AU2001246444A1 - Method for antigen-specific stimulation of t-lymphocytes with synthetic peptide libraries - Google Patents

Method for antigen-specific stimulation of t-lymphocytes with synthetic peptide libraries

Info

Publication number
AU2001246444A1
AU2001246444A1 AU2001246444A AU4644401A AU2001246444A1 AU 2001246444 A1 AU2001246444 A1 AU 2001246444A1 AU 2001246444 A AU2001246444 A AU 2001246444A AU 4644401 A AU4644401 A AU 4644401A AU 2001246444 A1 AU2001246444 A1 AU 2001246444A1
Authority
AU
Australia
Prior art keywords
amino acid
peptides
lymphocytes
antigen
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001246444A
Inventor
Nicole Faulhaber
Florian Kern
Elham Khatamzas
Petra Reinke
Ingolf-Pascal Surel
Hans-Dieter Volk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7632697&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001246444(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of AU2001246444A1 publication Critical patent/AU2001246444A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a method for the antigen-specific stimulation of T-lymphocytes with a synthetic peptide library, by preparing a plurality of peptides, each of said peptides comprising a fragment less than the whole of the total amino acid sequence of the antigen, each of said peptides being a minimum of 9 amino acid residues (AAs) in length, and the amino acid sequence of each peptide overlapping with the amino acid sequence of at least one other of said peptides; combining a plurality of the peptides from a) into a peptide library, said peptide library comprises a plurality of the peptides selected such that their collective overlapping amino acid sequences span the total amino acid sequence of the antigen; and incubating a suspension comprising CD8+ T lymphocytes, CD4+ T lymphocytes or a mixture of CD8+ and CD4+ with said peptide library in a single culture run.
AU2001246444A 2000-02-22 2001-02-17 Method for antigen-specific stimulation of t-lymphocytes with synthetic peptide libraries Abandoned AU2001246444A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10009341A DE10009341A1 (en) 2000-02-22 2000-02-22 Method for antigen-specific stimulation of T lymphocytes
DE10009341 2000-02-22
PCT/EP2001/001773 WO2001063286A2 (en) 2000-02-22 2001-02-17 Method for antigen-specific stimulation of t-lymphocytes with synthetic peptide libraries

Publications (1)

Publication Number Publication Date
AU2001246444A1 true AU2001246444A1 (en) 2001-09-03

Family

ID=7632697

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001246444A Abandoned AU2001246444A1 (en) 2000-02-22 2001-02-17 Method for antigen-specific stimulation of t-lymphocytes with synthetic peptide libraries

Country Status (9)

Country Link
US (1) US7994096B2 (en)
EP (1) EP1257290B2 (en)
JP (1) JP4846157B2 (en)
AT (1) ATE419867T1 (en)
AU (1) AU2001246444A1 (en)
DE (2) DE10009341A1 (en)
DK (1) DK1257290T4 (en)
ES (1) ES2317894T5 (en)
WO (1) WO2001063286A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003245729A1 (en) * 2002-06-27 2004-01-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating a cytotoxic t lymphocyte immune response
ITMI20031201A1 (en) * 2003-06-13 2004-12-14 Istituto Giannina Gaslini EPITOPES OF CITOMEGALOVIRUS PP65 PROTEIN
EP2094721B1 (en) * 2006-12-14 2018-02-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2648687T3 (en) * 2007-02-23 2018-01-05 Aileron Therapeutics, Inc. Triazole-linked macrocyclic peptides
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
CN101730708B (en) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 Stitched polypeptides
EP3023436A1 (en) 2007-07-03 2016-05-25 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
EP2197908A2 (en) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
AU2010204648B2 (en) 2009-01-14 2016-09-01 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9678061B2 (en) 2010-08-06 2017-06-13 Ludwig-Maximilians-Universität München Identification of T cell target antigens
SI2603600T1 (en) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
WO2013059525A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
JP6081483B2 (en) 2011-12-12 2017-02-15 セル・メディカ・リミテッド The process of proliferating T cells
DK3591047T3 (en) 2012-02-09 2022-10-24 Baylor College Medicine Peptide mixtures for the generation of multiviral CTLs with broad specificity
SG11201404648PA (en) 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
CN108912211A (en) 2012-02-15 2018-11-30 爱勒让治疗公司 Triazole crosslinking and thioether crosslinking peptidomimetic macrocyclic compound
EP2914256B1 (en) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2015047901A1 (en) * 2013-09-24 2015-04-02 Duke University Compositions, methods and kits for eliciting an immune response
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
BR112017005736A2 (en) 2014-09-24 2017-12-12 Aileron Therapeutics Inc peptidomimetic macrocycles and formulations thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016198470A2 (en) 2015-06-08 2016-12-15 Lophius Biosciences Gmbh Composition for determination of cell-mediated immune responsiveness
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
JP6999941B2 (en) 2015-09-18 2022-02-10 ベイラー カレッジ オブ メディスン Identification of immunogenic antigens from pathogens and their correlation with clinical efficacy
EP3203237B1 (en) 2016-02-03 2023-07-05 Nina Babel Urine-derived epithelial cell lines for diagnosis and therapy of an anti-bk-virus or anti-graft immune response
CN109475579A (en) * 2016-05-23 2019-03-15 昆士兰医学研究所理事会 CMV epitope
JP7219212B2 (en) 2016-09-06 2023-02-07 エフ．ホフマン－ラ ロシュ アーゲー MHC-binding peptide array and method of use thereof
EP3768833A1 (en) 2018-03-22 2021-01-27 Charité - Universitätsmedizin Berlin Crispr associated protein reactive t cell immunity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207161B1 (en) * 1986-07-16 2001-03-27 City Of Hope Induction of cytolytic T-lymphocytes with cytomegalovirus polypeptides
US5866344A (en) * 1991-11-15 1999-02-02 Board Of Regents, The University Of Texas System Antibody selection methods using cell surface expressed libraries
IL126843A (en) * 1996-05-23 2007-06-17 Scripps Research Inst Mhc class ii antigen-presenting systems and methods for activating cd4+t cells in vitro
DE69718341T2 (en) * 1996-10-08 2003-10-30 Bisys B V U METHOD AND MEANS FOR SELECTING PEPTIDES AND PROTEINS WITH SPECIFIC AFFINITY TO A TARGET MOLECULE
DE59913761D1 (en) * 1998-01-19 2006-09-21 Florian Kern METHOD FOR IDENTIFYING T-CELL STIMULATING PROTEIN FRAGMENTS

Also Published As

Publication number Publication date
DK1257290T3 (en) 2009-03-30
JP4846157B2 (en) 2011-12-28
ES2317894T3 (en) 2009-05-01
WO2001063286A2 (en) 2001-08-30
ES2317894T5 (en) 2013-06-17
DE50114639D1 (en) 2009-02-26
EP1257290A2 (en) 2002-11-20
US7994096B2 (en) 2011-08-09
JP2003523757A (en) 2003-08-12
DE10009341A1 (en) 2001-09-06
WO2001063286A3 (en) 2002-03-14
EP1257290B1 (en) 2009-01-07
DK1257290T4 (en) 2013-06-03
ATE419867T1 (en) 2009-01-15
EP1257290B2 (en) 2013-03-27
US20040106159A1 (en) 2004-06-03

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