DK1323820T3 - Fremgangsmåde til faciliteret isolering af heterologe proteiner fra bakterieceller - Google Patents
Fremgangsmåde til faciliteret isolering af heterologe proteiner fra bakteriecellerInfo
- Publication number
- DK1323820T3 DK1323820T3 DK03006278T DK03006278T DK1323820T3 DK 1323820 T3 DK1323820 T3 DK 1323820T3 DK 03006278 T DK03006278 T DK 03006278T DK 03006278 T DK03006278 T DK 03006278T DK 1323820 T3 DK1323820 T3 DK 1323820T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acid
- bacterial cells
- acid encoding
- heterologous proteins
- promoter
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000006166 lysate Substances 0.000 abstract 2
- 102000016943 Muramidase Human genes 0.000 abstract 1
- 108010014251 Muramidase Proteins 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 210000000805 cytoplasm Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960000274 lysozyme Drugs 0.000 abstract 1
- 235000010335 lysozyme Nutrition 0.000 abstract 1
- 239000004325 lysozyme Substances 0.000 abstract 1
- 210000001322 periplasm Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10605298P | 1998-10-28 | 1998-10-28 | |
PCT/US1999/024696 WO2000024873A1 (fr) | 1998-10-28 | 1999-10-21 | Procede de recuperation de polypeptides heterologues a partir de cellules bacteriennes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1323820T3 true DK1323820T3 (da) | 2009-03-16 |
Family
ID=22309219
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03006278T DK1323820T3 (da) | 1998-10-28 | 1999-10-21 | Fremgangsmåde til faciliteret isolering af heterologe proteiner fra bakterieceller |
DK99971031T DK1124941T3 (da) | 1998-10-28 | 1999-10-21 | Fremgangsmåde til isolering af heterologe polypeptider fra bakterieceller |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99971031T DK1124941T3 (da) | 1998-10-28 | 1999-10-21 | Fremgangsmåde til isolering af heterologe polypeptider fra bakterieceller |
Country Status (13)
Country | Link |
---|---|
US (2) | US6180367B1 (fr) |
EP (2) | EP1124941B1 (fr) |
JP (1) | JP3711326B2 (fr) |
AT (2) | ATE415469T1 (fr) |
AU (1) | AU752429B2 (fr) |
CA (1) | CA2346797C (fr) |
CY (1) | CY1109847T1 (fr) |
DE (2) | DE69911450T2 (fr) |
DK (2) | DK1323820T3 (fr) |
ES (2) | ES2207340T3 (fr) |
IL (2) | IL142269A0 (fr) |
PT (2) | PT1323820E (fr) |
WO (1) | WO2000024873A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA00009561A (es) * | 1998-03-30 | 2002-08-06 | Metabolix Inc | Cepas microbianas y procesos para la fabricacion de biomateriales. |
US7858339B1 (en) | 1998-10-28 | 2010-12-28 | Genentech, Inc. | Process for bacterial production of polypeptides |
AU4305501A (en) * | 1999-12-30 | 2001-07-16 | Intel Corporation | Optimized driver layout for integrated circuits with staggered bond pads |
US6784558B2 (en) * | 1999-12-30 | 2004-08-31 | Intel Corporation | Semiconductor device inlcluding optimized driver layout for integrated circuit with staggered bond pads |
MXPA04001566A (es) * | 2001-08-27 | 2004-05-17 | Genentech Inc | Un sistema para expresion y ensamblado de anticuerpos. |
US20030198682A1 (en) * | 2002-02-12 | 2003-10-23 | Gruber James V. | Composition and method for protecting labile active components during high temperature drying |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
US7195611B1 (en) * | 2002-12-31 | 2007-03-27 | Advanced Cardiovascular Systems, Inc. | Rapid exchange balloon catheter having a reinforced inner tubular member |
US20060134739A1 (en) * | 2003-03-11 | 2006-06-22 | Chatterjee Deb K | Synthesis of proteins by cell-free protein expression |
EP2327718B1 (fr) | 2003-11-21 | 2016-03-23 | Pfenex, Inc. | Systèmes d'expression ameliorés à sécrétion du système SEC |
CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
BRPI0515418A (pt) * | 2004-08-16 | 2008-07-22 | Nature Technology Corp | método para a produção de dna de plasmìdio super-enrolado fechado covalentemente e composição de matéria |
