DE60122361D1 - Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen - Google Patents

Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen

Info

Publication number
DE60122361D1
DE60122361D1 DE60122361T DE60122361T DE60122361D1 DE 60122361 D1 DE60122361 D1 DE 60122361D1 DE 60122361 T DE60122361 T DE 60122361T DE 60122361 T DE60122361 T DE 60122361T DE 60122361 D1 DE60122361 D1 DE 60122361D1
Authority
DE
Germany
Prior art keywords
hyperpolarized
solids
solving
cryostat
nmr analyzes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60122361T
Other languages
English (en)
Other versions
DE60122361T2 (de
Inventor
J H Ardenkjaer-Larsen
Oskar H E Axelsson
Klaes Koppel Golman
Georg Hansson
H Johannesson
R Servin
Mikkel Thaning
Lennart Hansson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0004034A external-priority patent/SE0004034D0/xx
Application filed by Amersham Health AS filed Critical Amersham Health AS
Publication of DE60122361D1 publication Critical patent/DE60122361D1/de
Application granted granted Critical
Publication of DE60122361T2 publication Critical patent/DE60122361T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Saccharide Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Soft Magnetic Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Complex Calculations (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Polarising Elements (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE60122361T 2000-11-03 2001-11-02 Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen Expired - Lifetime DE60122361T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0004034 2000-11-03
SE0004034A SE0004034D0 (sv) 2000-11-03 2000-11-03 Methods and devices for polarized material
US25697401P 2001-01-05 2001-01-05
US256974P 2001-01-05
PCT/EP2001/012736 WO2002037132A1 (en) 2000-11-03 2001-11-02 Methods and devices for dissolving hyperpolarised solid material for nmr analyses

Publications (2)

Publication Number Publication Date
DE60122361D1 true DE60122361D1 (de) 2006-09-28
DE60122361T2 DE60122361T2 (de) 2007-06-21

Family

ID=26655292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60122361T Expired - Lifetime DE60122361T2 (de) 2000-11-03 2001-11-02 Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen

Country Status (17)

