DK1330659T3 - Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser - Google Patents
Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyserInfo
- Publication number
- DK1330659T3 DK1330659T3 DK01992900T DK01992900T DK1330659T3 DK 1330659 T3 DK1330659 T3 DK 1330659T3 DK 01992900 T DK01992900 T DK 01992900T DK 01992900 T DK01992900 T DK 01992900T DK 1330659 T3 DK1330659 T3 DK 1330659T3
- Authority
- DK
- Denmark
- Prior art keywords
- resolving
- solid material
- cryostat
- sample
- nmr assays
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Soft Magnetic Materials (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Polarising Elements (AREA)
- Complex Calculations (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Spectrometry And Color Measurement (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0004034A SE0004034D0 (sv) | 2000-11-03 | 2000-11-03 | Methods and devices for polarized material |
US25697401P | 2001-01-05 | 2001-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1330659T3 true DK1330659T3 (da) | 2006-12-18 |
Family
ID=26655292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01992900T DK1330659T3 (da) | 2000-11-03 | 2001-11-02 | Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser |
Country Status (17)
Country | Link |
---|---|
US (1) | US7372274B2 (ko) |
EP (3) | EP1330182B1 (ko) |
JP (2) | JP3682044B2 (ko) |
KR (2) | KR100656313B1 (ko) |
CN (1) | CN100392422C (ko) |
AT (1) | ATE336727T1 (ko) |
AU (3) | AU2002216004B2 (ko) |
BR (1) | BR0115126B1 (ko) |
CA (1) | CA2427732C (ko) |
DE (1) | DE60122361T2 (ko) |
DK (1) | DK1330659T3 (ko) |
ES (1) | ES2269507T3 (ko) |
HU (2) | HU227603B1 (ko) |
IL (3) | IL155476A0 (ko) |
PT (1) | PT1330659E (ko) |
RU (2) | RU2281526C2 (ko) |
WO (1) | WO2002037132A1 (ko) |
Families Citing this family (85)
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EP1330182B1 (en) * | 2000-11-03 | 2015-05-27 | Ge Healthcare As | Device and method for producing a hyperpolarised nmr sample |
NO20031736D0 (no) * | 2003-04-15 | 2003-04-15 | Amersham Health As | Forbindelser |
NO20035626D0 (no) * | 2003-12-17 | 2003-12-17 | Amersham Health As | Metode |
US20050254998A1 (en) * | 2004-03-01 | 2005-11-17 | Ebara Corporation | Reactive detection chip and spotter suitable for manufacturing the chip |
GB0411072D0 (en) | 2004-05-18 | 2004-06-23 | Oxford Instr Superconductivity | Apparatus and method for performing in-vitro dnp-nmr measurements |
DE102004029632B4 (de) * | 2004-06-18 | 2011-06-09 | Bruker Biospin Gmbh | Verfahren und Vorrichtung zum Zuführen einer flüssigen Probe in ein NMR-Spektrometer |
PL1797102T3 (pl) | 2004-07-30 | 2015-10-30 | Ge Healthcare As | Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI |
GB0424725D0 (en) * | 2004-11-09 | 2004-12-08 | Oxford Instr Superconductivity | Cryostat assembly |
GB0507174D0 (en) * | 2005-04-08 | 2005-05-18 | Oxford Instr Molecular Biotool | Method of operating a dynamic nuclear polarization system |
GB0514303D0 (en) | 2005-07-12 | 2005-08-17 | Oxford Instr Molecular Biotool | Magnet assembly |
JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
US20090264732A1 (en) * | 2005-10-11 | 2009-10-22 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
WO2007064226A2 (en) | 2005-12-01 | 2007-06-07 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
EP1968426B1 (en) * | 2005-12-19 | 2013-09-25 | Techmin Pty Ltd | Induction coil sensing |
US8703102B2 (en) * | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
US9207298B2 (en) | 2011-03-23 | 2015-12-08 | Millikelvin Technologies Llc | Techniques, systems and machine readable programs for magnetic resonance |
