DK1272188T3 - Anvendelse af EGFR-tyrosinkinaseinhibitorer til behandling af brystcancer - Google Patents

Anvendelse af EGFR-tyrosinkinaseinhibitorer til behandling af brystcancer

Info

Publication number
DK1272188T3
DK1272188T3 DK00973002T DK00973002T DK1272188T3 DK 1272188 T3 DK1272188 T3 DK 1272188T3 DK 00973002 T DK00973002 T DK 00973002T DK 00973002 T DK00973002 T DK 00973002T DK 1272188 T3 DK1272188 T3 DK 1272188T3
Authority
DK
Denmark
Prior art keywords
breast cancer
tyrosine kinase
treatment
egfr tyrosine
kinase inhibitors
Prior art date
Application number
DK00973002T
Other languages
Danish (da)
English (en)
Inventor
Nigel James Bundred
Original Assignee
Univ Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Manchester filed Critical Univ Manchester
Application granted granted Critical
Publication of DK1272188T3 publication Critical patent/DK1272188T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK00973002T 1999-11-02 2000-11-01 Anvendelse af EGFR-tyrosinkinaseinhibitorer til behandling af brystcancer DK1272188T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9925958.2A GB9925958D0 (en) 1999-11-02 1999-11-02 Therapeutic use
PCT/GB2000/004190 WO2001032155A2 (en) 1999-11-02 2000-11-01 Use of egfr tyrosine kinase inhibitors for treating breast cancer

Publications (1)

Publication Number Publication Date
DK1272188T3 true DK1272188T3 (da) 2007-01-29

Family

ID=10863835

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00973002T DK1272188T3 (da) 1999-11-02 2000-11-01 Anvendelse af EGFR-tyrosinkinaseinhibitorer til behandling af brystcancer

Country Status (21)

Country Link
US (1) US7553815B1 (no)
EP (1) EP1272188B1 (no)
JP (1) JP2003513035A (no)
KR (1) KR100785359B1 (no)
CN (1) CN1197577C (no)
AT (1) ATE339957T1 (no)
AU (1) AU779190B2 (no)
BR (1) BR0015194A (no)
CA (1) CA2389411C (no)
CY (1) CY1106285T1 (no)
DE (1) DE60030889T2 (no)
DK (1) DK1272188T3 (no)
ES (1) ES2275556T3 (no)
GB (1) GB9925958D0 (no)
IL (1) IL149176A0 (no)
MX (1) MXPA02004272A (no)
NO (1) NO323206B1 (no)
NZ (1) NZ518696A (no)
PT (1) PT1272188E (no)
WO (1) WO2001032155A2 (no)
ZA (1) ZA200203431B (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ522444A (en) 2000-05-19 2004-09-24 Genentech Inc Gene detection assay for improving the likelihood of an effective response to an ErbB antagonist cancer therapy
EP1408980A4 (en) 2001-06-21 2004-10-20 Ariad Pharma Inc NEW QUINAZOLINES AND THEIR USE
US6872715B2 (en) * 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
JP2005507424A (ja) * 2001-10-29 2005-03-17 ノバルティス アクチエンゲゼルシャフト 固形腫瘍の処置における７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の使用
MEP36208A (en) * 2001-12-03 2011-02-10 Bayer Corp Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
KR20050037510A (ko) 2002-06-05 2005-04-22 세다르스-신나이 메디칼 센터 키나제 억제제를 사용하는 암 치료 방법
US20070059785A1 (en) * 2003-08-15 2007-03-15 Smithkline Beecham Corporation Biomarkers in cancer
PL1667992T3 (pl) 2003-09-19 2007-05-31 Astrazeneca Ab Pochodne chinazoliny
WO2005039588A2 (en) * 2003-10-22 2005-05-06 Novartis Ag Methods for determining the risk of developing liver and lung toxicity
US7701341B2 (en) * 2004-09-01 2010-04-20 Microsoft Corporation Device service provider interface
KR20180080371A (ko) 2005-01-21 2018-07-11 제넨테크, 인크. Ｈｅｒ 항체의 고정 용량 투여법
SI1850874T1 (sl) 2005-02-23 2014-01-31 Genentech, Inc. Podaljšanje časa za napredovanje bolezni ali za preživetje pri pacientkah z rakom na jajčnikih ob uporabi pertuzumaba
CN101003514A (zh) 2006-01-20 2007-07-25 上海艾力斯医药科技有限公司 喹唑啉衍生物、其制备方法及用途
WO2007091622A1 (ja) 2006-02-09 2007-08-16 Daiichi Sankyo Company, Limited 抗癌医薬組成物
CN1899616A (zh) * 2006-07-20 2007-01-24 中国人民解放军军事医学科学院生物工程研究所 非受体酪氨酸激酶c－Abl特异性抑制剂的新用途
ES2477497T3 (es) 2007-03-02 2014-07-17 Genentech, Inc. Predicción de la respuesta a un inhibidor de la dimerización de HER basado en la expresión de HER3 bajo
US9551033B2 (en) 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
CA2690334C (en) 2007-06-08 2017-02-14 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
MA33091B1 (fr) * 2009-03-11 2012-03-01 Ardea Biosciences Inc Combinaisons pharmaceutiques comprenant rdea119/bay 869766 pour le traitement de cancers specifiques
KR20150036824A (ko) 2009-03-20 2015-04-07 제넨테크, 인크. 이중특이적 항-ｈｅｒ 항체
US20120121586A1 (en) 2009-05-29 2012-05-17 Astrid Kiermaier Modulators for her2 signaling in her2 expressing patients with gastric cancer
RU2587619C2 (ru) 2010-02-18 2016-06-20 Дженентек, Инк. Антагонисты неурегулина и применение их в лечении злокачественного новообразования
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
EP2643353A1 (en) 2010-11-24 2013-10-02 Novartis AG Multispecific molecules
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
RU2014109093A (ru) 2011-08-17 2015-09-27 Дженентек, Инк. Антитела против нейрегулина и их применение
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
JP2015500638A (ja) 2011-11-30 2015-01-08 ジェネンテック， インコーポレイテッド 癌におけるｅｒｂｂ３変異
EP2788500A1 (en) 2011-12-09 2014-10-15 F.Hoffmann-La Roche Ag Identification of non-responders to her2 inhibitors
JP2015514710A (ja) 2012-03-27 2015-05-21 ジェネンテック， インコーポレイテッド Ｈｅｒ３阻害剤に関する診断及び治療
CN104813168B (zh) 2012-11-30 2017-10-20 霍夫曼-拉罗奇有限公司 需要pd‑l1抑制剂综合疗法的患者的鉴定
US20190151346A1 (en) 2016-05-10 2019-05-23 INSERM (Institute National de la Santé et de la Recherche Médicale) Combinations therapies for the treatment of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
DE69522717T2 (de) 1995-03-30 2002-02-14 Pfizer Chinazolinderivate
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
DK0831829T3 (da) * 1995-06-07 2003-12-15 Pfizer Heterocykliske, ringkondenserede pyrimidinderivater
CA2224435C (en) * 1995-07-06 2008-08-05 Novartis Ag Pyrrolopyrimidines and processes for the preparation thereof
CA2332331A1 (en) * 1998-05-15 1999-11-25 Francisco Robert Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
US20090202167A1 (en) 2006-08-28 2009-08-13 Koninklijke Philips Electronics N.V. Method and apparatus for image enhancement

