DK121685A - Fremgangsmaade til maerkning af nukleinsyrer og middel til anvendelse af fremgangsmaaden - Google Patents

Fremgangsmaade til maerkning af nukleinsyrer og middel til anvendelse af fremgangsmaaden Download PDF

Info

Publication number
DK121685A
DK121685A DK121685A DK121685A DK121685A DK 121685 A DK121685 A DK 121685A DK 121685 A DK121685 A DK 121685A DK 121685 A DK121685 A DK 121685A DK 121685 A DK121685 A DK 121685A
Authority
DK
Denmark
Prior art keywords
procedure
nucleic acids
marking nucleic
marking
acids
Prior art date
Application number
DK121685A
Other languages
Danish (da)
English (en)
Other versions
DK121685D0 (da
Inventor
Edvard Lewis Sheldon
Kary Banks Mullis
Corey Howard Levenson
Henry Rapoport
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of DK121685D0 publication Critical patent/DK121685D0/da
Publication of DK121685A publication Critical patent/DK121685A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
DK121685A 1984-03-21 1985-03-18 Fremgangsmaade til maerkning af nukleinsyrer og middel til anvendelse af fremgangsmaaden DK121685A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59181184A 1984-03-21 1984-03-21
US06/683,263 US4582789A (en) 1984-03-21 1984-12-18 Process for labeling nucleic acids using psoralen derivatives

Publications (2)

Publication Number Publication Date
DK121685D0 DK121685D0 (da) 1985-03-18
DK121685A true DK121685A (da) 1985-09-22

Family

ID=27081258

Family Applications (1)

Application Number Title Priority Date Filing Date
DK121685A DK121685A (da) 1984-03-21 1985-03-18 Fremgangsmaade til maerkning af nukleinsyrer og middel til anvendelse af fremgangsmaaden

Country Status (7)

