DK1219621T3 - Azaindolizinonderivater og cerebral funktionsforbedrende midler indeholdende disse som den aktive bestanddel - Google Patents

Azaindolizinonderivater og cerebral funktionsforbedrende midler indeholdende disse som den aktive bestanddel

Info

Publication number
DK1219621T3
DK1219621T3 DK00948260T DK00948260T DK1219621T3 DK 1219621 T3 DK1219621 T3 DK 1219621T3 DK 00948260 T DK00948260 T DK 00948260T DK 00948260 T DK00948260 T DK 00948260T DK 1219621 T3 DK1219621 T3 DK 1219621T3
Authority
DK
Denmark
Prior art keywords
alkyl
active ingredient
phenyl
hydrogen atom
cerebral function
Prior art date
Application number
DK00948260T
Other languages
Danish (da)
English (en)
Inventor
Seiichiro Kenkyusho Kawashima
Toshiyuki Kenkyusho Of Matsuno
Naoki Kenkyusho Of Zeny Fukuda
Kenichi Kenkyusho Of Ze Saitoh
Yoshimasa Kenkyusho Yamaguchi
Masaya Kenkyusho Of Ze Higashi
Original Assignee
Zenyaku Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo Kk filed Critical Zenyaku Kogyo Kk
Application granted granted Critical
Publication of DK1219621T3 publication Critical patent/DK1219621T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK00948260T 1999-07-30 2000-07-28 Azaindolizinonderivater og cerebral funktionsforbedrende midler indeholdende disse som den aktive bestanddel DK1219621T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21700299 1999-07-30
PCT/JP2000/005034 WO2001009131A1 (fr) 1999-07-30 2000-07-28 Derives d'azaindolizinone et ameliorants de la fonction cerebrale contenant lesdits derives en tant que principes actifs

Publications (1)

Publication Number Publication Date
DK1219621T3 true DK1219621T3 (da) 2004-02-02

Family

ID=16697291

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00948260T DK1219621T3 (da) 1999-07-30 2000-07-28 Azaindolizinonderivater og cerebral funktionsforbedrende midler indeholdende disse som den aktive bestanddel

Country Status (12)

Country Link
US (1) US6635652B1 (ko)
EP (1) EP1219621B1 (ko)
JP (1) JP4530597B2 (ko)
KR (1) KR100738136B1 (ko)
CN (1) CN1179962C (ko)
AT (1) ATE252580T1 (ko)
AU (1) AU766122B2 (ko)
CA (1) CA2387719C (ko)
DE (1) DE60006145T2 (ko)
DK (1) DK1219621T3 (ko)
ES (1) ES2209927T3 (ko)
WO (1) WO2001009131A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141579B2 (en) * 2001-01-30 2006-11-28 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient
EP2502925A1 (en) * 2004-10-27 2012-09-26 Janssen Pharmaceutica NV Pyridine imidazoles and aza-indoles as progesterone receptor modulators
JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
WO2008112641A2 (en) * 2007-03-09 2008-09-18 New York University Methods and compositions for treating thalamocortical dysrhythmia
US20090221554A1 (en) * 2008-02-28 2009-09-03 Zenyaku Kogyo Kabushiki Kaisha Method of treating cognitive impairment
WO2010077852A2 (en) * 2008-12-15 2010-07-08 The Regents Of The University Of California Method of inducing cleavage of amyloid precursor protein to form a novel fragment
EP2413929A4 (en) * 2009-04-02 2012-10-10 Zenyaku Kogyo Co Ltd PROCESS FOR TREATING COGNITIVE IMPAIRMENT
WO2010120872A2 (en) * 2009-04-14 2010-10-21 Kim Nicholas Green Method of decreasing pro-adam10 secretase and/or beta secretase levels
JP2012526818A (ja) * 2009-05-11 2012-11-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ユビキチン化タンパク質レベルの減少方法
AU2022275939A1 (en) * 2021-05-19 2023-11-16 Amyriad Pharma, Inc. Method of treating alzheimer's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514415A (en) * 1981-10-28 1985-04-30 Ciba Geigy Corporation Benzofuran-2(3H)-ones used as anti-inflammatory agents
FR2525602A1 (fr) 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4760083A (en) 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
JP2585086B2 (ja) * 1988-12-28 1997-02-26 大鵬薬品工業株式会社 ジアザビシクロアルカン誘導体
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury

Also Published As

Publication number Publication date
ES2209927T3 (es) 2004-07-01
CA2387719C (en) 2010-04-27
DE60006145D1 (de) 2003-11-27
CN1179962C (zh) 2004-12-15
CA2387719A1 (en) 2001-02-08
AU766122B2 (en) 2003-10-09
CN1377351A (zh) 2002-10-30
KR100738136B1 (ko) 2007-07-10
EP1219621A1 (en) 2002-07-03
DE60006145T2 (de) 2004-06-09
AU6180300A (en) 2001-02-19
EP1219621B1 (en) 2003-10-22
ATE252580T1 (de) 2003-11-15
JP4530597B2 (ja) 2010-08-25
US6635652B1 (en) 2003-10-21
KR20020016931A (ko) 2002-03-06
WO2001009131A1 (fr) 2001-02-08
EP1219621A4 (en) 2003-01-02

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