BR0115126A - Dispositivos para dissolver um material polarizado sólido, e para análise de resson ncia magnética nuclear, método para produzir uma solução contendo um material polarizado dissolvido, e, uso de um dispositivo - Google Patents

Dispositivos para dissolver um material polarizado sólido, e para análise de resson ncia magnética nuclear, método para produzir uma solução contendo um material polarizado dissolvido, e, uso de um dispositivo

Info

Publication number
BR0115126A
BR0115126A BR0115126-6A BR0115126A BR0115126A BR 0115126 A BR0115126 A BR 0115126A BR 0115126 A BR0115126 A BR 0115126A BR 0115126 A BR0115126 A BR 0115126A
Authority
BR
Brazil
Prior art keywords
polarized material
devices
solution containing
magnetic resonance
dissolving
Prior art date
Application number
BR0115126-6A
Other languages
English (en)
Other versions
BR0115126B1 (pt
Inventor
Jan Henrik Ardenkjaer-Larsen
Oskar H E Axelsson
Klaes Koppel Golman
Georg Hansson
H Johannesson
Rolf Servin
Mikkel Thaning
Lennart Hansson
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0004034A external-priority patent/SE0004034D0/xx
Application filed by Amersham Health As filed Critical Amersham Health As
Publication of BR0115126A publication Critical patent/BR0115126A/pt
Publication of BR0115126B1 publication Critical patent/BR0115126B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Soft Magnetic Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Complex Calculations (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Polarising Elements (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

"DISPOSITIVOS PARA DISSOLVER UM MATERIAL POLARIZADO SóLIDO, E PARA ANáLISE DE RESSON NCIA MAGNéTICA NUCLEAR, MéTODO PARA PRODUZIR UMA SOLUçãO CONTENDO UM MATERIAL POLARIZADO DISSOLVIDO, E, USO DE UM DISPOSITIVO". A presente invenção diz respeito a dispositivos e método para dissolver material polarizado sólido, ao mesmo tempo em que mantêm um alto nível de polarização. Em uma modalidade da presente invenção, um material é polarizado em um campo magnético forte em um criostato (2) e, por exemplo, solubilizado enquanto ainda dentro do criostato (2).
BRPI0115126-6A 2000-11-03 2001-11-02 Dispositivos para dissolver um material polarizado sólido, e método para produzir uma solução contendo material polarizado dissolvido BR0115126B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0004034-5 2000-11-03
SE0004034A SE0004034D0 (sv) 2000-11-03 2000-11-03 Methods and devices for polarized material
US25697401P 2001-01-05 2001-01-05
US60/256974 2001-01-05
PCT/EP2001/012736 WO2002037132A1 (en) 2000-11-03 2001-11-02 Methods and devices for dissolving hyperpolarised solid material for nmr analyses

Publications (2)

Publication Number Publication Date
BR0115126A true BR0115126A (pt) 2003-09-30
BR0115126B1 BR0115126B1 (pt) 2014-11-25

Family

ID=26655292

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0115126-6A BR0115126B1 (pt) 2000-11-03 2001-11-02 Dispositivos para dissolver um material polarizado sólido, e método para produzir uma solução contendo material polarizado dissolvido

Country Status (17)

