DK1294910T3 - Protein glykosyleringsmodifikation i Pichia Pastoris - Google Patents
Protein glykosyleringsmodifikation i Pichia PastorisInfo
- Publication number
- DK1294910T3 DK1294910T3 DK01955499T DK01955499T DK1294910T3 DK 1294910 T3 DK1294910 T3 DK 1294910T3 DK 01955499 T DK01955499 T DK 01955499T DK 01955499 T DK01955499 T DK 01955499T DK 1294910 T3 DK1294910 T3 DK 1294910T3
- Authority
- DK
- Denmark
- Prior art keywords
- genetically engineered
- pichia pastoris
- protein glycosylation
- glycosylation modification
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/165—Yeast isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01024—Alpha-mannosidase (3.2.1.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/84—Pichia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21567600P | 2000-06-30 | 2000-06-30 | |
PCT/IB2001/001514 WO2002000856A2 (en) | 2000-06-30 | 2001-06-29 | Protein glycosylation modification in pichia pastoris |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1294910T3 true DK1294910T3 (da) | 2009-03-02 |
Family
ID=22803912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01955499T DK1294910T3 (da) | 2000-06-30 | 2001-06-29 | Protein glykosyleringsmodifikation i Pichia Pastoris |
Country Status (13)
Country | Link |
---|---|
US (4) | US6803225B2 (de) |
EP (3) | EP2028275A3 (de) |
JP (1) | JP4092194B2 (de) |
KR (1) | KR100820367B1 (de) |
AT (1) | ATE414778T1 (de) |
AU (2) | AU7765801A (de) |
CA (1) | CA2411968C (de) |
DE (1) | DE60136623D1 (de) |
DK (1) | DK1294910T3 (de) |
ES (1) | ES2316462T3 (de) |
MX (1) | MXPA02012688A (de) |
PT (1) | PT1294910E (de) |
WO (1) | WO2002000856A2 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
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US7598055B2 (en) | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
US7863020B2 (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
PT1522590E (pt) | 2000-06-28 | 2009-10-26 | Glycofi Inc | Métodos para a produção de glicoproteínas modificadas |
CA2411968C (en) * | 2000-06-30 | 2009-12-15 | Flanders Interuniversity Institute For Biotechnology (Vib) | Protein glycosylation modification in pichia pastoris |
EP2359685B1 (de) | 2001-12-27 | 2013-12-04 | GlycoFi, Inc. | Verfahren für die rekombinante veränderung von kohlenhydratstrukturen des säugetiertyps |
EP1481057B1 (de) | 2002-03-07 | 2006-02-15 | Eidgenössische Technische Hochschule Zürich | System und methode zur herstellung von rekombinanten, glykosylierten protein in prokaryontischen wirtszellen |
JP4464269B2 (ja) | 2002-04-26 | 2010-05-19 | 協和発酵キリン株式会社 | 哺乳類型糖鎖生産メチロトロフ酵母 |
ITRM20020287A1 (it) * | 2002-05-22 | 2003-11-24 | Univ Roma | Cellule di lievito ingegnerizzate per la produzione di proteine ricombinanti. |
IL165717A0 (en) | 2002-06-26 | 2006-01-15 | Flanders Interuniversity Inst | A strain of methylotrophic yeast for producing proteins |
WO2004003205A1 (en) * | 2002-06-29 | 2004-01-08 | Korea Research Institute Of Bioscience And Biotechnology | Hansenula polymorpha mutant strains with defect in outer chain biosynthesis and the production of recombinant glycoproteins using the same strains |
US7332299B2 (en) * | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
