DK1202724T3 - Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer - Google Patents

Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer

Info

Publication number
DK1202724T3
DK1202724T3 DK00945140T DK00945140T DK1202724T3 DK 1202724 T3 DK1202724 T3 DK 1202724T3 DK 00945140 T DK00945140 T DK 00945140T DK 00945140 T DK00945140 T DK 00945140T DK 1202724 T3 DK1202724 T3 DK 1202724T3
Authority
DK
Denmark
Prior art keywords
chronic pain
mech
inhibitors
treating chronic
treating
Prior art date
Application number
DK00945140T
Other languages
Danish (da)
English (en)
Inventor
Alexander James Bridges
Richard John Booth
Haile Tecle
Yvonne Scaggs
Michael Kaufman
Stephen Douglas Barrett
Alistair Dixon
Kevin Lee
Robert Denham Pinnock
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK1202724T3 publication Critical patent/DK1202724T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK00945140T 1999-07-16 2000-07-05 Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer DK1202724T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14432099P 1999-07-16 1999-07-16
US14465999P 1999-07-16 1999-07-16
US14428099P 1999-07-16 1999-07-16
US14441999P 1999-07-16 1999-07-16
US14465899P 1999-07-16 1999-07-16
US14465599P 1999-07-16 1999-07-16
PCT/US2000/018348 WO2001005393A2 (en) 1999-07-16 2000-07-05 Method for treating chronic pain using mek inhibitors

Publications (1)

Publication Number Publication Date
DK1202724T3 true DK1202724T3 (da) 2004-01-26

Family

ID=27558291

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00945140T DK1202724T3 (da) 1999-07-16 2000-07-05 Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer

Country Status (17)

Country Link
EP (1) EP1202724B1 (de)
JP (1) JP2003504401A (de)
KR (1) KR20020016899A (de)
CN (1) CN1365277A (de)
AT (1) ATE250932T1 (de)
AU (1) AU5912500A (de)
CA (1) CA2378381A1 (de)
DE (1) DE60005688T2 (de)
DK (1) DK1202724T3 (de)
ES (1) ES2208364T3 (de)
HK (1) HK1047895A1 (de)
HU (1) HUP0202180A3 (de)
IL (1) IL147618A0 (de)
PL (1) PL352712A1 (de)
PT (1) PT1202724E (de)
TR (1) TR200200205T2 (de)
WO (1) WO2001005393A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL401637A1 (pl) 2002-03-13 2013-05-27 Array Biopharma Inc. N3 alkilowane pochodne benzimidazolu jako inhibitory MEK
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7781595B2 (en) * 2003-09-22 2010-08-24 S*Bio Pte Ltd. Benzimidazole derivatives: preparation and pharmaceutical applications
EP1682495A1 (de) 2003-10-21 2006-07-26 Warner-Lambert Company LLC Polymorphe form von n-[(r)-2,3-dihydroxypropoxy]-3,4-difluor-2-(2-fluor-4-iodophenylamino)benzamid
EP1529951A1 (de) 2003-11-06 2005-05-11 Gaveco AB Verfahren und System für die automatische Abschaltung der Brennstoffzufuhr
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
WO2005051302A2 (en) 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
CN1882347A (zh) 2003-11-21 2006-12-20 阿雷生物药品公司 Akt蛋白激酶抑制剂
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
ES2397825T3 (es) 2004-06-11 2013-03-11 Japan Tobacco, Inc. Derivados de 5-amino-2,4,7-trioxo-3,4,7,8-tetrahidro-2H-pirido[2,3-d]pirimidina y compuestos relacionados para el tratamiento del cáncer
EP1967516B1 (de) 2005-05-18 2009-11-04 Array Biopharma, Inc. 4-(Phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamid Derivate als MEK Inhibitoren zur Behandlung von hyperproliferativen Erkrankungen
ES2567133T3 (es) 2005-06-23 2016-04-20 Array Biopharma, Inc. Proceso para preparar compuestos de benzoimidazol
BRPI0617165B1 (pt) 2005-10-07 2023-10-03 Exelixis Inc Compostos inibidores mek, composições farmacêuticas que os contem e métodos de uso dos mesmos
JP5116245B2 (ja) * 2006-03-24 2013-01-09 地方独立行政法人 東京都立産業技術研究センター 自動分析装置に用いる検量線作成用化合物
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2054418B1 (de) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothienopyrimidine als akt-proteinkinase-inhibitoren
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
BRPI0713555A2 (pt) 2006-07-06 2012-03-20 Array Biopharma, Inc. ciclopenta [d] pirimidinas como inibidores de akt protéina cinase
CN111643496A (zh) 2006-12-14 2020-09-11 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
AU2008272830B8 (en) 2007-07-05 2013-12-12 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CA2692506C (en) 2007-07-05 2015-11-24 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
NZ586346A (en) 2008-01-09 2012-02-24 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
MX2010007546A (es) 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
WO2010051933A2 (en) 2008-11-10 2010-05-14 Bayer Schering Pharma Aktiengesellschaft Substituted sulphonamido phenoxybenzamides
JP2013508318A (ja) 2009-10-21 2013-03-07 バイエル・ファルマ・アクチェンゲゼルシャフト 置換されたベンゾスルホンアミド誘導体
CA2777430A1 (en) 2009-10-21 2011-04-28 Bayer Pharma Aktiengesellschaft Substituted benzosulphonamides
WO2011047796A1 (en) 2009-10-21 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Substituted halophenoxybenzamide derivatives
WO2012004714A2 (en) 2010-07-09 2012-01-12 Pfizer Limited Chemical compounds
WO2012055953A1 (en) 2010-10-29 2012-05-03 Bayer Pharma Aktiengesellschaft Substituted phenoxypyridines
HUE036513T2 (hu) 2011-04-01 2018-07-30 Genentech Inc AKT inhibitor vegyület és abirateron kombinációja terápiás kezelésekben való alkalmazásra
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
CN104837826B (zh) 2012-10-12 2018-07-27 埃克塞里艾克西斯公司 制备用于治疗癌症的化合物的新型方法
AR108257A1 (es) 2016-05-02 2018-08-01 Mei Pharma Inc Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
CA3023465A1 (en) 2016-05-20 2017-11-23 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
BR112019011121A2 (pt) 2016-12-09 2019-10-01 Xenon Pharmaceuticals Inc compostos de benzenossulfonamida e seu uso como agentes terapêuticos
JP7046968B2 (ja) * 2017-03-02 2022-04-04 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ ２－（置換フェニルヘテロ）芳香族カルボン酸系ｆｔｏ阻害剤、その製造方法およびその使用
CA3103600A1 (en) 2018-06-13 2019-12-19 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
CN112638879B (zh) 2018-08-31 2024-06-18 泽农医药公司 杂芳基取代的磺酰胺化合物及其作为治疗剂的用途
EP3844158A1 (de) 2018-08-31 2021-07-07 Xenon Pharmaceuticals Inc. Heteroarylsubstituierte sulfonamidverbindungen und deren verwendung als natriumkanalinhibitoren
TW202340177A (zh) 2021-12-30 2023-10-16 美商拜歐米富士恩股份有限公司 作為 flt3抑制劑之吡嗪化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL62219C (de) * 1945-05-07
US5155110A (en) * 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
JP2773836B2 (ja) * 1988-07-12 1998-07-09 富士通株式会社 集積回路用レイアウト配線のネット抽出方法
AU5610398A (en) * 1997-02-28 1998-09-18 Warner-Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
ATE344791T1 (de) * 1997-07-01 2006-11-15 Warner Lambert Co 2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren
ES2251851T3 (es) * 1999-01-13 2006-05-01 Warner-Lambert Company Llc Acidos sulfohidroxamicos y sulfohidroxamatos y su uso com inhibidores mek.
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
JP2002534446A (ja) * 1999-01-13 2002-10-15 ワーナー−ランバート・カンパニー ４′ヘテロアリールジアリールアミン
WO2000042003A1 (en) * 1999-01-13 2000-07-20 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors

Also Published As

Publication number Publication date
ES2208364T3 (es) 2004-06-16
WO2001005393A3 (en) 2001-05-10
DE60005688D1 (de) 2003-11-06
AU5912500A (en) 2001-02-05
JP2003504401A (ja) 2003-02-04
WO2001005393A2 (en) 2001-01-25
PL352712A1 (en) 2003-09-08
PT1202724E (pt) 2004-02-27
ATE250932T1 (de) 2003-10-15
HK1047895A1 (zh) 2003-03-14
EP1202724A2 (de) 2002-05-08
DE60005688T2 (de) 2004-04-29
HUP0202180A2 (en) 2002-10-28
KR20020016899A (ko) 2002-03-06
EP1202724B1 (de) 2003-10-01
IL147618A0 (en) 2002-08-14
CA2378381A1 (en) 2001-01-25
TR200200205T2 (tr) 2002-06-21
HUP0202180A3 (en) 2004-10-28
CN1365277A (zh) 2002-08-21

Similar Documents

Publication Publication Date Title
DK1202724T3 (da) Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer
DK1355889T3 (da) Substituerede triazoldiaminderivater som kinaseinhibitorer
IS5728A (is) Nýir hirflar af dípeptidýl peptíðasa IV
NL300242I1 (nl) Mega-carboxyaryl gesubstitueerde difenylureums alsraf kinaseremmers.
DK1997512T3 (da) Fremgangsmåder til behandling af TWEAK-relaterede tilstande
DK1132569T3 (da) Fremgangsmåde til behandling af en underjordisk formation
DE50202328D1 (de) Amidofunktionelle aminopolydiorganosiloxane
NO20031853L (no) Spiro-pyrimidin-2,4,6-trion metalloproteinaseinhibitorer
DK1363910T3 (da) Fremgangsmåder til behandling af P39-kinase-associerede tilstande og pyrrolotriazinforbindelser, der er anvendelige som kinase-inhibitorer
DZ3186A1 (fr) Ptéridinones utilisées comme inhibiteurs de kinase.
MA26775A1 (fr) Inhibiteurs de metalloproteases dihetero substituees.
DK1230247T3 (da) Fremgangsmåde til stabilisering af siloxanforbindelser
MA25758A1 (fr) Inhibiteurs de protease.
DK1143917T3 (da) Antikonvulsive derivater egnet til behandling af posttraumatisk stresssygdom
DZ2815A1 (fr) Inhibiteurs de protéase.
DK1177191T3 (da) Substituerede benzimidazoler, fremstilling og anvendelse deraf som midler til bekæmpelse af parasitiske protozoer
DK1126853T3 (da) Kontrolleret levering af antidepressine midler
ATE270113T1 (de) Zusammenstellungen zur verbesserten wundheilung
AU2003222462A1 (en) Method of performing soojichim acupuncture using bodycopy
DK0971714T3 (da) Metode til anvendelse af cyklooxygenase-2-inhibitorer til behandling og forebyggelse af demens
ITMI20001867A0 (it) Metodo di trattamento di reflui.
DK1427305T3 (da) Indretning til behandling af en presenning- eller klædelignende genstand
SE0004285L (sv) Sågklinga för träreduceringsanordningar
ITCN990005A0 (it) Segatrice multipla per legname.
FI20002046A0 (fi) Menetelmä laitureiden tms. vakavoittamiseksi ja siirtelemiseksi