Country Link
US (1) US7372274B2 (de)
EP (3) EP1330659B1 (de)
JP (2) JP3682044B2 (de)
KR (2) KR100794898B1 (de)
CN (1) CN100392422C (de)
AT (1) ATE336727T1 (de)
AU (3) AU1600402A (de)
BR (1) BR0115126B1 (de)
CA (1) CA2427732C (de)
DE (1) DE60122361T2 (de)
DK (1) DK1330659T3 (de)
ES (1) ES2269507T3 (de)
HU (2) HUP0302425A3 (de)
IL (3) IL155476A0 (de)
PT (1) PT1330659E (de)
RU (2) RU2281526C2 (de)
WO (1) WO2002037132A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100794898B1 (ko) * 2000-11-03 2008-01-14 지이 헬스케어 에이에스 분극된 ｎｍｒ 샘플을 위한 방법 및 장치
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
NO20035626D0 (no) * 2003-12-17 2003-12-17 Amersham Health As Metode
US20050254998A1 (en) * 2004-03-01 2005-11-17 Ebara Corporation Reactive detection chip and spotter suitable for manufacturing the chip
GB0411072D0 (en) * 2004-05-18 2004-06-23 Oxford Instr Superconductivity Apparatus and method for performing in-vitro dnp-nmr measurements
DE102004029632B4 (de) * 2004-06-18 2011-06-09 Bruker Biospin Gmbh Verfahren und Vorrichtung zum Zuführen einer flüssigen Probe in ein NMR-Spektrometer
KR20070063504A (ko) 2004-07-30 2007-06-19 지이 헬스케어 에이에스 조성물의 제조 방법, 조성물 및 그의 용도
GB0424725D0 (en) * 2004-11-09 2004-12-08 Oxford Instr Superconductivity Cryostat assembly
GB0507174D0 (en) * 2005-04-08 2005-05-18 Oxford Instr Molecular Biotool Method of operating a dynamic nuclear polarization system
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
JP2007021008A (ja) * 2005-07-20 2007-02-01 Hitachi Ltd Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置
EP1933884B1 (de) * 2005-10-11 2017-09-06 Huntington Medical Research Institutes Abbildungswirkstoffe und verfahren zu ihrer verwendung
WO2007064226A2 (en) 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
JP2009519786A (ja) * 2005-12-19 2009-05-21 テックミン ピーティーワイ リミテッド 誘導コイル検出
US8703102B2 (en) * 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
EP1986702A4 (de) 2006-02-21 2012-12-12 Avrum Belzer Hyperpolarisationsverfahren, systeme und zusammensetzungen
WO2011026103A2 (en) * 2009-08-31 2011-03-03 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US9207298B2 (en) 2011-03-23 2015-12-08 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
WO2012129512A1 (en) * 2011-03-23 2012-09-27 Millikelvin Technologies Llc Improved techniques, systems and machine readable programs for magnetic resonance
US7573268B2 (en) * 2006-02-22 2009-08-11 Los Alamos National Security, Llc Direct imaging of neural currents using ultra-low field magnetic resonance techniques
CN101506179B (zh) 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US20080229928A1 (en) * 2007-03-20 2008-09-25 Urbahn John A Sorption pump with integrated thermal switch
US20080240998A1 (en) 2007-03-28 2008-10-02 Urbahn John A Fluid path system for dissolution and transport of a hyperpolarized material
US8731640B2 (en) 2007-03-28 2014-05-20 General Electric Company Fluid path system for dissolution and transport of a hyperpolarized material
US20080242974A1 (en) 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance
WO2009027645A2 (en) * 2007-08-24 2009-03-05 The Universtiy Of Nottingham Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri)
EP2028505A3 (de) 2007-08-24 2010-03-17 Oxford Instruments Molecular Biotools Ltd. Kühleinheit einer DNP-Vorrichtung
RU2475770C2 (ru) * 2007-08-28 2013-02-20 Джи-И Хелткер Лимитед Устройство и установочный кожух для растворения и выведения замороженного поляризованного образца и контейнер для содержания такого образца
DE102007044016B4 (de) * 2007-09-14 2010-12-16 Bruker Biospin Gmbh Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer
US20100233089A1 (en) * 2007-10-05 2010-09-16 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
WO2009089007A2 (en) * 2008-01-08 2009-07-16 The University Of Georgia Research Foundation, Inc. Upper stack for a nuclear magnetic resonance spectrometer apparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus
JP4871311B2 (ja) * 2008-02-26 2012-02-08 株式会社日立製作所 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置
US8763410B2 (en) * 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
DK2268321T3 (da) 2008-05-02 2013-12-02 Gen Electric Fremgangsmåde til bestemmelse af alanintransaminase (alt)-aktivitet ved 13c-mr-detektion under anvendelse af hyperpolariseret 13c-pyruvat
DE102008033886B4 (de) * 2008-07-18 2012-03-08 Bruker Biospin Ag Apparatur zur Durchführung von DNP-NMR Messungen mit Kompensationsanordnung
WO2010020776A2 (en) * 2008-08-19 2010-02-25 Oxford Instruments Molecular Biotools Limited Dynamic nuclear polarisation system
US7633290B1 (en) * 2008-09-09 2009-12-15 General Electric Company Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent
WO2010061191A1 (en) * 2008-11-27 2010-06-03 Oxford Instruments Molecular Biotools Limited Apparatus for dynamic nuclear polarisation
