FR1482841A - Procédé pour la préparation de dérivés de benzodiazépine - Google Patents

Procédé pour la préparation de dérivés de benzodiazépine

Info

Publication number
FR1482841A
FR1482841A FR40552A FR1482841DA FR1482841A FR 1482841 A FR1482841 A FR 1482841A FR 40552 A FR40552 A FR 40552A FR 1482841D A FR1482841D A FR 1482841DA FR 1482841 A FR1482841 A FR 1482841A
Authority
FR
France
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR40552A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US415793A external-priority patent/US3398139A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of FR1482841A publication Critical patent/FR1482841A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C17/00—Surface treatment of glass, not in the form of fibres or filaments, by coating
    • C03C17/34—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions
    • C03C17/36—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal
    • C03C17/3602—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal the metal being present as a layer
    • C03C17/3668—Surface treatment of glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal the metal being present as a layer the multilayer coating having electrical properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
    • C09K5/08—Materials not undergoing a change of physical state when used

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Combustion & Propulsion (AREA)
  • Thermal Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Surface Treatment Of Glass Fibres Or Filaments (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Moulding By Coating Moulds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR40552A 1964-04-10 1965-12-02 Procédé pour la préparation de dérivés de benzodiazépine Expired FR1482841A (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US35891964A 1964-04-10 1964-04-10
US40019364A 1964-09-29 1964-09-29
US415793A US3398139A (en) 1964-04-10 1964-12-03 Process for preparing 2-amino-benzodiazepines
US73548468A 1968-04-09 1968-04-09
US73547868A 1968-04-09 1968-04-09
US73547668A 1968-04-09 1968-04-09
US73547968A 1968-04-09 1968-04-09
US73547568A 1968-04-09 1968-04-09

Publications (1)

Publication Number Publication Date
FR1482841A true FR1482841A (fr) 1967-06-02

Family

ID=27575413

Family Applications (8)

Application Number Title Priority Date Filing Date
FR12379A Expired FR1459759A (fr) 1964-04-10 1965-04-08 Procédé pour la préparation de dérivés de quinazoline
FR12562A Expired FR4621M (fr) 1964-04-10 1965-04-09
FR32729A Expired FR1447832A (fr) 1964-04-10 1965-09-27 Procédé pour la préparation de dérivés de benzodiazépine
FR40199A Expired FR4904M (fr) 1964-04-10 1965-11-30
FR40200A Expired FR1482840A (fr) 1964-04-10 1965-11-30 Procédé pour la préparation de dérivés de benzodiazépine
FR40400A Expired FR1476609A (fr) 1964-04-10 1965-12-01 Procédé pour la préparation de dérivés de benzodiazépine
FR40552A Expired FR1482841A (fr) 1964-04-10 1965-12-02 Procédé pour la préparation de dérivés de benzodiazépine
FR40563A Expired FR1476612A (fr) 1964-04-10 1965-12-02 Procédé pour la préparation de dérivés de benzodiazépine

Family Applications Before (6)

Application Number Title Priority Date Filing Date
FR12379A Expired FR1459759A (fr) 1964-04-10 1965-04-08 Procédé pour la préparation de dérivés de quinazoline
FR12562A Expired FR4621M (fr) 1964-04-10 1965-04-09
FR32729A Expired FR1447832A (fr) 1964-04-10 1965-09-27 Procédé pour la préparation de dérivés de benzodiazépine
FR40199A Expired FR4904M (fr) 1964-04-10 1965-11-30
FR40200A Expired FR1482840A (fr) 1964-04-10 1965-11-30 Procédé pour la préparation de dérivés de benzodiazépine
FR40400A Expired FR1476609A (fr) 1964-04-10 1965-12-01 Procédé pour la préparation de dérivés de benzodiazépine

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR40563A Expired FR1476612A (fr) 1964-04-10 1965-12-02 Procédé pour la préparation de dérivés de benzodiazépine

Country Status (14)

Country Link
US (5) US3523972A (fr)
BE (6) BE662354A (fr)
BR (5) BR6568738D0 (fr)
CH (10) CH507259A (fr)
DE (8) DE1618518A1 (fr)
DK (7) DK121123B (fr)
FI (1) FI46965C (fr)
FR (8) FR1459759A (fr)
GB (10) GB1082163A (fr)
IL (5) IL23270A (fr)
MY (2) MY6800112A (fr)
NL (8) NL6504628A (fr)
NO (4) NO122653B (fr)
SE (9) SE338779B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238610A (en) * 1979-12-20 1980-12-09 Hoffmann-La Roche Inc. Intermediates for the production of imidazobenzodiazepines
CA1157855A (fr) * 1980-07-31 1983-11-29 Albert E. Fischli Derives de benzodiazepine
US4472435A (en) * 1980-07-31 1984-09-18 Hoffman-La Roche Inc. Benzophenone derivatives useful in treating heart failure
US5326765A (en) * 1990-02-14 1994-07-05 Ortho Pharmaceutical Corporation 2,2,4-trialkyl-1,2-dihydroquinazoline-3-oxides
WO2004035581A1 (fr) * 2002-10-18 2004-04-29 Ono Pharmaceutical Co., Ltd. Composes de derives spiroheterocycliques et medicaments contenant lesdits composes comme principe actif
US7086167B2 (en) * 2004-04-16 2006-08-08 Empire Level Mfg. Corp. Overmolded vial for use with a level
CN115108968A (zh) * 2021-03-23 2022-09-27 上药康丽（常州）药业有限公司 一种3-(4-溴苯基)-哌啶的生产方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138586A (en) * 1964-06-23 Z-cycloalkylamino derivatives of
US3311612A (en) * 1967-03-28 Process for preparing
US3179656A (en) * 1965-04-20 Azepine x-oxidss
US3267110A (en) * 1960-06-03 1966-08-16 Smith Kline French Lab Trifluoromethyl substituted o-aminophenyl ketones
US3389176A (en) * 1961-09-11 1968-06-18 Hoffmann La Roche 2-aminophenyl-cycloalkyl-ketoximes
US3321467A (en) * 1963-11-27 1967-05-23 Hoffmann La Roche 3-halo-1, 4-benzodiazepin-2-ones
US3398139A (en) * 1964-04-10 1968-08-20 Hoffmann La Roche Process for preparing 2-amino-benzodiazepines

Also Published As

Publication number Publication date
BE662354A (fr) 1965-10-11
CH470401A (de) 1969-03-31
CH487908A (de) 1970-03-31
SE317384B (fr) 1969-11-17
NL6512614A (fr) 1966-03-30
SE345455B (fr) 1972-05-29
IL24258A (en) 1969-05-28
DE1545975A1 (de) 1969-11-20
FI46965C (fi) 1973-08-10
GB1124829A (en) 1968-08-21
FR1476609A (fr) 1967-04-14
DK133155B (da) 1976-03-29
BE673106A (fr) 1966-06-01
GB1124247A (en) 1968-08-21
DE1618518A1 (de) 1971-03-04
BR6575394D0 (pt) 1973-09-06
US3503975A (en) 1970-03-31
SE338779B (fr) 1971-09-20
BR6575398D0 (pt) 1973-09-06
NL7006996A (fr) 1970-09-23
GB1082164A (en) 1967-09-06
BE673107A (fr) 1966-06-01
GB1082163A (en) 1967-09-06
BE673108A (fr) 1966-06-01
FI46965B (fr) 1973-05-02
SE318281B (fr) 1969-12-08
FR1447832A (fr) 1966-07-29
DK117229B (da) 1970-03-31
BE673109A (fr) 1966-06-01
GB1124248A (en) 1968-08-21
DK133155C (da) 1976-09-06
CH462177A (de) 1968-09-15
DE1795500A1 (de) 1972-02-03
DE1545974A1 (de) 1969-12-11
NL7006995A (fr) 1970-09-23
MY6900183A (en) 1969-12-31
IL24703A (en) 1969-11-12
BR6573523D0 (pt) 1973-09-11
CH507215A (de) 1971-05-15
NL6802319A (fr) 1968-04-25
CH470399A (de) 1969-03-31
GB1124246A (en) 1968-08-21
BR6575397D0 (pt) 1973-09-06
FR1459759A (fr) 1966-06-17
SE318282B (fr) 1969-12-08
GB1124245A (en) 1968-08-21
BE670133A (fr) 1966-03-28
CH469722A (de) 1969-03-15
GB1082165A (en) 1967-09-06
DK115851B (da) 1969-11-17
IL24658A (en) 1970-01-29
FR4621M (fr) 1967-01-02
CH469008A (de) 1969-02-28
NL131734C (fr) 1971-06-15
US3485841A (en) 1969-12-23
FR1476612A (fr) 1967-04-14
MY6800112A (en) 1968-12-31
US3523972A (en) 1970-08-11
DK120752B (da) 1971-07-12
SE320081B (fr) 1970-02-02
DK125555B (da) 1973-03-05
CH462832A (de) 1968-09-30
NO120476B (fr) 1970-10-26
BR6568738D0 (pt) 1973-08-07
DK115108B (da) 1969-09-08
NL6515499A (fr) 1966-06-06
US3485823A (en) 1969-12-23
SE350756B (fr) 1972-11-06
SE320080B (fr) 1970-02-02
NO121951B (fr) 1971-05-03
GB1124244A (en) 1968-08-21
DE1545942A1 (de) 1969-12-18
NO121607B (fr) 1971-03-22
CH498844A (de) 1970-11-15
SE345458B (fr) 1972-05-29
FR1482840A (fr) 1967-06-02
NO122653B (fr) 1971-07-26
DK121123B (da) 1971-09-13
NL6504628A (fr) 1965-10-11
NL6515758A (fr) 1966-06-06
IL24659A (en) 1970-01-29
NL6515759A (fr) 1966-06-06
US3594364A (en) 1971-07-20
IL23270A (en) 1969-02-27
GB1082444A (en) 1967-09-06
DE1545964A1 (de) 1970-01-22
DE1545972A1 (de) 1970-07-02
CH507259A (de) 1971-05-15
FR4904M (fr) 1967-04-17
DE1695193A1 (de) 1971-04-08

Similar Documents

Publication Publication Date Title
FR1455059A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1428086A (fr) Procédé pour la préparation de dérivés de dibenzocycloheptatriène
FR1439925A (fr) Procédé pour la préparation de dérivés cyclopenténoniques
CH485741A (fr) Procédé de préparation de dérivés de benzodiazépines
FR1502968A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1482841A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1503278A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1415205A (fr) Procédé pour la préparation de dérivés de benzodiazépine
CH445504A (fr) Procédé pour la préparation de dérivés de la triazolone
FR1508490A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1453056A (fr) Procédé pour la préparation de dérivés de pyrimidine
FR1441437A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1462887A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1545214A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1503347A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1504118A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1503277A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1405699A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1447040A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1452504A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1457740A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1439424A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1446542A (fr) Procédé pour la préparation de dérivés de benzodiazépine
FR1429140A (fr) Procédé pour la préparation de dérivés de benzodiazépine
CH471137A (fr) Procédé pour la préparation de dérivés de benzodiazépines