Country Link
US (1) US4582789A (fr)
EP (2) EP0309006A1 (fr)
AU (1) AU589893B2 (fr)
DE (1) DE156287T1 (fr)
DK (1) DK121685A (fr)
ES (1) ES8606386A1 (fr)
IL (1) IL74658A (fr)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4959309A (en) * 1983-07-14 1990-09-25 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4724202A (en) * 1983-12-12 1988-02-09 Molecular Diagnostics, Inc. Use of non-hybridizable nucleic acids for the detection of nucleic acid hybridization
US4803297A (en) * 1984-03-21 1989-02-07 Cetus Corporation Carbamic acid ester useful for preparing a nucleic acid probe
US4705886A (en) * 1984-03-21 1987-11-10 Cetus Corporation Precursor to nucleic acid probe
US4751313A (en) * 1984-03-21 1988-06-14 Cetus Corporation Precursor to nucleic acid probe
US4754065A (en) * 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4824775A (en) * 1985-01-03 1989-04-25 Molecular Diagnostics, Inc. Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
US5026840A (en) * 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
ATE40572T1 (de) * 1985-01-10 1989-02-15 Molecular Diagnostics Inc Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben.
US5176995A (en) * 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US5656493A (en) * 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5333675C1 (en) * 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
ES8707343A1 (es) * 1985-06-13 1987-07-16 Amgen Un metodo para aislar una secuencia de acido nucleico objetivo seleccionada
US5273882A (en) * 1985-06-13 1993-12-28 Amgen Method and kit for performing nucleic acid hybridization assays
US4833251A (en) * 1985-06-25 1989-05-23 Siska Diagnostics, Inc. Compounds for tagging nucleic acid probes
JPS622164A (ja) * 1985-06-25 1987-01-08 シスカ・ダイアグノステイツクス・インコ−ポレ−テツド Ｎ４−（置換アミノ）シチジンを含む核酸プロ−ブ
CA1295559C (fr) * 1985-08-13 1992-02-11 Jannis Stavrianopoulos Methode d'etiquetage des sequences de polynucleotides
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5756696A (en) * 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US4797491A (en) * 1986-03-17 1989-01-10 Cetus Corporation Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane
US5276140A (en) * 1986-03-17 1994-01-04 Cetus Oncology Corporation Cross-linking agents
US5242797A (en) * 1986-03-21 1993-09-07 Myron J. Block Nucleic acid assay method
CA1338457C (fr) * 1986-08-22 1996-07-16 Henry A. Erlich Enzyme thermostable purifiee
GB8621337D0 (en) * 1986-09-04 1986-10-15 Agricultural Genetics Co Non-radioactive nucleic acid hybridization probes
US5912339A (en) * 1986-10-28 1999-06-15 The Johns Hopkins University Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
US4880750A (en) * 1987-07-09 1989-11-14 Miragen, Inc. Individual-specific antibody identification methods
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US6004745A (en) * 1987-09-21 1999-12-21 Gen-Probe Incorporated Hybridization protection assay
US5639604A (en) * 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
EP0310361A3 (fr) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Conjugat tridenté et méthode de sa mise en oeuvre
US5196351A (en) * 1987-09-30 1993-03-23 Beckman Instruments, Inc. Bidentate conjugate and method of use thereof
US4914210A (en) * 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
US4994385A (en) * 1987-10-30 1991-02-19 Abbott Laboratories Heterobifunctional coupling agents
DK641487A (da) 1987-12-07 1989-06-08 Gluetech Aps Fremgangsmaade til modificering af polymeroverflader
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
WO1989006702A1 (fr) * 1988-01-21 1989-07-27 Chemex Pharmaceuticals, Inc. Inhibition selective de l'expression de genes par des oligonucleotides photo-activables
DE3804243A1 (de) * 1988-02-11 1989-08-24 Max Planck Gesellschaft Teils einzel- und teils doppelstraengige nukleinsaeuresonde und verfahren zu ihrer herstellung
DE68916671T2 (de) * 1988-03-18 1995-03-02 Baylor College Medicine Mutationsnachweis durch kompetitiven Oligonukleotid-Priming.
JPH03503894A (ja) * 1988-03-25 1991-08-29 ユニバーシィティ　オブ　バージニア　アランミ　パテンツ　ファウンデイション オリゴヌクレオチド　ｎ‐アルキルホスホラミデート
US6326136B1 (en) * 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
US4868311A (en) * 1988-04-02 1989-09-19 The Trustees Of Columbia University In The City Of New York Biotinylated psoralens
US5824796A (en) * 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
WO1990003370A1 (fr) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVES DE PYRAZOLO[3,4-d]PYRIMIDINE
USRE38416E1 (en) 1988-09-28 2004-02-03 Epoch Biosciences, Inc. Cross-linking oligonucleotides
US5998135A (en) * 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
US5049489A (en) * 1989-04-17 1991-09-17 The Standard Oil Company 16S rRNA oligonucleotide probes for the identification of sulfate-reducing bacteria
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5151369A (en) * 1989-07-13 1992-09-29 Miles Inc. Lithium salts as red blood cell lysing and hemoglobin denaturing reagents
JP2646814B2 (ja) * 1990-08-07 1997-08-27 アイシン精機株式会社 核酸等の検定方法
JPH04222600A (ja) * 1990-12-21 1992-08-12 Aisin Seiki Co Ltd ナフトール誘導体ホスフェートによる核酸等の検定方法
EP0580754A1 (fr) * 1991-04-18 1994-02-02 The Salk Institute For Biological Studies Oligodesoxynucleotides et oligonucleotides utiles en tant que pieges pour des proteines qui se lient selectivement a des sequences definies d'adn
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DK0519338T3 (da) * 1991-06-20 1996-10-28 Hoffmann La Roche Forbedrede fremgangsmåder til nukleinsyreamplifikation
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
US6136601A (en) * 1991-08-21 2000-10-24 Epoch Pharmaceuticals, Inc. Targeted mutagenesis in living cells using modified oligonucleotides
US5426025A (en) * 1992-05-28 1995-06-20 Florida State University Species-specific DNA probes for vibrio vulnificus methods and kits
FR2695036B1 (fr) * 1992-09-03 1994-10-28 Goupil Jean Jacques Huile contenant du 5-méthoxypsoralène à une concentration de 60 à 100 PPM et son utilisation pour le traitement du psoriasis.
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
EP0679196B1 (fr) * 1993-01-07 2004-05-26 Sequenom, Inc. Sequen age d'adn par spectrometrie de masse
DE4302241A1 (de) * 1993-01-27 1994-07-28 Boehringer Mannheim Gmbh Neues Biotinylierungsreagenz
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5747352A (en) * 1994-05-23 1998-05-05 Beckman Instruments, Inc. Reagents and methods for the rapid and quantitative assay of pharmacological agents
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
WO1997006166A1 (fr) * 1995-08-03 1997-02-20 Dade Chemistry Systems Inc. Conjugues de quinidine et leur utilisation dans des immunodosages
US6297027B1 (en) 1996-07-31 2001-10-02 Purina Mills, Inc. Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6277592B1 (en) 1996-07-31 2001-08-21 Purina Mills, Inc. Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof
EP0954612A2 (fr) * 1996-11-06 1999-11-10 Sequenom, Inc. Diagnostics de l'adn fondes sur la spectrometrie de masse
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
CA2268740C (fr) 1996-11-06 2010-07-20 Sequenom, Inc. Immobilisation haute densite d'acides nucleiques
JP2001524808A (ja) * 1996-12-10 2001-12-04 ジーントレイス・システムズ・インコーポレイテッド 放出可能な不揮発性の質量標識分子
US6268131B1 (en) 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US7060431B2 (en) * 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US7071324B2 (en) * 1998-10-13 2006-07-04 Brown University Research Foundation Systems and methods for sequencing by hybridization
US6187566B1 (en) 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
NZ528967A (en) 1999-06-22 2005-03-24 Invitrogen Corp Improved primers and methods for the amplification and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) * 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
ATE492652T1 (de) * 2000-02-07 2011-01-15 Illumina Inc Nukleinsäuredetektionsverfahren mit universellem priming
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
AU2001268468A1 (en) 2000-06-13 2001-12-24 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
WO2002057414A2 (fr) * 2000-10-20 2002-07-25 Expression Diagnostics, Inc. Evaluation du niveau d'expression leucocytaire
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
EP1950305A1 (fr) 2001-05-09 2008-07-30 Monsanto Technology, LLC Gènes tyr et utilisations associées
AU2002308633A1 (en) 2001-05-09 2002-11-18 Monsanto Technology Llc Metabolite transporters
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
AU2003256289A1 (en) * 2002-06-26 2004-01-19 Human Genome Sciences, Inc. Modified shine-dalgarno sequences and methods of use thereof
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US20040265870A1 (en) * 2003-04-09 2004-12-30 Invitrogen Corporation Methods of synthesizing and labeling nucleic acid molecules
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
JP2007529199A (ja) 2003-10-23 2007-10-25 イルミジェン バイオサイエンシーズ， インコーポレイテッド ウイルス感染に対する抵抗性に関連する遺伝子である、ｏａｓ１における変異の検出
WO2006029184A2 (fr) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes permettant de diagnostiquer et de surveiller les troubles associes a l'inflammation
ATE428421T1 (de) 2004-09-17 2009-05-15 Eisai R&D Man Co Ltd Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US7550583B2 (en) * 2005-02-04 2009-06-23 Geno Sensor Corp. Method of isolating, labeling and profiling small RNAs
EP1885889A4 (fr) * 2005-05-11 2010-01-20 Expression Diagnostics Inc Procedes de surveillance de l'etat fonctionnel de transplants a l'aide de panels de genes
WO2007015578A1 (fr) 2005-08-02 2007-02-08 Eisai R & D Management Co., Ltd. Procédé d’analyse de l’effet d’un inhibiteur de vascularisation
JP2007043937A (ja) * 2005-08-09 2007-02-22 Matsushita Electric Ind Co Ltd 遺伝子検出方法
CN102716490A (zh) * 2005-09-01 2012-10-10 卫材R&D管理有限公司 药物组合物的崩解性的改善方法
CA2627598C (fr) 2005-11-07 2013-06-25 Eisai R & D Management Co., Ltd. Utilisation d'une combinaison de substance anti-angiogenique et d'inhibiteur de kinase c-kit
NZ570008A (en) 2006-02-09 2011-10-28 Univ South Florida Detection of ovarian cancer by elevated levels of Bcl-2 in urine