DE102008063703B3 (de) * 2008-12-19 2010-06-17 Bruker Biospin Ag Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe
RU2543704C2 (ru) 2009-04-02 2015-03-10 ДжиИ ХЕЛТКЕР ЛИМИТЕД Применение магнитно-резонансной визуализирующей среды, содержащей гиперполяризованный 13с-пируват, для обнаружения воспаления или инфекции
US20100251732A1 (en) * 2009-04-06 2010-10-07 General Electric Company Apparatus and method for introduction of a material into a cryogenic system
US8636980B2 (en) * 2009-06-19 2014-01-28 Koninklijke Philips N.V. MRI thermometry combined with hyperpolarisation device using photons with orbital angular momentum
CN102803941A (zh) * 2009-06-19 2012-11-28 皇家飞利浦电子股份有限公司 具有使用具有轨道角动量的光子的超级化设备的mri
EP2476009A1 (de) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr-detektion mit hyperpolarisierter 13-c-fructose
US8427161B2 (en) * 2009-12-18 2013-04-23 General Electric Company Method and apparatus for generating hyperpolarized materials
EP2348327B1 (de) * 2010-01-18 2013-11-27 Bruker BioSpin AG Verfahren zur NMR-Messung in Lösung unter Verwendung von dynamischer Kernpolarisation (DNP) mit Einfangen von freien Radikalen
US9222995B2 (en) * 2010-02-16 2015-12-29 Koninklijke Philips N.V. Apparatus and method for dispensing a hyperpolarized fluid
JP5758982B2 (ja) * 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 過分極基質の製造方法およびｍｒｉのための方法
KR101858269B1 (ko) 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제
KR101206727B1 (ko) 2011-01-03 2012-11-30 한국표준과학연구원 저자기장 핵자기공명 장치 및 저자기장 핵자기공명 방법
US8786284B2 (en) * 2011-01-11 2014-07-22 Bridge12 Technologies, Inc. Integrated high-frequency generator system utilizing the magnetic field of the target application
US9714995B2 (en) 2011-03-23 2017-07-25 Millikelvin Technologies Llc Techniques, systems and machine readable programs for magnetic resonance
US9110132B2 (en) * 2011-08-05 2015-08-18 Chris Chiodo Electrical and fluid connection system for magnetic imaging
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
US9329245B2 (en) * 2012-04-11 2016-05-03 Bruker Biospin Ag MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
KR101887736B1 (ko) * 2012-07-02 2018-09-11 밀리켈빈 테크놀로지스 엘엘씨 자기 공명을 위한 기술들, 시스템들 및 기계 판독가능 프로그램들
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
DE102013219453B8 (de) 2013-09-26 2014-10-02 Bruker Biospin Ag DNP-Vorrichtung
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
US20150198681A1 (en) * 2014-01-15 2015-07-16 Prudhvi Raju Chintalapati Method for transporting an NMR sample spaced horizontally and vertically from a cryo-magnetic system using a vibration isolated motorized curvilinear Transport Carrier with dual end-effector and method for telescoping the Carrier to different cryo-magnetic systems at different heights
GB2540729B (en) * 2015-05-01 2018-03-21 Oxford Instruments Nanotechnology Tools Ltd Superconducting magnet
DE102016203891B4 (de) * 2016-03-09 2019-07-11 Numares Ag Verfahren zur Durchführung einer NMR-Messung und NMR-Spektrometer-Anordnung
US10481222B2 (en) * 2017-07-24 2019-11-19 General Electric Company Fluid path insert for a cryogenic cooling system
EP3674699B1 (de) 2017-08-23 2022-08-03 Osaka University Kernspinhochpolarisationsverfahren und hochpolarisationsvorrichtung
US10520561B2 (en) 2017-09-27 2019-12-31 General Electric Company System and method for hyperpolarizing a substance and quenching radicals therein
US11500044B2 (en) * 2018-02-19 2022-11-15 Bruker France Sas Nuclear spin hyperpolarization in a porous matrix
US10677874B2 (en) * 2018-02-20 2020-06-09 Wisconsin Alumni Research Foundation System and method for control of hyperpolarized gas-phase contamination in spectroscopic magnetic resonance imaging
US11035807B2 (en) * 2018-03-07 2021-06-15 General Electric Company Thermal interposer for a cryogenic cooling system
DE102019201071B4 (de) * 2019-01-29 2020-11-05 Bruker Biospin Gmbh Vorrichtung zum schnellen Probenwechsel in einem NMR-Spektrometer mit Durchflusszelle
US10942237B2 (en) 2019-05-07 2021-03-09 GE Precision Healthcare LLC System and method for hyperpolarizing a substance
US11925786B2 (en) 2019-05-15 2024-03-12 GE Precision Healthcare LLC System and method for drawing a solution
EP3832333A1 (de) 2019-12-02 2021-06-09 Universität Wien Verfahren und vorrichtung zur abgabe eines flüssigen probematerials an ein spektrometersetup
JPWO2022092322A1 (de) * 2020-11-02 2022-05-05
DE102020214887B4 (de) 2020-11-26 2022-08-04 Bruker Switzerland Ag Magnetsystem zur Durchführung von 2-Feld-NMR-Experimenten und zugehöriges Nachrüstverfahren
DE102021206392A1 (de) 2021-06-22 2022-12-22 Bruker Biospin Gmbh Autonomes Herunterkühlen eines supraleitfähigen, trocken-gekühlten MR-Magnetspulensystems
GB202111734D0 (en) 2021-08-16 2021-09-29 Cambridge Entpr Ltd Hyperpolarisation method and product

