BR0115124A - Dispositivo para fundir uma amostra hiperpolarizada sólida, método para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo e método - Google Patents

Dispositivo para fundir uma amostra hiperpolarizada sólida, método para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo e método

Info

Publication number
BR0115124A
BR0115124A BR0115124-0A BR0115124A BR0115124A BR 0115124 A BR0115124 A BR 0115124A BR 0115124 A BR0115124 A BR 0115124A BR 0115124 A BR0115124 A BR 0115124A
Authority
BR
Brazil
Prior art keywords
sample
hyperpolarized sample
fused
producing
solid
Prior art date
Application number
BR0115124-0A
Other languages
English (en)
Other versions
BR0115124B1 (pt
Inventor
Jan Henrik Ardenkjaer-Larsen
Oskar H E Axelsson
Klaes Koppel Golman
Georg Hansson
H Johannesson
Rolf Servin
Mikkel Thaning
Lennart Hansson
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0004034A external-priority patent/SE0004034D0/xx
Priority claimed from NO20012256A external-priority patent/NO20012256D0/no
Application filed by Amersham Health As filed Critical Amersham Health As
Publication of BR0115124A publication Critical patent/BR0115124A/pt
Publication of BR0115124B1 publication Critical patent/BR0115124B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

"DISPOSITIVO PARA FUNDIR UMA AMOSTRA HIPERPOLARIZADA SóLIDA, MéTODO PARA PRODUZIR UMA AMOSTRA HIPERPOLARIZADA FUNDIDA, E, USO DE UM DISPOSITIVO OU MéTODO". A presente invenção diz respeito a dispositivos e método para fundir amostra polarizada sólida ao mesmo tempo em que mantêm um alto nível de polarização. Em uma modalidade da presente invenção, uma amostra é polarizada em úm copo de retenção da amostra (9) em um campo magnético forte em um meio de polarização (3a, 3b, 3c) em um criostato (2) e, em seguida, fundida dentro do criostato (2) pelo meio de fusão, tal como um laser (8), conectado por meio de uma fibra ótica (4) ao interior do criostato.
BRPI0115124-0A 2000-11-03 2001-11-02 dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo. BR0115124B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0004034A SE0004034D0 (sv) 2000-11-03 2000-11-03 Methods and devices for polarized material
US25697401P 2001-01-05 2001-01-05
NO20012256A NO20012256D0 (no) 2001-05-08 2001-05-08 Fremgangsmåte og anordning for polarisert materiale
PCT/EP2001/012737 WO2002036005A1 (en) 2000-11-03 2001-11-02 Methods and devices for polarised nmr samples

Publications (2)

Publication Number Publication Date
BR0115124A true BR0115124A (pt) 2003-09-30
BR0115124B1 BR0115124B1 (pt) 2012-12-25

Family

ID=27353364

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0115124-0A BR0115124B1 (pt) 2000-11-03 2001-11-02 dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo.

Country Status (7)

