * 1999-09-06 2001-03-15 Dnavec Research Inc. Paramyxoviruses comprising modified transcription start sequence
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
CN1248740C (zh) 2000-03-30 2006-04-05 株式会社载体研究所 使用仙台病毒载体的aids病毒疫苗
CN100531802C (zh) * 2000-06-01 2009-08-26 株式会社载体研究所 含有血凝素活性膜蛋白质的假型逆转录病毒载体
CA2414077A1 (en) * 2000-06-27 2002-01-03 Dnavec Research Inc. Virus vector for introducing gene into renal cells
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
CA2430112C (en) * 2000-11-27 2010-07-27 Dnavec Research Inc. Paramyxovirus vector encoding angiogenesis gene and use thereof
JPWO2003092738A1 (ja) * 2002-04-30 2005-09-08 株式会社ディナベック研究所 ヘマグルチニン活性を低下させた薬剤または遺伝子運搬組成物
WO2004022731A1 (ja) * 2002-09-04 2004-03-18 Dnavec Research Inc. シアル酸結合活性を有する膜蛋白質をエンベロープに含むウイルスベクターをグラム陽性菌由来ノイラミニダーゼを用いて製造する方法
JPWO2004038029A1 (ja) * 2002-10-24 2006-02-23 株式会社ディナベック研究所 Ｔ細胞に遺伝子を導入する方法
DE602004025810D1 (de) * 2003-06-30 2010-04-15 Dnavec Research Inc Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen
DE10333217A1 (de) * 2003-07-22 2005-03-10 Biomay Prod & Handel Polypeptide, hierfür kodierende Nucleinsäuren aus dem Schimmelpilz Cladosporium herbarum sowie deren Herstellung und Verwendung in Diagnostik und Therapie
CA2554198A1 (en) * 2004-01-22 2005-08-04 Dnavec Research Inc. Process for producing virus vector
WO2005097988A1 (ja) * 2004-03-23 2005-10-20 Dnavec Research Inc. 組織の維持および／または修復に関連する骨髄関連細胞
CA2627485C (en) 2005-10-28 2017-02-21 Katsuyuki Mitomo Gene transfer into airway epithelial stem cell by using lentiviral vector pseudotyped with rna virus or dna virus spike protein
KR101336386B1 (ko) * 2011-06-17 2013-12-04 전북대학교병원 림프관 생성 유도제
EP3782628B1 (en) 2013-03-15 2024-08-07 Elixirgen Therapeutics, Inc. Methods of using zscan4 for rejuvenating human cells
MY187966A (en) * 2013-04-26 2021-11-02 Genomatica Inc Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
US20160312261A1 (en) * 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
WO2021174121A1 (en) * 2020-02-27 2021-09-02 Icahn School Of Medicine At Mount Sinai Vegfr-3-activating agents and oncolytic viruses and uses thereof for the treatment of cancer

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US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
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IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
FR2717495B1 (fr) * 1994-03-18 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
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WO1997016539A1 (fr) 1995-11-01 1997-05-09 Dnavec Research Inc. Virus sendai recombinant
US6274712B1 (en) * 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
EP1179594B1 (en) 1999-05-18 2008-06-25 Dnavec Research Inc. Ribonucleoprotein complex in paramyxovirus
KR100739938B1 (ko) 1999-05-18 2007-07-16 가부시키가이샤 디나벡크 겐큐쇼 엔벨로프 유전자 결손 파라믹소과 바이러스 벡터
US20030022376A1 (en) 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US20020169306A1 (en) 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
US20030166252A1 (en) 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US7226786B2 (en) 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US7314614B1 (en) * 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
CA2389743C (en) 1999-11-02 2010-02-23 Dnavec Research Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
SE0000285D0 (sv) * 1999-12-07 2000-01-31 Mika Lahtinen Medical implant
CA2397903A1 (en) 2000-01-19 2001-07-26 Dnavec Research Inc. Use of paramyxovirus vector for gene transfer into blood vessel
CN100531802C (zh) 2000-06-01 2009-08-26 株式会社载体研究所 含有血凝素活性膜蛋白质的假型逆转录病毒载体
JPWO2002031138A1 (ja) 2000-10-06 2004-02-19 株式会社ディナベック研究所 骨格筋に外来遺伝子を導入するためのパラミクソウイルスベクター
JP2002142770A (ja) 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
CA2430112C (en) 2000-11-27 2010-07-27 Dnavec Research Inc. Paramyxovirus vector encoding angiogenesis gene and use thereof
WO2005097988A1 (ja) * 2004-03-23 2005-10-20 Dnavec Research Inc. 組織の維持および／または修復に関連する骨髄関連細胞

Also Published As

Publication number Publication date
EP1344829A1 (en) 2003-09-17
ATE393235T1 (de) 2008-05-15
DE60133767T2 (de) 2009-06-25
DE60133767D1 (de) 2008-06-05
AU2002224113A1 (en) 2002-06-03
US20110212059A1 (en) 2011-09-01
CN100357443C (zh) 2007-12-26
CA2430112C (en) 2010-07-27
JPWO2002042481A1 (ja) 2004-03-25
US20040005296A1 (en) 2004-01-08
WO2002042481A1 (fr) 2002-05-30
EP1344829B1 (en) 2008-04-23
ES2305138T3 (es) 2008-11-01
CN1487999A (zh) 2004-04-07
JP4212357B2 (ja) 2009-01-21
EP1344829A4 (en) 2005-01-05
KR100812884B1 (ko) 2008-03-11
US8211868B2 (en) 2012-07-03
KR20030074627A (ko) 2003-09-19
CA2430112A1 (en) 2003-05-27
US20100158867A1 (en) 2010-06-24

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