DK118791D0 - 1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler - Google Patents
1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidlerInfo
- Publication number
- DK118791D0 DK118791D0 DK911187A DK118791A DK118791D0 DK 118791 D0 DK118791 D0 DK 118791D0 DK 911187 A DK911187 A DK 911187A DK 118791 A DK118791 A DK 118791A DK 118791 D0 DK118791 D0 DK 118791D0
- Authority
- DK
- Denmark
- Prior art keywords
- oner
- preparation
- benzopyrane
- benzoxazine
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28779688A | 1988-12-21 | 1988-12-21 | |
PCT/US1989/005526 WO1990006921A1 (en) | 1988-12-21 | 1989-12-15 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
Publications (2)
Publication Number | Publication Date |
---|---|
DK118791A DK118791A (da) | 1991-06-19 |
DK118791D0 true DK118791D0 (da) | 1991-06-19 |
Family
ID=23104392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK911187A DK118791D0 (da) | 1988-12-21 | 1991-06-19 | 1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0459983A1 (da) |
JP (1) | JPH04502322A (da) |
AU (1) | AU634994B2 (da) |
DK (1) | DK118791D0 (da) |
FI (1) | FI912995A0 (da) |
HU (2) | HUT58310A (da) |
RU (1) | RU2118321C1 (da) |
WO (1) | WO1990006921A1 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69127690T2 (de) * | 1990-06-20 | 1998-02-12 | Pharmacia & Upjohn Company Kal | Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate |
US5302613A (en) * | 1990-06-29 | 1994-04-12 | The Upjohn Company | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
US5252735A (en) * | 1990-06-29 | 1993-10-12 | The Upjohn Company | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
ATE128128T1 (de) * | 1990-06-29 | 1995-10-15 | Upjohn Co | Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one. |
IL112764A0 (en) * | 1994-03-18 | 1995-05-26 | Ferrer Int | New chromene derivatives |
CA2182932A1 (en) * | 1995-08-10 | 1997-02-11 | Koju Watanabe | Chromone derivative, process for preparing same and pharmaceutical composition |
DE19850131A1 (de) * | 1998-10-30 | 2000-05-04 | Merck Patent Gmbh | Chromenon- und Chromanonderivate |
AU3704400A (en) * | 1999-03-04 | 2000-09-21 | E.I. Du Pont De Nemours And Company | Fused bicyclic oxazinone and thiazinone fungicides |
EP1257537B1 (en) | 2000-01-24 | 2007-05-30 | AstraZeneca AB | Therapeutic morpholino-substituted compounds |
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
PL211300B1 (pl) | 2002-04-17 | 2012-05-31 | Cytokinetics Inc | Związek i kompozycja zawierająca ten związek |
JP2005533119A (ja) | 2002-07-17 | 2005-11-04 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
CN100430389C (zh) * | 2002-08-16 | 2008-11-05 | 阿斯利康(瑞典)有限公司 | 抑制磷酸肌醇3-激酶β |
JP4646626B2 (ja) | 2002-08-16 | 2011-03-09 | アストラゼネカ アクチボラグ | ホスホイノシチド3−キナーゼβの阻害 |
KR101099409B1 (ko) | 2003-06-06 | 2011-12-27 | 아렉시스 악티에볼라그 | 피부 상태 또는 암 치료를 위한 scce 저해제로서의융합된 헤테로사이클 화합물의 용도 |
CN100518740C (zh) * | 2003-06-06 | 2009-07-29 | 阿里克斯股份公司 | 杂环化合物作为scce抑制剂的制药用途 |
KR20060066722A (ko) | 2003-08-13 | 2006-06-16 | 쿠도스 파마슈티칼스 리미티드 | 아미노피론 및 atm억제제로서의 이의 용도 |
CA2546920A1 (en) * | 2003-12-09 | 2005-06-23 | Joel Moss | Methods for suppressing an immune response or treating a proliferative disorder |
US20070238731A1 (en) | 2004-09-20 | 2007-10-11 | Kudos Pharmaceuticals Limited | Dna-Pk Inhibitors |
