DK1326632T3 - Protease-inhibitorer til behandling af infektioner af hepatitisvirus - Google Patents
Protease-inhibitorer til behandling af infektioner af hepatitisvirusInfo
- Publication number
- DK1326632T3 DK1326632T3 DK01986607T DK01986607T DK1326632T3 DK 1326632 T3 DK1326632 T3 DK 1326632T3 DK 01986607 T DK01986607 T DK 01986607T DK 01986607 T DK01986607 T DK 01986607T DK 1326632 T3 DK1326632 T3 DK 1326632T3
- Authority
- DK
- Denmark
- Prior art keywords
- proteosome
- activity
- inhibit
- release
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000151716 DE10051716A1 (de) | 2000-10-12 | 2000-10-12 | Mittel zur Hemmung der Freisetzung, Reifung und Replikation von Retroviren |
DE2001149398 DE10149398A1 (de) | 2001-10-03 | 2001-10-03 | Mittel zur Behandlung von Hepatitis-Virusinfektionen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1326632T3 true DK1326632T3 (da) | 2007-01-15 |
Family
ID=26007405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01986607T DK1326632T3 (da) | 2000-10-12 | 2001-10-11 | Protease-inhibitorer til behandling af infektioner af hepatitisvirus |
Country Status (12)
Country | Link |
---|---|
US (2) | US20040106539A1 (fr) |
EP (4) | EP2305291A1 (fr) |
JP (2) | JP2004510826A (fr) |
AT (1) | ATE338564T1 (fr) |
AU (1) | AU2002218133A1 (fr) |
CA (1) | CA2425632A1 (fr) |
CY (1) | CY1105835T1 (fr) |
DE (1) | DE50110956D1 (fr) |
DK (1) | DK1326632T3 (fr) |
ES (1) | ES2272558T3 (fr) |
PT (1) | PT1326632E (fr) |
WO (1) | WO2002030455A2 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4248593A (en) * | 1992-05-14 | 1993-12-13 | Mark Holodniy | Polymerase chain reaction assays for monitoring antiviral therapy |
WO2002101012A2 (fr) * | 2001-06-08 | 2002-12-19 | Children's Hospital Research Foundation | Regulation de l'expression transgenique suivant une transduction par aav |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
ATE481104T1 (de) | 2002-04-05 | 2010-10-15 | Virologik Gmbh | Mittel zur behandlung von flaviviridae- infektionen |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
WO2004004749A1 (fr) * | 2002-07-03 | 2004-01-15 | Charite - Universitätsmedizin Berlin | Inhibiteurs du proteaseome pour le traitement de sujets infectes par un herpes-virus |
US20050222043A1 (en) * | 2002-07-25 | 2005-10-06 | Karl Stangl | Use of proteasome inhibitor in the treatment of fibrotic diseases |
CN101791306A (zh) * | 2003-06-20 | 2010-08-04 | 加利福尼亚大学董事会 | 盐孢菌酰胺及其使用方法 |
JP2007523862A (ja) * | 2003-06-20 | 2007-08-23 | ネレアス ファーマシューティカルズ インコーポレイテッド | 癌、炎症及び感染性疾患の治療のための、[3.2.0]複素環式化合物およびそれらの類縁体の使用 |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US20050112562A1 (en) * | 2003-11-10 | 2005-05-26 | Rigel Pharmaceuticals, Inc. | Inhibition of retroviral replication through modulation of the host cell ubiquitylation |
CN103554222A (zh) | 2004-04-15 | 2014-02-05 | 欧尼斯治疗公司 | 用于抑制蛋白酶体酶的化合物 |
US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
WO2006017346A1 (fr) * | 2004-07-13 | 2006-02-16 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH A ND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER | Traitement d'infections virales au moyen d'inhibiteurs de proteasome |
JP5676071B2 (ja) | 2004-12-03 | 2015-02-25 | ダナ ファーバー キャンサー インスティテュート,インコーポレイテッド | 腫瘍性疾患を治療するための組成物及び方法 |
US20090018146A1 (en) * | 2005-01-27 | 2009-01-15 | Research Development Corporation | Combination Therapy with Triterpenoid Compounds and Proteasome Inhibitors |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US20060193844A1 (en) * | 2005-02-28 | 2006-08-31 | Proteolix, Inc. | Methods for enzyme inhibition |
AU2006311584B2 (en) | 2005-11-09 | 2012-03-08 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
WO2007092944A2 (fr) * | 2006-02-08 | 2007-08-16 | Introgen Therapeutics, Inc. | Compositions et procedes impliquant une therapie de gene et une modulation de proteasome |
DE102006026464A1 (de) * | 2006-06-01 | 2007-12-06 | Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma | Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus |
AU2007261345B2 (en) | 2006-06-19 | 2012-02-23 | Onyx Therapeutics, Inc. | Peptide epoxyketones for proteasome inhibition |
US20080280968A1 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
KR20170125413A (ko) | 2007-10-04 | 2017-11-14 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
KR20110011645A (ko) * | 2008-05-12 | 2011-02-08 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 프로테아좀 저해제로서의 살리노스포라마이드 유도체 |
WO2010024384A1 (fr) * | 2008-08-29 | 2010-03-04 | 国立大学法人大阪大学 | Composition d’antivirus de l’hépatite c |
CA2741312C (fr) | 2008-10-21 | 2020-10-27 | Onyx Therapeutics, Inc. | Therapie de combinaison avec des peptides epoxycetones |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
DE102009027754A1 (de) | 2009-07-15 | 2011-05-05 | Schubert, Ulrich, Dr. | Verfahren zur Hemmung der Reifung von dendritischen Zellen |
DE102009028015A1 (de) | 2009-07-24 | 2011-01-27 | Virologik Gmbh | Mittel zur Behandlung von Hepatitis C-Infektionen |
WO2011009961A1 (fr) * | 2009-07-24 | 2011-01-27 | Virologik Gmbh | Association d'inhibiteurs du protéasome et de médicaments anti-hépatite dans le traitement de l'hépatite |
JP5919196B2 (ja) * | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | 転移抑制のためのペプチドエポキシケトンの使用 |
WO2011087822A1 (fr) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Inhibiteurs du protéasome et leurs procédés de préparation, d'épuration et d'utilisation |
WO2011089167A1 (fr) | 2010-01-19 | 2011-07-28 | Virologik Gmbh | Inhibiteur du protéasome destiné à traiter le vih |
SG183843A1 (en) | 2010-03-01 | 2012-10-30 | Onyx Therapeutics Inc | Compounds for immunoproteasome inhibition |
MX2012011604A (es) | 2010-04-07 | 2013-02-27 | Onyx Therapeutics Inc | Inhibidor de inmunoproteasoma de péptido epoxicetona cristalino. |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
GB2506085A (en) | 2011-10-21 | 2014-03-19 | Abbvie Inc | Combination treatment (eg with ABT-072 or ABT-333) of DAAS for use in treating HCV |
DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
KR20190137963A (ko) | 2012-05-08 | 2019-12-11 | 오닉스 세라퓨틱스, 인크. | 펩티드 프로테아좀 억제제 제제화를 위한 사이클로덱스트린 복합체화 방법 |
JP2015524394A (ja) | 2012-07-09 | 2015-08-24 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ |
US20150328240A1 (en) * | 2014-05-19 | 2015-11-19 | Carl Hilliard | Product and delivery system for application of antimicrobial treatment designed to inhibit pathegens from entering or leaving a respitory system and to remove pathogens from wounds, ears or other body cavities, and methods of use |
JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
CN114901291A (zh) | 2019-10-18 | 2022-08-12 | 托皮科斯药品公司 | 抗菌有机硅烷 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0652290A1 (fr) * | 1993-09-07 | 1995-05-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Méthode de régulation de NF-kappa B |
US6913767B1 (en) * | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
US5872206A (en) | 1994-10-06 | 1999-02-16 | The General Hospital Corporation | Compositions and methods for interfering wtih hepatitis B virus infection |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
EP2314598A1 (fr) * | 1996-10-18 | 2011-04-27 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la protéase NS3 du virus de l'hépatite C |
EP1017398A1 (fr) | 1997-09-25 | 2000-07-12 | Proscript, Inc. | INIHIBITEURS DE PROTEASOME, INHIBITEURS DES VOIES DE L'UBIQUITINE OU AGENTS ENTRAVANT L'ACTIVATION DE NF-$g(k)B PAR LES VOIES DE l'UBIQUITINE PROTEASOME POUR TRAITER DES MALADIES INFLAMMATOIRES ET DES MALADIES AUTOIMMUNES |
CA2219867A1 (fr) | 1997-10-31 | 1999-04-30 | Jiangping Wu | Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique |
GB9806815D0 (en) * | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
AU750369B2 (en) * | 1998-04-23 | 2002-07-18 | Cortech, Inc. | Cysteine protease inhibitors |