WO2008051290A2 (fr) * 2006-04-07 2008-05-02 Xdx, Inc. Expression d'acide nucléique en réponse aux stéroïdes et prévision de l'activité d'une maladie
RU2448708C3 (ru) * 2006-05-18 2017-09-28 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое средство против рака щитовидной железы
EP2027295A2 (fr) 2006-05-25 2009-02-25 Monsanto Technology LLP Procédé d'identification de locus quantitatifs résistant aux maladies dans le soja, et compositions associées
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
KR101472600B1 (ko) * 2006-08-28 2014-12-15 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암에 대한 항종양제
EP2102367A2 (fr) * 2006-11-09 2009-09-23 XDX, Inc. Procedes pour diagnostiquer et surveiller l'etat d'un lupus erythemateux systemique
WO2008092094A2 (fr) * 2007-01-26 2008-07-31 University Of South Florida Procédé et matériaux pour la détection, le diagnostic et la gestion du cancer des ovaires
WO2008093855A1 (fr) * 2007-01-29 2008-08-07 Eisai R & D Management Co., Ltd. Composition destinée au traitement d'un cancer de l'estomac de type indifférencié
BRPI0810083B8 (pt) * 2007-03-28 2020-10-06 Monsanto Technology Llc métodos para estabelecer onde uma planta de soja ou semente de soja deve ser cultivada, de melhoramento da planta de soja, para selecionar uma semente de soja, de distribuição de uma planta de soja, para isolar sementes de soja de maturidade precoce indeterminada, e para determinar se uma planta de soja tem um grupo de maturidade
KR20100037590A (ko) 2007-06-08 2010-04-09 바이오겐 아이덱 엠에이 인코포레이티드 항 ｔｎｆ 반응 또는 무반응을 예측하기 위한 바이오마커
WO2009018465A1 (fr) * 2007-07-31 2009-02-05 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Vaccination avec des protozoaires tués mais métaboliquement actifs (kbma) avec des agonistes de récepteur de type toll
BRPI0815841A2 (pt) 2007-08-29 2015-09-01 Monsanto Technology Llc Métodos e composições para melhoramento de traços preferidos.
WO2009060945A1 (fr) * 2007-11-09 2009-05-14 Eisai R & D Management Co., Ltd. Combinaison d'une substance antiangiogénique et d'un complexe de platine antitumoral
EP2271201B1 (fr) 2008-04-24 2014-07-09 Monsanto Technology LLC Procédé pour identifier des locus de caractères quantitatifs résistant à la rouille asiatique du soja et compositions associées
US9207242B2 (en) 2008-10-09 2015-12-08 The University Of Hong Kong Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
BR112012032462A2 (pt) 2010-06-25 2016-11-08 Eisai R&D Man Co Ltd agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.
EP2418286A1 (fr) 2010-08-10 2012-02-15 QIAGEN GmbH Procédé amélioré pour l'amplification isotherme d'acides nucléiques
CN103402519B (zh) 2011-04-18 2015-11-25 卫材R&D管理有限公司 肿瘤治疗剂
EP2710144B1 (fr) 2011-05-19 2020-10-07 Agena Bioscience, Inc. Procédés d'identification d'acides nucléiques multiplexés
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
WO2014005125A2 (fr) 2012-06-29 2014-01-03 Biotium, Inc. Composés fluorescents et utilisation de ceux-ci
CN104755463A (zh) 2012-12-21 2015-07-01 卫材R&D管理有限公司 非晶态形式的喹啉衍生物及其生产方法
MX368099B (es) 2013-05-14 2019-09-19 Eisai R&D Man Co Ltd Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
CN106231893B (zh) 2014-02-21 2019-10-18 先正达参股股份有限公司 与玉米增加的能育性相关的遗传基因座
KR102329681B1 (ko) 2014-08-28 2021-11-23 에자이 알앤드디 매니지먼트 가부시키가이샤 고순도의 퀴놀린 유도체 및 이를 제조하는 방법
BR112017017428A2 (pt) 2015-02-25 2018-04-03 Eisai R&D Management Co., Ltd. ?método para supressão do amargor de derivado de quinolina?
CA2978226A1 (fr) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Association d'un antagoniste de pd-1 et d'un inhibiteur des tyrosines kinases vegfr/fgfr/ret pour traiter le cancer
EP3286327B1 (fr) 2015-04-24 2021-11-10 Agena Bioscience, Inc. Procédé multiplexé d'identification et de quantification d'allèles mineurs et de polymorphismes
EP3286328B1 (fr) 2015-04-24 2020-10-21 Agena Bioscience, Inc. Méthodes multiplex pour la detection et la quantification de variants mineurs
WO2016187284A1 (fr) 2015-05-19 2016-11-24 The University Of Chicago Procédés et compositions pour déterminer le ph
BR112017027227B1 (pt) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd Agente anti-câncer
US20210096129A1 (en) * 2017-04-12 2021-04-01 The University Of Chicago Methods and Compositions for Spacial and Temporal Measurement of Catalytic Activity
KR20200112906A (ko) 2018-01-25 2020-10-05 바이오젠 엠에이 인코포레이티드 척추 근위축증의 치료 방법
EP3924739A1 (fr) 2019-02-12 2021-12-22 Biogen MA Inc. Biomarqueurs de la leucoencéphalopathie multifocale progressive
CN112698025B (zh) * 2020-12-14 2022-10-18 四川沃文特生物技术有限公司 抗原或抗体包被磁微粒的方法、应用及试剂盒
CN112920174B (zh) * 2021-02-02 2022-11-04 上海交通大学 一种光敏感型化合物及其制备方法和应用
CN116262760A (zh) * 2023-01-18 2023-06-16 杭州纽龙生物科技有限公司 一种生物素化异硫氰酸荧光素的制备方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124598A (en) * 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
CA1219824A (fr) * 1981-04-17 1987-03-31 David C. Ward Nucleotides modifies, leur preparation et leur emploi
CA1180647A (fr) * 1981-07-17 1985-01-08 Cavit Akin Methode de diagnostic d'hybridation de polynucleotides par emission de lumiere
US4652533A (en) * 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods

Also Published As

Publication number Publication date
AU4018885A (en) 1985-09-26
US4582789A (en) 1986-04-15
EP0309006A1 (fr) 1989-03-29
DK121685D0 (da) 1985-03-18
DE156287T1 (de) 1986-05-22
IL74658A (en) 1989-06-30
IL74658A0 (en) 1985-06-30
ES8606386A1 (es) 1986-04-16
AU589893B2 (en) 1989-10-26
EP0156287A2 (fr) 1985-10-02
EP0156287A3 (fr) 1987-06-03
ES541437A0 (es) 1986-04-16

Similar Documents

Publication Publication Date Title
DK121685A (da) Fremgangsmaade til maerkning af nukleinsyrer og middel til anvendelse af fremgangsmaaden
DK235683D0 (da) Fremgangsmade til identificering og karakterisering af organismer
DK162124C (da) Maerkede nucleinsyresonder og addukter til fremstilling heraf
DK230685D0 (da) Apparat og fremgangsmaade til neddrivning af foringsroer eller lederoer
DK33982A (da) Fremgangsmaade og udstyr til konstatering af dna-beskadigelse
DK164486D0 (da) Molekylaert orienteret formstofnet og fremgangsmaade til fremstilling af dette
DK195585A (da) 4'-deschlorrebeccamycin og fremgangsmaade til fremstilling af samme
DK352183D0 (da) Fremgangsmade og papir til rna-bestemmelse samt anvendelse af papiret
DK408685A (da) Daek og fremgangsmaade til montering af daek
DK86586A (da) Fremgangsmaade og apparatur til beroeringsfri detektering af vaekster
DK263286D0 (da) Forskallingsbraet og fremgangsmaade til fremstilling af dette
DK260786D0 (da) Fremgangsmaade til konditionering af haar og middel til anvendelse vedfremgangsmaaden
DK492785A (da) Fremgangsmaade til fremstilling af milbemycinderivater og forbindelser til anvendelse ved fremgangsmaaden
DK382284D0 (da) Fremgangsmaade til fremstilling af 7-acylamino-3-hydroxy-cephem-4-carbxylsyrer og 7-acylamino-3-hydroxy-1-dethia-1-oxacephem-4-carboxylsrer
DK423483A (da) Fremgangsmaade til maerkning af huder, skind og lignende arkformige materialer
DK121985A (da) Gentenologisk fremgangsmaade til fremstilling af human-ny-interferon og middel til udfoerelse af fremgangsmaaden
DK162239C (da) Fremgangsmaade til fremstilling af inosin og/eller guanosin
DK608985D0 (da) Krystallinsk 1-benzhydryl-4-allyl-piperazindihydrochlorid og fremgangsmaade til fremstilling af samme
DK411285A (da) Fremgangsmaade og apparat til sproejtning af landbrugsafgroeder
DK82188A (da) Middel og fremgangsmaade til stabilisering af o-halogenpyridylphosphater
DK183686D0 (da) Fremgangsmaade og indretning til kloevning af plader
DK229986A (da) Fremgangsmaade til fremstilling af 2-thiocromenylidenethylacetoacetater
DK216685D0 (da) Beta-carbolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling af samme
DK67684D0 (da) Murbinder og fremgangsmade til isaetning af samme
DK550385D0 (da) Radioaktivt maerkede lipoproteiner og fremgangsmaade til fremstilling heraf

Legal Events

Date Code Title Description
PBP Patent lapsed
AHB Application shelved due to non-payment