Country Link
US (2) US7102354B2 (pt)
CN (1) CN1294424C (pt)
AU (1) AU1403902A (pt)
BR (1) BR0115124B1 (pt)
CA (1) CA2427726C (pt)
IL (1) IL155475A0 (pt)
WO (1) WO2002036005A1 (pt)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036005A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for polarised nmr samples
EP2204662A1 (en) * 2000-11-03 2010-07-07 GE Healthcare AS Device for hyperpolarising and dissolving solid material for NMR analyses
US6515260B1 (en) † 2001-11-07 2003-02-04 Varian, Inc. Method and apparatus for rapid heating of NMR samples
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
US7246939B1 (en) * 2003-10-23 2007-07-24 Gultekin David H Measurement of thermal diffusivity, thermal conductivity, specific heat, specific absorption rate, thermal power, heat transfer coefficient, heat of reaction and membrane permeability by nuclear magnetic resonance
DE102004050737B4 (de) * 2004-10-19 2012-01-05 Bruker Biospin Gmbh Vorrichtung zum Bestimmen des Fett- oder Ölgehaltes einer Probe
GB0507174D0 (en) * 2005-04-08 2005-05-18 Oxford Instr Molecular Biotool Method of operating a dynamic nuclear polarization system
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
JP2007021008A (ja) * 2005-07-20 2007-02-01 Hitachi Ltd Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置
EP1968426B1 (en) * 2005-12-19 2013-09-25 Techmin Pty Ltd Induction coil sensing
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
EP1986702A4 (en) 2006-02-21 2012-12-12 Avrum Belzer METHODS, SYSTEMS AND COMPOSITIONS FOR HYPERPORALIZATION
GB0605031D0 (en) * 2006-03-13 2006-04-19 Oxford Instr Molecular Biotool NMR inspection apparatus
US7205764B1 (en) * 2006-04-11 2007-04-17 Varian, Inc. Method and apparatus for increasing the detection sensitivity in a high resolution NMR analysis
EA200802319A1 (ru) * 2006-05-11 2009-06-30 Белл Хеликоптер Текстрон, Инк. Способ и устройство для ремонта элементов конструкции
EP2018545A4 (en) * 2006-05-12 2011-03-09 Massachusetts Inst Technology BIRADIC POLARIZERS FOR DYNAMIC NUCLEAR POLARIZATION
US20090311189A1 (en) * 2006-05-12 2009-12-17 Massachusetts Institute Of Technology Temperature-jump dynamic nuclear polarization
WO2008022410A1 (en) * 2006-08-25 2008-02-28 Commonwealth Scientific And Industrial Research Organisation Method and apparatus for nano-scale squid
KR101502180B1 (ko) 2006-08-30 2015-03-12 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
WO2008086525A2 (en) * 2007-01-11 2008-07-17 University Of Kansas High-throughput systems for magic-angle spinning nuclear magnetic resonance
WO2008115859A2 (en) * 2007-03-16 2008-09-25 The General Hospital Corporation System and method for displaying medical imaging spectral data as hysometric maps
US8731640B2 (en) 2007-03-28 2014-05-20 General Electric Company Fluid path system for dissolution and transport of a hyperpolarized material
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance
US9227173B2 (en) 2007-06-22 2016-01-05 General Electric Company Methods for dynamic filtration of pharmaceutical products
US20080314836A1 (en) * 2007-06-22 2008-12-25 General Electric Company Methods and devices for dynamic filtration of pharmaceutical products
WO2009027645A2 (en) * 2007-08-24 2009-03-05 The Universtiy Of Nottingham Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri)
DE102007044016B4 (de) * 2007-09-14 2010-12-16 Bruker Biospin Gmbh Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US8575932B2 (en) * 2008-01-08 2013-11-05 The University Of Georgia Research Foundation, Inc. Upper stack for a nuclear magnetic resonance spectrometer aaparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus
US8763410B2 (en) * 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
CN102083470B (zh) 2008-05-02 2015-05-20 通用电气公司 应用超极化13c-丙酮酸盐,通过13c-mr检测测定丙氨酸转氨酶(alt)活性的方法
ES2342958B2 (es) * 2008-09-03 2011-07-04 Emite Ingenieria Slne Analizador de multiples entradas y multiples salidas.
WO2010028164A1 (en) * 2008-09-05 2010-03-11 The Government Of Usa, As Repesented By The Secretary, Department Of Health And Human Services Device and method for microwave assisted cryo-sample processing
US7633290B1 (en) 2008-09-09 2009-12-15 General Electric Company Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent
JP5868311B2 (ja) 2009-04-02 2016-02-24 ジーイー・ヘルスケア・リミテッド 炎症又は感染の検出のための過分極１３ｃピルビン酸塩を含む磁気共鳴造影媒体の使用
IN2012DN02418A (pt) 2009-08-31 2015-08-21 Millikelvin Technologies Llc
CA2772489A1 (en) 2009-08-31 2011-03-03 Brain Watch Ltd. Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders
JP5744032B2 (ja) 2009-09-10 2015-07-01 ジーイー・ヘルスケア・リミテッド 過分極１３ｃ−フルクトースを用いる１３ｃ−ｍｒ検出
US8427161B2 (en) * 2009-12-18 2013-04-23 General Electric Company Method and apparatus for generating hyperpolarized materials
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
CA2797472C (en) 2010-05-03 2018-07-03 Ge Healthcare Limited Hyperpolarized lactate contrast agent for determination of ldh activity
US8786284B2 (en) * 2011-01-11 2014-07-22 Bridge12 Technologies, Inc. Integrated high-frequency generator system utilizing the magnetic field of the target application
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
EP2847591A1 (en) 2012-05-07 2015-03-18 Albeda Innovation ApS Intra-operative cancer diagnosis based on a hyperpolarized marker
WO2015000838A1 (en) 2013-07-01 2015-01-08 Bracco Imaging Spa Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
DE102013219453B8 (de) * 2013-09-26 2014-10-02 Bruker Biospin Ag DNP-Vorrichtung
EP2891500B1 (en) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity
WO2016179523A1 (en) * 2015-05-06 2016-11-10 The Regents Of The University Of California Apparatus and method for nuclear magnetic resonance utilizing dynamic nuclear polarization
DE102016203891B4 (de) * 2016-03-09 2019-07-11 Numares Ag Verfahren zur Durchführung einer NMR-Messung und NMR-Spektrometer-Anordnung
US10481222B2 (en) * 2017-07-24 2019-11-19 General Electric Company Fluid path insert for a cryogenic cooling system
JP2020504286A (ja) 2017-08-10 2020-02-06 中国科学技▲術▼大学Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｓｃｉｅｎｃｅ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｏｆ Ｃｈｉｎａ パルス式電子常磁性共鳴分光計
DE102017010575B3 (de) 2017-11-15 2019-02-21 Frank Rößner Methode zur Charakterisierung von Silicamaterialien und Organo-Silicakompositmaterialien
US11035807B2 (en) * 2018-03-07 2021-06-15 General Electric Company Thermal interposer for a cryogenic cooling system
CN113009389B (zh) * 2019-12-19 2022-09-23 中国科学院宁波材料技术与工程研究所 一种激光加热高温核磁共振探头和装置