EP1601761A1 (de) | 2003-03-12 | 2005-12-07 | VIB vzw | Verbesserte proteinsekretion in eukaryotischen zellen |
US7507573B2 (en) | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
KR100604994B1 (ko) | 2004-01-30 | 2006-07-26 | 한국생명공학연구원 | 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법 |
US20080299616A1 (en) * | 2004-07-22 | 2008-12-04 | Byung-Kwon Choi | Malate Synthase Regulatory Sequences for Heterologous Gene Expression in Pichia |
EP1888761B1 (de) | 2005-05-11 | 2010-09-29 | ETH Zurich | Rekombinante n-glykosylierte proteine aus prokaryontischen zellen |
CN101313216A (zh) * | 2005-09-22 | 2008-11-26 | 普洛茨股份有限公司 | 酵母突变体中产生的糖基化多肽及其使用方法 |
CA2628725A1 (en) * | 2005-11-15 | 2007-05-31 | Glycofi, Inc. | Production of glycoproteins with reduced o-glycosylation |
WO2007067564A2 (en) | 2005-12-08 | 2007-06-14 | Amgen Inc. | Improved host cells and culture methods |
KR101812400B1 (ko) * | 2007-04-03 | 2017-12-27 | 옥시레인 유케이 리미티드 | 분자의 글리코실화 |
EP3427749A1 (de) | 2008-02-20 | 2019-01-16 | GlaxoSmithKline Biologicals SA | Biokonjugate aus rekombinanten n-glykosylierten proteinen aus prokaryontischen zellen |
WO2010111687A2 (en) * | 2009-03-27 | 2010-09-30 | Academia Sinica | Methods and compositions for immunization against virus |
US8815242B2 (en) * | 2009-05-27 | 2014-08-26 | Synageva Biopharma Corp. | Avian derived antibodies |
EP2456463A4 (de) * | 2009-07-24 | 2013-12-04 | Merck Sharp & Dohme | Rekombinante ektodomänenexpression von herpes-simplex-virus-glycoproteinen in hefe |
US9598682B2 (en) | 2009-09-29 | 2017-03-21 | Vib Vzw | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
EP2494050A4 (de) * | 2009-10-30 | 2013-10-30 | Merck Sharp & Dohme | In glycoengineerter pichia pastoris hergestellter granulozytenkolonienstimulierender faktor |
JP2013511272A (ja) | 2009-11-19 | 2013-04-04 | オキシレイン ユーケー リミテッド | 哺乳類様複合n−グリカンを生成する酵母株 |
TR201803015T4 (tr) | 2009-11-19 | 2018-03-21 | Glaxosmithkline Biologicals Sa | Prokaryotik hücrelerde immünojenik polisakaridler üreten biyosentetik sistem. |
EP3281639B1 (de) | 2010-05-06 | 2020-11-11 | GlaxoSmithKline Biologicals S.A. | Konjugatimpstoffe mit kapselförmigen gram-positiven bakterien |
RU2604811C2 (ru) | 2010-05-27 | 2016-12-10 | Мерк Шарп Энд Домэ Корп. | Способ получения антител с улучшенными свойствами |
JP2013535198A (ja) | 2010-07-30 | 2013-09-12 | グリコド | 哺乳類のグリコシル化経路を有する酵母人工染色体 |
WO2012042387A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | De-mannosylation of phosphorylated n-glycans |
JP6151183B2 (ja) | 2010-09-29 | 2017-06-21 | オキシレイン ユーケー リミテッド | マンノース−1−ホスホ−6−マンノース結合からキャップを外すことおよびリン酸化n−グリカンを脱マンノシル化することができるマンノシダーゼならびに哺乳動物細胞による糖タンパク質の取り込みを促進する方法 |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
WO2012127045A1 (en) | 2011-03-23 | 2012-09-27 | Glycode | A yeast recombinant cell capable of producing gdp-fucose |
EP2714732A4 (de) | 2011-05-25 | 2014-12-10 | Merck Sharp & Dohme | Verfahren zur herstellung fc-haltiger polypeptide mit verbesserten eigenschaften |
CN104024849A (zh) | 2011-08-12 | 2014-09-03 | 生命科技公司 | 用于高通量聚糖分析的装置、方法、计算机程序产品和试剂盒 |
KR20190114003A (ko) | 2012-03-15 | 2019-10-08 | 옥시레인 유케이 리미티드 | 폼페병의 치료를 위한 방법 및 물질 |
WO2014088836A1 (en) | 2012-12-03 | 2014-06-12 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
WO2014093240A1 (en) | 2012-12-10 | 2014-06-19 | The General Hospital Corporation | Bivalent il-2 fusion toxins |
WO2014138188A1 (en) | 2013-03-07 | 2014-09-12 | The General Hospital Corporation | Human ctla4 mutants and use thereof |
US9689016B2 (en) * | 2013-12-18 | 2017-06-27 | Caliber Biotherapeutics, Llc | Method for in vivo production of deglycosylated recombinant proteins used as substrate for downstream protein glycoremodeling |
SG11201700446XA (en) * | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
MX2017006127A (es) | 2014-11-11 | 2017-11-08 | Clara Foods Co | Metodos y composiciones para produccion de proteina de clara de huevo. |
WO2020041483A1 (en) * | 2018-08-21 | 2020-02-27 | Clara Foods Co. | Modification of protein glycosylation in microorganisms |
CN109797115B (zh) * | 2019-01-12 | 2022-07-12 | 贵州大学 | 一株产纳豆激酶和β-葡萄糖苷酶解淀粉芽孢杆菌GZU05及其应用方法 |
CN110438027B (zh) * | 2019-06-05 | 2022-08-26 | 贵州大学 | 产多种酶类的解淀粉芽孢杆菌菌株gutu06及其筛选方法 |
BR112022000545A2 (pt) | 2019-07-11 | 2022-04-05 | Clara Foods Co | Composições de proteína e produtos de consumo destas |
US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
WO2024032891A1 (en) | 2022-08-11 | 2024-02-15 | Vib Vzw | Glyco-engineered yeast for therapeutic protein production |
Family Cites Families (23)
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US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4837148A (en) | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
US4818700A (en) | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
US4812405A (en) | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
EP0314096B1 (de) | 1987-10-29 | 1994-01-12 | Zymogenetics, Inc. | Verfahren zur Regulierung der Proteinglycosylierung |
US5135854A (en) | 1987-10-29 | 1992-08-04 | Zymogenetics, Inc. | Methods of regulating protein glycosylation |
WO1991005057A1 (en) * | 1989-09-28 | 1991-04-18 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Cd4 production in pichia pastoris |
ES2107520T3 (es) | 1991-12-16 | 1997-12-01 | Ciba Geigy Ag | Endoproteasa dibasica recombinante situada en el reticulo endoplasmico y usos de la misma. |
DE4301932A1 (de) | 1992-08-07 | 1994-02-10 | Boehringer Mannheim Gmbh | Hefewirtsstämme mit Defekten in der N-Glycosylierung |
US5834251A (en) | 1994-12-30 | 1998-11-10 | Alko Group Ltd. | Methods of modifying carbohydrate moieties |
JPH08336387A (ja) * | 1995-06-12 | 1996-12-24 | Green Cross Corp:The | ピキア属酵母由来の糖鎖伸長タンパク及びそのdna |
JPH09261A (ja) * | 1995-06-16 | 1997-01-07 | Green Cross Corp:The | 糖蛋白質の製造方法 |
IT1288879B1 (it) | 1996-04-19 | 1998-09-25 | Danieli Off Mecc | Dispositivo per la sostituzione dei cilindri in una gabbia di laminazione per lamiere e/o larghi piatti |
CA2382184A1 (en) * | 1999-08-19 | 2001-03-01 | Kirin Beer Kabushiki Kaisha | Novel yeast mutants and process for producing glycoprotein containing mammalian type sugar chain |
PT1522590E (pt) * | 2000-06-28 | 2009-10-26 | Glycofi Inc | Métodos para a produção de glicoproteínas modificadas |
CA2411968C (en) * | 2000-06-30 | 2009-12-15 | Flanders Interuniversity Institute For Biotechnology (Vib) | Protein glycosylation modification in pichia pastoris |
IL165717A0 (en) * | 2002-06-26 | 2006-01-15 | Flanders Interuniversity Inst | A strain of methylotrophic yeast for producing proteins |
WO2004003205A1 (en) | 2002-06-29 | 2004-01-08 | Korea Research Institute Of Bioscience And Biotechnology | Hansenula polymorpha mutant strains with defect in outer chain biosynthesis and the production of recombinant glycoproteins using the same strains |
US7507573B2 (en) * | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
US8270413B2 (en) | 2005-11-28 | 2012-09-18 | Cisco Technology, Inc. | Method and apparatus for self-learning of VPNS from combination of unidirectional tunnels in MPLS/VPN networks |
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2001
- 2001-06-29 CA CA002411968A patent/CA2411968C/en not_active Expired - Lifetime
- 2001-06-29 AU AU7765801A patent/AU7765801A/xx active Pending
- 2001-06-29 JP JP2002506172A patent/JP4092194B2/ja not_active Expired - Lifetime
- 2001-06-29 DE DE60136623T patent/DE60136623D1/de not_active Expired - Lifetime
- 2001-06-29 AU AU2001277658A patent/AU2001277658B2/en not_active Expired
- 2001-06-29 US US09/896,594 patent/US6803225B2/en not_active Expired - Lifetime
- 2001-06-29 ES ES01955499T patent/ES2316462T3/es not_active Expired - Lifetime
- 2001-06-29 AT AT01955499T patent/ATE414778T1/de active
- 2001-06-29 KR KR1020027018059A patent/KR100820367B1/ko active IP Right Grant
- 2001-06-29 EP EP08019986A patent/EP2028275A3/de not_active Withdrawn
- 2001-06-29 PT PT01955499T patent/PT1294910E/pt unknown
- 2001-06-29 EP EP10011501A patent/EP2267135A3/de not_active Withdrawn
- 2001-06-29 MX MXPA02012688A patent/MXPA02012688A/es active IP Right Grant
- 2001-06-29 WO PCT/IB2001/001514 patent/WO2002000856A2/en active Application Filing
- 2001-06-29 DK DK01955499T patent/DK1294910T3/da active
- 2001-06-29 EP EP01955499A patent/EP1294910B1/de not_active Revoked
-
2003
- 2003-09-25 US US10/672,484 patent/US8354268B2/en not_active Expired - Lifetime
-
2009
- 2009-04-16 US US12/424,924 patent/US8663971B2/en not_active Expired - Fee Related
-
2014
- 2014-01-10 US US14/152,329 patent/US9359628B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP2028275A2 (de) | 2009-02-25 |
KR100820367B1 (ko) | 2008-04-07 |
MXPA02012688A (es) | 2004-09-10 |
PT1294910E (pt) | 2009-02-16 |
JP4092194B2 (ja) | 2008-05-28 |
ATE414778T1 (de) | 2008-12-15 |
US20140154738A1 (en) | 2014-06-05 |
US9359628B2 (en) | 2016-06-07 |
EP1294910A2 (de) | 2003-03-26 |
WO2002000856A3 (en) | 2003-01-03 |
EP2028275A3 (de) | 2009-05-06 |
AU2001277658B2 (en) | 2006-10-19 |
DE60136623D1 (de) | 2009-01-02 |
KR20030074117A (ko) | 2003-09-19 |
US6803225B2 (en) | 2004-10-12 |
WO2002000856A2 (en) | 2002-01-03 |
EP2267135A3 (de) | 2011-09-14 |
US20100267084A1 (en) | 2010-10-21 |
US8663971B2 (en) | 2014-03-04 |
US20040038381A1 (en) | 2004-02-26 |
EP2267135A2 (de) | 2010-12-29 |
US8354268B2 (en) | 2013-01-15 |
CA2411968A1 (en) | 2002-01-03 |
AU7765801A (en) | 2002-01-08 |
ES2316462T3 (es) | 2009-04-16 |
EP1294910B1 (de) | 2008-11-19 |
JP2004501635A (ja) | 2004-01-22 |
US20020188109A1 (en) | 2002-12-12 |
CA2411968C (en) | 2009-12-15 |
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