US20060156998A1 (en) * | 2005-01-19 | 2006-07-20 | Shawn Bridy | Protective collar for animals |
MY143274A (en) | 2005-12-22 | 2011-04-15 | Genentech Inc | Recombinant production of heparin binding proteins |
US20080125580A1 (en) | 2006-07-14 | 2008-05-29 | Genentech, Inc. | Refolding of Recombinant Proteins |
DK2431470T3 (da) * | 2006-11-30 | 2018-01-29 | Novozymes As | DNase expression i rekombinante værtsceller |
KR101491867B1 (ko) * | 2007-01-31 | 2015-02-10 | 피페넥스 인크. | 증가된 발현을 위한 박테리아 리더 서열 |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2008134461A2 (fr) | 2007-04-27 | 2008-11-06 | Dow Global Technologies, Inc. | Procédé pour rapidement cribler des hôtes microbiens et identifier certaines souches ayant un rendement et/ou une qualité d'expression des protéines hétérologues améliorés |
US9017966B2 (en) * | 2007-05-23 | 2015-04-28 | Nature Technology Corporation | E. coli plasmid DNA production |
US20110020830A1 (en) * | 2008-03-31 | 2011-01-27 | Schneider Jane C | Design for rapidly cloning one or more polypeptide chains into an expression system |
ES2370947B1 (es) * | 2009-12-23 | 2012-11-02 | Consejo Superior De Investigaciones Científicas (Csic) | Sistema de autolisis celular para el procesado de la biomasa bacteriana en la produccion de polihidroxialcanoatos en pseudomonas putida kt2440 |
KR101222889B1 (ko) | 2010-02-25 | 2013-01-17 | 고려대학교 산학협력단 | 이중프로모터를 포함하는 발현 시스템 및 그 시스템을 이용한 유전자 과다 발현 방법 |
WO2013147043A1 (fr) * | 2012-03-29 | 2013-10-03 | 株式会社シノテスト | Procédé de détection ou de dosage d'acide nucléique et kit de réactifs afférent |
GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
KR20160029731A (ko) | 2013-03-12 | 2016-03-15 | 더 제너럴 하스피탈 코포레이션 | 변형된 뮐러관 억제 물질(mis) 단백질 및 질환 치료를 위한 그 용도 |
EP3079712B1 (fr) | 2013-12-11 | 2022-02-02 | The General Hospital Corporation | Utilisation de protéines d'hormone anti-mullerienne (amh) pour la contraception et la préservation de la réserve ovarienne |
JP6803328B2 (ja) * | 2014-08-28 | 2021-01-06 | シンセティック バイオロジクス,インコーポレイテッド | 大腸菌ベースでのベータラクタマーゼ生産 |
MX2018011834A (es) * | 2016-03-29 | 2019-03-06 | Geltor Inc | Expresión de proteínas en bacterias gram negativas en la que la relación del volumen periplasmático con respecto al volumen citoplasmático está entre 0.5:1 y 10:1. |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
GB201814590D0 (en) * | 2018-09-07 | 2018-10-24 | Oxford Biomedica Ltd | Viral vector production system |
JP2022024197A (ja) * | 2018-09-28 | 2022-02-09 | Spiber株式会社 | 組換え細胞、組換え細胞の破砕方法及び目的タンパク質の製造方法 |
CN113993885A (zh) | 2019-04-12 | 2022-01-28 | 格尔托公司 | 重组弹性蛋白及其生产 |
JP7259131B2 (ja) | 2019-08-05 | 2023-04-17 | ワッカー ケミー アクチエンゲゼルシャフト | 発酵法で組換えタンパク質を放出する細菌株 |
EP4127205A1 (fr) * | 2020-04-03 | 2023-02-08 | Novozymes A/S | Processus de fermentation en milieu liquide |
EP3926039A1 (fr) * | 2020-06-17 | 2021-12-22 | AB Enzymes GmbH | Utilisation d'une nucléase pour réduire la viscosité et/ou empêcher une augmentation de la viscosité d'un bouillon de fermentation |
WO2023019197A1 (fr) * | 2021-08-11 | 2023-02-16 | Duke University | Expression et purification rapides de protéines thermostables, y compris la taq polymérase |
WO2024133316A1 (fr) * | 2022-12-23 | 2024-06-27 | Thermo Fisher Scientific Baltics Uab | Système fermé pour l'expression de protéines recombinées à l'aide d'e. coli et procédés de production de cultures de cellules clarifiées à partir de celui-ci |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595658A (en) | 1982-09-13 | 1986-06-17 | The Rockefeller University | Method for facilitating externalization of proteins synthesized in bacteria |
US4637980A (en) | 1983-08-09 | 1987-01-20 | Smithkline Beckman Corporation | Externalization of products of bacteria |
EP0155189A3 (fr) * | 1984-03-16 | 1987-09-16 | Genentech, Inc. | Expression d'une protéine dégradant la paroi d'une cellule et cellules-hôtes contenant l'ADN codant pour une telle protéine |
DE3507648A1 (de) | 1985-03-05 | 1986-09-11 | Klöckner-Humboldt-Deutz AG, 5000 Köln | Vorrichtung und verfahren zum warmhalten von fluessigen metallschmelzen |
JPH0640832B2 (ja) | 1985-05-10 | 1994-06-01 | 味の素株式会社 | インタ−ロイキン2ポリペプチドの回収方法 |
SE8505027D0 (sv) * | 1985-10-24 | 1985-10-24 | Kabigen Ab | A lytic virulent phage, a hostcell containing same and a process for protein production |
US5169772A (en) | 1988-06-06 | 1992-12-08 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase from flavobacterium heparinum |
US5512456A (en) | 1990-05-25 | 1996-04-30 | James Madison University | Method for the improved production and recovery of poly-β-hydroxybutyrate from transformed Escherichia coli |
RU2043415C1 (ru) | 1992-02-18 | 1995-09-10 | Биотехнологическая компания "Биосервис" | ВЕКТОР PEL 5b, ПРЕДНАЗНАЧЕННЫЙ ДЛЯ ЭКСПРЕССИИ ЧУЖЕРОДНОЙ ДНК |
RU2071503C1 (ru) | 1992-02-18 | 1997-01-10 | Биотехнологическая компания "Биосервис" | ВЕКТОР pЕL5С, ПРЕДНАЗНАЧЕННЫЙ ДЛЯ ЭКСПРЕССИИ ЧУЖЕРОДНОЙ ДНК |
RU2071501C1 (ru) | 1992-02-18 | 1997-01-10 | Биотехнологическая компания "Биосервис" | Вектор реl25а, предназначенный для экспрессии чужеродного днк |
WO1994012214A1 (fr) * | 1992-12-01 | 1994-06-09 | Protein Design Labs, Inc. | Anticorps humanises reagissant avec la cd-18 |
-
1999
- 1999-10-21 PT PT03006278T patent/PT1323820E/pt unknown
- 1999-10-21 US US09/422,712 patent/US6180367B1/en not_active Expired - Lifetime
- 1999-10-21 AT AT03006278T patent/ATE415469T1/de active
- 1999-10-21 EP EP99971031A patent/EP1124941B1/fr not_active Expired - Lifetime
- 1999-10-21 EP EP03006278A patent/EP1323820B1/fr not_active Expired - Lifetime
- 1999-10-21 DE DE69911450T patent/DE69911450T2/de not_active Expired - Lifetime
- 1999-10-21 IL IL14226999A patent/IL142269A0/xx unknown
- 1999-10-21 JP JP2000578427A patent/JP3711326B2/ja not_active Expired - Lifetime
- 1999-10-21 DK DK03006278T patent/DK1323820T3/da active
- 1999-10-21 DK DK99971031T patent/DK1124941T3/da active
- 1999-10-21 WO PCT/US1999/024696 patent/WO2000024873A1/fr active IP Right Grant
- 1999-10-21 PT PT99971031T patent/PT1124941E/pt unknown
- 1999-10-21 ES ES99971031T patent/ES2207340T3/es not_active Expired - Lifetime
- 1999-10-21 AU AU12195/00A patent/AU752429B2/en not_active Expired
- 1999-10-21 AT AT99971031T patent/ATE250125T1/de active
- 1999-10-21 DE DE69939991T patent/DE69939991D1/de not_active Expired - Lifetime
- 1999-10-21 ES ES03006278T patent/ES2318070T3/es not_active Expired - Lifetime
- 1999-10-21 CA CA002346797A patent/CA2346797C/fr not_active Expired - Lifetime
-
2000
- 2000-06-29 US US09/607,756 patent/US6258560B1/en not_active Expired - Lifetime
-
2001
- 2001-03-27 IL IL142269A patent/IL142269A/en not_active IP Right Cessation
-
2009
- 2009-02-18 CY CY20091100188T patent/CY1109847T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2346797A1 (fr) | 2000-05-04 |
PT1124941E (pt) | 2004-02-27 |
IL142269A0 (en) | 2002-03-10 |
AU1219500A (en) | 2000-05-15 |
ATE415469T1 (de) | 2008-12-15 |
DE69911450D1 (de) | 2003-10-23 |
ES2318070T3 (es) | 2009-05-01 |
IL142269A (en) | 2010-12-30 |
DE69911450T2 (de) | 2004-07-22 |
DE69939991D1 (de) | 2009-01-08 |
US6258560B1 (en) | 2001-07-10 |
ATE250125T1 (de) | 2003-10-15 |
JP2002528071A (ja) | 2002-09-03 |
DK1124941T3 (da) | 2004-02-02 |
EP1323820B1 (fr) | 2008-11-26 |
EP1323820A2 (fr) | 2003-07-02 |
US6180367B1 (en) | 2001-01-30 |
PT1323820E (pt) | 2009-03-05 |
WO2000024873A1 (fr) | 2000-05-04 |
JP3711326B2 (ja) | 2005-11-02 |
CY1109847T1 (el) | 2014-09-10 |
ES2207340T3 (es) | 2004-05-16 |
EP1124941A1 (fr) | 2001-08-22 |
WO2000024873A9 (fr) | 2000-11-02 |
EP1124941B1 (fr) | 2003-09-17 |
AU752429B2 (en) | 2002-09-19 |
EP1323820A3 (fr) | 2003-07-09 |
CA2346797C (fr) | 2008-09-23 |
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