CA2643306C (en) | 2006-02-21 | 2016-05-03 | Millikelvin Technologies Llc | Hyperpolarization methods, systems and compositions |
US7573268B2 (en) * | 2006-02-22 | 2009-08-11 | Los Alamos National Security, Llc | Direct imaging of neural currents using ultra-low field magnetic resonance techniques |
ES2432393T3 (es) | 2006-08-30 | 2013-12-03 | Ge Healthcare As | Procedimiento de polarización nuclear dinámica (PND), y compuestos y composiciones para su uso en el procedimiento |
US7631507B2 (en) * | 2006-11-02 | 2009-12-15 | General Electric Company | Methods and devices for polarized samples for use in MRI |
EP2117607A4 (en) * | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | IMAGING AGENTS AND METHODS OF USE |
US20080229928A1 (en) * | 2007-03-20 | 2008-09-25 | Urbahn John A | Sorption pump with integrated thermal switch |
US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
US20080242974A1 (en) | 2007-04-02 | 2008-10-02 | Urbahn John A | Method and apparatus to hyperpolarize materials for enhanced mr techniques |
US7519492B2 (en) * | 2007-05-02 | 2009-04-14 | General Electric Company | Apparatus and method for fully automated closed system quality control of a substance |
WO2009027645A2 (en) * | 2007-08-24 | 2009-03-05 | The Universtiy Of Nottingham | Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) |
EP2028505A3 (en) | 2007-08-24 | 2010-03-17 | Oxford Instruments Molecular Biotools Ltd. | Coolant assembly of a DNP apparatus |
KR101546208B1 (ko) * | 2007-08-28 | 2015-08-20 | 지이 헬쓰케어 리미티드 | 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐 |
DE102007044016B4 (de) * | 2007-09-14 | 2010-12-16 | Bruker Biospin Gmbh | Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer |
US20100233089A1 (en) * | 2007-10-05 | 2010-09-16 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
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WO2009089007A2 (en) * | 2008-01-08 | 2009-07-16 | The University Of Georgia Research Foundation, Inc. | Upper stack for a nuclear magnetic resonance spectrometer apparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus |
JP4871311B2 (ja) * | 2008-02-26 | 2012-02-08 | 株式会社日立製作所 | 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置 |
US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
EP2268321B1 (en) | 2008-05-02 | 2013-10-09 | General Electric Company | Method of determining alanine transaminase (ALT) activity by 13C-MR detection using hyperpolarised 13C-pyruvate |
DE102008033886B4 (de) * | 2008-07-18 | 2012-03-08 | Bruker Biospin Ag | Apparatur zur Durchführung von DNP-NMR Messungen mit Kompensationsanordnung |
WO2010020776A2 (en) * | 2008-08-19 | 2010-02-25 | Oxford Instruments Molecular Biotools Limited | Dynamic nuclear polarisation system |
US7633290B1 (en) * | 2008-09-09 | 2009-12-15 | General Electric Company | Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent |
WO2010061191A1 (en) * | 2008-11-27 | 2010-06-03 | Oxford Instruments Molecular Biotools Limited | Apparatus for dynamic nuclear polarisation |
DE102008063703B3 (de) * | 2008-12-19 | 2010-06-17 | Bruker Biospin Ag | Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe |
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AU2010286413B2 (en) * | 2009-08-31 | 2014-11-20 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
JP5744032B2 (ja) | 2009-09-10 | 2015-07-01 | ジーイー・ヘルスケア・リミテッド | 過分極13c−フルクトースを用いる13c−mr検出 |
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EP2788035B1 (en) | 2011-12-05 | 2016-03-09 | Bracco Imaging S.p.A | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis |
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US20150198681A1 (en) * | 2014-01-15 | 2015-07-16 | Prudhvi Raju Chintalapati | Method for transporting an NMR sample spaced horizontally and vertically from a cryo-magnetic system using a vibration isolated motorized curvilinear Transport Carrier with dual end-effector and method for telescoping the Carrier to different cryo-magnetic systems at different heights |
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EP3674699B1 (en) | 2017-08-23 | 2022-08-03 | Osaka University | Nuclear spin high polarization method and high polarization device |
US10520561B2 (en) | 2017-09-27 | 2019-12-31 | General Electric Company | System and method for hyperpolarizing a substance and quenching radicals therein |
CN111971569B (zh) * | 2018-02-19 | 2023-04-25 | 布鲁克法国股份公司 | 多孔基质中的核自旋超极化 |
US10677874B2 (en) * | 2018-02-20 | 2020-06-09 | Wisconsin Alumni Research Foundation | System and method for control of hyperpolarized gas-phase contamination in spectroscopic magnetic resonance imaging |
US11035807B2 (en) * | 2018-03-07 | 2021-06-15 | General Electric Company | Thermal interposer for a cryogenic cooling system |
DE102019201071B4 (de) * | 2019-01-29 | 2020-11-05 | Bruker Biospin Gmbh | Vorrichtung zum schnellen Probenwechsel in einem NMR-Spektrometer mit Durchflusszelle |
US10942237B2 (en) | 2019-05-07 | 2021-03-09 | GE Precision Healthcare LLC | System and method for hyperpolarizing a substance |
US11925786B2 (en) | 2019-05-15 | 2024-03-12 | GE Precision Healthcare LLC | System and method for drawing a solution |
EP3832333A1 (en) | 2019-12-02 | 2021-06-09 | Universität Wien | Method and device for delivering a liquid sample material to a spectrometer setup |
WO2022092322A1 (ja) * | 2020-11-02 | 2022-05-05 | 国立大学法人大阪大学 | 原子核スピンの高偏極化方法、高偏極化試料の製造方法、高偏極化試料の製造装置及び高偏極化キット |
DE102020214887B4 (de) | 2020-11-26 | 2022-08-04 | Bruker Switzerland Ag | Magnetsystem zur Durchführung von 2-Feld-NMR-Experimenten und zugehöriges Nachrüstverfahren |
DE102021206392A1 (de) | 2021-06-22 | 2022-12-22 | Bruker Biospin Gmbh | Autonomes Herunterkühlen eines supraleitfähigen, trocken-gekühlten MR-Magnetspulensystems |
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2001
- 2001-11-02 EP EP01982459.8A patent/EP1330182B1/en not_active Expired - Lifetime
- 2001-11-02 IL IL15547601A patent/IL155476A0/xx unknown
- 2001-11-02 HU HU0303091A patent/HU227603B1/hu not_active IP Right Cessation
- 2001-11-02 AU AU2002216004A patent/AU2002216004B2/en not_active Expired
- 2001-11-02 JP JP2002539834A patent/JP3682044B2/ja not_active Expired - Lifetime
- 2001-11-02 DE DE60122361T patent/DE60122361T2/de not_active Expired - Lifetime
- 2001-11-02 ES ES01992900T patent/ES2269507T3/es not_active Expired - Lifetime
- 2001-11-02 AT AT01992900T patent/ATE336727T1/de active
- 2001-11-02 KR KR1020037006098A patent/KR100656313B1/ko not_active IP Right Cessation
- 2001-11-02 CN CNB018217435A patent/CN100392422C/zh not_active Expired - Lifetime
- 2001-11-02 EP EP09009604A patent/EP2204662A1/en not_active Withdrawn
- 2001-11-02 EP EP01992900A patent/EP1330659B1/en not_active Expired - Lifetime
- 2001-11-02 KR KR1020037006099A patent/KR100794898B1/ko active IP Right Grant
- 2001-11-02 CA CA002427732A patent/CA2427732C/en not_active Expired - Lifetime
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- 2001-11-02 RU RU2003112008/28A patent/RU2281526C2/ru active
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- 2001-11-02 JP JP2002538821A patent/JP4061192B2/ja not_active Expired - Fee Related
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