FR2779653B1 (fr) * | 1998-06-11 | 2002-12-20 | Inst Nat Sante Rech Med | Utilisation de composes modulateurs du proteasome en therapie |
AU762373B2 (en) | 1998-10-20 | 2003-06-26 | Millennium Pharmaceuticals, Inc. | Method for monitoring proteasome inhibitor drug action |
AU1930900A (en) * | 1998-12-04 | 2000-06-26 | University Of Maryland Biotechnology Institute | Use of protease inhibitors to modulate cellular pathways, immunity and therapiesassociated therewith |
US6329171B1 (en) * | 1999-09-30 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | 23484, A novel human ubiquitin protease |
CA2396677A1 (fr) * | 1999-12-23 | 2001-06-28 | The Board Of Regents Of The University Of Texas System | Inhibition de proteases cellulaires |
-
2001
- 2001-10-11 CA CA002425632A patent/CA2425632A1/fr not_active Abandoned
- 2001-10-11 AT AT01986607T patent/ATE338564T1/de active
- 2001-10-11 WO PCT/DE2001/003908 patent/WO2002030455A2/fr active IP Right Grant
- 2001-10-11 DK DK01986607T patent/DK1326632T3/da active
- 2001-10-11 EP EP10182253A patent/EP2305291A1/fr not_active Ceased
- 2001-10-11 EP EP10182351A patent/EP2301565A1/fr not_active Withdrawn
- 2001-10-11 US US10/398,993 patent/US20040106539A1/en not_active Abandoned
- 2001-10-11 AU AU2002218133A patent/AU2002218133A1/en not_active Abandoned
- 2001-10-11 EP EP04090076A patent/EP1430903A1/fr not_active Ceased
- 2001-10-11 JP JP2002533894A patent/JP2004510826A/ja active Pending
- 2001-10-11 DE DE50110956T patent/DE50110956D1/de not_active Expired - Lifetime
- 2001-10-11 EP EP01986607A patent/EP1326632B1/fr not_active Expired - Lifetime
- 2001-10-11 PT PT01986607T patent/PT1326632E/pt unknown
- 2001-10-11 ES ES01986607T patent/ES2272558T3/es not_active Expired - Lifetime
-
2006
- 2006-12-06 CY CY20061101761T patent/CY1105835T1/el unknown
-
2007
- 2007-04-04 US US11/732,797 patent/US20070265194A1/en not_active Abandoned
-
2008
- 2008-10-07 JP JP2008260772A patent/JP2009046507A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2301565A1 (fr) | 2011-03-30 |
AU2002218133A1 (en) | 2002-04-22 |
CA2425632A1 (fr) | 2002-04-18 |
CY1105835T1 (el) | 2011-02-02 |
EP1326632B1 (fr) | 2006-09-06 |
EP1430903A1 (fr) | 2004-06-23 |
US20040106539A1 (en) | 2004-06-03 |
DE50110956D1 (de) | 2006-10-19 |
EP2305291A1 (fr) | 2011-04-06 |
US20070265194A1 (en) | 2007-11-15 |
EP1326632A2 (fr) | 2003-07-16 |
JP2009046507A (ja) | 2009-03-05 |
PT1326632E (pt) | 2007-01-31 |
WO2002030455A3 (fr) | 2002-08-08 |
ES2272558T3 (es) | 2007-05-01 |
ATE338564T1 (de) | 2006-09-15 |
JP2004510826A (ja) | 2004-04-08 |
WO2002030455A2 (fr) | 2002-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1326632T3 (da) | Protease-inhibitorer til behandling af infektioner af hepatitisvirus | |
MX9603909A (es) | Derivados de sulfonamida como inhibidores de proteasa aspartilo. | |
MY138860A (en) | Hiv protease inhibitors. | |
AP1717A (en) | Sulfonamide inhibitors of aspartyl protease. | |
EE04376B1 (et) | Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsedretroviirusliku proteaasi inhibiitorid | |
AP9600827A0 (en) | Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease. | |
NO974148L (no) | Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer | |
DK1052250T3 (da) | Sulfonylalkanoylamino-hydroxyethylamino-sulfonamider som inhibitorer af retroviral protease | |
ATE196288T1 (de) | N-(3-amino-2-hydroxybutyl)sulfonamid-derivate as hiv-protease-inhibitoren | |
ATE229033T1 (de) | Heterocyclocarbonyl-aminosäure-hydroxyethylamin - sulfonamid inhibitoren retroviraler proteasen | |
NO992228D0 (no) | 1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor | |
FI963073A0 (fi) | Makrosykliset difluorisatonijohdannaiset, jotka ovat käyttökelpoisia viruksia vastustavina aineina | |
MY117535A (en) | Hiv protease inhibitors | |
MX9708057A (es) | Sulfonamidas que contienen thf inhibidoras de la aspartilproteasa. | |
MX9708055A (es) | Inhibidores de aspartil proteasa consistentes en sulfonamida que contiene heterociclo oxigenado. |