CA2219867A1 - Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique - Google Patents
Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique Download PDFInfo
- Publication number
- CA2219867A1 CA2219867A1 CA002219867A CA2219867A CA2219867A1 CA 2219867 A1 CA2219867 A1 CA 2219867A1 CA 002219867 A CA002219867 A CA 002219867A CA 2219867 A CA2219867 A CA 2219867A CA 2219867 A1 CA2219867 A1 CA 2219867A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- proteasome
- lac
- inhibitor
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002219867A CA2219867A1 (fr) | 1997-10-31 | 1997-10-31 | Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique |
PCT/CA1998/001010 WO1999022729A1 (fr) | 1997-10-31 | 1998-10-29 | Utilisation d'inhibiteurs de proteasomes dans le traitement du cancer, de l'inflammation, de maladies autoimmunes, du rejet du greffon et du choc septique |
EP98951135A EP0967976A1 (fr) | 1997-10-31 | 1998-10-29 | Utilisation d'inhibiteurs de proteasomes dans le traitement du cancer, de l'inflammation, de maladies autoimmunes, du rejet du greffon et du choc septique |
CA002276013A CA2276013A1 (fr) | 1997-10-31 | 1998-10-29 | Utilisation d'inhibiteurs de pro-teasomes dans le traitement du cancer, de l'inflammation, de ma-ladies autoimmunes, du rejet du greffon et du choc septique |
AU97318/98A AU770798B2 (en) | 1997-10-31 | 1998-10-29 | The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock |
JP52505499A JP2001508465A (ja) | 1997-10-31 | 1998-10-29 | ガン、炎症、自己免疫疾患、移植片拒絶反応および敗血症性ショックを処置するためのプロテアソーム阻害因子の使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002219867A CA2219867A1 (fr) | 1997-10-31 | 1997-10-31 | Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2219867A1 true CA2219867A1 (fr) | 1999-04-30 |
Family
ID=4161712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002219867A Abandoned CA2219867A1 (fr) | 1997-10-31 | 1997-10-31 | Utilisation d'inhibiteurs du proteasome dans le traitement du cancer, de l'inflammation, des maladies auto-immunes, du rejet de greffe et du choc septique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0967976A1 (fr) |
JP (1) | JP2001508465A (fr) |
AU (1) | AU770798B2 (fr) |
CA (1) | CA2219867A1 (fr) |
WO (1) | WO1999022729A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2726367C2 (ru) * | 2016-03-28 | 2020-07-13 | Пресидж Байосайенсиз, Инк. | Фармацевтические комбинации для лечения злокачественной опухоли |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69920940T2 (de) * | 1998-10-20 | 2005-11-17 | Millennium Pharmaceuticals, Inc., Cambridge | Verfahren zur überwachung der proteasomeinhibitorarzneimitteleffekte |
JP2011195590A (ja) * | 1999-10-20 | 2011-10-06 | Osteoscreen Inc | 骨および毛成長を刺激するためのプロテアソーム活性のインヒビター |
US6692927B2 (en) * | 2000-03-03 | 2004-02-17 | University Of South Florida | Bax degradation involvement in tumor survival and progression |
DK1326632T3 (da) | 2000-10-12 | 2007-01-15 | Viromics Gmbh | Protease-inhibitorer til behandling af infektioner af hepatitisvirus |
WO2002080907A1 (fr) * | 2001-04-03 | 2002-10-17 | Millennium Pharmaceuticals, Inc. | Combinaison d'analogue de lactacystine et de medicament immunosuppresseur permettant la prolongation de la survie d'une allogreffe |
US7112588B2 (en) | 2001-05-21 | 2006-09-26 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
DE60218153T2 (de) | 2001-05-21 | 2007-06-28 | Alcon Inc. | Verwendung von proteasom-inhibitoren zur behandlung des trockenen auges |
WO2003084551A1 (fr) | 2002-04-05 | 2003-10-16 | Viromics Gmbh | Agent de traitement d'infections par flaviviridae |