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US528710A (en) * 1894-11-06 Glass-house pot or tank
US4642206A (en) * 1983-06-27 1987-02-10 Syracuse University Production of spin polarized fusion fuels
US5258710A (en) * 1992-03-27 1993-11-02 General Electric Company Cryogenic probe for NMR microscopy
US5408181A (en) * 1993-08-30 1995-04-18 Auburn International, Inc. NMR system for measuring polymer properties
US5626137A (en) * 1995-10-02 1997-05-06 General Electric Company Apparatus and methods for magnetic resonance (MR) angiography using fluids polarized at low temperatures
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
DE69829231T2 (de) * 1997-12-12 2006-04-06 Medi-Physics, Inc. Verfahren zum Sammeln und Auftauen polarisierter Gase, dessen Sammler und Heizmanschette
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6125654A (en) 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
WO2000072031A1 (en) * 1999-05-19 2000-11-30 Nycomed Imaging As Methods of magnetic resonance imaging (mri) using contract agent solutions formed from the dissolution of hyperpolarised materials
DE19937566C2 (de) * 1999-08-09 2001-06-28 Forschungszentrum Juelich Gmbh Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators
US20040049108A1 (en) * 2000-11-03 2004-03-11 Ardenkjaer-Larsen Jan Henrik Methods and devices for polarised nmr samples
WO2002036005A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for polarised nmr samples
US6515260B1 (en) * 2001-11-07 2003-02-04 Varian, Inc. Method and apparatus for rapid heating of NMR samples
US7205764B1 (en) * 2006-04-11 2007-04-17 Varian, Inc. Method and apparatus for increasing the detection sensitivity in a high resolution NMR analysis

Also Published As

Publication number Publication date
CN1294424C (zh) 2007-01-10
IL155475A0 (en) 2003-11-23
CN1484510A (zh) 2004-03-24
US20060192559A1 (en) 2006-08-31
US7102354B2 (en) 2006-09-05
AU1403902A (en) 2002-05-15
US20050225328A1 (en) 2005-10-13
WO2002036005A1 (en) 2002-05-10
CA2427726C (en) 2012-01-24
BR0115124B1 (pt) 2012-12-25
CA2427726A1 (en) 2002-05-10

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: GE HEALTHCARE AS (NO)

Free format text: ALTERADO DE: AMERSHAM HEALTH AS

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2012, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2486 DE 28-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.