Country Link
US (1) US7372274B2 (pt)
EP (3) EP1330182B1 (pt)
JP (2) JP3682044B2 (pt)
KR (2) KR100794898B1 (pt)
CN (1) CN100392422C (pt)
AT (1) ATE336727T1 (pt)
AU (3) AU2002214039B2 (pt)
BR (1) BR0115126B1 (pt)
CA (1) CA2427732C (pt)
DE (1) DE60122361T2 (pt)
DK (1) DK1330659T3 (pt)
ES (1) ES2269507T3 (pt)
HU (2) HU227603B1 (pt)
IL (3) IL155476A0 (pt)
PT (1) PT1330659E (pt)
RU (2) RU2281526C2 (pt)
WO (1) WO2002037132A1 (pt)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2269507T3 (es) * 2000-11-03 2007-04-01 Amersham Health As Procedimiento y dispositivo de disolucion de material solido hiperpolarizado para analisis de rmn.
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
NO20035626D0 (no) * 2003-12-17 2003-12-17 Amersham Health As Metode
US20050254998A1 (en) * 2004-03-01 2005-11-17 Ebara Corporation Reactive detection chip and spotter suitable for manufacturing the chip
GB0411072D0 (en) * 2004-05-18 2004-06-23 Oxford Instr Superconductivity Apparatus and method for performing in-vitro dnp-nmr measurements
DE102004029632B4 (de) * 2004-06-18 2011-06-09 Bruker Biospin Gmbh Verfahren und Vorrichtung zum Zuführen einer flüssigen Probe in ein NMR-Spektrometer
EP1797102B1 (en) 2004-07-30 2015-05-27 Ge Healthcare As Composition comprising triarylmethyl radical, useful in mri diagnostics
GB0424725D0 (en) * 2004-11-09 2004-12-08 Oxford Instr Superconductivity Cryostat assembly
GB0507174D0 (en) 2005-04-08 2005-05-18 Oxford Instr Molecular Biotool Method of operating a dynamic nuclear polarization system
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
JP2007021008A (ja) * 2005-07-20 2007-02-01 Hitachi Ltd Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置
WO2007044867A2 (en) * 2005-10-11 2007-04-19 Huntington Medical Research Institutes Imaging agents and methods of use thereof
ES2375089T3 (es) 2005-12-01 2012-02-24 Ge Healthcare As Procedimiento de la polarización nuclear dinámica(dnp) que usa un radical tritilo y un ión metálico paramagnético.
JP2009519786A (ja) * 2005-12-19 2009-05-21 テックミン ピーティーワイ リミテッド 誘導コイル検出
AU2007254464B2 (en) 2006-02-21 2013-02-21 Avrum Belzer Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US9207298B2 (en) 2011-03-23 2015-12-08 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
US7573268B2 (en) * 2006-02-22 2009-08-11 Los Alamos National Security, Llc Direct imaging of neural currents using ultra-low field magnetic resonance techniques
KR101502180B1 (ko) 2006-08-30 2015-03-12 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20100092391A1 (en) * 2007-01-11 2010-04-15 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US20080229928A1 (en) * 2007-03-20 2008-09-25 Urbahn John A Sorption pump with integrated thermal switch
US20080240998A1 (en) * 2007-03-28 2008-10-02 Urbahn John A Fluid path system for dissolution and transport of a hyperpolarized material
US8731640B2 (en) 2007-03-28 2014-05-20 General Electric Company Fluid path system for dissolution and transport of a hyperpolarized material
US20080242974A1 (en) 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance
EP2028505A3 (en) 2007-08-24 2010-03-17 Oxford Instruments Molecular Biotools Ltd. Coolant assembly of a DNP apparatus
WO2009027645A2 (en) * 2007-08-24 2009-03-05 The Universtiy Of Nottingham Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri)
MX2010002195A (es) * 2007-08-28 2010-08-02 Ge Healthcare Ltd Boquilla para un polarizador para una polarizacion de giro nuclear dinamico (dnp).
DE102007044016B4 (de) * 2007-09-14 2010-12-16 Bruker Biospin Gmbh Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer
US20100233089A1 (en) * 2007-10-05 2010-09-16 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US8575932B2 (en) * 2008-01-08 2013-11-05 The University Of Georgia Research Foundation, Inc. Upper stack for a nuclear magnetic resonance spectrometer aaparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus
JP4871311B2 (ja) * 2008-02-26 2012-02-08 株式会社日立製作所 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置
US8763410B2 (en) 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
CN102083470B (zh) 2008-05-02 2015-05-20 通用电气公司 应用超极化13c-丙酮酸盐,通过13c-mr检测测定丙氨酸转氨酶(alt)活性的方法
DE102008033886B4 (de) * 2008-07-18 2012-03-08 Bruker Biospin Ag Apparatur zur Durchführung von DNP-NMR Messungen mit Kompensationsanordnung
WO2010020776A2 (en) * 2008-08-19 2010-02-25 Oxford Instruments Molecular Biotools Limited Dynamic nuclear polarisation system
US7633290B1 (en) * 2008-09-09 2009-12-15 General Electric Company Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent
WO2010061191A1 (en) * 2008-11-27 2010-06-03 Oxford Instruments Molecular Biotools Limited Apparatus for dynamic nuclear polarisation
DE102008063703B3 (de) * 2008-12-19 2010-06-17 Bruker Biospin Ag Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe
JP5868311B2 (ja) 2009-04-02 2016-02-24 ジーイー・ヘルスケア・リミテッド 炎症又は感染の検出のための過分極１３ｃピルビン酸塩を含む磁気共鳴造影媒体の使用
US20100251732A1 (en) * 2009-04-06 2010-10-07 General Electric Company Apparatus and method for introduction of a material into a cryogenic system
RU2526895C2 (ru) * 2009-06-19 2014-08-27 Конинклейке Филипс Электроникс Н.В. Мрт с гиперполяризационным устройством, использующим фотоны с орбитальным угловым моментом
EP2443444A1 (en) * 2009-06-19 2012-04-25 Koninklijke Philips Electronics N.V. Mri thermometry combined with hyperpolarisation device using photons with orbital angular momentum
CA2772190A1 (en) * 2009-08-31 2011-03-03 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
EP2476009A1 (en) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr detection using hyperpolarised 13c-fructose
US8427161B2 (en) * 2009-12-18 2013-04-23 General Electric Company Method and apparatus for generating hyperpolarized materials
EP2348327B1 (en) * 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
EP2537042A1 (en) * 2010-02-16 2012-12-26 Koninklijke Philips Electronics N.V. Optical hyperpolarisation with light endowed with orbital angular momentum
US9694090B2 (en) 2010-04-08 2017-07-04 Bracco Imaging S.P.A. Process for preparing hyperpolarized substrates and method for MRI
WO2011138269A1 (en) 2010-05-03 2011-11-10 Ge Healthcare Limited Hyperpolarized lactate contrast agent for determination of ldh activity
KR101206727B1 (ko) * 2011-01-03 2012-11-30 한국표준과학연구원 저자기장 핵자기공명 장치 및 저자기장 핵자기공명 방법
US8786284B2 (en) * 2011-01-11 2014-07-22 Bridge12 Technologies, Inc. Integrated high-frequency generator system utilizing the magnetic field of the target application
AU2012230778A1 (en) * 2011-03-23 2013-10-10 Millikelvin Technologies Llc Improved techniques, systems and machine readable programs for magnetic resonance
US9714995B2 (en) 2011-03-23 2017-07-25 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
US9110132B2 (en) * 2011-08-05 2015-08-18 Chris Chiodo Electrical and fluid connection system for magnetic imaging
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids
US9329245B2 (en) * 2012-04-11 2016-05-03 Bruker Biospin Ag MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material
EP2847591A1 (en) 2012-05-07 2015-03-18 Albeda Innovation ApS Intra-operative cancer diagnosis based on a hyperpolarized marker
CA2878010A1 (en) * 2012-07-02 2014-01-09 Millikelvin Technologies Llc Improved techniques, systems and machine readable programs for magnetic resonance
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
DE102013219453B8 (de) 2013-09-26 2014-10-02 Bruker Biospin Ag DNP-Vorrichtung
US20150198681A1 (en) * 2014-01-15 2015-07-16 Prudhvi Raju Chintalapati Method for transporting an NMR sample spaced horizontally and vertically from a cryo-magnetic system using a vibration isolated motorized curvilinear Transport Carrier with dual end-effector and method for telescoping the Carrier to different cryo-magnetic systems at different heights
GB2540729B (en) * 2015-05-01 2018-03-21 Oxford Instruments Nanotechnology Tools Ltd Superconducting magnet
DE102016203891B4 (de) * 2016-03-09 2019-07-11 Numares Ag Verfahren zur Durchführung einer NMR-Messung und NMR-Spektrometer-Anordnung
US10481222B2 (en) * 2017-07-24 2019-11-19 General Electric Company Fluid path insert for a cryogenic cooling system
WO2019039477A1 (ja) 2017-08-23 2019-02-28 国立大学法人大阪大学 原子核スピンの高偏極化方法及び高偏極化装置
US10520561B2 (en) 2017-09-27 2019-12-31 General Electric Company System and method for hyperpolarizing a substance and quenching radicals therein
WO2019159154A1 (en) * 2018-02-19 2019-08-22 Bruker France Sas Nuclear spin hyperpolarization in a porous matrix
US10677874B2 (en) * 2018-02-20 2020-06-09 Wisconsin Alumni Research Foundation System and method for control of hyperpolarized gas-phase contamination in spectroscopic magnetic resonance imaging
US11035807B2 (en) * 2018-03-07 2021-06-15 General Electric Company Thermal interposer for a cryogenic cooling system
DE102019201071B4 (de) * 2019-01-29 2020-11-05 Bruker Biospin Gmbh Vorrichtung zum schnellen Probenwechsel in einem NMR-Spektrometer mit Durchflusszelle
US10942237B2 (en) 2019-05-07 2021-03-09 GE Precision Healthcare LLC System and method for hyperpolarizing a substance
US11925786B2 (en) 2019-05-15 2024-03-12 GE Precision Healthcare LLC System and method for drawing a solution
EP3832333A1 (en) 2019-12-02 2021-06-09 Universität Wien Method and device for delivering a liquid sample material to a spectrometer setup
JPWO2022092322A1 (pt) * 2020-11-02 2022-05-05
DE102020214887B4 (de) 2020-11-26 2022-08-04 Bruker Switzerland Ag Magnetsystem zur Durchführung von 2-Feld-NMR-Experimenten und zugehöriges Nachrüstverfahren
GB202111734D0 (en) 2021-08-16 2021-09-29 Cambridge Entpr Ltd Hyperpolarisation method and product

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1196820A (en) * 1967-11-25 1970-07-01 Jeol Ltd Sample Holder for a Nuclear Magnetic Resonance Instrument.
US4642206A (en) * 1983-06-27 1987-02-10 Syracuse University Production of spin polarized fusion fuels
US5258710A (en) * 1992-03-27 1993-11-02 General Electric Company Cryogenic probe for NMR microscopy
US5408181A (en) * 1993-08-30 1995-04-18 Auburn International, Inc. NMR system for measuring polymer properties
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
JP2001503646A (ja) 1996-03-29 2001-03-21 ローレンス バークレー ナショナル ラボラトリィ 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強
JP2002508687A (ja) * 1997-06-19 2002-03-19 ナイコムド イメージング エーエス 磁気共鳴（ｍｒ）イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像（ｏｒｍｉ）法
DE19742548C2 (de) * 1997-09-26 1999-10-07 Otten Ernst Wilhelm Magneteinrichtung für Tansport und Aufbewahrung kernspinpolarisierter Gase und Verfahren zur Entnahme dieser Gase
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6125654A (en) * 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
DE19937566C2 (de) * 1999-08-09 2001-06-28 Forschungszentrum Juelich Gmbh Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
ES2269507T3 (es) * 2000-11-03 2007-04-01 Amersham Health As Procedimiento y dispositivo de disolucion de material solido hiperpolarizado para analisis de rmn.
US20040049108A1 (en) * 2000-11-03 2004-03-11 Ardenkjaer-Larsen Jan Henrik Methods and devices for polarised nmr samples
WO2002036005A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for polarised nmr samples
US6515260B1 (en) * 2001-11-07 2003-02-04 Varian, Inc. Method and apparatus for rapid heating of NMR samples

Also Published As

Publication number Publication date
WO2002037132A8 (en) 2003-12-04
EP1330182B1 (en) 2015-05-27
HUP0302425A2 (hu) 2003-10-28
EP1330659B1 (en) 2006-08-16
RU2281526C2 (ru) 2006-08-10
IL155476A0 (en) 2003-11-23
KR100794898B1 (ko) 2008-01-14
JP4061192B2 (ja) 2008-03-12
BR0115126B1 (pt) 2014-11-25
ATE336727T1 (de) 2006-09-15
CA2427732A1 (en) 2002-05-10
DE60122361T2 (de) 2007-06-21
RU2006111607A (ru) 2007-10-20
IL155476A (en) 2010-02-17
EP1330659A1 (en) 2003-07-30
ES2269507T3 (es) 2007-04-01
KR100656313B1 (ko) 2006-12-13
KR20030048452A (ko) 2003-06-19
DK1330659T3 (da) 2006-12-18
AU2002216004B2 (en) 2007-01-04
EP2204662A1 (en) 2010-07-07
AU1600402A (en) 2002-05-15
RU2003112008A (ru) 2005-02-27
DE60122361D1 (de) 2006-09-28
IL155475A (en) 2007-06-17
CA2427732C (en) 2009-04-14
PT1330659E (pt) 2006-12-29
CN1484768A (zh) 2004-03-24
JP2004512882A (ja) 2004-04-30
KR20030066650A (ko) 2003-08-09
RU2386140C2 (ru) 2010-04-10
US20040066193A1 (en) 2004-04-08
AU2002214039B2 (en) 2007-05-17
HUP0302425A3 (en) 2011-04-28
HU227603B1 (hu) 2011-09-28
HUP0303091A2 (en) 2004-01-28
JP3682044B2 (ja) 2005-08-10
EP1330182A1 (en) 2003-07-30
JP2004512537A (ja) 2004-04-22
US7372274B2 (en) 2008-05-13
CN100392422C (zh) 2008-06-04
WO2002037132A1 (en) 2002-05-10

Similar Documents

Publication Publication Date Title
BR0115126A (pt) Dispositivos para dissolver um material polarizado sólido, e para análise de resson ncia magnética nuclear, método para produzir uma solução contendo um material polarizado dissolvido, e, uso de um dispositivo
Breit et al. Phase shifts of the Skyrmion breathing mode
BR0115124A (pt) Dispositivo para fundir uma amostra hiperpolarizada sólida, método para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo e método
Feldman Quasi-long-range order in nematics confined in random porous media
GB0411072D0 (en) Apparatus and method for performing in-vitro dnp-nmr measurements
BR9813244A (pt) Processo de investigação por ressonância magnética de uma amostra, preferivelmente de um corpo animal humano ou não humano, composição, meio de contraste, e, composição administrável
GB0501346D0 (en) Method of carrying out dynamic nuclear polarization
Jonischkeit et al. Generating long-lasting H1 and C13 hyperpolarization in small molecules with parahydrogen-induced polarization
ATE365334T1 (de) Vorrichtung zur ermittlung von ort und orientierung eines invasiven geräts
BR9908551A (pt) Redistribuição de carga magnética em elemento de polarização para marcador eas magneto-mecânico
Richardson et al. A structural study of tris (. beta.-diketonate) europium (III) complexes in solution using magnetic circularly polarized luminescence spectroscopy
NO20026231L (no) NMR-verktöy med aktiv RF-spoilerantenne
Bolz et al. Magnetic properties of superconducting tin-europium-molybdenum sulfides
Jones et al. Test of a continuously polarized 3He neutron spin filter with NMR-based polarization inversion on a single-crystal diffractometer
Bothner-By et al. Spin-locked states of homonuclear two-spin systems
Smirnov et al. High-field EPR imaging
Ball et al. Radiation damping artifacts in 2D COSY NMR experiments
Mikushev et al. Suppression of the defect contribution to nuclear spin-lattice relaxation by long rf magnetic pulses for the particular case of 23NaCl
Andreev et al. Passive potassium transport by symbiosomes from broad bean root nodules
DE60017072D1 (de) Minimalinvasive Katheter-Sonde für Kernresonanz-Spektrometrie
Hacura et al. Three‐body‐like spectral behavior near the ν2 mode of supracritical fluid CO2
Yamada 1H-nuclear magnetic resonance evidence for acto-myosin-dependent structural changes of the intracellular water of frog skeletal muscle fiber
Clough et al. The change of frequency of methyl group tunnelling rotation following deuteration
Nagata et al. EPR in the Impure Heisenberg Linear Chain CsMn1− xCoxCl3· 2H2O
Sünnetçioğlu et al. Hyperfine structure and relaxation times of 4-Oxo-TEMPO/methyl alcohol solutions in weak and strong fields

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: GE HEALTHCARE AS (NO)

Free format text: ALTERADO DE: AMERSHAM HEALTH AS

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 25/11/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2486 DE 28-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.