DK1257290T4 - Fremgangsmåde til antigen-specifik stimulation af T-lymfocytter med syntetiske peptidbiblioteker - Google Patents

Fremgangsmåde til antigen-specifik stimulation af T-lymfocytter med syntetiske peptidbiblioteker

Info

Publication number
DK1257290T4
DK1257290T4 DK01919295.4T DK01919295T DK1257290T4 DK 1257290 T4 DK1257290 T4 DK 1257290T4 DK 01919295 T DK01919295 T DK 01919295T DK 1257290 T4 DK1257290 T4 DK 1257290T4
Authority
DK
Denmark
Prior art keywords
amino acid
peptides
lymphocytes
antigen
acid sequence
Prior art date
Application number
DK01919295.4T
Other languages
English (en)
Other versions
DK1257290T3 (da
Inventor
Florian Kern
Hans-Dieter Volk
Petra Reinke
Nicole Faulhaber
Ingolf-Pascal Surel
Elham Khatamzas
Original Assignee
Florian Kern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7632697&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1257290(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Florian Kern filed Critical Florian Kern
Publication of DK1257290T3 publication Critical patent/DK1257290T3/da
Application granted granted Critical
Publication of DK1257290T4 publication Critical patent/DK1257290T4/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
DK01919295.4T 2000-02-22 2001-02-17 Fremgangsmåde til antigen-specifik stimulation af T-lymfocytter med syntetiske peptidbiblioteker DK1257290T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10009341A DE10009341A1 (de) 2000-02-22 2000-02-22 Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten
PCT/EP2001/001773 WO2001063286A2 (de) 2000-02-22 2001-02-17 Verfahren zur antigen-spezifischen stimulation von t-lymphozyten mit synthetischen peptidbibliotheken

Publications (2)

Publication Number Publication Date
DK1257290T3 DK1257290T3 (da) 2009-03-30
DK1257290T4 true DK1257290T4 (da) 2013-06-03

Family

ID=7632697

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01919295.4T DK1257290T4 (da) 2000-02-22 2001-02-17 Fremgangsmåde til antigen-specifik stimulation af T-lymfocytter med syntetiske peptidbiblioteker

Country Status (9)

Country Link
US (1) US7994096B2 (da)
EP (1) EP1257290B2 (da)
JP (1) JP4846157B2 (da)
AT (1) ATE419867T1 (da)
AU (1) AU2001246444A1 (da)
DE (2) DE10009341A1 (da)
DK (1) DK1257290T4 (da)
ES (1) ES2317894T5 (da)
WO (1) WO2001063286A2 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003492A1 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
WO2004002415A2 (en) * 2002-06-27 2004-01-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating a cytotoxic t lymphocyte immune response
ITMI20031201A1 (it) * 2003-06-13 2004-12-14 Istituto Giannina Gaslini Epitopi della proteina pp65 di citomegalovirus
WO2008076904A1 (en) 2006-12-14 2008-06-26 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2678941C (en) * 2007-02-23 2018-11-27 Aileron Therapeutics, Inc. Triazole macrocycle systems
EP2155782A2 (en) 2007-03-26 2010-02-24 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
EP2197908A2 (en) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
CA2744088A1 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2601521B1 (en) 2010-08-06 2018-05-02 Ludwig-Maximilians-Universität München Identification of t cell target antigens
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
US10351824B2 (en) 2011-12-12 2019-07-16 Cell Medica Limited Process of expanding T cells
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
EP2822572B1 (en) 2012-02-15 2020-06-10 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2914256B1 (en) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3049092A4 (en) * 2013-09-24 2017-09-06 Duke University Compositions, methods and kits for eliciting an immune response
CA2961029A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
CN106999541A (zh) 2014-09-24 2017-08-01 艾瑞朗医疗公司 拟肽大环化合物及其用途
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
WO2016198470A2 (en) 2015-06-08 2016-12-15 Lophius Biosciences Gmbh Composition for determination of cell-mediated immune responsiveness
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
US11167024B2 (en) 2015-09-18 2021-11-09 Baylor College Of Medicine Immunogenic antigen identification from a pathogen and correlation to clinical efficacy
EP3203237B1 (en) 2016-02-03 2023-07-05 Nina Babel Urine-derived epithelial cell lines for diagnosis and therapy of an anti-bk-virus or anti-graft immune response
CN109475579A (zh) * 2016-05-23 2019-03-15 昆士兰医学研究所理事会 Cmv表位
WO2018046468A1 (en) 2016-09-06 2018-03-15 F. Hoffmann-La Roche Ag Mhc-bound peptide arrays and methods of use thereof
CA3094176A1 (en) 2018-03-22 2019-09-26 Charite-Universitatsmedizin Berlin Crispr associated protein reactive t cell immunity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207161B1 (en) * 1986-07-16 2001-03-27 City Of Hope Induction of cytolytic T-lymphocytes with cytomegalovirus polypeptides
US5866344A (en) * 1991-11-15 1999-02-02 Board Of Regents, The University Of Texas System Antibody selection methods using cell surface expressed libraries
DE69737070T2 (de) * 1996-05-23 2007-06-21 The Scripps Research Institute, La Jolla Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten
ATE230850T1 (de) * 1996-10-08 2003-01-15 Bisys B V U Verfahren und mittel zur auswahl von peptiden und proteinen mit spezifischer affinität zu einem zielmolekül
DE59913761D1 (de) * 1998-01-19 2006-09-21 Florian Kern Verfahren zum identifizieren von t-zell-stimulierenden proteinfragmenten

Also Published As

Publication number Publication date
ATE419867T1 (de) 2009-01-15
US20040106159A1 (en) 2004-06-03
WO2001063286A3 (de) 2002-03-14
JP4846157B2 (ja) 2011-12-28
US7994096B2 (en) 2011-08-09
AU2001246444A1 (en) 2001-09-03
ES2317894T5 (es) 2013-06-17
DK1257290T3 (da) 2009-03-30
EP1257290B1 (de) 2009-01-07
ES2317894T3 (es) 2009-05-01
EP1257290A2 (de) 2002-11-20
EP1257290B2 (de) 2013-03-27
DE50114639D1 (de) 2009-02-26
DE10009341A1 (de) 2001-09-06
WO2001063286A2 (de) 2001-08-30
JP2003523757A (ja) 2003-08-12

Similar Documents

Publication Publication Date Title
DK1257290T3 (da) Fremgangsmåde til antigen-specifik stimulation af T-lymfocytter med syntetiske peptidbiblioteker
RU2770447C2 (ru) Способ лечения рака
Yu et al. Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes
Benacerraf Opinion: a hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes
Germain Special regulatory T‐cell review: a rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm
Mair et al. NKp46 expression discriminates porcine NK cells with different functional properties
Loftus et al. Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART127–35
PT1024191E (pt) Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
SG135053A1 (en) Generation and selection of protein library in silico
WO2005005651A3 (en) T cell receptor sequence and method for detecting and treating rheumatoid arthritis
ATE449787T1 (de) Tumorantigene und ctl-klone, die durch ein neues verfahren isoliert wurden
CN114174829A (zh) T细胞受体的选择
Fukumoto et al. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation
Stryhn et al. Shared fine specificity between T-cell receptors and an antibody recognizing a peptide/major histocompatibility class I complex.
Lorenz et al. Unbiased identification of T-cell receptors targeting immunodominant peptide–MHC complexes for T-cell receptor immunotherapy
US20100136019A1 (en) Modulating regulatory t cell activity via interleukin 35
Huetter et al. Characterization of BAY 1905254, an immune checkpoint inhibitor targeting the immunoglobulin-like domain containing receptor 2 (ILDR2)
Maccalli et al. TCR beta-chain variable region-driven selection and massive expansion of HLA-class I-restricted antitumor CTL lines from HLA-A* 0201+ melanoma patients.
Ishizaka T cell factors involved in the regulation of IgE synthesis
Cairo et al. The Vγ2/Vδ2 T‐cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vγ2/Jγ1. 2 subset
DK0499555T3 (da) Rekombinante DNA-molekyler, der koder for en T-celleantigenreceptorkæde, fremgangsmåde til deres fremstilling, antistoffer
Pieczenik Are the universes of antibodies and antigens symmetrical?
Sennino et al. Coexpression of MHC class I–restricted neoTCRs and ectopic CD8 receptors in precision genome engineered CD4 T cells significantly potentiates antigen-specific effector functions
US20230158132A1 (en) Novel tumor-specific antigens for acute lymphoblastic leukemia (all) and uses thereof
Jacobsen et al. Extended antigen specific cellular responses by single-cell immune profiling