Also Published As

Publication number Publication date
AU779190B2 (en) 2005-01-13
CN1197577C (zh) 2005-04-20
PT1272188E (pt) 2007-01-31
ATE339957T1 (de) 2006-10-15
GB9925958D0 (en) 1999-12-29
AU1155901A (en) 2001-05-14
EP1272188A2 (en) 2003-01-08
ES2275556T3 (es) 2007-06-16
KR20020064306A (ko) 2002-08-07
JP2003513035A (ja) 2003-04-08
IL149176A0 (en) 2002-11-10
MXPA02004272A (es) 2003-08-20
CN1387437A (zh) 2002-12-25
CY1106285T1 (el) 2011-10-12
NZ518696A (en) 2004-12-24
NO20022065L (no) 2002-06-24
WO2001032155A3 (en) 2002-05-10
DE60030889T2 (de) 2007-04-05
NO323206B1 (no) 2007-01-22
KR100785359B1 (ko) 2007-12-18
CA2389411A1 (en) 2001-05-10
WO2001032155A2 (en) 2001-05-10
ZA200203431B (en) 2003-02-26
NO20022065D0 (no) 2002-04-30
BR0015194A (pt) 2002-06-18
DE60030889D1 (de) 2006-11-02
US7553815B1 (en) 2009-06-30
EP1272188B1 (en) 2006-09-20
CA2389411C (en) 2009-09-01

Similar Documents

Publication Publication Date Title
DK1272188T3 (da) Anvendelse af EGFR-tyrosinkinaseinhibitorer til behandling af brystcancer
NO20060398L (no) Anvendelse av en kombinasjon av en epidermal vekstfaktor reseptor kinase inhibitor og cytotoksiske midler for behandling og hemming av kreft
DK1255537T3 (da) Farnesylproteintransferasehæmmere til behandling af brystcancer
IL154949A0 (en) Imidazole derivatives as raf kinase inhibitors
MY138059A (en) Use of ikb-kinase inhibitors in pain therapy
DK1373215T3 (da) Gelanamycinderivater egnet til behandling af cancer
DE60332604D1 (de) Azolylaminoazine als proteinkinasehemmer
EA200300906A1 (ru) Новые спиротрициклические производные и их применение в качестве ингибиторов фосфодиэстеразы-7
EA200501849A1 (ru) Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
MY169308A (en) Treatment of tnf? related disorders
CY1106766T1 (el) Παραγωγα πυριδινης ως αναστολεις raf κινασης
TNSN04015A1 (en) Combination therapy for the treatment of cancer
MX2007006927A (es) Combinacion de inhibidor de tirosina cinasa y her-2/neu para terapia de cancer.
CY1106289T1 (el) Χρηση αναστολεων υποδοχεος προγεστepονης για τη θepαπευτικη αντιμετωπιση του καρκινου του μαστου που ειναι ανθεκτικος σε στepοειδη
DE602004016950D1 (de) Verwendung von cyclin-d1-hemmern zur brustkrebsbehandlung
HK1080733A1 (en) Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, a cox-2 inhibitor and a taxol
TR200101693T2 (tr) Lemfotoksin (LT) sentezlenme yolunun inhibitörleri kullanılarak foliküler lemfomaların tedavisi.
DE60111515D1 (de) Kombinationstherapie mit keratinozyten-wachstumfaktor und ein epidermis-wachstumfaktor inhibitor
GB0121494D0 (en) Compounds
EA200200853A1 (ru) Применение 2-метилтиазолидин-3,3-дикарбоновой кислоты (2-мтдк) и/или ее физиологически совместимых солей для лечения и/или предупреждения рака
GEP201606538B (en) Preoperative treatment of post operative pain
NO20024545D0 (no) Fremgangsmåte for behandling av kongestiv hjertefeil
MXPA03010451A (es) Nuevos metodos para el tratamiento y prevencion del dolor.
EA200600987A1 (ru) Применение сирамезина в лечении злокачественных опухолей
ECSP003651A (es) Nuevos compuestos espiroheterociclicos utiles como inhibidores reversibles de cisteina-proteasas