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1196820A (en) * 1967-11-25 1970-07-01 Jeol Ltd Sample Holder for a Nuclear Magnetic Resonance Instrument.
US4642206A (en) * 1983-06-27 1987-02-10 Syracuse University Production of spin polarized fusion fuels
US5258710A (en) * 1992-03-27 1993-11-02 General Electric Company Cryogenic probe for NMR microscopy
US5408181A (en) * 1993-08-30 1995-04-18 Auburn International, Inc. NMR system for measuring polymer properties
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
WO1997037239A1 (en) 1996-03-29 1997-10-09 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
AU8119298A (en) * 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
DE19742548C2 (de) * 1997-09-26 1999-10-07 Otten Ernst Wilhelm Magneteinrichtung für Tansport und Aufbewahrung kernspinpolarisierter Gase und Verfahren zur Entnahme dieser Gase
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6125654A (en) * 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
DE19937566C2 (de) * 1999-08-09 2001-06-28 Forschungszentrum Juelich Gmbh Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
KR100794898B1 (ko) * 2000-11-03 2008-01-14 지이 헬스케어 에이에스 분극된 ｎｍｒ 샘플을 위한 방법 및 장치
US20040049108A1 (en) * 2000-11-03 2004-03-11 Ardenkjaer-Larsen Jan Henrik Methods and devices for polarised nmr samples
CN1294424C (zh) * 2000-11-03 2007-01-10 通用电气医疗集团股份有限公司 极化核磁共振样本的方法和装置
US6515260B1 (en) * 2001-11-07 2003-02-04 Varian, Inc. Method and apparatus for rapid heating of NMR samples