DE10217254A1 (de) | 2002-04-15 | 2003-10-23 | Proteosys Ag | Verwendung von Substanzen zur Behandlung von Tumoren |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
EP1565193B1 (fr) | 2002-11-06 | 2013-04-24 | Dana-Farber Cancer Institute, Inc. | Compositions de traitement du cancer au moyen d'inhibiteur PS-341 de la proteasome |
CN1823070A (zh) * | 2003-06-20 | 2006-08-23 | 加利福尼亚大学董事会 | 盐孢菌酰胺及其使用方法 |
BRPI0411677A (pt) | 2003-06-20 | 2006-08-29 | Nereus Pharmaceuticals Inc | métodos de uso de compostos heterocìclicos [3.2.0] e seus análogos |
AU2005212311A1 (en) * | 2004-02-06 | 2005-08-25 | The University Of Chicago | An anti-inflammatory, cytoprotective factor derivable from a probiotic organism |
AU2006249323B2 (en) | 2005-05-27 | 2012-08-30 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
DE102006026464A1 (de) * | 2006-06-01 | 2007-12-06 | Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma | Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus |
US20100240581A1 (en) * | 2006-11-13 | 2010-09-23 | The Trustees Of Columbia University In The City Of New York | Selective proteasome inhibitors for treating diabetes |
EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
CN102089312A (zh) | 2008-05-12 | 2011-06-08 | 尼瑞斯药品公司 | 作为蛋白酶体抑制剂的Salinosporamide衍生物 |
JP2010004750A (ja) * | 2008-06-24 | 2010-01-14 | Institute For Rheumatic Diseases Co Ltd | 自己免疫疾患による組織傷害の発症または発症可能性の診断方法、およびその利用 |
SG195655A1 (en) * | 2008-11-13 | 2013-12-30 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
CN102711729B (zh) | 2009-08-21 | 2015-04-01 | 诺万公司 | 局部用凝胶 |
DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
DE102010039631A1 (de) * | 2010-08-22 | 2012-02-23 | Ulrich Schubert | Pharmazeutische Zusammensetzungen mit immunmodulatorischen Eigenschaften |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
EP2681286B1 (fr) | 2011-02-28 | 2018-08-15 | Novan, Inc. | Particules de silice modifiées par des groupements s-nitrosothiols libérant de l'oxyde nitrique et procédés de fabrication associés |
WO2012164398A2 (fr) * | 2011-06-01 | 2012-12-06 | Netherlands Cancer Institute | Modulation du système ubiquitine-protéasome (ups) |
KR101757373B1 (ko) * | 2015-07-24 | 2017-07-26 | 울산과학기술원 | 프로테아좀 억제제 스크리닝용 조성물 및 이를 이용한 프로테아좀 억제제 스크리닝 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08507754A (ja) * | 1993-02-10 | 1996-08-20 | ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | Mhc−1拘束性抗原提示におけるatp−ユビキチン依存蛋白分解の役割およびそのインヒビター |
US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
US5834487A (en) * | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
-
1997
- 1997-10-31 CA CA002219867A patent/CA2219867A1/fr not_active Abandoned
-
1998
- 1998-10-29 WO PCT/CA1998/001010 patent/WO1999022729A1/fr not_active Application Discontinuation
- 1998-10-29 EP EP98951135A patent/EP0967976A1/fr not_active Ceased
- 1998-10-29 JP JP52505499A patent/JP2001508465A/ja active Pending
- 1998-10-29 AU AU97318/98A patent/AU770798B2/en not_active Ceased
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2726367C2 (ru) * | 2016-03-28 | 2020-07-13 | Пресидж Байосайенсиз, Инк. | Фармацевтические комбинации для лечения злокачественной опухоли |
US11135198B2 (en) | 2016-03-28 | 2021-10-05 | Presage Biosciences, Inc. | Pharmaceutical combinations for the treatment of cancer |
Also Published As
Publication number | Publication date |
---|---|
WO1999022729A1 (fr) | 1999-05-14 |
EP0967976A1 (fr) | 2000-01-05 |
AU770798B2 (en) | 2004-03-04 |
AU9731898A (en) | 1999-05-24 |
JP2001508465A (ja) | 2001-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20040126 |