DK1196397T3 - Metabotrope glutamatreceptorantagonister og anvendelse deraf til behandling af sygdomme i centralnervesystemet - Google Patents
Metabotrope glutamatreceptorantagonister og anvendelse deraf til behandling af sygdomme i centralnervesystemetInfo
- Publication number
- DK1196397T3 DK1196397T3 DK00936465T DK00936465T DK1196397T3 DK 1196397 T3 DK1196397 T3 DK 1196397T3 DK 00936465 T DK00936465 T DK 00936465T DK 00936465 T DK00936465 T DK 00936465T DK 1196397 T3 DK1196397 T3 DK 1196397T3
- Authority
- DK
- Denmark
- Prior art keywords
- metabotropic glutamate
- treatment
- nervous system
- central nervous
- receptor antagonists
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US13727299P | 1999-06-02 | 1999-06-02 |
Publications (1)
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DK1196397T3 true DK1196397T3 (da) | 2006-01-02 |
Family
ID=22476587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DK00936465T DK1196397T3 (da) | 1999-06-02 | 2000-06-02 | Metabotrope glutamatreceptorantagonister og anvendelse deraf til behandling af sygdomme i centralnervesystemet |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP1196397B1 (fr) |
JP (1) | JP2003500480A (fr) |
CN (2) | CN1361768A (fr) |
AT (1) | ATE302194T1 (fr) |
AU (2) | AU778063C (fr) |
CA (1) | CA2376024A1 (fr) |
CH (1) | CH1196397H1 (fr) |
DE (1) | DE60022050C5 (fr) |
DK (1) | DK1196397T3 (fr) |
ES (1) | ES2249272T3 (fr) |
HK (1) | HK1048635A1 (fr) |
IL (1) | IL146871A0 (fr) |
MX (1) | MXPA01012445A (fr) |
NZ (1) | NZ515894A (fr) |
WO (1) | WO2000073283A1 (fr) |
Families Citing this family (60)
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TWI298068B (en) * | 2000-06-21 | 2008-06-21 | Dainippon Sumitomo Pharma Co | Pharmaceutical composition for schizophrenia |
EA006486B1 (ru) * | 2001-01-31 | 2005-12-29 | Х. Лундбекк А/С | Применение антагонистов рецептора gal3 при лечении депрессии и/или тревоги и соединения, полезные в таких способах |
DE10124953A1 (de) * | 2001-05-21 | 2002-12-12 | Marlies Knipper | Substanz für die therapeutische Behandlung von Tinnitus |
CA2461603A1 (fr) * | 2001-09-24 | 2003-04-03 | Elan Pharmaceuticals, Inc. | Amines substituees pour le traitement de la maladie d'alzheimer |
DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
ES2316777T3 (es) * | 2002-02-15 | 2009-04-16 | Glaxo Group Limited | Moduladores de receptores vainilloides. |
TWI314041B (en) * | 2002-10-21 | 2009-09-01 | Sankyo Agro Co Ltd | Quinolyl-3-carboxamide compound |
CA2513824A1 (fr) * | 2003-01-31 | 2004-08-19 | Astrazeneca Ab | Derives de quinoxaline satures et leur utilisation en tant que ligands du recepteur du glutamate metabotropique |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
US7932272B2 (en) | 2003-09-30 | 2011-04-26 | Eisai R&D Management Co., Ltd. | Antifungal agent containing heterocyclic compound |
ES2476840T3 (es) * | 2005-03-04 | 2014-07-15 | F. Hoffmann-La Roche Ag | Derivados de piridina-2-carboxamida como antagonistas de MGLUR5 |
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AU2007296964B2 (en) * | 2006-09-11 | 2012-05-31 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutanate receptors |
EP2091944B1 (fr) | 2006-11-17 | 2011-05-18 | Pfizer Inc. | Composés bicyclocarboxyamides substitués |
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TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
EP2139879B1 (fr) | 2007-03-22 | 2012-07-11 | AstraZeneca AB | Dérivés de quinoléine destinés au traitement de maladies inflammatoires |
SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
MX2010003913A (es) * | 2007-10-12 | 2010-04-27 | Novartis Ag | Moduladores de los receptores de glutamato metabotropicos para el tratamiento de enfermedades de parkinson. |
US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
KR20110036797A (ko) * | 2008-07-25 | 2011-04-11 | 하. 룬트벡 아크티에 셀스카브 | 아다만틸 디아미드 유도체 및 이의 용도 |
RU2510396C2 (ru) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов |
CA2742042A1 (fr) | 2008-10-23 | 2010-04-29 | Vertex Pharmaceuticals Incorporated | Modulateurs du regulateur de la conductance transmembranaire de la mucoviscidose |
US8513282B2 (en) | 2008-10-23 | 2013-08-20 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
US8927549B2 (en) | 2008-11-21 | 2015-01-06 | High Point Pharmaceuticals, Llc | Adamantyl benzamide derivatives |
EP2373649B1 (fr) | 2008-11-28 | 2013-01-23 | Janssen Pharmaceuticals, Inc. | Dérivés d'indole et de benzoxazine comme modulateurs des récepteurs métabotropiques au glutamate |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
CA2760741C (fr) | 2009-05-12 | 2018-05-01 | Addex Pharma S.A. | Derives de 1,2,3-triazolo[4,3-a]pyridine et leur utilisation pour le traitement ou la prevention de troubles neurologiques et psychiatriques |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
WO2011087758A1 (fr) * | 2009-12-22 | 2011-07-21 | H. Lundbeck A/S | Dérivés amide de l'adamantyle et utilisations associées |
EP2544688B1 (fr) | 2010-03-02 | 2016-09-07 | President and Fellows of Harvard College | Procédés et compositions pour le traitement du syndrome d'angelman |
WO2011150380A1 (fr) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Méthodes de traitement du syndrome de l'x fragile, du syndrome de down, de l'autisme et des troubles associés |
WO2012009646A1 (fr) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Méthodes de traitement du syndrome de l'x fragile, du syndrome de down, de l'autisme et de troubles associés |
US8513430B2 (en) | 2010-07-27 | 2013-08-20 | High Point Pharmaceuticals, Llc | Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators |
WO2012054724A1 (fr) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Méthodes de traitement de troubles épileptiques |
CA2814998C (fr) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | Derives de 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2 |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
JP5617799B2 (ja) | 2010-12-07 | 2014-11-05 | 信越化学工業株式会社 | 化学増幅レジスト材料及びパターン形成方法 |
TWI538905B (zh) | 2010-12-22 | 2016-06-21 | H 朗德貝克公司 | 雙環[3.2.1]辛基醯胺衍生物及其用途 |
WO2012158474A1 (fr) * | 2011-05-17 | 2012-11-22 | Merck Sharp & Dohme Corp. | Modulateurs allostériques positifs du récepteur m1 au quinoline-amide à liaison n |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
ME03518B (fr) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Combinaisons comprenant des modulateurs allostériques positifs de sous-type 2 de récepteurs glutamatergiques métabotropes et leur utilisation |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
KR102529578B1 (ko) * | 2014-08-29 | 2023-05-09 | (주)아모레퍼시픽 | 신규 아다만탄 유도체 화합물 |
CN104860901B (zh) * | 2015-04-20 | 2017-04-19 | 北京工业大学 | 一种苯并噻唑‑2‑羧酸的制备方法 |
WO2017103851A1 (fr) * | 2015-12-17 | 2017-06-22 | Astex Therapeutics Limited | Quinoléine-3-carboxamides utilisés comme inhibiteurs de h-pgds |
JP7185631B2 (ja) | 2017-02-03 | 2022-12-07 | サータ セラピューティクス プロプライエタリー リミテッド | 抗線維化化合物 |
TW201908311A (zh) | 2017-06-13 | 2019-03-01 | 英商葛蘭素史克智慧財產發展有限公司 | 化合物 |
CN111269203A (zh) * | 2018-12-04 | 2020-06-12 | 上海中泽医药科技有限公司 | N-环己基-呋喃-2-甲酰胺类化合物及制法和应用 |
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GB1329447A (en) * | 1969-10-27 | 1973-09-05 | Squibb & Sons Inc | 4-adamantylaminoalkylamino-2-styryl-quinolines salts and derivatives thereof |
WO1996005818A1 (fr) * | 1994-08-19 | 1996-02-29 | Nps Pharmaceuticals, Inc. | Procedes et composes actifs au niveau des recepteurs de glutamate metabotropiques, destines au traitement d'affections et de troubles neurologiques |
JPH10504569A (ja) * | 1994-08-24 | 1998-05-06 | イーライ・リリー・アンド・カンパニー | 向代謝性グルタメート受容体拮抗剤としてのピロリジニルジカルボン酸誘導体 |
US5707985A (en) * | 1995-06-07 | 1998-01-13 | Tanabe Seiyaku Co. Ltd. | Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators |
AU710128B2 (en) | 1995-07-26 | 1999-09-16 | Astrazeneca Ab | Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases |
WO1999003822A1 (fr) * | 1997-07-18 | 1999-01-28 | Georgetown University | Ligands des recepteurs bicycliques metabotropiques du glutamate |
CA2311131A1 (fr) * | 1997-11-21 | 1999-06-03 | Nps Pharmaceuticals, Inc. | Antagonistes des recepteurs du glutamate metabotropes, utilises pour le traitement de maladies du systeme nerveux central |
-
2000
- 2000-06-02 CN CN00810658A patent/CN1361768A/zh active Pending
- 2000-06-02 CH CH00936465T patent/CH1196397H1/de unknown
- 2000-06-02 DK DK00936465T patent/DK1196397T3/da active
- 2000-06-02 WO PCT/US2000/015222 patent/WO2000073283A1/fr active IP Right Grant
- 2000-06-02 JP JP2000621349A patent/JP2003500480A/ja active Pending
- 2000-06-02 CN CNA2005101186507A patent/CN1789246A/zh active Pending
- 2000-06-02 NZ NZ515894A patent/NZ515894A/xx unknown
- 2000-06-02 DE DE60022050T patent/DE60022050C5/de not_active Expired - Fee Related
- 2000-06-02 EP EP00936465A patent/EP1196397B1/fr not_active Expired - Lifetime
- 2000-06-02 MX MXPA01012445A patent/MXPA01012445A/es active IP Right Grant
- 2000-06-02 IL IL14687100A patent/IL146871A0/xx unknown
- 2000-06-02 EP EP05017791A patent/EP1595871A3/fr not_active Withdrawn
- 2000-06-02 CA CA002376024A patent/CA2376024A1/fr not_active Abandoned
- 2000-06-02 AU AU51780/00A patent/AU778063C/en not_active Ceased
- 2000-06-02 ES ES00936465T patent/ES2249272T3/es not_active Expired - Lifetime
- 2000-06-02 AT AT00936465T patent/ATE302194T1/de not_active IP Right Cessation
-
2003
- 2003-01-30 HK HK03100778.5A patent/HK1048635A1/zh unknown
-
2005
- 2005-02-11 AU AU2005200633A patent/AU2005200633A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2376024A1 (fr) | 2000-12-07 |
EP1595871A3 (fr) | 2005-11-30 |
AU778063B2 (en) | 2004-11-11 |
MXPA01012445A (es) | 2003-09-10 |
EP1595871A2 (fr) | 2005-11-16 |
AU2005200633A1 (en) | 2005-03-17 |
ATE302194T1 (de) | 2005-09-15 |
ES2249272T3 (es) | 2006-04-01 |
HK1048635A1 (zh) | 2003-04-11 |
JP2003500480A (ja) | 2003-01-07 |
IL146871A0 (en) | 2002-08-14 |
EP1196397A1 (fr) | 2002-04-17 |
AU5178000A (en) | 2000-12-18 |
NZ515894A (en) | 2003-09-26 |
EP1196397B1 (fr) | 2005-08-17 |
CN1361768A (zh) | 2002-07-31 |
CN1789246A (zh) | 2006-06-21 |
CH1196397H1 (de) | 2007-05-31 |
DE60022050T2 (de) | 2006-06-14 |
AU778063C (en) | 2005-12-15 |
DE60022050D1 (de) | 2005-09-22 |
WO2000073283A1 (fr) | 2000-12-07 |
DE60022050C5 (de) | 2007-10-11 |
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