Also Published As

Publication number Publication date
EP2204662A1 (de) 2010-07-07
DK1330659T3 (da) 2006-12-18
EP1330659A1 (de) 2003-07-30
KR100794898B1 (ko) 2008-01-14
KR20030066650A (ko) 2003-08-09
RU2006111607A (ru) 2007-10-20
HU227603B1 (hu) 2011-09-28
BR0115126B1 (pt) 2014-11-25
AU2002214039B2 (en) 2007-05-17
JP3682044B2 (ja) 2005-08-10
HUP0302425A2 (hu) 2003-10-28
US7372274B2 (en) 2008-05-13
WO2002037132A1 (en) 2002-05-10
RU2003112008A (ru) 2005-02-27
KR20030048452A (ko) 2003-06-19
EP1330659B1 (de) 2006-08-16
CN100392422C (zh) 2008-06-04
CA2427732A1 (en) 2002-05-10
IL155475A (en) 2007-06-17
IL155476A0 (en) 2003-11-23
CA2427732C (en) 2009-04-14
CN1484768A (zh) 2004-03-24
AU1600402A (en) 2002-05-15
IL155476A (en) 2010-02-17
KR100656313B1 (ko) 2006-12-13
JP2004512537A (ja) 2004-04-22
DE60122361T2 (de) 2007-06-21
HUP0302425A3 (en) 2011-04-28
EP1330182B1 (de) 2015-05-27
RU2281526C2 (ru) 2006-08-10
PT1330659E (pt) 2006-12-29
BR0115126A (pt) 2003-09-30
AU2002216004B2 (en) 2007-01-04
JP4061192B2 (ja) 2008-03-12
RU2386140C2 (ru) 2010-04-10
ATE336727T1 (de) 2006-09-15
ES2269507T3 (es) 2007-04-01
JP2004512882A (ja) 2004-04-30
WO2002037132A8 (en) 2003-12-04
HUP0303091A2 (en) 2004-01-28
US20040066193A1 (en) 2004-04-08
EP1330182A1 (de) 2003-07-30

Similar Documents

Publication Publication Date Title
DE60122361D1 (de) Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen
CA2427726A1 (en) Methods and devices for polarised nmr samples
CN101427142B (zh) 采用极化测定检测方法的光纤电流传感器
TR201905368T4 (tr) Bir iş parçası içeren bir cihaz için bir rezonans çalıştırma sisteminde kullanılan bir yay elemanını ayarlama yöntemi
WO2002086541A3 (en) Nmr logging in the earth's magnetic field
ATE348323T1 (de) Faseroptische rückstreu-polarimetrie
Kärger et al. On the use of pulsed field gradients in a high-field NMR spectrometer to study restricted diffusion in zeolites
Kojima et al. Correlation of temperature dependence of quasielastic-light-scattering intensity and α-relaxation time
WO2003021239A1 (fr) Appareil de mesure d'information sur un composant particulier
ATE166463T1 (de) Verfahren und vorrichtung zum messen eines elektrischen wechselstromes mit temperaturkompensation
BR0010425A (pt) Aparelho e processo de gradiometria magnética
DE69407529D1 (de) Vorrichtung zur Überwachung der Phasenverschiebung zwischen zwei Taktsignalen
DE59410157D1 (de) Vorrichtung und Verfahren zur Erzeugung optisch detektierbarer Signale durch Anlegen elektrischer Potentiale an Probenflüssigkeiten
Homrighausen et al. Microscale fiber-integrated vector magnetometer with on-tip field biasing using N-V ensembles in diamond microcrystals
WO2002010722A1 (fr) Dispositif d'observation de trajectoire lumineuse
ATE314658T1 (de) Vorrichtung zum messen des ruhestromes einer elektronischen vorrichtung
ATE299269T1 (de) Verfahren zur temperaturkompensierten elektro- optischen messung einer elektrischen spannung und vorrichtung zur durchführung des verfahrens
DE60017072D1 (de) Minimalinvasive Katheter-Sonde für Kernresonanz-Spektrometrie
Levola et al. Magnetic specific heat and structural phase transitions in (CH 3) 4 NMnCl 3 (TMMC) and TMMC: Cu 2+ studied by crystal optics
SU1242732A2 (ru) Способ измерени механических воздействий на стержневой резонатор
CN105510236A (zh) 一种观察微纳尺度蛋白质晶体从溶液中析出的方法
SU1167442A1 (ru) Способ определени амплитудно-частотных характеристик резонансных колебаний контакт-деталей радиокомпонентов
FR2344209A7 (fr) Instrument de controle de l'alimentation de bobines de commande de relais
DE602004006864D1 (de) Vorrichtung und Verfahren zur Verarbeitung eines digitalen bit-zu-bit polarisationsverschachtelten Signals in einem optischen Übertragungsystem
SU881642A1 (ru) Датчик магнитостатического вариометра

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 1330659

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB