DK133155B - Quinazolinderivater og syreadditionssalte deraf til anvendelse som mellemprodukter ved fremstilling af benzodiazepinderivater - Google Patents

Quinazolinderivater og syreadditionssalte deraf til anvendelse som mellemprodukter ved fremstilling af benzodiazepinderivater

Info

Publication number
DK133155B
DK133155B DK301070AA DK301070A DK133155B DK 133155 B DK133155 B DK 133155B DK 301070A A DK301070A A DK 301070AA DK 301070 A DK301070 A DK 301070A DK 133155 B DK133155 B DK 133155B
Authority
DK
Denmark
Prior art keywords
derivatives
manufacture
intermediate products
benzodiazepin
additional salts
Prior art date
Application number
DK301070AA
Other languages
English (en)
Other versions
DK133155C (da
Inventor
G F Field
L H Sternbach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US415793A external-priority patent/US3398139A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK133155B publication Critical patent/DK133155B/da
Application granted granted Critical
Publication of DK133155C publication Critical patent/DK133155C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C17/00—Surface treatment of glass, not in the form of fibres or filaments, by coating
    • C03C17/34—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions
    • C03C17/36—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal
    • C03C17/3602—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal the metal being present as a layer
    • C03C17/3668—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal the metal being present as a layer the multilayer coating having electrical properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
    • C09K5/08—Materials not undergoing a change of physical state when used

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Combustion & Propulsion (AREA)
  • Thermal Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Moulding By Coating Moulds (AREA)
  • Glass Compositions (AREA)
  • Surface Treatment Of Glass Fibres Or Filaments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK301070A 1964-04-10 1970-06-10 Quinazolinderivater og syreadditionssalte deraf til anvendelse som mellemprodukter ved fremstilling af benzodiazepinderivater DK133155C (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US35891964A 1964-04-10 1964-04-10
US40019364A 1964-09-29 1964-09-29
US415793A US3398139A (en) 1964-04-10 1964-12-03 Process for preparing 2-amino-benzodiazepines
DK624065AA DK125555B (da) 1964-04-10 1965-12-03 Fremgangsmåde til fremstilling af 1,2-dihydro-5-aryl-5H- eller 1,2-dihydro-5-aryl-3H-1,4-benzodiazepin-4-oxider, 4-deoxyderivater deraf eller syreadditionssalte deraf.
US73547568A 1968-04-09 1968-04-09
US73547668A 1968-04-09 1968-04-09
US73547968A 1968-04-09 1968-04-09
US73547868A 1968-04-09 1968-04-09
US73548468A 1968-04-09 1968-04-09

Publications (2)

Publication Number Publication Date
DK133155B true DK133155B (da) 1976-03-29
DK133155C DK133155C (da) 1976-09-06

Family

ID=27575413

Family Applications (7)

Application Number Title Priority Date Filing Date
DK182565AA DK121123B (da) 1964-04-10 1965-04-09 Fremgangsmåde til fremstilling af 1,2-dihydro-4-phenyl-quinazolin-3-oxider eller syradditionssalte deraf.
DK492765AA DK120752B (da) 1964-04-10 1965-09-24 Fremgangsmåde til fremstilling af 5-aryl-3H-1,4-benzodiazepin-4-oxider.
DK621565AA DK117229B (da) 1964-04-10 1965-12-02 Fremgangsmåde til fremstilling af 2-substituerede 4-aryl-quinazolin-3-oxider.
DK624065AA DK125555B (da) 1964-04-10 1965-12-03 Fremgangsmåde til fremstilling af 1,2-dihydro-5-aryl-5H- eller 1,2-dihydro-5-aryl-3H-1,4-benzodiazepin-4-oxider, 4-deoxyderivater deraf eller syreadditionssalte deraf.
DK163566AA DK115108B (da) 1964-04-10 1966-03-29 Fremgangsmåde til fremstilling af 2-amino-benzophenon-β-oximer.
DK163466AA DK115851B (da) 1964-04-10 1966-03-29 Fremgangsmåde til fremstilling af 1,2-dihydro-4-aryl-quinazoliner eller syreadditionssalte deraf.
DK301070A DK133155C (da) 1964-04-10 1970-06-10 Quinazolinderivater og syreadditionssalte deraf til anvendelse som mellemprodukter ved fremstilling af benzodiazepinderivater

Family Applications Before (6)

Application Number Title Priority Date Filing Date
DK182565AA DK121123B (da) 1964-04-10 1965-04-09 Fremgangsmåde til fremstilling af 1,2-dihydro-4-phenyl-quinazolin-3-oxider eller syradditionssalte deraf.
DK492765AA DK120752B (da) 1964-04-10 1965-09-24 Fremgangsmåde til fremstilling af 5-aryl-3H-1,4-benzodiazepin-4-oxider.
DK621565AA DK117229B (da) 1964-04-10 1965-12-02 Fremgangsmåde til fremstilling af 2-substituerede 4-aryl-quinazolin-3-oxider.
DK624065AA DK125555B (da) 1964-04-10 1965-12-03 Fremgangsmåde til fremstilling af 1,2-dihydro-5-aryl-5H- eller 1,2-dihydro-5-aryl-3H-1,4-benzodiazepin-4-oxider, 4-deoxyderivater deraf eller syreadditionssalte deraf.
DK163566AA DK115108B (da) 1964-04-10 1966-03-29 Fremgangsmåde til fremstilling af 2-amino-benzophenon-β-oximer.
DK163466AA DK115851B (da) 1964-04-10 1966-03-29 Fremgangsmåde til fremstilling af 1,2-dihydro-4-aryl-quinazoliner eller syreadditionssalte deraf.

Country Status (14)

Country Link
US (5) US3485841A (da)
BE (6) BE662354A (da)
BR (5) BR6568738D0 (da)
CH (10) CH507215A (da)
DE (8) DE1618518A1 (da)
DK (7) DK121123B (da)
FI (1) FI46965C (da)
FR (8) FR1459759A (da)
GB (10) GB1082163A (da)
IL (5) IL23270A (da)
MY (2) MY6800112A (da)
NL (8) NL6504628A (da)
NO (4) NO121607B (da)
SE (9) SE338779B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238610A (en) * 1979-12-20 1980-12-09 Hoffmann-La Roche Inc. Intermediates for the production of imidazobenzodiazepines
CA1157855A (en) * 1980-07-31 1983-11-29 Albert E. Fischli Benzodiazepine derivatives
US4472435A (en) * 1980-07-31 1984-09-18 Hoffman-La Roche Inc. Benzophenone derivatives useful in treating heart failure
US5326765A (en) * 1990-02-14 1994-07-05 Ortho Pharmaceutical Corporation 2,2,4-trialkyl-1,2-dihydroquinazoline-3-oxides
US20060019977A1 (en) * 2002-10-18 2006-01-26 Ono Pharmaceutical Co., Ltd. Spiroheterocyclic derivative compounds and drugs comprising the compound as the active ingredient
US7086167B2 (en) * 2004-04-16 2006-08-08 Empire Level Mfg. Corp. Overmolded vial for use with a level
CN115108968A (zh) * 2021-03-23 2022-09-27 上药康丽（常州）药业有限公司 一种3-(4-溴苯基)-哌啶的生产方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138586A (en) * 1964-06-23 Z-cycloalkylamino derivatives of
US3179656A (en) * 1965-04-20 Azepine x-oxidss
US3311612A (en) * 1967-03-28 Process for preparing
US3267110A (en) * 1960-06-03 1966-08-16 Smith Kline French Lab Trifluoromethyl substituted o-aminophenyl ketones
US3389176A (en) * 1961-09-11 1968-06-18 Hoffmann La Roche 2-aminophenyl-cycloalkyl-ketoximes
US3321467A (en) * 1963-11-27 1967-05-23 Hoffmann La Roche 3-halo-1, 4-benzodiazepin-2-ones
US3398139A (en) * 1964-04-10 1968-08-20 Hoffmann La Roche Process for preparing 2-amino-benzodiazepines

Also Published As

Publication number Publication date
GB1124244A (en) 1968-08-21
GB1082164A (en) 1967-09-06
SE345458B (da) 1972-05-29
IL24258A (en) 1969-05-28
CH462177A (de) 1968-09-15
DK115108B (da) 1969-09-08
IL24703A (en) 1969-11-12
US3503975A (en) 1970-03-31
GB1124246A (en) 1968-08-21
GB1124245A (en) 1968-08-21
NL6802319A (da) 1968-04-25
DE1545975A1 (de) 1969-11-20
GB1124247A (en) 1968-08-21
FR4621M (da) 1967-01-02
FR1459759A (fr) 1966-06-17
NL7006995A (da) 1970-09-23
CH469722A (de) 1969-03-15
DK115851B (da) 1969-11-17
FR1476612A (fr) 1967-04-14
SE318282B (da) 1969-12-08
GB1082165A (en) 1967-09-06
DE1795500A1 (de) 1972-02-03
GB1082163A (en) 1967-09-06
NO122653B (da) 1971-07-26
SE318281B (da) 1969-12-08
CH487908A (de) 1970-03-31
BE670133A (da) 1966-03-28
BR6575398D0 (pt) 1973-09-06
CH470401A (de) 1969-03-31
DE1695193A1 (de) 1971-04-08
BE673108A (da) 1966-06-01
CH469008A (de) 1969-02-28
IL23270A (en) 1969-02-27
CH470399A (de) 1969-03-31
BE662354A (da) 1965-10-11
FR1476609A (fr) 1967-04-14
IL24659A (en) 1970-01-29
FR1482841A (fr) 1967-06-02
SE320081B (da) 1970-02-02
GB1124829A (en) 1968-08-21
SE345455B (da) 1972-05-29
NL6515759A (da) 1966-06-06
NO121607B (da) 1971-03-22
CH507215A (de) 1971-05-15
BR6568738D0 (pt) 1973-08-07
NL7006996A (da) 1970-09-23
DE1545972A1 (de) 1970-07-02
SE338779B (da) 1971-09-20
NO121951B (da) 1971-05-03
CH498844A (de) 1970-11-15
GB1124248A (en) 1968-08-21
BR6575397D0 (pt) 1973-09-06
DK125555B (da) 1973-03-05
FR1482840A (fr) 1967-06-02
US3523972A (en) 1970-08-11
US3485823A (en) 1969-12-23
SE317384B (da) 1969-11-17
DE1618518A1 (de) 1971-03-04
NL6515758A (da) 1966-06-06
NO120476B (da) 1970-10-26
NL6515499A (da) 1966-06-06
DE1545942A1 (de) 1969-12-18
DK120752B (da) 1971-07-12
DE1545964A1 (de) 1970-01-22
NL131734C (da) 1971-06-15
MY6900183A (en) 1969-12-31
BE673109A (da) 1966-06-01
NL6512614A (da) 1966-03-30
US3485841A (en) 1969-12-23
CH462832A (de) 1968-09-30
SE350756B (da) 1972-11-06
BE673106A (da) 1966-06-01
BE673107A (da) 1966-06-01
DE1545974A1 (de) 1969-12-11
BR6573523D0 (pt) 1973-09-11
DK121123B (da) 1971-09-13
GB1082444A (en) 1967-09-06
IL24658A (en) 1970-01-29
DK133155C (da) 1976-09-06
FR4904M (da) 1967-04-17
BR6575394D0 (pt) 1973-09-06
FR1447832A (fr) 1966-07-29
DK117229B (da) 1970-03-31
FI46965C (fi) 1973-08-10
US3594364A (en) 1971-07-20
FI46965B (da) 1973-05-02
CH507259A (de) 1971-05-15
MY6800112A (en) 1968-12-31
NL6504628A (da) 1965-10-11
SE320080B (da) 1970-02-02

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