CN101115747A (zh) | 2005-02-09 | 2008-01-30 | 库多斯药物有限公司 | Atm抑制剂 |
AR054438A1 (es) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
EP2208728A4 (en) * | 2007-09-19 | 2011-12-21 | Inst Med Molecular Design Inc | HETEROCYCLIC DERIVATIVE DERIVATIVE DERIVATIVE TO 11 -? - HYDROXYSTEROIDDEHYDROGENASE TYPE I |
US9326986B2 (en) * | 2008-09-29 | 2016-05-03 | Glaxosmithkline Llc | Quinazolinone, quinolone and related analogs as sirtuin modulators |
US8399460B2 (en) | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
US8530470B2 (en) | 2011-04-13 | 2013-09-10 | Astrazeneca Ab | Chromenone derivatives |
RU2468018C1 (ru) * | 2011-10-06 | 2012-11-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | Способ получения производных 4-оксо-4h-хроменов, содержащих винильную и енаминную группировки |
ES2648154T3 (es) * | 2012-01-26 | 2017-12-28 | Daiichi Sankyo Company, Limited | Derivado de cromona que tiene un efecto promotor de la osteogénesis |
WO2014030688A1 (ja) * | 2012-08-24 | 2014-02-27 | 第一三共株式会社 | 鎖状側鎖を有するクロモン誘導体 |
RU2666999C2 (ru) | 2013-03-04 | 2018-09-13 | Астразенека Аб | Комбинированное лечение |
CN108947952B (zh) * | 2017-05-24 | 2021-09-21 | 中国医学科学院药物研究所 | 2-取代氨基-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物及其制备方法和用途 |
CN108929329B (zh) * | 2017-05-24 | 2020-12-11 | 中国医学科学院药物研究所 | 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物 |
AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
AU2022268900A1 (en) | 2021-05-03 | 2023-11-16 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
TWI829179B (zh) | 2021-05-27 | 2024-01-11 | 美商佩特拉製藥公司 | 用於治療疾病之磷酸肌醇3-激酶(pi3k)異位色烯酮抑制劑 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2205913A1 (de) * | 1972-02-08 | 1973-08-16 | Thiemann Chem Pharm Fab | 2-amino-3-hydroxy-chromon-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE2555290A1 (de) * | 1975-12-09 | 1977-06-16 | Boehringer Mannheim Gmbh | Neue benzopyron-derivate und verfahren zu ihrer herstellung |
US4412071A (en) * | 1982-05-17 | 1983-10-25 | The Upjohn Company | Antiatherosclerotic compositions |
ZA873745B (en) * | 1986-06-04 | 1988-10-26 | Daiichi Seiyaku Co | Benzopyran derivatives |
IL89840A (en) * | 1988-04-06 | 1996-10-31 | Lipha | Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them |
-
1989
- 1989-12-15 HU HU90394A patent/HUT58310A/hu unknown
- 1989-12-15 EP EP90900649A patent/EP0459983A1/en not_active Ceased
- 1989-12-15 AU AU48071/90A patent/AU634994B2/en not_active Ceased
- 1989-12-15 WO PCT/US1989/005526 patent/WO1990006921A1/en not_active Application Discontinuation
- 1989-12-15 JP JP2501394A patent/JPH04502322A/ja active Pending
- 1989-12-15 RU SU4895676A patent/RU2118321C1/ru active
-
1991
- 1991-06-19 DK DK911187A patent/DK118791D0/da not_active Application Discontinuation
- 1991-06-19 FI FI912995A patent/FI912995A0/fi unknown
-
1995
- 1995-06-23 HU HU95P/P00411P patent/HU211339A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
HU900394D0 (en) | 1991-09-30 |
JPH04502322A (ja) | 1992-04-23 |
RU2118321C1 (ru) | 1998-08-27 |
AU4807190A (en) | 1990-07-10 |
EP0459983A1 (en) | 1991-12-11 |
WO1990006921A1 (en) | 1990-06-28 |
HUT58310A (en) | 1992-02-28 |
DK118791A (da) | 1991-06-19 |
AU634994B2 (en) | 1993-03-11 |
HU211339A9 (en) | 1995-11-28 |
FI912995A0 (fi) | 1991-06-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |